Clinical Trials on Motor Neuron Disease

Total 380065 results

Merit E. Cudkowicz, MD
Calico Life Sciences LLC

Enrolling by invitation

HEALEY ALS Platform Trial - Regimen F ABBV-CLS-7262

Amyotrophic Lateral Sclerosis

United States
Merit E. Cudkowicz, MD
Seelos Therapeutics, Inc.

Completed

HEALEY ALS Platform Trial - Regimen E SLS-005 - Trehalose

Amyotrophic Lateral Sclerosis

United States
Merit E. Cudkowicz, MD
Prilenia Therapeutics

Completed

HEALEY ALS Platform Trial - Regimen D Pridopidine

Amyotrophic Lateral Sclerosis

United States
Merit E. Cudkowicz, MD
Ra Pharmaceuticals

Completed

HEALEY ALS Platform Trial - Regimen A Zilucoplan

Amyotrophic Lateral Sclerosis

United States
Merit E. Cudkowicz, MD
Biohaven Pharmaceuticals, Inc.

Completed

HEALEY ALS Platform Trial - Regimen B Verdiperstat

Amyotrophic Lateral Sclerosis

United States
Seoul National University Bundang Hospital

Active, not recruiting

Factors Associated With Success of NIPPV in ALS Patients

ALS

Korea, Republic of
Orion Corporation, Orion Pharma

Completed

Effects of Oral Levosimendan (ODM-109) on Respiratory Function in Patients With ALS (REFALS)

Amyotrophic Lateral Sclerosis

Canada, United States, Australia, Austria, United Kingdom, Germany, Finland, Spain, France, Italy, Sweden, Netherlands, Belgium, Ireland
University of Florida
ALS Association; Holy Cross Hospital, Florida

Completed

Impact of Nuedexta on Bulbar Physiology and Function in ALS

Amyotrophic Lateral Sclerosis

United States
Istituti Clinici Scientifici Maugeri SpA
Azienda Ospedaliera Città della Salute e della Scienza di Torino

Completed

Italian Validation of the Beaumont Behavioural Inventory (BBI) (BBI)

Amyotrophic Lateral Sclerosis

Italy
Peking University Third Hospital

Completed

Investigation on Home Care Needs of ALS Patients and Their Caregivers

Amyotrophic Lateral Sclerosis

China
Knopp Biosciences
Biogen

Completed

Dexpramipexole Japanese PK Study

Amyotrophic Lateral Sclerosis

United Kingdom
University of Missouri-Columbia
Band of Hope Foundation

Completed

Open Label Study: Treatment of ALS Fatigue With PolyMVA

Amyotrophic Lateral Sclerosis

United States
University of Kansas Medical Center

Completed

ALS Study Determining Various Biomarkers and Strength Comparison After Exercise (ADVANCE)

Amyotrophic Lateral Sclerosis

United States
University of Aarhus
Aarhus University Hospital; University of Aalborg, Denmark; The Danish National... and other collaborators

Unknown

Restore Motor Function Through Robotic Arm Exoskeleton and Brain Computer Interface (REMAP)

Amyotrophic Lateral Sclerosis

Denmark
University of Michigan

Completed

Developing a Discrimination Model to Diagnose ALS

Amyotrophic Lateral Sclerosis

United States
Royan Institute

Completed

Intravenous Injection of Adipose Derived Mesenchymal Stem Cell for ALS

Amyotrophic Lateral Sclerosis

Iran, Islamic Republic of
Massachusetts General Hospital
ALS Association

Completed

Longitudinal Study of Outcomes Measures in ALS Trials

Amyotrophic Lateral Sclerosis

United States
University of Roma La Sapienza

Completed

Acetylcholine Receptors From Human Muscles as Pharmacological Target for ALS (AchALS)

Amyotrophic Lateral Sclerosis
Knopp Biosciences

Completed

Dexpramipexole SAD/MAD Study

Amyotrophic Lateral Sclerosis

United States
Knopp Biosciences

Completed

Study to Evaluate the QTC Interval in Healthy Volunteers Dosed With Dexpramipexole (QTC = Electrocardiogram (ECG) Interval Measured From the Onset of the QRS Complex to the End of the T Wave Corrected for Heart Rate)

Amyotrophic Lateral Sclerosis

United States
Johns Hopkins University
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Noninvasive Ventilation in ALS Patients With Mild Respiratory Involvement

Amyotrophic Lateral Sclerosis

United States
NeuroSense Therapeutics Ltd.

Active, not recruiting

A Phase IIb, Multi-Center, Multinational, Double-Blind, Placebo-Controlled Study, With an Open Label Extension, to Evaluate Safety, Tolerability and Efficacy of PrimeC in Subjects With ALS (PARADIGM)

Amyotrophic Lateral Sclerosis | ALS

Israel, Italy, Canada
Amylyx Pharmaceuticals Inc.
Massachusetts General Hospital Neurology Clinical Research Institute

Completed

Open Label Extension Study of AMX0035 in Patients With ALS (CENTAUR-OLE)

Amyotrophic Lateral Sclerosis | ALS

United States
Richard Bedlack, M.D., Ph.D.
Ultragenyx Pharmaceutical Inc

Completed

A Pilot Trial of Triheptanoin for People With Amyotrophic Lateral Sclerosis (PALS)

ALS

United States
University of Kansas Medical Center
Gilead Sciences

Unknown

Safety and Efficacy of Ranolazine for the Treatment of Amyotrophic Lateral Sclerosis

ALS

United States
Biogen

Recruiting

Observational, Postmarketing Surveillance Study of Spinraza Injection (Nusinersen Sodium) (STANDARD)

Muscular Atrophy, Spinal

Korea, Republic of
Fondazione Policlinico Universitario Agostino Gemelli...

Completed

Ultrasound-assisted vs Landmark Based Intrathecal Administration of Nusinersen

Muscular Atrophy, Spinal | Ultrasound

Italy
Hoffmann-La Roche

Completed

Bioavailability and Bioequivalence of Two Risdiplam Tablets in Healthy Participants

Muscular Atrophy, Spinal

United States
Hoffmann-La Roche

Completed

A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics and Safety and Tolerability of a Single Oral Dose of Risdiplam Compared to Matched Healthy Participants With Normal Hepatic Function

Muscular Atrophy, Spinal

United States
Barrow Neurological Institute
Massachusetts General Hospital; Genentech, Inc.; ALS Association; Barrow Neurological...

Completed

A Trial of Tocilizumab in ALS Subjects (TCZALS-001)

Motor Neuron Disease | Amyotrophic Lateral Sclerosis | ALS | Lou Gehrig's Disease

United States
Mayo Clinic
National Institute of Neurological Disorders and Stroke (NINDS)

Recruiting

Biospecimen Biorepository for the Study of ALS, ALS-FTD and Similar Neurodegenerative Disorders

Amyotrophic Lateral Sclerosis

United States
Columbia University

Recruiting

Amyotrophic Lateral Sclerosis (ALS) Families Project

ALS

United States
Mitsubishi Tanabe Pharma America Inc.
Massachusetts General Hospital

Active, not recruiting

Radicava® (Edaravone) Findings in Biomarkers From ALS (REFINE-ALS)

Amyotrophic Lateral Sclerosis | ALS

United States, Canada
University of Michigan
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

A P300 Brain Computer Interface to Operate Power Wheelchair Tilt

Healthy | Amyotrophic Lateral Sclerosis
Teva Branded Pharmaceutical Products R&D, Inc.

Completed

Talampanel for Amyotrophic Lateral Sclerosis (ALS) (ALS)

ALS

United States, Netherlands, Canada, Italy, Spain, Belgium, France, Germany, Hungary, Israel
AGIR à Dom

Not yet recruiting

Satisfaction of Patients With Amyotrophic Lateral Sclerosis Regarding Home Assisted Teleconsultation (VNI_SLA)

ALS | Charcot Disease

France
Biogen

Recruiting

A Study of Spinraza (Nusinersen) Exposure in Pregnant Women With Spinal Muscular Atrophy (SMA) Within Existing SMA Registries

Muscular Atrophy, Spinal

United States
Biogen

Completed

Non-Interventional, Postmarketing Surveillance Study of Nusinersen Sodium Injection (PANDA)

Muscular Atrophy, Spinal

China
Indiana University School of Medicine
Cure SMA

Completed

International SMA Patient Registry

Muscular Atrophy, Spinal

United States
University Hospital Freiburg
Novo Nordisk A/S

Completed

Pilot Study of Growth Hormon to Treat SMA Typ II and III

Muscular Atrophy, Spinal

Germany
Aalborg University Hospital
University of Aarhus

Not yet recruiting

Structural and Functional Networks in ALS: An Insight Into Pseudobulbar Affect

Amyotrophic Lateral Sclerosis | Pseudobulbar Affect
University Hospital, Angers

Recruiting

Social Cognition in Patients With Amyotrophic Lateral Sclerosis (COSISLA)

Social Cognition

France
Centre Hospitalier Universitaire de Nice

Recruiting

Development and Test of a Headset for BCI Until Obtaining an Efficient and Comfortable System That Can be Used in Daily Practice by ALS People (TECH-ICOPA)

Nervous System Diseases | Neuromuscular Diseases | Neurodegenerative Diseases | Motor Neuron Disease | Amyotrophic Lateral Sclerosis | Spinal Cord Diseases | Alternative Communication Devices

France
Hadassah Medical Organization

Recruiting

Investigation of the Epidemiological Factors Associated With the Development of Amyotrophic Lateral Sclerosis (ALS) (EpidALS)

ALS

Israel
NeuroSense Therapeutics Ltd.

Completed

Open Label Study to Evaluate Ciprofloxacin/Celecoxib Combination in Patients With ALS

Amyotrophic Lateral Sclerosis | ALS

Israel
Tokyo Medical University

Completed

Perampanel for Sporadic Amyotrophic Lateral Sclerosis (ALS)

ALS

Japan
Milton S. Hershey Medical Center

Completed

Remote Pulmonary Function Testing in Amyotrophic Lateral Sclerosis (Pilot)

ALS

United States
University of North Carolina, Chapel Hill

Completed

Analysis of Post-Translational Modifications of a Critical Protein Implicated in Amyotrophic Lateral Sclerosis (SOD1)

ALS

United States
US Department of Veterans Affairs
ALS Association

Completed

National Registry of Veterans With Amyotrophic Lateral Sclerosis and DNA Bank (ALS Registry)

ALS

United States
Fondazione Policlinico Universitario Agostino Gemelli...
University of Messina; Istituto Giannina Gaslini; University of Milan; Ospedale...

Recruiting

Natural History of SMA (iSMAR)

Muscular Atrophy, Spinal

Italy

Clinical Trials on Motor Neuron Disease

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