Clinical Trials on Myotonic Dystrophy, Type 1 (DM1) in South Africa

Total 159 results

Pfizer

Terminated

Study Of Bosutinib With Capecitabine In Solid Tumors And Locally Advanced Or Metastatic Breast Cancer

Advanced Breast Cancer (Parts 1 and 2) | Advanced Pancreatic Cancer (Part 1) | Advanced Colorectal Cancer (Part 1) | Advanced Cholangiocarcinoma (Part 1) | Advanced Glioblastoma Multiforme (Part 1)

United States, Spain, Hong Kong, Belgium, Australia, France
Erasmus Medical Center
Universitaire Ziekenhuizen KU Leuven; ZonMw: The Netherlands Organisation for... and other collaborators

Terminated

Effect of Lamotrigine on Cognition in NF1 (NF1-EXCEL)

Neurofibromatosis Type 1

Spain, Belgium, Netherlands
Novo Nordisk A/S

Completed

Comparison of Efficacy and Safety of Insulin Detemir and Insulin Glargine in Patients With Type 1 Diabetes

Diabetes | Diabetes Mellitus, Type 1

Germany, Austria, South Africa
National Institute of Diabetes and Digestive and...

Completed

Diabetes Control and Complications Trial (DCCT)

Type 1 Diabetes Mellitus

United States, Canada
Lexicon Pharmaceuticals
Sanofi

Completed

Efficacy, Safety, and Tolerability Study of Sotagliflozin as Adjunct Therapy in Adult Patients With Type 1 Diabetes Mellitus Who Have Inadequate Glycemic Control With Insulin Therapy (inTandem1)

Type 1 Diabetes Mellitus

United States, Canada
Siolta Therapeutics, Inc.

Active, not recruiting

Allergic Disease Onset Prevention Study (adored)

Atopic Dermatitis | Type 1 Hypersensitivity

United States, Australia, Puerto Rico
AstraZeneca

Completed

Clinical Utility and Safety of Pramlintide in Subjects With Type 1 and Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus | Type 1 Diabetes Mellitus

United States
Janssen-Cilag International NV

Completed

A Clinical Trial Comparing the Efficacy of Tenofovir Disoproxil Fumarate/Emtricitabine/Rilpivirine (TDF/FTC/RPV) Versus TDF/FTC/Efavirenz (TDF/FTC/EFV) in Patients With Undetectable Plasma HIV-1 RNA on Current First-line Treatment (SALIF)

Human Immunodeficiency Virus-type 1 Infection

South Africa, Kenya, Thailand, Uganda, Cameroon, Senegal
Medtronic Diabetes

Recruiting

Multi-center Trial in Adult and Pediatric Patients With Type 1 Diabetes Using Hybrid Closed Loop System and Control at Home

Type 1 Diabetes

United States, Spain, New Zealand, Canada, France, Germany, Italy, Sweden, United Kingdom
Mannkind Corporation

Terminated

Safety and Efficacy of Technosphere® Insulin Inhalation Powder and Lantus® Compared to Humalog® and Lantus® Over 16-Weeks

Diabetes, Type 1

United States, Brazil
ViiV Healthcare
GlaxoSmithKline; Janssen Pharmaceuticals

Completed

Study to Assess the Effects of Cabotegravir (CAB) and Rilpivirine (RPV) Long-Acting (LA) Injections Following Sub-cutaneous (SC) Administration Compared With Intramuscular (IM) Administration in Adult Participants Living With Human Immunodeficiency Virus (HIV-1) Infection in the FLAIR Study

Human Immunodeficiency Virus Type 1 (HIV-1)

United States, Spain, Canada, United Kingdom, South Africa, Japan
Sanofi

Completed

Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 1 Diabetes Mellitus (EDITION IV)

Type 1 Diabetes Mellitus

United States, Canada, Czech Republic, Denmark, Estonia, Finland, Hungary, Japan, Latvia, Netherlands, Puerto Rico, Romania, Sweden
Sanofi

Completed

Comparison of SAR342434 to Humalog as the Rapid Acting Insulin in Adult Patients With Type 1 Diabetes Mellitus Also Using Insulin Glargine (SORELLA1)

Type 1 Diabetes Mellitus

Japan, Spain, Germany, United States, France, Hungary, Poland, Russian Federation
Alkermes, Inc.

Recruiting

A Study to Evaluate the Safety and Effectiveness of ALKS 2680 in Subjects With Narcolepsy Type 1 (ALKS 2680-201) (Vibrance-1)

Narcolepsy Type 1

United States
Novo Nordisk A/S

Completed

Efficacy and Safety of Insulin Detemir Versus Neutral Protamine Hagedorn (NPH) Insulin in Pregnant Women With Type 1 Diabetes

Diabetes | Diabetes Mellitus, Type 1

Israel, Poland, United Kingdom, Denmark, Spain, France, Austria, Norway, Russian Federation, Canada, Croatia, Argentina, South Africa, Australia, Ireland, Brazil, Finland
Sanofi

Completed

Comparison of the Safety and Efficacy of HOE901-U300 With Lantus in Children and Adolescents With Type 1 Diabetes Mellitus (EDITION JUNIOR)

Type 1 Diabetes Mellitus

France, Czechia, Chile, Israel, Spain, Hungary, Mexico, Serbia, Japan, Canada, Brazil, Sweden, Denmark, Argentina, United States, Bulgaria, Germany, Italy, Latvia, North Macedonia, Poland, Romania, Russian Federation, United Kingdom
Novo Nordisk A/S

Completed

Comparison of Human Insulin Produced by the Current Process and the NN729 Process in Type 1 Diabetes

Diabetes | Diabetes Mellitus, Type 1

Malaysia, Australia, Hong Kong, Philippines
MacroGenics
Eli Lilly and Company

Terminated

Protege Encore Study- Clinical Trial of Teplizumab (MGA031) in Children and Adults With Recent-Onset Type 1 Diabetes Mellitus

Type 1 Diabetes Mellitus

United States, Israel, United Kingdom, Poland, France, Germany, Belgium, Finland, India, Ukraine, Spain, Czechia, Italy, Mexico, Netherlands, Romania
MacroGenics
Eli Lilly and Company

Completed

The Protégé Study - Clinical Trial of MGA031 in Children and Adults With Recent-Onset Type 1 Diabetes Mellitus

Type 1 Diabetes Mellitus

United States, Spain, Israel, Canada, India, Czechia, Ukraine, Sweden, Latvia, Mexico, Germany, Poland, Romania, Estonia, Netherlands, United Kingdom
Australian and New Zealand Urogenital and Prostate...

Recruiting

ANZUP - Non-clear Cell Post Immunotherapy CABozantinib (UNICAB) (UNICAB)

Renal Cell Carcinoma | Sarcomatoid Renal Cell Carcinoma | Papillary Renal Cell Carcinoma Type 1 | Papillary Renal Cell Carcinoma Type 2 | Chromophobe Renal Cell Carcinoma | Xp11.2 Translocation-Related Renal Cell Carcinoma

Australia
Merck Sharp & Dohme LLC

Active, not recruiting

Oral ISL QM as PrEP in Cisgender Women at High Risk for HIV-1 Infection (MK-8591-022) (Impower-022)

Prophylaxis | Human Immunodeficiency Virus Type 1 | HIV-I

United States, South Africa, Uganda
Regeneron Pharmaceuticals
Bayer

Active, not recruiting

Study of a High-Dose Aflibercept in Participants With Diabetic Eye Disease (PHOTON)

Type 2 Diabetes Mellitus | Diabetic Macular Edema | Type 1 Diabetes Mellitus

United States, Puerto Rico, Japan, United Kingdom, Canada, Czechia, Germany, Hungary
Novo Nordisk A/S

Completed

Long Term Safety Trial to Compare Insulin Treatment With Preprandial Inhaled Human Insulin to s.c. Insulin Aspart Both Combined With NPH in Subjects With Type 1 Diabetes

Diabetes | Diabetes Mellitus, Type 1

Australia
Hoffmann-La Roche

Completed

A Study to Investigate the Efficacy and Safety of RG7774 in Patients With Diabetes Mellitus Type 1 or Type 2 With Treatment-Naive Diabetic Retinopathy (CANBERRA)

Diabetic Retinopathy

United States, United Kingdom, Spain, Poland, Slovakia, Australia, Puerto Rico
Mannkind Corporation

Completed

Clinical Trial Evaluating Technosphere® Insulin Versus Insulin Aspart in Subjects With Type 1 Diabetes Mellitus Over a 24-week Treatment Period

Type 1 Diabetes Mellitus

United States, Brazil, Russian Federation, Ukraine
Eli Lilly and Company

Completed

A Study in Participants With Type I Diabetes Mellitus (IMAGINE 3)

Diabetes Mellitus, Type 1

United Kingdom, United States, Australia, Canada, Poland, Denmark, Spain, Croatia, Sweden, Greece, Belgium, France, New Zealand, South Africa, Israel, Brazil, Ireland, Netherlands, Lithuania, Slovakia
Novo Nordisk A/S

Completed

Comparison of Two NN1250 Formulations Versus Insulin Glargine, All in Combination With Insulin Aspart in Subjects With Type 1 Diabetes

Diabetes | Diabetes Mellitus, Type 1

United States, Sweden, Norway, Germany, Australia
Provention Bio, a Sanofi Company

Recruiting

Teplizumab in Pediatric Stage 2 Type 1 Diabetes (PETITE-T1D)

Diabetes Mellitus, Type 1

United States
Akcea Therapeutics
Ionis Pharmaceuticals, Inc.

Completed

The Approach Open Label Study: A Study of Volanesorsen (Formerly IONIS-APOCIIIRx) in Participants With Familial Chylomicronemia Syndrome

Familial Chylomicronemia Syndrome | Lipoprotein Lipase Deficiency | Hyperlipoproteinemia Type 1

United States, Canada, Germany, Israel, Italy, South Africa, Spain, United Kingdom, Brazil, France, Netherlands
Australian and New Zealand Urogenital and Prostate...
Bristol-Myers Squibb

Active, not recruiting

Phase II Sequential Treatment Trial of Single Agent Nivolumab, Then Combination Ipilimumab + Nivolumab in Metastatic or Unresectable Non-Clear Cell Renal Cell Carcinoma (ANZUP1602) (UNISoN)

Renal Cell Carcinoma | Sarcomatoid Renal Cell Carcinoma | Papillary Renal Cell Carcinoma Type 1 | Papillary Renal Cell Carcinoma Type 2 | Chromophobe Renal Cell Carcinoma | Xp11 Translocation Carcinoma

Australia
Mannkind Corporation

Completed

Safety of Inhaled Insulin With Type 1 and Type 2 Diabetes

Diabetes, Type 2 | Diabetes, Type 1

United States, Spain, Canada, Russian Federation, Czech Republic, Poland, Ukraine, United Kingdom
Takeda

Terminated

A Study of TAK-994 in Adults With Narcolepsy

Narcolepsy Type 1 (NT 1)

United States, Italy, Finland, Canada, Hungary, Czechia, France, Japan, Korea, Republic of, Spain
Novo Nordisk A/S

Completed

Comparison of NN1250 Plus Insulin Aspart With Insulin Glargine Plus Insulin Aspart in Type 1 Diabetes (BEGIN™)

Diabetes | Diabetes Mellitus, Type 1

United States, France, United Kingdom, Russian Federation, Germany, South Africa
Boehringer Ingelheim
Eli Lilly and Company

Completed

Empagliflozin as Adjunctive to Insulin Therapy Over 26 Weeks in Patients With T1DM (EASE-3)

Diabetes Mellitus, Type 1

United States, United Kingdom, Canada, Italy, Hungary, Spain, Sweden, Australia, Netherlands, France, Czechia, Finland, Germany, Greece, Ireland, Latvia, Mexico, New Zealand, Norway, Poland, Portugal, Romania, Russian Federation, South...
University of Alabama at Birmingham
National Cancer Institute (NCI); Children's Hospital of Philadelphia; Washington... and other collaborators

Completed

A Randomized Placebo-Controlled Study of Lovastatin in Children With Neurofibromatosis Type 1 (STARS)

Neurofibromatosis Type 1

United States, Australia
Grifols Therapeutics LLC

Terminated

Study of Human Plasma-Derived Alpha1-Proteinase Inhibitor in Subjects With New-Onset Type 1 Diabetes Mellitus

Type 1 Diabetes Mellitus

United States
Tibotec Pharmaceuticals, Ireland

Completed

TMC278-TiDP6-C209: A Clinical Trial in Treatment Naive HIV-1 Patients Comparing TMC278 to Efavirenz in Combination With Tenofovir + Emtricitabine.

HIV Infections | HIV-1 | Human Immunodeficiency Virus Type 1

United States, Australia, France, United Kingdom, Taiwan, Spain, Argentina, Portugal, Romania, South Africa, Canada, Denmark, Sweden, Netherlands, Brazil, Puerto Rico, Austria, Russian Federation, Thailand, Mexico
Synvista Therapeutics, Inc
Juvenile Diabetes Research Foundation

Terminated

Study of Alagebrium in Patients With Insulin-Dependent Type 1 Diabetes and Microalbuminuria

Diabetes Mellitus, Type 1 | Diabetic Nephropathy

Australia, Denmark
Precigen Actobio T1D, LLC
TFS Trial Form Support; Intrexon Actobiotics NV, d/b/a Precigen Actobio

Completed

A Study to Assess the Safety and Tolerability of Different Doses of AG019 Administered Alone or in Combination With Teplizumab in Participants With Recently Diagnosed Type 1 Diabetes Mellitus (T1D)

Diabetes Mellitus, Type 1

United States, Belgium
Mannkind Corporation

Terminated

Evaluate Safety of Technosphere® Insulin (TI) in Diabetic Subjects With Moderate Obstructive Pulmonary Disease

Type 2 Diabetes Mellitus | Asthma | Type 1 Diabetes Mellitus | Moderate Chronic Obstructive Pulmonary Disease

United States, Russian Federation, Ukraine
Sanford Health
National Ataxia Foundation; Beyond Batten Disease Foundation; Pitt Hopkins Research... and other collaborators

Recruiting

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford (CoRDS)

Mitochondrial Diseases | Retinitis Pigmentosa | Myasthenia Gravis | Eosinophilic Gastroenteritis | Multiple System Atrophy | Leiomyosarcoma | Leukodystrophy | Anal Fistula | Spinocerebellar Ataxia Type 3 | Friedreich Ataxia | Kennedy Disease | Lyme Disease | Hemophagocytic Lymphohistiocytosis | Spinocerebellar Ataxia... and other conditions

United States, Australia
Novo Nordisk A/S

Completed

A Trial Investigating the Efficacy and Safety of Insulin Degludec in Children and Adolescents With Type 1 Diabetes Mellitus (BEGIN™)

Diabetes | Diabetes Mellitus, Type 1

Germany, France, United States, Japan, Netherlands, Russian Federation, Bulgaria, United Kingdom, North Macedonia, South Africa, Italy, Finland
Novo Nordisk A/S

Completed

Comparison of NN5401 Plus Insulin Aspart With Insulin Detemir Plus Insulin Aspart in Type 1 Diabetes (BOOST™)

Diabetes | Diabetes Mellitus, Type 1

United States, Poland, Puerto Rico, Russian Federation, United Kingdom, Denmark, France, Israel, Australia, Romania
Novo Nordisk A/S

Completed

A Trial Investigating the Efficacy and Safety of Insulin Degludec/Insulin Aspart Once Daily Plus Insulin Aspart for the Remaining Meals Versus Insulin Detemir Once or Twice Daily Plus Meal Time Insulin Aspart in Children and Adolescents With Type 1 Diabetes Mellitus

Diabetes | Diabetes Mellitus, Type 1

United States, India, Russian Federation, Belgium, Spain, Israel, Croatia, Serbia, North Macedonia, South Africa, Slovenia, Brazil, Poland, Canada, Czechia
GlaxoSmithKline
Juvenile Diabetes Research Foundation

Terminated

TRX4 Monoclonal Antibody in Type 1 Diabetes (T1 DM) (TTEDD)

Diabetes Mellitus, Type 1

United States, Canada
Bayer

Recruiting

A Study to Learn How Well the Study Treatment Finerenone Works and How Safe it is in People With Long-term Decrease in the Kidneys' Ability to Work Properly (Chronic Kidney Disease) Together With Type 1 Diabetes (FINE-ONE)

Chronic Kidney Disease | Type 1 Diabetes Mellitus

United Kingdom, United States, Korea, Republic of, Denmark, Germany, Italy, China, Spain, Canada
Takeda
Takeda Development Center Americas, Inc.

Completed

Wake and Sleep State Transitions on a Portable Electroencephalogram (EEG) Device in Narcolepsy Type 1 (NT1) and Healthy Participants

Healthy Volunteers | Narcolepsy Type 1

United States
Takeda

Recruiting

A Study of TAK-861 for the Treatment of Selected Central Hypersomnia Conditions

Narcolepsy Type 1 | Narcolepsy Type 2

Spain, Germany, United States, Italy, Netherlands, Japan, France, Norway, Australia, Finland, Switzerland, Sweden
Memorial Sloan Kettering Cancer Center
Fox Chase Cancer Center; Pharmacyclics LLC.

Terminated

Ibrutinib for Patients With Follicular Lymphoma Without Complete Response to Initial Chemoimmunotherapy

Follicular Lymphoma | Follicular Lymphoma, Grade 1 | Follicular Lymphoma, Grade 2 | Follicular Lymphoma Grade IIIa

United States
Queensland Centre for Gynaecological Cancer
The University of Queensland; Queensland University of Technology

Active, not recruiting

Improving the Treatment for Women With Early Stage Cancer of the Uterus (feMMe)

Complex Endometrial Hyperplasia With Atypia | Grade 1 Endometrial Endometrioid Adenocarcinoma

Australia, New Zealand

Clinical Trials on Myotonic Dystrophy, Type 1 (DM1) in South Africa

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Cameroon

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

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