Clinical Trials on Normal, Glaucoma & Retinal Pathology in South Africa

Total 484 results

Qlaris Bio, Inc.

Completed

A Study to Evaluate Safety and Tolerability of QLS-101 in NTG

Normal Tension Glaucoma (NTG)

United States
North-West University, South Africa
Medical Research Council, South Africa; National Research Foundation of South...

Active, not recruiting

Exercise, Arterial Modulation and Nutrition in Youth South Africa Study (ExAMIN-Youth)

Hypertension | Childhood Obesity | Retinal Artery Stenosis

South Africa
Allergan

Completed

Safety and Efficacy of AGN208397 in the Treatment of Macular Edema Associated With Retinal Vein Occlusion (RVO)

Macular Edema | Retinal Vein Occlusion

South Africa, Canada, United States, Australia, Israel
Pharmaceutical Research Network

Completed

Assessing Cosopt Switch Patients

Ocular Hypertension | Open-Angle Glaucoma | Exfoliation Syndrome | Glaucoma, Pigmentary

United States
Allergan

Completed

A Study of the Safety and Efficacy of a New Treatment for Diabetic Macular Edema

Diabetic Macular Edema

Spain, South Africa, Canada, Czech Republic, Germany, Israel, Australia, Portugal, United States, Philippines
Chicago Center for Vision Research

Completed

Study of Medical Treatment of Low-Pressure (Normal Tension) Glaucoma

Glaucoma, Open Angle

United States
Allergan

Completed

Safety and Efficacy Study of Dexamethasone Versus Ranibizumab in Patients With Diabetic Macular Edema

Macular Edema

France, Spain, Belgium, United States, South Africa, Denmark, Netherlands, Israel, Portugal, United Kingdom, Italy, Germany
Allergan

Completed

A Study of the Safety and Efficacy of a New Treatment for Macular Edema Resulting From Retinal Vein Occlusion

Macular Edema | Retinal Vein Occlusion

France, United States, Canada, Taiwan, Australia, Austria, Czechia, Portugal, Germany, Israel, Philippines, Mexico, South Africa
Notal Vision Inc.

Recruiting

Home OCT Guided Management Study of Subjects Diagnosed With Neovascular-AMD

Retinal Neovascularization

United States
University of Sydney

Completed

Open Label Extension of a Clinical Trial of Intravitreal Triamcinolone for Diabetic Macular Oedema-TDMX Study

Diabetic Macular Oedema

Australia
University of Sydney
University of Melbourne; The University of Western Australia; Marsden Eye Specialists

Completed

A Multicentre Randomised Clinical Trial of Laser Treatment Plus Intravitreal Triamcinolone for Diabetic Macular Oedema

Diabetic Macular Oedema

Australia
Advanced Eye Research Associates

Active, not recruiting

Assessment of Biomarker Profile in Diabetic Macular Edema With Intravitreal Aflibercept Injection

Diabetic Macular Edema

United States
University of Sydney

Completed

Intravitreal Triamcinolone for Clinically Significant Diabetic Macular Oedema That Persists After Laser Treatment (TDMO)

Diabetic Macular Oedema

Australia
University of Sydney

Recruiting

Near-Infrared Light Photobiomodulation Treatment for Retinal Vein Occlusion Macular Oedema (NIRVO)

Retinal Vein Occlusion | Macula Edema

Australia
Clement K. Chan

Completed

Ranibizumab for Treating Submacular Vascularized Pigment Epithelial Detachments

Retinal Pigment Epithelial Detachment

United States
Allergan

Completed

Study of OZURDEX® in the Treatment of Diabetic Macular Oedema (DME) in Australia - The AUSSIEDEX Study

Diabetic Macular Oedema

Australia
Ripple Therapeutics Pty Ltd
Novotech (Australia) Pty Limited

Active, not recruiting

Safety and Efficacy of IBE-814 Intravitreal (IVT) Implant - A Sustained, Low Dose Dexamethasone Therapy

Diabetic Macular Oedema | Retinal Vein Occlusion With Macular Oedema

Australia, New Zealand, Hong Kong, Canada
Novartis Pharmaceuticals

Completed

A Comparison of Ranibizumab and Aflibercept for the Development of Geographic Atrophy in (Wet) AMD Patients (RIVAL)

Age-Related Macular Degeneration

Australia
University of Sydney

Completed

Near Infrared Photobiomodulation Treatment for Diabetic Macular Oedema (NIRD)

Diabetic Macular Oedema

Australia
Palmetto Retina Center, LLC
Pfizer; Eyetech Pharmaceuticals

Completed

Evaluation of Macugen Treatment of Macular Edema Due to Branch Retinal Vein Occlusion

Branch Retinal Vein Occlusion

United States
Steba Biotech S.A.

Terminated

Safety and Preliminary Efficacy Study of WST11 (Stakel®)-Mediated VTP Therapy in Subjects With CNV Associated With AMD

Macular Degeneration | Choroidal Neovascularization

United States, France
Bayer

Completed

A Study in Patients With Wet Age-related Macular Degeneration or Diabetic Macular Edema to Assess the freQuency of Use of Intravitreal Aflibercept in Routine Clinical Practices in Latin America (AQUILA)

Macular Degeneration

Mexico, Argentina, Colombia, Costa Rica
Palmetto Retina Center, LLC

Completed

A Safety and Efficacy Trial of a Treat and Extend Protocol Using Ranibizumab With and Without Laser Photocoagulation for Diabetic Macular Edema (TREX-DME)

Diabetic Macular Edema

United States
GlaxoSmithKline

Completed

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GSK2798745 in Participants With Diabetic Macular Edema

Macular Edema

Australia, United States, New Zealand
Allergan

Completed

Safety and Efficacy of a New Treatment in Vitrectomized Subjects With Diabetic Macular Edema

Diabetic Macular Edema | Vitrectomy

United States, Australia
Outlook Therapeutics, Inc.

Completed

A Clinical Effectiveness Study Examining the Efficacy and Safety of ONS-5010 in Subjects With Neovascular Age-related Macular Degeneration (AMD)

Age-related Macular Degeneration | Wet Macular Degeneration | Neovascular Age-related Macular Degeneration

Australia
Allergan

Completed

Safety and Efficacy of a New Therapy as Adjunctive Therapy to Anti-vascular Endothelial Growth Factor (Anti-VEGF) in Subjects With Wet Age-Related Macular Degeneration (AMD)

Choroidal Neovascularization | Age-Related Maculopathy

United States, Australia, Philippines
Exonate Limited
Novotech (Australia) Pty Limited

Completed

A Study to Evaluate the Safety and Tolerability of EXN407

Diabetic Macular Edema

Australia
Novartis Pharmaceuticals

Completed

Comparison of Treatment Regimens Using Ranibizumab: Intensive (Resolution of Intra- and Sub-retinal Fluid) vs Relaxed (Resolution of Intra-retinal Fluid and/or Sub-retinal Fluid >200µm at the Foveal Centre) (FLUID)

Subfoveal Choroidal Neovascularization CNV Secondary to Wet Age-related Macular Degeneration AMD

Australia
Retina Macula Specialists of Miami, LLC
Allergan

Unknown

Increase in Capillary Plexus Density Level Following the Use of Ozurdex for the Treatment of DME (ICOD)

Diabetic Retinopathy | Diabetic Macular Edema | Retinal Ischemia

United States
Allergan

Terminated

A Study Using Intravitreal Injections of a Small Interfering RNA in Patients With Age-Related Macular Degeneration

Age-Related Macular Degeneration | Choroid Neovascularization

United States, Australia, Philippines
Marsden Eye Specialists

Completed

To Evaluate the Comparative Efficacy of Lucentis (Ranibizumab) 0.5mg Intravitreal Injection in Patients With Diabetic Macular Oedema (DME) With Well Controlled and Poorly Controlled Diabetes Mellitus (CONTROL)

Diabetic Macular Oedema

Australia
Novartis

Completed

Safety and Efficacy of Oral PTK787 in Patients With Subfoveal Choroidal Neovascularization Secondary to Age-Related Macular Degeneration (AMD) (ADVANCE)

Wet Age-Related Macular Degeneration

Australia, United States
Cumberland Pharmaceuticals

Completed

Study to Assess Safety and Efficacy of Ifetroban for Treatment of Portal Hypertension in Cirrhotic Patients

Liver Cirrhosis | Portal Hypertension

United States
AbbVie

Completed

A Study to Evaluate an Updated Dexamethasone Intravitreal (Into the Eye) Applicator in Adult Participants With Macular Edema Due to Diseases of the Retina

Macular Edema

United States
TargeGen

Terminated

Open-Label, Pilot Study of TG100801 in Patients With Choroidal Neovascularization Due to AMD

Macular Degeneration | Choroidal Neovascularization

United States
Opthea Limited

Completed

Study Evaluating the Safety, Pharmacokinetics and Pharmacodynamics of OPT-302 With or Without Lucentis™ in Patients With Wet AMD

Eye Diseases | Macular Degeneration | Retinal Degeneration | Retinal Diseases | Neovascularization, Pathologic

United States
Lpath, Inc.
Pfizer

Terminated

iSONEP to Treat Persistent Pigment Epithelial Detachment (PED) in Subjects With Exudative Age-Related Macular Degeneration (AMD) or Polypoidal Choroidal Vasculopathy (PCV) (PED)

Pigment Epithelial Detachment

United States
ONL Therapeutics

Completed

ONL1204 Ophthalmic Solution in Patients With Geographic Atrophy Associated With Age-related Macular Degeneration

Geographic Atrophy

New Zealand, Australia
Allergan

Completed

Safety and Efficacy of Brimonidine Intravitreal Implant in Patients With Geographic Atrophy Due to Age-related Macular Degeneration (AMD)

Macular Degeneration

Korea, Republic of, Australia, Portugal, Germany, United States, Philippines, Italy
Ionis Pharmaceuticals, Inc.

Withdrawn

Safety and Efficacy of IONIS-FB-Lrx in up to 120 Patients 55 and Older With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD)

Geographic Atrophy | Age Related Macular Degeneration

Australia, United States, New Zealand
Ophthotech Corporation

Terminated

Phase 2A Open Label Safety Study of Fovista® (Anti-PDGF BB) Regimen Administered in Combination With Anti-VEGF Therapy to Study Sub-Retinal Fibrosis in Neovascular AMD

Age-related Macular Degeneration

United States
Johns Hopkins University
Juvenile Diabetes Research Foundation; Genentech, Inc.

Withdrawn

Combined aPproach to Treatment Using Ranibizumab and Efalizumab for Diabetic Macular Edema Study: The CAPTURE DME Study (CAPTURE)

Diabetic Macular Edema

United States
University of California, San Francisco
Genentech, Inc.

Completed

Seven Year Update of Macular Degeneration Patients (SEVEN UP)

Age-related Macular Degeneration

United States
Genaera Corporation

Terminated

A Safety and Efficacy Study of Squalamine Lactate for Injection (MSI-1256F) for "Wet" Age-Related Macular Degeneration

"Wet" Age-Related Macular Degeneration

United States
GlaxoSmithKline

Completed

An Extension to Study MD7108240

Macular Degeneration

Italy, United States, Australia
Opthea Limited

Completed

A Dose Ranging Study of OPT-302 With Aflibercept for Persistent Diabetic Macular Edema

Diabetic Macular Edema

United States, Israel, Australia, Latvia
Neurotech Pharmaceuticals

Terminated

Study of the Intravitreal Implantation of NT-503-3 Encapsulated Cell Technology (ECT) for the Treatment of Recurrent Choroidal Neovascularization (CNV) Secondary to Age-related Macular Degeneration (AMD)

Macular Degeneration

United States, Israel
Regeneron Pharmaceuticals

Completed

Study of Intravitreal (IVT) REGN910-3 and IVT REGN910 in Patients With Either Neovascular ("Wet") Age Related Macular Degeneration (AMD) or Diabetic Macular Edema (DME)

Diabetic Macular Edema | Neovascular Age-Related Macular Degeneration

United States
Apellis Pharmaceuticals, Inc.

Completed

Study of Pegcetacoplan (APL-2) Therapy in Patients With Geographic Atrophy (FILLY)

Geographic Atrophy

United States, Australia, New Zealand

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