Clinical Trials on Opioid Tolerance

Total 3531 results

Vanderbilt University Medical Center

Recruiting

Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure

Parkinson Disease | Multiple System Atrophy | Orthostatic Hypotension | Pure Autonomic Failure | Autonomic Failure

United States
Icahn School of Medicine at Mount Sinai

Completed

Droxidopa in Treating Patients With Neurogenic Hypotension

Shy-Drager Syndrome | Orthostatic Hypotension

United States
Goldfinch Bio, Inc.

Terminated

A Study to Understand the Genetics and Clinical Course of Focal Segmental Glomerulosclerosis (FSGS), Treatment-Resistant Minimal Change Disease (TR-MCD), and Diabetic Nephropathy (DN)

Diabetic Nephropathies | Glomerulosclerosis, Focal Segmental | Minimal Change Disease

United States
Marinella Temprosa
National Institute on Aging (NIA)

Enrolling by invitation

The Diabetes Prevention Program Outcomes Study AD/ADRD Project (DPPOS-4)

Diabetes | Dementia | PreDiabetes | Alzheimer Disease | Dementia, Vascular

United States
Istituto Clinico Humanitas
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta; Fondazione Salvatore...

Completed

Anti-Cholinergic Receptors Antibodies, Autonomic Profile and Dysautonomia Symptoms in PAF, ALS and POTS (DISAUT-AB) (DISAUT-AB)

Amyotrophic Lateral Sclerosis | Postural Orthostatic Tachycardia Syndrome | Pure Autonomic Failure | Anti-Cholinergic Receptors Antibodies

Italy
Medical College of Wisconsin
Children's Hospital and Health System Foundation, Wisconsin

Completed

Autonomic Profiles in Pediatric Patients With Cyclic Vomiting Syndrome (CVS), Irritable Bowel Syndrome (IBS),Postural Orthostatic Tachycardia Syndrome (POTS), Functional Abdominal Pain (FAP) or Chronic Nausea

Irritable Bowel Syndrome | Abdominal Pain | Postural Orthostatic Tachycardia Syndrome | Vomiting Syndrome | Chronic Nausea
Arbelaez, Ana Maria
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Novo... and other collaborators

Completed

Pilot and Feasibility Study for the Treatment of Pre-diabetes in Patients With Cystic Fibrosis

Pancreatic Insufficiency | Cystic Fibrosis Related Diabetes

United States
Vrinnevi Hospital
Linkoeping University

Not yet recruiting

Orthostatic Hypotension and Blood Pressure Variability in Persons Undergoing Hemodialysis

Chronic Kidney Disease Requiring Chronic Dialysis
Universitätsklinik für Neurologie, Innsbruck

Recruiting

Abdominal Binders to Treat Orthostatic Hypotension in Parkinsonian Syndromes (ABOH-PS)

Parkinson Disease | Multiple System Atrophy, Parkinson Variant | Orthostatic; Hypotension, Neurogenic

Austria
University of Pittsburgh
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

Behavioral Economics for Activity Motivation in Adolescents (BEAM)

Polycystic Ovary Syndrome | Insulin Resistance | PreDiabetes | Type 2 Diabetes

United States
Vanderbilt University Medical Center

Recruiting

Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms

Multiple System Atrophy | Pure Autonomic Failure | Autonomic Failure | Orthostatic; Hypotension, Neurogenic | Orthostatic; Hypotension, Parkinsonism

United States
University of Chicago
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Northwestern...

Recruiting

Technology-Supported Treatment of Sleep Apnea in Prediabetes (TECH)

PreDiabetes | Sleep Apnea | Overweight or Obesity

United States
Boston Scientific Corporation

Completed

Observation of ImageReady™ MR Conditional Pacing System in China

Vasovagal Syncope | Arhythmia | Atrioventricular Heart-block | Chronic Bundle Branch or Branch Block | Carotid Sinus Hypersensitivity Reaction Syndrome

China
Chelsea Therapeutics

Completed

Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) (NOH303)

Multiple System Atrophy | Neurogenic Orthostatic Hypotension | Dopamine Beta Hydroxylase Deficiency | Non-Diabetic Autonomic Neuropathy

United States, Australia, Canada, New Zealand
Helse Stavanger HF
University Hospital, Akershus

Unknown

Challenge Test for Acetylsalicylic Acid Hypersensitivity

Asthma, Aspirin-Induced | ASA Intolerant Asthma | Asthma Aspirin-sensitive | Asthma, Nasal Polyps, and Aspirin Intolerance

Norway
Prof. Dr. Paul Brinkkoetter
German Research Foundation; Medical Faculty and the Faculty of Natural Sciences... and other collaborators

Recruiting

The FOrMe Registry (The German Focal Segmental Glomerulosclerosis and Minimal Change Disease Registry) (FOrMe)

Glomerulosclerosis, Focal Segmental | Minimal Change Disease | Idiopathic Nephrotic Syndrome

Germany
Theravance Biopharma

Recruiting

Phase 3 Efficacy and Durability of Ampreloxetine for the Treatment of Symptomatic nOH in Participants With Multiple System Atrophy (CYPRESS)

MSA - Multiple System Atrophy | Symptomatic Neurogenic Orthostatic Hypotension

United States, Spain, United Kingdom, Hungary, Italy, Argentina, Austria, Poland, Germany, Portugal, Belgium, Brazil, Denmark, Canada, France, Chile, Estonia
Vanderbilt University Medical Center
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

CPAP for the Treatment of Supine Hypertension

Parkinson Disease | Multiple System Atrophy | Neurogenic Orthostatic Hypotension | Pure Autonomic Failure | Supine Hypertension | Autonomic Failure

United States
Vanderbilt University Medical Center
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients

Parkinson Disease | Multiple System Atrophy | Neurogenic Orthostatic Hypotension | Pure Autonomic Failure | Autonomic Failure

United States
CENTOGENE GmbH Rostock

Completed

Screening for the Transthyretin-Related Familial Amyloidotic Polyneuropathy (TTR FAP) (TRAP2-1)

Neuropathic Pain | Orthostatic Hypotension | Cardiac Failure | Gastrointestinal Disorders | Polyneuropathy, Amyloid

Spain, Austria, Hungary, North Macedonia, Poland, Serbia
Hospitalsenheden Vest
Boehringer Ingelheim; Erasmus Medical Center; University of Aarhus; Catharina Ziekenhuis... and other collaborators

Completed

Adherence and Coagulation Assays in Dabigatran-treated Patients With Atrial Fibrillation (ARCADE)

Thrombosis | Atrial Fibrillation | Bleeding | Medication Adherence | Drug Effect | Anticoagulants; Circulating, Hemorrhagic Disorder | Drug Use | Blood Coagulation Disorder | Laboratory Problem | Drug Toxicity | Blood Clot | Blood Coagulation Tests | Drug Intolerance

Denmark
Vanderbilt University Medical Center
National Institute of Neurological Disorders and Stroke (NINDS)

Completed

Norepinephrine Transporter Blockade as a Pathological Biomarker in Neurogenic Orthostatic Hypotension (6103)

Parkinson's Disease | Multiple System Atrophy | Orthostatic Hypotension | Pure Autonomic Failure

United States
Qianfoshan Hospital

Not yet recruiting

Application of Hyperspectral Imaging in the Diagnosis of Glomerular Diseases

Diabetic Nephropathies | Glomerulonephritis, IGA | Nephrosis, Lipoid | Glomerulonephritis, Membranous | Hyperspectral Imaging
University of Michigan

Recruiting

Recurrence Post-transplant Observational Study in Focal Segmental Glomerulosclerosis and Minimal Change Disease (RESOLVE)

Focal Segmental Glomerulosclerosis | Minimal Change Disease | FSGS | MCD

United States
Jordan Collaborating Cardiology Group

Recruiting

Clinical Association Between Obstructive Sleep Apnea, Facial Pigmentation, and Vasovagal Symptoms. (VasOSA)

Smoking | Obstructive Sleep Apnea | Acanthosis Nigricans | Vasovagal Syncope

Jordan
National Institute of Neurological Disorders and...

Terminated

Clinical Autonomic Disorders: A Training Protocol

Healthy Volunteers | Posttraumatic Stress Disorder | Postural Tachycardia Syndrome | Pseudopheochromocytoma | Neurocardiogenic Syncope

United States
DiaSorin Inc.

Completed

Fecal Calprotectin Collection Protocol (CALFE)

Irritable Bowel Syndrome | Abdominal Pain | Constipation | Inflammatory Bowel Diseases | Weight Loss | Celiac Disease | Crohn Disease | Ulcerative Colitis | Diverticulitis | Food Intolerance | Chronic Diarrhea | Indeterminate Colitis | Distension

United States
University of Sao Paulo General Hospital

Completed

Effects of Myo-inositol in Women With Polycystic Ovary Syndrome

Polycystic Ovary Syndrome | Glucose Intolerance | Resistance, Insulin

Brazil
OMNI Medical Services, LLC
OMNI Medical Services Inc

Recruiting

Outcomes Mandate National Integration With Cannabis as Medicine (OMNI-Can)

Depression | COVID-19 | Epilepsy | Multiple Sclerosis | Glaucoma | Cancer | Covid19 | Chronic Pain | Parkinson Disease | Inflammatory Bowel Diseases | Hepatitis C | Insomnia | HIV/AIDS | Amyotrophic Lateral Sclerosis | Fibromyalgia | Anxiety | Bipolar Disorder | Seizures | Crohn Disease | Traumatic Brain Injury | Ulcerative Colitis | Sickle... and other conditions

United States
University of Michigan

Completed

Tumor Necrosis Factor Inhibition in Focal Segmental Glomerulosclerosis and Treatment Resistant Minimal Change Disease

Focal Segmental Glomerulosclerosis | Minimal Change Disease | FSGS | MCD

United States
Dasman Diabetes Institute

Recruiting

Kuwait Adult Diabetes Epidemiological Multidisciplinary (KADEM) Program (KADEM)

PreDiabetes | NAFLD - Nonalcoholic Fatty Liver Disease | Diabetes Mellitus Type 2, Diabetes Mellitus Type 1

Kuwait
Johns Hopkins University
Fusion Health

Completed

Recruitment Strategies Comparing Different Strategies in Sleep Apnea and Prediabetes

Sleep Disorder | Obstructive Sleep Apnea | Pre Diabetes

United States
Northwell Health
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

A Pilot Trial of taVNS for SRNS in Children (kidNEY-VNS) (kidNEY-VNS)

Focal Segmental Glomerulosclerosis | Minimal Change Disease | Nephrotic Syndrome in Children

United States
Northwell Health
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

taVNS for FRNS in Children (kidNEY-VNS)

Focal Segmental Glomerulosclerosis | Minimal Change Disease | Nephrotic Syndrome in Children

United States
Valentina Puentmann
Bayer; Alcedis GmbH

Recruiting

Myocardial Protection in Patients With Post-acute Inflammatory Cardiac Involvement Due to COVID-19 (MYOFLAME-19)

Microvascular Angina | Left Ventricular Dysfunction | Vascular Inflammation | Exercise Intolerance | Remodeling, Left Ventricle | Remodeling, Vascular | COVID-19 Associated Cardiac Involvement

Germany, Austria
Theravance Biopharma

Terminated

Phase 3 Clinical Effect Durability of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure (REDWOOD)

Parkinson's Disease (PD) | MSA | Symptomatic Neurogenic Orthostatic Hypotension | Pure Autonomic Failure (PAF)

United States, Spain, United Kingdom, Canada, France, Estonia, Australia, Israel, Denmark, Italy, Poland, New Zealand, Germany, Ukraine, Austria, Bulgaria, Portugal, Hungary, Russian Federation
Juvantia Pharma Ltd
Santhera Pharmaceuticals

Unknown

Fipamezole in Neurogenic Orthostatic Hypotension (Foehn)

Parkinson's Disease | Multiple System Atrophy | Symptomatic Neurogenic Orthostatic Hypotension (NOH)

France, Portugal
Vanderbilt University Medical Center

Recruiting

Evaluating the Prevalence of Acute Hepatic Porphyria in Postural Tachycardia Syndrome

Postural Orthostatic Tachycardia Syndrome | Acute Hepatic Porphyria

United States
Brigham and Women's Hospital
Biohaven Pharmaceuticals, Inc.

Completed

Effect of Verdiperstat on Microglial Activation in Well-characterized MSA Patients

Multiple System Atrophy | Multiple System Atrophy, Parkinson Variant (Disorder) | Multiple System Atrophy, Cerebellar Variant | Multiple System Atrophy (MSA) With Orthostatic Hypotension

United States
Chelsea Therapeutics

Terminated

A Clinical Study of Patients With Symptomatic NOH to Assess Sustained Effects of Droxidopa Therapy

Parkinson's Disease | Pure Autonomic Failure | Dopamine Beta Hydroxylase Deficiency | Symptomatic Neurogenic Orthostatic Hypotension | Multiple Systems Atrophy

United States
Uniformed Services University of the Health Sciences

Recruiting

Ivabradine for Long-Term Effects of COVID-19 With POTS Cohort (COVIVA)

Postural Orthostatic Tachycardia Syndrome | Long Haul COVID

United States
Pacific Coast Family Medical Group

Enrolling by invitation

Disease Prevention in Clinical Practice Base on Patient Specific Physiology (STOPDISEASE)

Cancer | Atherosclerosis | Atrial Fibrillation | Insulin Resistance | Dementia | PreDiabetes | Type2 Diabetes | NASH - Nonalcoholic Steatohepatitis | Diastolic Dysfunction | Carotid Plaque
Vanderbilt University Medical Center
American Heart Association

Not yet recruiting

Long COVID Immune Profiling

Long COVID | Autonomic Dysfunction | POTS - Postural Orthostatic Tachycardia Syndrome
Milton S. Hershey Medical Center
Dysautonomia International

Completed

Standing Cognition and Co-morbidities of POTS Evaluation (SCOPE)

Postural Tachycardia Syndrome | Ehlers-Danlos Syndrome

United States
Brigham and Women's Hospital
Northeastern University

Completed

Patient Safety Learning Laboratory: Making Acute Care More Patient-Centered (PSLL)

Venous Thromboembolism | Patient Fall | Adverse Drug Event | Severe Hypoglycemia | Hospital Acquired Pressure Ulcer | Central Line-Associated Bloodstream Infection (CLABSI) | Catheter-Associated Infection | Opioid-Related Severe Adverse Drug Event | Severe Hospital Acquired Delerium | Rapid Response Related...

United States
Icahn School of Medicine at Mount Sinai

Active, not recruiting

VNS for Long-COVID-19

Postural Tachycardia Syndrome | Post-COVID-19 Syndrome | Dysautonomia

United States
Karolinska Institutet
Karolinska University Hospital

Active, not recruiting

Physical Training in Patients With POTS After Covid-19 (POTS-ReCOV)

Covid19 | Postural Orthostatic Tachycardia Syndrome | Post-acute Covid-19 Syndrome

Sweden
Karolinska Institutet
Karolinska University Hospital

Enrolling by invitation

Effects of Individual Tailored Physical Exercise in Patients With POTS After COVID-19 - a Randomized Controlled Study

COVID-19 | Postural Orthostatic Tachycardia Syndrome | Post COVID-19 Condition | Post-Acute COVID-19 Syndrome

Sweden
University of Oxford
Medical Research Council

Completed

Deep Brain Stimulation for Autonomic and Gait Symptoms in Multiple System Atrophy (STAG-MSA)

Multiple System Atrophy | Gait Disorders, Neurologic | Bladder, Neurogenic | Autonomic Failure | Postural Hypotension

United Kingdom
Seoul National University Hospital
Seoul National University Bundang Hospital; Chung-Ang University Hosptial,... and other collaborators

Recruiting

KOrea Renal Biobank NEtwoRk System TOward NExt-generation Analysis (KORNERSTONE)

Lupus Nephritis | Focal Segmental Glomerulosclerosis | IgA Nephropathy | Glomerular Disease | Minimal Change Disease | Membranous Nephropathy | Crescentic Glomerulonephritis

Korea, Republic of

Clinical Trials on Opioid Tolerance

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Drug Interventions

CROs by country

CROs in Italy

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