Clinical Trials on PIK3CA Mutation-Related Tumors

Total 2252 results

Technische Universität Dresden

Terminated

Vemurafenib Plus Cobimetinib After Radiosurgery in Patients With BRAF-mutant Melanoma Brain Metastases (RadioCoBRIM)

Brain Metastases | Malignant Melanoma Stage IV | BRAF V600 Mutation

Germany
Changhai Hospital

Completed

Real-world Study on Adjuvant Octreotide Therapy in pNETs

Pancreatic Neuroendocrine Tumor G2
University of South Florida
National Cancer Institute (NCI)

Completed

Modafinil in Treating Children With Memory and Attention Problems Caused by Cancer Treatment for a Brain Tumor

Fatigue | Brain and Central Nervous System Tumors | Neurotoxicity | Cognitive/Functional Effects | Psychosocial Effects of Cancer and Its Treatment

United States
Jonsson Comprehensive Cancer Center
National Institutes of Health (NIH)

Terminated

Rosiglitazone in Treating Patients With Pituitary Tumors

Brain and Central Nervous System Tumors

United States
HaEmek Medical Center, Israel

Unknown

Safety and Efficacy of an Ablation Catheter for the Treatment of Pancreatic Premalignant Cyctic Lesions. (yes)

Pancreatic Cancer | Pancreatic Cyst | Pancreatic Neuroendocrine Tumor | Pancreatic Cancer Stage
Italian Association Neuroendocrine Tumors

Recruiting

Protocol ITANET - Registry

Gastro-entero Pancreatic Neuroendocrine Tumors

Italy
Medical University of Lublin

Completed

Treg, Th17 Cells, NKT in Epithelial Ovarian Tumor

Ovarian Cancer | Unexplained Infertility | Borderline Ovarian Tumors | Benign Ovarian Tumor

Poland
Ipsen

Completed

Quality-Of-Life QLQ-GINET21 Questionnaire In The Treatment Of Patients With Gastrointestinal Neuroendocrine Tumours (QUALINETS)

Gastrointestinal Neuroendocrine Tumours

Spain, Portugal
Ipsen

Completed

Quality of Life, Treatment Experience and Cost of Treatment With Somatostatin Analogues in Patients With Gastroenteropancreatic Neuroendocrine Tumours (STREET)

Gastroenteropancreatic Neuroendocrine Tumours

Sweden
University Health Network, Toronto

Withdrawn

Maintenance Treatment With Bevacizumab and Atezolizumab for Ovarian Cancer

Fallopian Tube Cancer | Primary Peritoneal Cancer | Ovarian Endometrioid Tumor | TP53 Mutation

Canada
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Trabectedin in Treating Young Patients With Recurrent or Refractory Soft Tissue Sarcoma or Ewing's Family of Tumors

Recurrent Ewing Sarcoma | Recurrent Childhood Rhabdomyosarcoma | Previously Treated Childhood Rhabdomyosarcoma | Recurrent Childhood Soft Tissue Sarcoma | Peripheral Primitive Neuroectodermal Tumor

United States, Canada
St. Jude Children's Research Hospital
Novartis Pharmaceuticals

Completed

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Glioma | Neoplasms | Glioblastoma | Neoplasms, Neuroepithelial | Central Nervous System Neoplasms | Brain Cancer | Brain Tumor | Ependymoma | Medulloblastoma | Anaplastic Astrocytoma | Anaplastic Ganglioglioma | Anaplastic Ependymoma | Anaplastic Oligodendroglioma | Pineoblastoma | Recurrent Medulloblastoma | CNS Tumor | Pediatric... and other conditions

United States
Merck Sharp & Dohme LLC
Eisai Inc.

Active, not recruiting

A Study of Lenvatinib (MK-7902) in Pediatric Participants With Relapsed or Refractory Solid Malignancies (MK-7902-013/E7080) (E7080-G000-231)

Relapsed or Refractory Solid Tumors

United States, Argentina, Australia, Belgium, Croatia, Czechia, France, Guatemala, Hungary, Israel, Italy, Korea, Republic of, New Zealand, Peru, Russian Federation, Serbia, South Africa, Spain, Sweden, Turkey
OncoMed Pharmaceuticals, Inc.

Completed

A Dose Escalation Study of OMP-52M51 in Subjects With Solid Tumors

Relapsed or Refractory Solid Tumors

United States
The University of Texas Health Science Center at...

Completed

Oral Hydroxychloroquine Plus Oral Sorafenib to Treat Patients With Refractory or Relapsed Solid Tumors

Refractory or Relapsed Solid Tumors

United States
Nanjing First Hospital, Nanjing Medical University

Recruiting

99mTc Labeled FAP Targeted Molecular Probe in Early Diagnosis of Tumors

Pancreatic Cancer | Lung Cancer | Head and Neck Tumor

China
Recursion Pharmaceuticals Inc.

Recruiting

A Study of REC-4881 in Participants With Cancers Which Have an AXIN1 or APC Mutation

Solid Tumor | APC Gene Mutation | AXIN1 Gene Mutation

United States
Institute of Hematology & Blood Diseases Hospital

Withdrawn

Dasatinib Combined With Chemotherapy in Relapsed t(8;21) Acute Myeloid Leukemia With KIT D816 Mutation

Relapsed AML | T(8;21) | C-KIT Mutation

China
Fudan University
M.D. Anderson Cancer Center; Henan Cancer Hospital; Jiangsu Cancer Institute... and other collaborators

Recruiting

Genomic Study of Relapse Esophageal Cancer After Radiotherapy

Esophageal Cancer | Radiation Exposure | Gene Mutation-Related Cancer

China
J.M. de Laat
Radboud University Medical Center; University Medical Center Groningen; Maastricht... and other collaborators

Recruiting

Precision Radiotherapy Using MR-linac for Pancreatic Neuroendocrine Tumours in MEN1 Patients (PRIME)

Multiple Endocrine Neoplasia Type 1 | Neuroendocrine Tumor of Pancreas

Netherlands
Theriva Biologics SL

Completed

Phase I Dose Escalation Study of Intravenous VCN-01 With or Without Gemcitabine and Abraxane® in Patients With Advanced Solid Tumors

Pancreatic Adenocarcinoma | Locally Advanced Solid Tumors | Metastatic Solid Tumors

Spain
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Lenvatinib and Everolimus in Treating Patients With Advanced, Unresectable Carcinoid Tumors

Neuroendocrine Neoplasm | Multiple Endocrine Neoplasia Type 1 | Advanced Carcinoid Tumor | Digestive System Neuroendocrine Neoplasm | Unresectable Carcinoid Tumor

United States
Theodore Laetsch

Terminated

A Phase II Study of Sirolimus and Erlotinib in Recurrent/Refractory Germ Cell Tumors

Relapsed / Recurrent Germ Cell Tumors

United States
Immix Biopharma Australia Pty Ltd

Active, not recruiting

IMX-110 in Patients With Advanced Solid Tumors

Breast Cancer | Pancreatic Cancer | Ovarian Cancer | Advanced Solid Tumors | Solid Tumor, Adult

United States, Australia
Shanghai Jiao Tong University School of Medicine

Recruiting

Treatment of Advanced Endocrine Tumor With Iindividualized mRNA Neoantigen Vaccine (mRNA-0523-L001)

Medullary Thyroid Cancer | Pancreatic Neuroendocrine Tumor | Adrenal Cortical Carcinoma | Thymic Neuroendocrine Carcinoma

China
Masonic Cancer Center, University of Minnesota

Terminated

Amifostine to Protect From Side Effects of PSCT in Treating Patients With Solid Tumors

Sarcoma | Kidney Cancer | Ovarian Cancer | Brain and Central Nervous System Tumors | Chordoma | Neuroblastoma | Retinoblastoma | Liver Cancer | Childhood Germ Cell Tumor

United States
Yale University
National Cancer Institute (NCI)

Terminated

Indium In 111 Pentetreotide in Treating Patients With Refractory Cancer

Kidney Cancer | Head and Neck Cancer | Lung Cancer | Brain and Central Nervous System Tumors | Intraocular Melanoma | Melanoma (Skin) | Pheochromocytoma | Islet Cell Tumor | Gastrointestinal Carcinoid Tumor | Neoplastic Syndrome | Neuroendocrine Carcinoma of the Skin | Childhood Langerhans Cell Histiocytosis

United States
Philipps University Marburg Medical Center

Unknown

Prospective Evaluation of the Diagnostic Efficacy of a EUS Guided FNB Needle (AQUIRE®)

Lymph Node Disease | Tumors of the Pancreas | Submucosal Tumor of Gastrointestinal Tract (Disorder)

Germany
National Cancer Institute (NCI)

Completed

Sapanisertib and Ziv-Aflibercept in Treating Patients With Recurrent Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Recurrent Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | Ovarian Carcinoma | Pancreatic Neuroendocrine Tumor | Unresectable Solid Neoplasm | Fibrolamellar Carcinoma

United States
Novartis Pharmaceuticals

Completed

Safety and Tolerability of Pasireotide LAR in Combination With Everolimus in Advanced Metastatic NETs (COOPERATE-1)

Gastroenteropancreatic Neuroendocrine Tumor of the Pulmonary ot Gastroenteropancreatic System

Germany
European Organisation for Research and Treatment...
Ipsen

Withdrawn

Lanreotide Combined With Telotristat Ethyl or Placebo for the First-line Treatment in Patients With Advanced Well Differentiated Small Intestinal Neuroendocrine Tumours (siNET) With Highly-functioning Carcinoid Syndrome (TELEFIRST)

Small Intestinal NET | Carcinoid Heart Disease
Grupo Espanol de Tumores Neuroendocrinos
Roche Pharma AG; Ipsen

Active, not recruiting

Trial of Cabozantinib Plus Atezolizumab in Advanced and Progressive Neoplasms of the Endocrine System. The CABATEN Study (CABATEN)

Adenocarcinoma | Neuroendocrine Tumor | Pheochromocytoma | Paraganglioma | Anaplastic Thyroid Cancer

Spain
Rigel Pharmaceuticals
Nationwide Children's Hospital

Not yet recruiting

Study of Olutasidenib and Temozolomide in HGG

Astrocytoma | High Grade Glioma | Oligodendroglioma | Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma, H3 K27M-Mutant | WHO Grade III Glioma | Metastatic Brain Tumor | Spinal Tumor | Astrocytoma, Grade III | Astrocytoma, Grade IV | IDH1 Mutation | WHO Grade IV Glioma | Thalamus Tumor | IDH1 R132 | IDH1 R132C | IDH1 R132H and other conditions

United States, Australia, United Kingdom, Canada, Germany, Netherlands
Sue O'Dorisio
National Cancer Institute (NCI)

Completed

Comparative Study of Sensitivity of Ga-DOTATOC PET vs Octreoscan SPECT + CT

Neuroendocrine Tumor | Neuroblastoma | Somatostatinoma | Adult Medulloblastoma | Childhood Medulloblastoma

United States
Sorrento Therapeutics, Inc.

Withdrawn

Study of STI-3031 in Patients With Selected Relapsed or Refractory Solid Tumors

Solid Tumor | Relapsed Solid Tumor | Refractory Tumor
Istituto Clinico Humanitas

Unknown

A Clinical Trial With a New Needle Device Comparing Two Needles for EUS_FNA of Solid Lesions. (EUS-FNA)

Pancreatic Cancer | Neuroendocrine Tumors | GIST | Lymphadenopathies | Gastric Wall Tumor

Italy
Turning Point Therapeutics, Inc.

Terminated

A Study of TPX-0131, a Novel Oral ALK Tyrosine Kinase Inhibitor, in Patients With ALK+ Advanced or Metastatic NSCLC

Non-Small Cell Lung Cancer | NSCLC | Non Small Cell Lung Cancer | Advanced Solid Tumor | Metastatic Solid Tumor | ALK Gene Mutation

United States, Australia, Korea, Republic of
University Medical Center Nijmegen

Active, not recruiting

Early Salpingectomy (Tubectomy) With Delayed Oophorectomy in BRCA1/2 Gene Mutation Carriers (TUBA)

Ovarian Cancer | BRCA1 Gene Mutation | BRCA2 Gene Mutation

Netherlands
Lei Li

Unknown

Homologous Recombination Deficiency Status in Epithelial Ovarian Cancer

Epithelial Ovarian Cancer | BRCA1 Mutation | BRCA2 Mutation | Homologous Recombination Deficiency | Prognosis | Chinese

China
Lei Li

Completed

A Study on Association Between HR Genes and the HRD Status in Chinese Epithelial Ovarian Cancer

Epithelial Ovarian Cancer | BRCA1 Mutation | BRCA2 Mutation | Homologous Recombination Deficiency | Prognosis | Chinese | Homologous Recombination Genes

China
RenJi Hospital
Peking University First Hospital; Shanghai Zhongshan Hospital; First Affiliated... and other collaborators

Recruiting

Frequency, Clinical Phenotype and Genetic Analysis of Heritable Kidney Cancer Syndromes

Kidney Cancer | Renal Cell Carcinoma | ALK Gene Mutation | MET Gene Mutation | HLRCC | Renal Tumor Histology | Cutaneous Leiomyoma | BAP1 Tumor Predisposition Syndrome | VHL Syndrome | Birt-Hogg-Dube Syndrome | Familial Renal Cancer | FLCN Gene Mutation | FH Gene Mutation | Cutaneous Leiomyomata With Uterine Leiomyomata

China
University of Michigan Rogel Cancer Center

Recruiting

Multicenter Trial of ESK981 in Patients With Select Solid Tumors

Pancreatic Adenocarcinoma | Pancreatic Neuroendocrine Tumor | Pancreatic Neuroendocrine Carcinoma | Adenosquamous Carcinoma | Gastrointestinal Neuroendocrine Tumor | Gastrointestinal Neuroendocrine Carcinoma | Neuroendocrine Prostate Carcinoma

United States
French Innovative Leukemia Organisation
Acute Leukemia French Association

Completed

A Non-interventional Ambispective Real-world Cohort of rEfractory and reLapsed (R/R) FLT3 Mutated Acute MyEloid Leukemia (AML) Patients Treated With Gilteritinib in FrANCE (ELEGANCE)

Relapsed Adult AML | Refractory AML | FLT3-TKD Mutation | FLT3-ITD

France
Jewish General Hospital

Completed

SUV on 68Ga-DOTATATE PET/CT and Ki-67 Index in Neuro-Endocrine Tumors

Neuroendocrine Tumors

Canada
University Hospital, Bordeaux

Completed

PET-CT Imaging of Neuro-endocrine Tumors and Preliminary Clinical Evaluation (GALTEP)

Neuroendocrine Tumors

France
Memorial Sloan Kettering Cancer Center

Completed

Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Rare Cancer

Sarcoma | Lymphoma | Kidney Cancer | Testicular Germ Cell Tumor | Head and Neck Cancer | Ovarian Cancer | Neuroblastoma | Retinoblastoma | Liver Cancer | Extragonadal Germ Cell Tumor | Childhood Germ Cell Tumor

United States
Children's Hospitals and Clinics of Minnesota
M.D. Anderson Cancer Center; Massachusetts General Hospital; Washington University... and other collaborators

Recruiting

International Ovarian & Testicular Stromal Tumor Registry (OTST)

Ovarian Small Cell Carcinoma | Testicular Stromal Tumors | Ovarian Sex-cord Stromal Tumor

United States
National Cancer Institute (NCI)

Completed

Erlotinib and Temozolomide in Treating Young Patients With Recurrent or Refractory Solid Tumors

Recurrent Childhood Medulloblastoma | Recurrent Childhood Ependymoma | Recurrent Neuroblastoma | Recurrent Osteosarcoma | Recurrent Childhood Rhabdomyosarcoma | Previously Treated Childhood Rhabdomyosarcoma | Recurrent Childhood Soft Tissue Sarcoma | Recurrent Childhood Malignant Germ Cell Tumor | Recurrent... and other conditions

United States
Huashan Hospital
Shandong Provincial Hospital

Unknown

Gut Microbiota and Glioblastoma Multiforme Prognosis

Gut Microbiota, Glioblastoma Multiforme, Microglia, Tumor Related Macrophagocyte, Prognosis
Gynecologic Oncology Group
National Cancer Institute (NCI)

Completed

Paclitaxel in Treating Patients With Ovarian Stromal Cancer

Adult Type Ovarian Granulosa Cell Tumor | Ovarian Gynandroblastoma | Ovarian Sertoli-Leydig Cell Tumor | Ovarian Sex Cord Tumor With Annular Tubules | Ovarian Steroid Cell Tumor

United States, Japan

Clinical Trials on PIK3CA Mutation-Related Tumors

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Mauritania

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations