Clinical Trials on Pancreatic Beta Cell Function

Total 946 results

University Health Network, Toronto

Completed

Mechanism of Fatty Acid-Induced Impairment of Glucose-Stimulated Insulin Secretion

Insulin Resistance Syndrome X | Pancreatic Beta Cell Function

Canada
Kyunghee University Medical Center
Sanofi; Korea University Guro Hospital; Hanyang University; The Catholic University... and other collaborators

Completed

Study To Evaluate Beta Cell Function and Glycemic Outcome by Intensive Insulin Therapy (KIIT)

Type 2 Diabetes Mellitus | Pancreatic Beta Cell Function | Glucotoxicity

Korea, Republic of
Shanghai 10th People's Hospital

Completed

Related Mechanisms of RBP4 in Glycolipid Metabolism

Beta Cell Dysfunction

China
University of British Columbia

Completed

Evaluation of Low-cost Techniques for Detecting Sickle Cell Disease and β-thalassemia in Nepal and Canada

Sickle Cell Disease | Beta-Thalassemia | Sickle Cell Trait | Sickle Cell-Beta Thalassemia | Sickle Cell-SS Disease

Canada, Nepal
Northwestern University
GlaxoSmithKline; National Comprehensive Cancer Network; Robert H. Lurie Cancer...

Completed

Temozolomide and Pazopanib Hydrochloride in Treating Patients With Advanced Pancreatic Neuroendocrine Tumors That Cannot Be Removed By Surgery

Recurrent Islet Cell Carcinoma | Pancreatic Alpha Cell Carcinoma | Pancreatic Beta Islet Cell Carcinoma | Pancreatic Delta Cell Carcinoma | Pancreatic G-cell Carcinoma

United States
M.D. Anderson Cancer Center

Withdrawn

Pre-transplant Immunosuppression and Donor Stem Cell Transplant for the Treatment of Severe Hemoglobinopathies

Sickle Cell Disease | Sickle Beta Thalassemia | Beta Thalassemia Major | Sickle Cell-SS Disease | Sickle Beta 0 Thalassemia | Sickle Beta Plus Thalassemia

United States
Maastricht University Medical Center

Completed

Restriction of Dietary AGEs to Prevent Diabetes in Overweight Individuals

Diet | Vascular Function | Insulin Sensitivity/Resistance | Beta-cell Function | Advanced Glycation Endproducts | AGEs

Netherlands
National Heart, Lung, and Blood Institute (NHLBI)

Enrolling by invitation

Investigating the Mechanistic Effects of Mitapivat in Subjects With Sickle Cell Disease

Sickle Cell Anemia | Sickle Beta Thalassemia | Sickle Cell Thalassemia | Sickle Beta Zero Thalassemia | Sickle Cell Pain | Hbss | Hbsc | Sickle Cell Syndrome Variant

United States
Bispebjerg Hospital
Danish Heart Foundation

Completed

Effect of Beta Blocker Treatment on Endothelial Function in Patients With Type 2 Diabetes or Chronic Heart Failure

Endothelial Function | Beta Blocker

Denmark
Vertex Pharmaceuticals Incorporated
CRISPR Therapeutics

Recruiting

Evaluation of Efficacy and Safety of a Single Dose of CTX001 in Participants With Transfusion-Dependent β-Thalassemia and Severe Sickle Cell Disease

Hematologic Diseases | Genetic Diseases, Inborn | Sickle Cell Disease | Hemoglobinopathies | Sickle Cell Anemia | Thalassemia | Beta-Thalassemia

United States, Italy, Germany, Saudi Arabia
Vertex Pharmaceuticals Incorporated
CRISPR Therapeutics

Enrolling by invitation

A Long-term Follow-up Study in Participants Who Received CTX001

Hematologic Diseases | Genetic Diseases, Inborn | Sickle Cell Disease | Hemoglobinopathies | Sickle Cell Anemia | Thalassemia | Beta-Thalassemia

United States, Canada, Italy, United Kingdom, Germany
Kenneth Ataga, MD
Augusta University

Completed

Hepcidin Levels in Sickle Cell Disease (SCD)

Sickle Cell Anemia | Sickle - Beta Thalassemia
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Cord Blood Transplantation for Sickle Cell Anemia and Thalassemia

Hematologic Diseases | Anemia, Sickle Cell | Beta-Thalassemia | Hematopoietic Stem Cell Transplantation

United States, Canada
Nova Laboratories Limited

Completed

Pharmacokinetics of Oral Hydroxyurea Solution (HUPK)

Sickle Cell Disease | Sickle Cell Hemoglobin C | Sickle Cell-beta-thalassemia | Sickle-Cell; Hemoglobin Disease, Thalassemia

United Kingdom, Jamaica
University of Milan
Luigi Sacco University Hospital

Completed

Effects of COVID-19 Infection on Beta-cell Function in Euglycemic Patients (COBETOX)

COVID19 | BETA-CELL FUNCTION

Italy
National Heart, Lung, and Blood Institute (NHLBI)

Not yet recruiting

Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease

Sickle Cell Disease | Sickle Cell Disorders | Hb-SS Disease | Hemoglobin S | Disease Sickle Cell Anemia | Hemoglobin Beta Thalassemia Disease

United States
Phoenicia BioScience
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

The BENeFiTS Trial in Beta Thalassemia Intermedia (PB04-001)

Sickle Cell Disease | Beta Thalassemia Intermedia

United States, Canada
Northwell Health

Completed

HSCT For Patients With High Risk Hemoglobinopathies Using Reduced Intensity

Sickle Cell Disease | Beta Thalassemia-Major

United States
Editas Medicine, Inc.

Not yet recruiting

A Long-Term Follow-Up Study of Participants With Sickle Cell Disease or Transfusion Dependent β-Thalassemia Who Received EDIT-301

Sickle Cell Disease | Hemoglobinopathies | Transfusion-dependent Beta-Thalassemia
Emory University
Patient-Centered Outcomes Research Institute

Completed

Decision Aid for Therapeutic Options In Sickle Cell Disease

Sickle Cell Disease | Sickle Cell Anemia | Hemoglobin SC | Hemoglobin SS | Hemoglobin Beta Thalassemia

United States
Toronto Metropolitan University
Mitacs

Recruiting

Adaptive Music Therapy for Psychosocial and Cognitive Functions of Older Adults (AMT)

Stress, Psychological | Loneliness | Emotion Regulation | Well Being | Executive Functions | Functional Abilities

Canada
Novartis Pharmaceuticals

Completed

Study of Efficacy and Safety of PDR001 in Patients With Advanced or Metastatic, Well-differentiated, Non-functional Neuroendocrine Tumors of Pancreatic, Gastrointestinal (GI), or Thoracic Origin or Poorly-differentiated Gastroenteropancreatic Neuroendocrine Carcinoma (GEP-NEC)

Well-differentiated Non-functional NET of Thoracic Origin | Well-differentiated Non-functional NET of Gastrointestinal Origin | Well-differentiated Non-functional NET of Pancreatic Origin | Poorly-differentiated Gastroenteropancreatic Neuroendocrine Carcinoma

United States, Italy, Spain, Japan, Belgium, Netherlands, Germany, France, Canada, Austria, United Kingdom, Australia
Martin Angst

Completed

Evaluation of Immune Signaling Networks in Healthy Human Volunteers

Normal Immune Cell Function

United States
Clinica Universidad de Navarra, Universidad de...
Instituto de Salud Carlos III

Completed

Dysfunctional Adiposity and Glucose Impairment (DICAMANO)

Insulin Resistance | Body Composition | Cardiovascular Risk Factor | Obesity, Abdominal | Visceral Obesity | Carbohydrate Intolerance | Beta-cell Function | Oral Glucose Tolerance Test
Regeneron Pharmaceuticals

Recruiting

A Natural History Study in Pediatric Participants With Hearing Loss Due to OTOF, GJB2, or GJB2/GJB6 Mutations (ENSEMBLE)

Congenital Hearing Loss Secondary to Biallelic Mutations in the Otoferlin Gene (OTOF) | Biallelic Mutations in the Gap Junction Beta 2 (GJB2) Gene | Digenic Mutations in GJB2/Gap Junction Beta 6 (GJB6) Genes

United States
Foundation for Liver Research

Withdrawn

Pancreatic Enzyme Suppletion in Pancreatic Cancer (EPC)

Adenocarcinoma of the Pancreas | Normal Pancreatic Exocrine Function

Netherlands
Hillel Yaffe Medical Center

Unknown

Prevalence Of Microalbuminuria Among Children Suffering From Sickle Cell Nephropathy and Sickle Cell/Beta-Thalassemia

Sickle Cell Anemia | Beta-Thalassemia | Microalbuminuria
Amsterdam UMC, location VUmc

Completed

Sitagliptin Prophylaxis for Glucocorticoid-Induced Impairment of Glucose Metabolism in Males With the Metabolic Syndrome (SPHINX)

Diabetes Mellitus | Steroid Diabetes | Glucocorticoid-induced Diabetes | Beta-cell Function

Netherlands
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia

Sickle Cell Anemia | Beta Thalassemia

United States
Columbia University

Active, not recruiting

Stem Cell Transplant in Sickle Cell Disease and Thalassemia

Sickle Cell Disease | Beta Thalassemia

United States
Assiut University

Not yet recruiting

Pumilio1 (PUM1) Expression, Sickle Cell Anemia, β-thalassemia Intermedia

Sickle Cell Disease, Beta Thalassemia Intermedia
Memorial Sloan Kettering Cancer Center

Recruiting

A Study of Immune Suppression Treatment for People With Sickle Cell Disease or β-Thalassemia Who Are Going to Receive an Allogeneic Hematopoietic Cell Transplantation (HCT)

Sickle Cell Disease | Thalassemia | Thalassemia, Beta

United States
National Institute of Allergy and Infectious Diseases...

Recruiting

Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants

Malaria | Sickle Cell Disease | Alpha and Beta Thalassemia | Human Physiology

United States
bluebird bio

Completed

A Study Evaluating the Safety and Efficacy of LentiGlobin BB305 Drug Product in β-Thalassemia Major (Also Referred to as Transfusion-dependent β-Thalassemia [TDT]) and Sickle Cell Disease

Sickle Cell Disease | Beta-Thalassemia Major

France
Nanfang Hospital of Southern Medical University
Peking University People's Hospital; Sun Yat-sen University; Guangzhou First... and other collaborators

Unknown

Mesenchymal Stem Cells for Treatment of Poor Graft Function After Allogeneic Hematopoietic Stem Cell Transplant

Mesenchymal Stem Cells | Hematological Diseases | Stem Cell Transplantation, Hematopoietic | Poor Graft Function

China
Memorial Sloan Kettering Cancer Center

Terminated

T-cell Depleted Hematopoietic Stem Cell Boosts Without Conditioning for Poor Marrow Graft Function Following Allogeneic Hematopoietic Stem Cell Transplantation

Hematopoietic Stem Cell Transplant | Poor Marrow Graft Function

United States
National Cancer Institute (NCI)

Completed

In Vitro Study of Peripheral Blood Mononuclear Cell Function in Healthy Individuals and Patients

Cell Function

United States
University of Florida
Wakunaga Pharmaceutical Co., Ltd.

Completed

The Effect of Aged Garlic Extract Supplementation on Immune System

Improvement in Immune Cell Function in Healthy Humans

United States
University of Florida
Kyowa Hakko Bio Co., Ltd.

Completed

Oral Glutathione Supplementation in Older Healthy Adults and Its Effect on the Number of Healthy Days Experienced During Four Months of Supplementation Compared to Placebo (GSH)

Improvement in Immune Cell Function in Elderly Humans

United States
Paul Szabolcs

Recruiting

T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemias

Sickle Cell Anemia | Diamond-blackfan Anemia | Beta-thalassemia Major

United States
National Cancer Institute (NCI)

Recruiting

APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation

Pancreatic Acinar Cell Carcinoma | Pancreatic Adenosquamous Carcinoma | Pancreatic Squamous Cell Carcinoma | Resectable Pancreatic Acinar Cell Carcinoma | Resectable Pancreatic Adenocarcinoma | Resectable Pancreatic Adenosquamous Carcinoma | Resectable Pancreatic Carcinoma

United States
National Heart, Lung, and Blood Institute (NHLBI)
National Institutes of Health Clinical Center (CC); National Cancer Institute...

Recruiting

Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure

Stem Cell Transplantation | Sickle Cell Disease | Thalassemia | Graft vs Host Disease

United States
Cyprus Institute of Neurology and Genetics

Recruiting

Study of the Role of Genetic Modifiers in Hemoglobinopathies (INHERENT)

Sickle Cell Disease | Hemoglobinopathies | Thalassemia Alpha | Thalassemia, Beta

United States, Denmark, Spain, Belgium, Portugal, Congo, The Democratic Republic of the, Greece, Argentina, Brunei Darussalam, Cyprus, Israel, Italy, Nigeria, Malaysia, Angola, Pakistan
Sangamo Therapeutics

Enrolling by invitation

Long - Term Follow Up of Sickle Cell Disease and Beta-thalassemia Subjects Previously Exposed to BIVV003 or ST-400.

Blood and Lymphatic Diseases

United States
Kang YU
CARsgen Therapeutics Co., Ltd.

Active, not recruiting

Clinical Study of Redirected Autologous T Cells With a Chimeric Antigen Receptor in Patients With Malignant Tumors

Hepatocellular Carcinoma | B Cell Lymphoma | Pancreatic Carcinoma | Myeloma | B Cell Leukemia | Adenocarcinoma of Esophagogastric Junction

China
Ain Shams University

Unknown

Study Of Efficacy,Safety of Combined Deferasirox and Deferiprone Versus Combined Deferiprone and Desferal In Conditions of Iron Overload

Sickle Cell Disease | Beta-thalassemia Major | Iron Hemosiderosis

Egypt
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Recruiting

The PLATINUM Trial: Optimizing Chemotherapy for the Second-Line Treatment of Metastatic BRCA1/2 or PALB2-Associated Metastatic Pancreatic Cancer

Pancreatic Adenocarcinoma | Pancreatic Ductal Adenocarcinoma | Stage IV Pancreatic Cancer AJCC v8 | Pancreatic Carcinoma | Pancreatic Acinar Cell Carcinoma | Pancreatic Adenosquamous Carcinoma | Pancreatic Squamous Cell Carcinoma

United States
Seoul National University Bundang Hospital
Samsung Medical Center; Wonju Severance Christian Hospital

Recruiting

Carvedilol in HF With Preserved EF

Heart Failure With Preserved Ejection Fraction | Myocardial Strain | Beta Blocker

Korea, Republic of
University of Haifa

Completed

Playfulness in Online and Face-to-face Interactions, From Adulthood to Aging (Play)

Aging | Executive Function | Social Behavior | Cognitive Function 1, Social | Aging Well

Israel
Amsterdam UMC, location VUmc
National Research Council, Institute of Biomedical Engineering

Completed

PREDnisolone-induced Beta-cell Dysfunction Prevented by EXenatide (PREDEX)

Glucocorticoid-induced Glucometabolic Abnormalities | Glucocorticoid-induced Beta-cell Dysfunction

Netherlands

Clinical Trials on Pancreatic Beta Cell Function

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