Clinical Trials on Progressive Multiple Sclerosis

Total 11114 results

Duke University
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and other collaborators

Completed

The CARRA Registry (CARRA Registry)

Systemic Lupus Erythematosus | Vasculitis | Systemic Sclerosis | Juvenile Idiopathic Arthritis | Localized Scleroderma | Sarcoid | Juvenile Dermatomyositis | Fibromyalgia, Primary | Mixed Connective Tissue Disease | Juvenile Ankylosing Spondylitis | Auto-inflammatory Disease | Idiopathic Uveitis Idiopathic

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant

Lymphoma | Myelodysplastic Syndromes | Leukemia | Testicular Germ Cell Tumor | Breast Cancer | Chronic Myeloproliferative Disorders | Ovarian Cancer | Gestational Trophoblastic Tumor | Neuroblastoma | Multiple Myeloma and Plasma Cell Neoplasm | Myelodysplastic/Myeloproliferative Diseases | Graft Versus Host...

United States
Salarius Pharmaceuticals, LLC

Enrolling by invitation

A Rollover Protocol to Allow for Continued Access to the LSD1 Inhibitor Seclidemstat (SP-2577)

Ewing Sarcoma | Myxoid Liposarcoma | Desmoplastic Small Round Cell Tumor | Angiomatoid Fibrous Histiocytoma | Extraskeletal Myxoid Chondrosarcoma | Clear Cell Sarcoma | Myoepithelial Tumor | Sclerosing Epithelioid Fibrosarcoma | Low Grade Fibromyxoid Sarcoma

United States
Children's Oncology Group
National Cancer Institute (NCI)

Recruiting

A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia

Down Syndrome | Myeloid Leukemia Associated With Down Syndrome | B Acute Lymphoblastic Leukemia Associated With Down Syndrome

United States
GeoVax, Inc.
National Cancer Institute (NCI)

Recruiting

SARS-CoV-2 Vaccine (GEO-CM04S1) Versus mRNA SARS-COV-2 Vaccine in Patients With Blood Cancer

Lymphoma | Leukemia | Plasma Cell Myeloma | Hematopoietic and Lymphoid System Neoplasm | COVID-19 Infection

United States
University of Alabama at Birmingham

Recruiting

Study to Evaluate the Role of Siltuximab in Treatment of Cytokine Release Syndrome (CRS) and Immune Effector Cell Associated Neurotoxicity (ICANS) Related to CAR-T Cell Therapy

Lymphoma, Non-Hodgkin | Multiple Myeloma | Acute Lymphoblastic Leukemia | Cytokine Release Syndrome | ICANS

United States
University of Chicago

Recruiting

Dyspnea and Cardiotoxicity in Multiple Myeloma Patients Who Receive Carfilzomib

Multiple Myeloma | Cardiotoxicity | Dyspnea | Shortness of Breath

United States
University of Colorado, Denver
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Recruiting

Tofacitinib for Immune Skin Conditions in Down Syndrome

Psoriasis | Down Syndrome | Vitiligo | Hidradenitis Suppurativa | Alopecia Areata | Atopic Dermatitis / Eczema

United States
CellCentric Ltd.

Recruiting

Study to Evaluate CCS1477 in Haematological Malignancies

Acute Myeloid Leukemia | Multiple Myeloma | Non Hodgkin Lymphoma | Peripheral T Cell Lymphoma | Haematological Malignancy | Higher-risk Myelodysplastic Syndrome

United Kingdom, United States, France, Sweden, Spain
National Institute of Allergy and Infectious Diseases...

Recruiting

Natural History and Genetics of Food Allergy and Related Conditions

Eosinophilic Esophagitis | Atopic Dermatitis | Food Allergy | Loeys-Dietz Syndrome

United States
Fundación Pública Andaluza para la gestión de la...

Active, not recruiting

Ixazomib in the Prophylaxis of Chronic Graft-versus-host Disease.

Multiple Myeloma | Hematopoietic Stem Cell Transplantation

Spain
Barbara Ann Karmanos Cancer Institute

Completed

DISCO Application for the Improvement of Financial Outcomes in Patients With Hematologic Cancer

Chronic Lymphocytic Leukemia | Plasma Cell Myeloma | Chronic Myelogenous Leukemia, BCR-ABL1 Positive

United States
ProQR Therapeutics

Terminated

Study to Evaluate the Efficacy Safety and Tolerability of QR-421a in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene With Early to Moderate Vision Loss (Celeste)

Eye Diseases | Retinitis Pigmentosa | Eye Diseases, Hereditary | Vision Disorders | Retinal Disease | Eye Disorders Congenital | Usher Syndrome Type 2 | Deaf Blind

United States, United Kingdom
University of Oxford
Medical Research Council

Completed

Deep Brain Stimulation for Autonomic and Gait Symptoms in Multiple System Atrophy (STAG-MSA)

Multiple System Atrophy | Gait Disorders, Neurologic | Bladder, Neurogenic | Autonomic Failure | Postural Hypotension

United Kingdom
Minsk Scientific-Practical Center for Surgery,...
Belarusian State Medical University

Completed

Pneumococcal Vaccination of Multiple Myeloma Patients on Novel Agents

Multiple Myeloma | Febrile Neutropenia | Pneumococcal Pneumonia | Pneumococcal Infection

Belarus
Natera, Inc.
Houston Perinatal Associates; Lyndhurst Clinical Research; Dr. Carpenter Maternal... and other collaborators

Completed

Multiple Gestation Study

Trisomy 21 | Trisomy 18 | Trisomy 13 | Sex Chromosome Abnormalities

United States, India, Malaysia
Natera, Inc.
Montefiore Medical Center; Tufts Medical Center; MOUNT SINAI HOSPITAL; Long Island...

Completed

High Risk Multiple Gestation Study

Trisomy 21 | Trisomy 18 | Trisomy 13 | Sex Chromosome Abnormalities

United States
Ascend Biopharmaceuticals Ltd

Completed

A Study of the Efficacy and Safety of ASN-002 in Adult Patients With Low-risk Nodular Basal Cell Carcinoma (ASN-002-001)

Basal Cell Nevus Syndrome | Skin Neoplasm | Nodular Basal Cell Carcinoma of Skin

Australia
Abant Izzet Baysal University
Hacettepe University

Unknown

Interrater Reliability of Infant Motor Profile (IMP)

Cerebral Palsy | Down Syndrome | Premature Infants | Spina Bifida | Metabolic Disorders | Low; Birthweight, Extremely (999 Grams or Less)
Celgene

Completed

A Study to Determine Final Geriatric Assessment in Haematology (GAH) Score as a Tool for Predicting Tolerance to Treatment in Elderly Patients (≥ 65 Years) With Haematologic Neoplasms

Myelodysplastic Syndromes | Multiple Myeloma | Leukemia, Lymphocytic, Chronic, B-Cell | Leukemia Myeloid Acute

Spain
University of Rochester

Terminated

Fludarabine, Cyclophosphamide, and Total-Body Irradiation Followed by Cyclosporine and Mycophenolate Mofetil in Treating Patients Who Are Undergoing a Donor Umbilical Cord Blood Transplant for Hematologic Cancer

Lymphoma | Myelodysplastic Syndromes | Leukemia | Chronic Myeloproliferative Disorders | Multiple Myeloma | Graft Versus Host Disease | Myelodysplastic/Myeloproliferative Neoplasms

United States
Novartis Pharmaceuticals

Completed

A Trial to Evaluate the Safety, Local Tolerability, Pharmacokinetics and Pharmacodynamics of LDE225 on Skin Basal Cell Carcinomas in Gorlin Syndrome Patients

Treatment for Basal Cell Carcinomas (BCCs) in Gorlin Syndrome Patients

Austria, Switzerland
Georgetown University
National Institute of Environmental Health Sciences (NIEHS); University of...

Completed

Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome

Irritable Bowel Syndrome | Fibromyalgia | Interstitial Cystitis | Chronic Fatigue Syndrome | Gulf War Illness | Multiple Chemical Sensitivity

United States
Hospital Clinic of Barcelona
Instituto de Salud Carlos III; European Union

Completed

Prevention of Left Ventricular Dysfunction During Chemotherapy (OVERCOME)

Lymphoma | Acute Myeloid Leukemia | Multiple Myeloma | Lymphoid Neoplasm | Autologous Hematopoietic Stem Cell Transplantation | Precursor-cell Lymphoblastic Leukemia-Lymphoma

Spain
University Hospital, Bordeaux

Completed

Assessment of Ambulatory Polygraphy in the Detection of Sleep Apnea in Multiple System Atrophy (SAMSA)

Sleep Apnea Syndromes | Multiple System Atrophy

France
Amgen

Completed

Chemotherapy Related Anemia in Patients With Non-Myeloid Malignancies

Lymphoma | Breast Neoplasms | Lung Neoplasms | Multiple Myeloma | Chronic Lymphocytic Leukemia
O & O Alpan LLC

Unknown

Investigating Lysosomal Storage Diseases in Minority Groups

Fabry Disease | Niemann-Pick Disease | Gaucher Disease | Pompe Disease | Lysosomal Storage Disorders

United States
Brigham and Women's Hospital
Bristol-Myers Squibb

Recruiting

Rheumatology-based Adaptive Intervention for Social Determinants and Health Equity (RAISE)

Rheumatoid Arthritis | Systemic Sclerosis | Inflammatory Arthritis | Psoriatic Arthritis | Sjogren's Syndrome | Juvenile Rheumatoid Arthritis | Ankylosing Spondylitis | Undifferentiated Connective Tissue Diseases | Lupus | Sacroiliitis | Sicca Syndrome | Mixed Connective Tissue Disease | Palindromic Arthritis | Enteropathic...

United States
Salarius Pharmaceuticals, LLC
National Pediatric Cancer Foundation

Active, not recruiting

Clinical Trial of SP-2577 (Seclidemstat) in Patients With Relapsed or Refractory Ewing or Ewing-related Sarcomas

Ewing Sarcoma | Myxoid Liposarcoma | Fibromyxoid Tumor | Sarcoma,Soft Tissue | Desmoplastic Small Round Cell Tumor | Angiomatoid Fibrous Histiocytoma | Extraskeletal Myxoid Chondrosarcoma | Clear Cell Sarcoma | Primary Pulmonary Myxoid Sarcoma | Myoepithelial Tumor | Sclerosing Epithelioid Fibrosarcoma

United States
Northside Hospital, Inc.
Blood and Marrow Transplant Group of Georgia

Not yet recruiting

CAR T-cell Therapy in Patients With Renal Dysfunction

Multiple Myeloma | Acute Lymphoblastic Leukemia, Adult | Non-hodgkin Lymphoma,B Cell

United States
University of Colorado, Denver
National Cancer Institute (NCI)

Recruiting

Integrated Actionable Aging Assessment for Cancer Patients Pilot

Kidney Cancer | Leukemia | Myeloid Leukemia | Breast Cancer | Multiple Myeloma | Hodgkin Lymphoma | Prostate Cancer | Bladder Cancer | Lymphoid Leukemia | Monocytic Leukemia

United States
University of North Carolina, Chapel Hill
The Hospital for Sick Children; Washington University School of Medicine; McGill... and other collaborators

Recruiting

Characterizing the Upper Airway Manifestations in Primary Ciliary Dyskinesia and Primary Immunodeficiencies

Primary Ciliary Dyskinesia | Kartagener Syndrome | Primary Immune Deficiency

United States, Canada
Joseph M. Still Research Foundation, Inc.

Recruiting

Association of Cytokines With the Development of Complications in Burn and Toxic Epidermal Necrolysis (TENS) Patients

Inflammatory Response | Deep Vein Thrombosis | Multi Organ Failure | Nosocomial Infection

United States
Hospices Civils de Lyon

Not yet recruiting

Pregnancy in Women With Rare Multisystemic Vascular Diseases: COGRare5 Study (COGRare5)

Arteriovenous Malformations | Marfan Syndrome | Osler Rendu Disease | Vascular Anomaly | Lymphedema Primary | Cerebrospinal; Disorder

France
National Cancer Institute (NCI)

Recruiting

Natural History and Management of Von Hippel-Lindau (VHL) Associated Pancreatic Neuroendocrine Tumors

Neuroendocrine Tumors | Von Hippel-Lindau Disease | VHL Pancreatic Neuroendocrine Tumors

United States
University Hospital Tuebingen

Recruiting

First Trimester Screening for Trisomy 21, 18, 13 and 22q11.2 Deletion Syndrome (ReFaPo02)

Pregnancy

Germany
Imperial College London

Recruiting

Multiple Breath Washout, a Clinimetric Dataset

Bronchiectasis | Sleep Disorder | Asthma | Cystic Fibrosis | Bronchitis | Primary Ciliary Dyskinesia

United Kingdom
Barbara Ann Karmanos Cancer Institute

Completed

COVID-19 VAX Booster Dosing in Patients With Hematologic Malignancies

Multiple Myeloma | AL Amyloidosis | Chronic Lymphocytic Leukemia

United States
Rhythm Pharmaceuticals, Inc.

Completed

Setmelanotide (RM-493), Melanocortin-4 Receptor (MC4R) Agonist, in Bardet-Biedl Syndrome (BBS) and Alström Syndrome (AS) Participants With Moderate to Severe Obesity

Bardet Biedl Syndrome (BBS) | Alström Syndrome (AS)

United States, United Kingdom, France, Canada, Puerto Rico, Spain
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed, Non-metastatic Desmoplastic Medulloblastoma

Medulloblastoma | Nevoid Basal Cell Carcinoma Syndrome | Desmoplastic/Nodular Medulloblastoma | Medulloblastoma With Extensive Nodularity

United States, Canada, Puerto Rico, Australia
H. Lee Moffitt Cancer Center and Research Institute

Completed

Calcineurin Inhibitor-Free GVHD Prevention Regimen After Related Haplo PBSCT

Myelodysplastic Syndromes | Primary Myelofibrosis | Multiple Myeloma | Hodgkin Lymphoma | Non-Hodgkin's Lymphoma | Chronic Myelomonocytic Leukemia | Chronic Myeloid Leukemia | Acute Leukemia in Remission

United States
Masonic Cancer Center, University of Minnesota

Terminated

Stem Cell Transplant for Hematological Malignancy

Multiple Myeloma | AML | MDS | Non-hodgkin's Lymphoma | Leukemia, Lymphocytic, Acute | Hodgkin's Disease | Leukemia, Myeloid, Chronic | Leukemia, Lymphocytic, Chronic | JMML

United States
Physio-Assist
University Hospital, Marseille; CEISO

Terminated

Evaluation of the Safety of the Medical Device Simeox® (SIMETOL)

Cystic Fibrosis | Chronic Bronchitis | Chronic Obstructive Airway Disease | Broncho-degenerative Disease | Idiopathic Bronchiectasis | Ciliary Dyskinesia

France
Virginia Commonwealth University
Genzyme, a Sanofi Company

Completed

Reduced Intensity Total Body Irradiation + Thymoglobulin Followed by Allogeneic PBSCT

Acute Myeloid Leukemia | Leukemia | Multiple Myeloma | Hodgkin Lymphoma | Non-Hodgkin's Lymphoma | Chronic Lymphocytic Leukemia | Myelodysplastic Syndrome | Chronic Myelogenous Leukemia

United States
Sequenom, Inc.
Friends Research Institute, Inc.

Terminated

Clinical Performance of the MaterniT21 PLUS LDT in Multiple Gestation Pregnancies

Down Syndrome | Turner Syndrome | Edwards Syndrome | Patau Syndrome

United States
Triemli Hospital

Completed

A Cohort Study of Patients Treated With Brachytherapy for Selected Desmoid Patients in Gardner Syndrome

Colorectal Carcinoma | Desmoid Tumor | Gardner Syndrome
Nemours Children's Clinic

Recruiting

Genetics of Pediatric-Onset Motor Neuron and Neuromuscular Diseases

Charcot-Marie-Tooth Disease | Motor Neuron Disease | Amyotrophic Lateral Sclerosis | Muscular Dystrophy | Spinal Muscular Atrophy | Neuromuscular Disease | Spinal Muscular Atrophy With Respiratory Distress 1 | Peroneal Muscular Atrophy

United States
dr. Laura C. G. de Graaff-Herder

Recruiting

GROWing Up With Rare GENEtic Syndromes (GROW UR GENES)

Disorders of Sex Development | Congenital Adrenal Hyperplasia | Tuberous Sclerosis | Kallmann Syndrome | Prader-Willi Syndrome | Neurofibromatosis | Rett Syndrome | 22q11 Deletion Syndrome | Turner Syndrome | Noonan Syndrome | Allan-Herndon-Dudley Syndrome | Saethre-Chotzen Syndrome | Congenital Hypopituitarism | Cornelia... and other conditions

Netherlands
National Cancer Institute (NCI)

Completed

Sorafenib in Treating Patients With Metastatic or Unresectable Solid Tumors, Multiple Myeloma, or Non-Hodgkin's Lymphoma With or Without Impaired Liver or Kidney Function

Stage II Multiple Myeloma | Stage III Multiple Myeloma | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma | Recurrent Adult Diffuse Large Cell Lymphoma | Recurrent Adult Diffuse Mixed Cell Lymphoma and other conditions

United States
M.D. Anderson Cancer Center

Active, not recruiting

Combination Chemotherapy and Ponatinib Hydrochloride in Treating Patients With Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia | Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Philadelphia Chromosome Positive | B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 | Untreated Adult Acute Lymphoblastic Leukemia | Accelerated Phase Chronic Myelogenous Leukemia,... and other conditions

United States

Clinical Trials on Progressive Multiple Sclerosis

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Luxembourg

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations