Clinical Trials on ROS1 Gene Mutation

Total 1908 results

Pierre Fabre Medicament
Clinact

Completed

A Retrospective Non Interventional Study on First Line Treatment for Patients With BRAFV600E Mutant Metastatic Colorectal Cancer (mCRC) (CAPSTAN CRC)

Metastatic Colorectal Cancer | BRAF V600E Mutation Positive

France, United Kingdom, Spain, Belgium, Germany, Italy, Austria
International Academy of Osteopathy

Completed

The Effect of the Release of the Intrathoracic Fascia on Thoracic Rotation Mobility

Thoracic | Fascia; Inflammation | Rotation

Belgium
VA Office of Research and Development

Completed

Weight Loss Intervention for Individuals With Lower Extremity Amputation (MOVE-LEAP)

Lower Extremity Amputation

United States
Novartis Pharmaceuticals

Terminated

Phase III Study Investigating the Efficacy and Safety of Ruxolitinib in Early Myelofibrosis Patients With High Molecular Risk Mutations. (ReTHINK)

Myelofibrosis With High Molecular Risk Mutations

Belgium, Spain, United Kingdom, Hungary, Italy, Japan, Taiwan, Germany, Canada, Singapore, Austria, Australia, France, Israel, Sweden, Switzerland, Hong Kong, Greece, Turkey, Brazil, Russian Federation, Denmark, Portugal, Norway, Poland
UNICANCER

Completed

Letrozole in Preventing Breast Cancer in Postmenopausal Women With a BRCA1 or BRCA2 Mutation (LIBER)

Breast Cancer | Hereditary Breast/Ovarian Cancer (brca1, brca2) | brca1 Mutation Carrier | brca2 Mutation Carrier

France
National Cancer Institute (NCI)

Terminated

Ipilimumab With or Without Dabrafenib, Trametinib, and/or Nivolumab in Treating Patients With Melanoma That Is Metastatic or Cannot Be Removed by Surgery

Metastatic Melanoma | Stage III Cutaneous Melanoma AJCC v7 | Stage IV Cutaneous Melanoma AJCC v6 and v7 | Stage IIIC Cutaneous Melanoma AJCC v7 | BRAF V600E Mutation Present | BRAF V600K Mutation Present | Stage IIIA Cutaneous Melanoma AJCC v7 | Stage IIIB Cutaneous Melanoma AJCC v7

United States
Instituto Nacional de Cancerologia de Mexico
Roche Pharma AG

Completed

Alectinib in Combination With Bevacizumab in ALK Positive NSCLC

ALK Gene Rearrangement Positive | Non-Squamous Non-Small Cell Neoplasm of Lung

Mexico
Astellas Pharma Inc

Active, not recruiting

A Study of ASP2215 Versus Salvage Chemotherapy In Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) With FLT3 Mutation

Acute Myeloid Leukemia With FMS-like Tyrosine Kinase (FLT3) Mutation

China, Malaysia, Russian Federation, Singapore, Thailand
Maastricht University Medical Center

Recruiting

PCSK9 Polymorphism and Risk of Cardiac Rupture

Post-Infarction Heart Rupture | Gene Polymorphism

Italy
Peking University Cancer Hospital & Institute

Not yet recruiting

To Identify KRAS Gene and Safe Margin in Association With Outcome in Colorectal Liver Metastases Following Ultrasound-guided Radiofrequency Ablation

Colorectal Cancer | Radiofrequency Ablation | Liver Metastasis | KRAS Gene | Safe Margin
Istituto Ortopedico Rizzoli
University of Bologna; Istituto Nazionale Assicurazione contro gli Infortuni... and other collaborators

Completed

Evaluation of the Stability of Osseointegrated Implant in Amputees (METACOS)

Amputation | Prosthesis Migration

Italy
Joshua Hustedt

Enrolling by invitation

Targeted Muscle Reinnervation Study (TMR) (TMR)

Amputation

United States
US Department of Veterans Affairs

Completed

Evidence Based Amputee Rehabilitation (EBAR) Program (EBAR)

Diabetes Mellitus | Amputation Stumps

United States
Stephen Bagley, MD, MSCE
University of Pennsylvania; Incyte Corporation

Recruiting

All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma

Glioma | Astrocytoma | Oligodendroglioma | IDH Mutation

United States
Bayer

Completed

A Study Called EPI VITRAKVI to Compare Treatment Results in Patients With Infantile Fibrosarcoma (IFS), a Type of Connective Soft Tissue Cancer, Who Received a Treatment Called Larotrectinib From a Study Called SCOUT With Patient Data From an External Database (EPI VITRAKVI)

Locally Advanced or Metastatic Infantile Fibrosarcoma Harboring an NTRK Gene Fusion | Infantile Fibrosarcoma

France
Beijing Tiantan Hospital
Beijing Municipal Science & Technology Commission

Completed

Genetic Identification of Monogenic Disorders in Early-onset Stroke Using Targeted Next Generation Sequencing Panel (MDEOS)

Transient Ischemic Attack | Stroke, Acute | Single-gene Disorders

China
Merrimack Pharmaceuticals

Terminated

A Study of MM-111 and Paclitaxel With Trastuzumab in Patients HER2 Positive Carcinomas of the Distal Esophagus, Gastroesophageal (GE) Junction and Stomach

Stomach Cancer | Gastroesophageal Junction Cancer | HER-2 Gene Amplification | Esophagus Cancer

United States
GCS Ramsay Santé pour l'Enseignement et la Recherche

Not yet recruiting

Evaluation of Factors Associated With Return to Sports Activity Six Months After Anterior Shoulder Stabilisation With Latarjet. (ERASME)

Shoulder Luxation

France
Bernadette Dian Novita, MD.,PhD

Completed

OBSERVATIONAL STUDY OF COMPARISON EFFECTIVITY BETWEEN REMDESIVIR AND FAVIPIRAVIR IN SURABAYA, INDONESIA

Duration of Hospitalization | Clinical Manifestation of COVID-19

Indonesia
Johns Hopkins Bloomberg School of Public Health
University of Washington; Amputee Coalition of America

Completed

Self-Management Program for Persons With Limb Loss

Depression | Pain | Anxiety | Amputation

United States
Danish Pain Research Center
Pfizer

Completed

Gabapentin in Phantom and Stump Pain

Amputation of Lower Limb

Denmark
Seoul National University Hospital

Unknown

Empirical vs Tailored Therapy for H. Pylori Infection

Helicobacter Pylori Infection | Helicobacter Pylori 23S rRNA Clarithromycin Resistance Mutation

Korea, Republic of
Cynvenio Biosystems

Unknown

A Pilot Surveillance Study to Monitor Natural Killer Cells and Circulating Tumor Cells in Women With Previously Treated Non-metastatic Triple Negative Breast Cancer and Women With Previously Treated Non-metastatic Breast Cancer With a Confirmed BRCA Mutation.

Triple Negative Breast Cancer | BRCA Mutation | Natural Killer Cells

United States
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

PARP-inhibitor on Advanced Metastatic Breast Cancer in Germline PALB2 Mutations Carriers (PALB2-PARPi-01)

Metastatic Breast Cancer in Germline-PALB2 Mutations Carriers
Arog Pharmaceuticals, Inc.

Completed

A Safety and Tolerability Study of Crenolanib in Combination With Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia Patients With FLT3 Mutations

Newly Diagnosed AML With FLT3 Activating Mutations

United States
Number 2 Children's Hospital, Ho Chi Minh City

Recruiting

Genotype, Phenotype, and Disease Progression of Developmental Epileptic Encephalopathy With Onset Before 2 Years of Age

Child Development | Epilepsy; Seizure | Gene Abnormality | Early Onset Disorder

Vietnam
858 Therapeutics, Inc.

Recruiting

A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies (ERADIC8)

Breast Cancer | Gastric Cancer | Colorectal Cancer | Ovarian Cancer | Prostate Cancer | Endometrial Cancer | Epithelial Ovarian Cancer | BRCA1 Mutation | BRCA2 Mutation | Advanced or Metastatic Solid Tumors | ER+ Breast Cancer | Castrate Resistant Prostate Cancer | BRCA Mutation

United States
Relay Therapeutics, Inc.

Recruiting

First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Advanced Solid Tumor Patients and in Combination With Fulvestrant in Patients With Advanced Breast Cancer

Breast Cancer | Advanced Breast Cancer | Metastatic Breast Cancer | Solid Tumor, Adult | HER2-negative Breast Cancer | Unresectable Solid Tumor | PIK3CA Mutation

United States, Spain, France, Italy
Shanghai General Hospital, Shanghai Jiao Tong University...

Not yet recruiting

An Expanded Clinical Study Evaluating the AAV2-RPE65 Gene Therapy(LX101) in Patients With LCA

To Evaluate the Scaling Clinical Study of AAV2-RPE65 Gene Therapy Agent (LX101) in Patients With Congenital Amaurosis (LCA)
XuanwuH 2
University of Cologne

Recruiting

Early Diagnosis of SCD Based on Radiogenomics

Alzheimer Disease | Subjective Cognitive Decline | Neuroimaging | Gene

China
Aesculap AG
Raylytic GmbH; B. Braun Medical France

Recruiting

Evaluation of Medium Cross-linked Polyethylene With and Without Vitamin E for Total Knee Arthroplasty (VIKEP)

Arthritis, Rheumatoid | Osteoarthritis, Knee | Joint Instability | Intra-Articular Fractures | Genu Valgum or Varum

France, Germany
Centre Hospitalier Universitaire de la Réunion

Not yet recruiting

Contribution of Oncogenetics in Breast Cancer in Reunion Epidemiology of Breast Cancer in Reunion: Study of the Reunion Mutation on BRCA2 (CanSeR-OGen)

Breast Cancer | BRCA2 Mutation | Genetic Disease
Piramal Enterprises Limited
Melanoma Research Foundation Breakthrough Consortium

Suspended

Study of an Oral Cdk Inhibitor Administered With an Oral BRAF Inhibitor in Patients With Advanced or Inoperable Malignant Melanoma With BRAF Mutation

Advanced or Inoperable Malignant Melanoma With BRAF Mutation

United States
Royal Marsden NHS Foundation Trust

Recruiting

Inherited Cancer Early Diagnosis (ICED) Study (ICED)

Lynch Syndrome | Familial Adenomatous Polyposis | Hereditary Diffuse Gastric Cancer | Peutz-Jeghers Syndrome | Cowden Syndrome | Li Fraumeni Syndrome | MutYH-associated Polyposis | SMAD4 Gene Mutation

United Kingdom
Cairo University

Recruiting

Glenohumeral Internal Rotation Deficit Among Professional Athletes

Internal Rotation Contracture-shoulder

Egypt
Duke University

Completed

Glenohumeral Rotation After Throwing: RCT Comparing the Sleeper Stretch to the 90/90 Hip Lift With Balloon Blow Exercise

Internal Rotation Contracture-shoulder

United States
HaEmek Medical Center, Israel

Withdrawn

Penetration of Ertapenem Into Bone

Amputation

Israel
Xiaoxiang Chen

Recruiting

Anlotinib Combined With Dose-reduced Olaparib in Patients With Platinum-Sensitive Recurrent Ovarian Cancer (ANLOLA)

Neoplasms | Neoplasms by Histologic Type | Urogenital Neoplasms | Neoplasms by Site | Carcinoma | Neoplasms, Glandular and Epithelial | Genital Neoplasms, Female | Ovarian Diseases | Adnexal Diseases | Carcinoma, Ovarian Epithelial | Ovarian Cancer | Angiogenesis | Genital Diseases, Female | Antineoplastic Agents | BRCA1... and other conditions

China
Orthofix s.r.l.

Completed

Retrospective Evaluation of GGPSP's Safety and Clinical Performance for the Treatment of Lower Limbs Deformities.

Joint Diseases | Genu Varum | Genu Valgum | Knee Deformity | Ankle Deformity | Length Inequality, Leg | Discrepancy Length; Congenital | Deformity of Limb

Italy
Gruppo Italiano Malattie EMatologiche dell'Adulto

Recruiting

Venetoclax and Azacitidine for the Management of Molecular Relapse/Progression in Adult NPM1-mutated Acute Myeloid Leukemia

Acute Myeloid Leukemia | Acute Myeloid Leukemia, in Relapse | NPM1 Mutation

Italy
National Cancer Institute (NCI)

Completed

Veliparib, Carboplatin, and Paclitaxel in Treating Patients With Advanced Solid Cancer

Hereditary Breast and Ovarian Cancer Syndrome | Adult Solid Neoplasm | BRCA1 Mutation Carrier | BRCA2 Mutation Carrier

United States
National Taiwan University Hospital

Completed

HPI in Older Patients Undergoing Major Gastrointestinal Surgery

the Severity and Duration of Intraoperative Hypotension

Taiwan
King Saud University

Completed

Effect of Hot Pack on Labor Pain, Duration of Labor, and Satisfaction of Primigravidae Women in Saudi Arabia

Labor Pain | Satisfaction | Duration of Labor

Saudi Arabia
Degan Lu
Wu Jieping Medical Foundation

Not yet recruiting

A Single Center, Single Arm Clinical Study on the Treatment of Advanced Non-small Cell Lung Cancer With Positive EGFR Sensitive Mutations and Failed EGFR TKIs With the Combination of Enrotinib and Paclitaxel Monoclonal Antibody

Lung Cancer | Anlotinib | TKI Resistance | EGFR Sensitive Mutation | Pianzumab
National Cancer Institute (NCI)

Recruiting

Testing the Addition of an Anti-cancer Drug, SNDX-5613, to the Standard Chemotherapy Treatment (Daunorubicin and Cytarabine) for Newly Diagnosed Patients With Acute Myeloid Leukemia That Has Changes in NPM1 or MLL/KMT2A Gene

Acute Myeloid Leukemia With KMT2A Rearrangement | Acute Myeloid Leukemia With NPM1 Mutation

United States
Kyoto University
Osaka University; Mie University; Tokushima University; Tokyo Metropolitan Geriatric... and other collaborators

Completed

Repurposing Bromocriptine for Abeta Metabolism in Alzheimer's Disease (REBRAnD)

Familial Alzheimer Disease (FAD) | PSEN1 Mutation

Japan
Memorial Sloan Kettering Cancer Center

Recruiting

A Study of Selinexor in People With Wilms Tumors and Other Solid Tumors

Solid Tumor | Rhabdoid Tumor | Wilms Tumor | Nephroblastoma | Malignant Peripheral Nerve Sheath Tumors | MPNST | XPO1 Gene Mutation

United States
Mohamed Abdel-Rahman

Recruiting

Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome

Renal Cell Carcinoma | Hepatocellular Carcinoma | Mesothelioma | Cholangiocarcinoma | Uveal Melanoma | Cutaneous Melanoma | Meningioma Atypical | BAP1 Gene Mutation

United States
Assistance Publique Hopitaux De Marseille

Unknown

Evaluation of a Hysteroscopic Morcellator in Hysteroscopic Treatment of Submucosal Fibroids

Evaluate Both Technics on Procedure Duration | Characteristics and Perioperative Complications

France
Fundamenta Therapeutics, Ltd.
The First Affiliated Hospital of Zhengzhou University

Not yet recruiting

Safety and Efficacy of ThisCART19A Bridging Hematopoietic Stem Cell Transplantation in Patients With Refractory or Relapsed B-cell Acute Lymphoblastic Leukemia

Allogeneic, CAR-T, Protein Sequestration, Non-gene Edited

Clinical Trials on ROS1 Gene Mutation

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Malaysia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations