Clinical Trials on Ras-mutated Metastatic Colorectal Cancer

Total 11463 results

National Cancer Institute (NCI)
NRG Oncology

Completed

Whole-Brain Radiation Therapy or Stereotactic Radiosurgery With or Without Lapatinib Ditosylate in Treating Patients With Brain Metastasis From HER2-Positive Breast Cancer

Recurrent Breast Carcinoma | Invasive Breast Carcinoma | Metastatic Malignant Neoplasm in the Brain | Stage IV Breast Cancer AJCC v6 and v7 | HER2-Positive Breast Carcinoma

United States, Korea, Republic of, Canada
Duke University
National Cancer Institute (NCI)

Completed

Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Tumors

Brain and Central Nervous System Tumors | Metastatic Cancer | Neuroblastoma

United States
Rigshospitalet, Denmark
Odense University Hospital; Aarhus University Hospital; Region Capital Denmark; Candys Foundation

Completed

Postoperative Pain, Why Still in Hospital and DAOH Following TORS for SCCUP & OSAS

Pain, Postoperative | Postoperative Pain | Analgesia | Surgery | Cancer of Head and Neck | Oropharyngeal Cancer | Carcinoma of Unknown Primary

Denmark
Universitaire Ziekenhuizen KU Leuven

Unknown

Metachronic Brain Metastases After Esophagectomy for Esophageal Cancer (METABREC) (METABREC)

Esophageal Neoplasms | Brain Metastases | Esophagectomy

United States, France, Netherlands, Sweden, Belgium, Ireland
Fondazione per la Ricerca Ospedale Maggiore

Completed

Secondary Cancers in Myeloproliferative Neoplasms (MPN-K Study) (MPN-K)

Polycythemia Vera | Essential Thrombocythemia | Myelofibrosis

Israel, United Kingdom, Czechia, Germany, Italy, Spain
Hospices Civils de Lyon

Unknown

Radioiodine-avid Bone Metastases From Thyroid Cancer Without Structural Abnormality

Bone Metastases | Thyroid Cancer
Sun Yat-sen University

Unknown

A Study of the Gene Mutation Status in Cerebrospinal Fluid, Blood and Tumor Tissue of Non-small Cell Lung Cancer Patients With Brain Metastases

Lung Cancer | Brain Metastases | Cerebrospinal Fluid | Next-generation Sequencing

China
Head and Neck Cancer International Group

Completed

Ascertaining the Radiologic Prognostic Importance of Extranodal Extension on Imaging (iENE) in Head and Neck Cancer (EPIC-iENE DATA)

Head and Neck Squamous Cell Carcinoma | Extranodal Extension | Human Papilloma Virus Related Carcinoma

Switzerland, United Kingdom, United States, Germany, Australia, France, Spain, Denmark
Maastricht University Medical Center

Active, not recruiting

Time to Treatment and Disease-free Survival of Patients With High-risk Head-neck Cutaneous Squamous Cell Carcinoma

Recurrence | Carcinoma, Squamous Cell | Skin Cancer | Metastasis | Carcinoma, Squamous Cell of Head and Neck | Carcinoma, Squamous Cell, Skin

Netherlands
M.D. Anderson Cancer Center

Active, not recruiting

Sitravatinib and Nivolumab for the Treatment of Metastatic or Advanced Clear Cell Renal Cell Cancer

Metastatic Clear Cell Renal Cell Carcinoma | Advanced Clear Cell Renal Cell Carcinoma | Stage IV Renal Cell Cancer AJCC v8

United States
National Cancer Institute (NCI)

Completed

Nivolumab, Cabozantinib S-Malate, and Ipilimumab in Treating Patients With Recurrent Stage IV Non-small Cell Lung Cancer

Metastatic Lung Non-Squamous Non-Small Cell Carcinoma | Recurrent Lung Non-Squamous Non-Small Cell Carcinoma | Stage IV Lung Non-Small Cell Cancer AJCC v7

United States
xCures

Terminated

Biomarker Research Study for Patients With FGFR-Mutant Bladder Cancer Receiving Erdafitinib

Transitional Cell Carcinoma | Bladder Cancer | Urothelial Carcinoma | Metastatic Urothelial Carcinoma | FGFR2 Gene Mutation | FGFR3 Gene Mutation | FGFR2 Amplification | Bladder Urothelial Carcinoma | Locally Advanced Urothelial Carcinoma | Refractory Bladder Carcinoma | Refractory Bladder Urothelial Carcinoma and other conditions

United States
University of Washington
National Cancer Institute (NCI)

Completed

TLR8 Agonist VTX-2337 and Cetuximab in Treating Patients With Locally Advanced, Recurrent, or Metastatic Squamous Cell Cancer of Head and Neck

Tongue Cancer | Recurrent Metastatic Squamous Neck Cancer With Occult Primary | Recurrent Salivary Gland Cancer | Recurrent Squamous Cell Carcinoma of the Hypopharynx | Recurrent Squamous Cell Carcinoma of the Larynx | Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity | Recurrent Squamous... and other conditions

United States
Rennes University Hospital
Roche Pharma AG; National Research Agency, France

Completed

BMS_PD-L1_onco : Assessment of the PD-L1 Protein as a Biomarker in Oncology and Hematology (BMS_PD-L1)

Hodgkin Lymphoma | Non-small Cell Lung Cancer | Diffuse Large B-cell Lymphoma | Metastatic Breastcancer

France
Northwestern University
National Cancer Institute (NCI); Pfizer

Terminated

Palbociclib in Treating Patients With Metastatic HER-2 Positive Breast Cancer With Brain Metastasis

Stage IV Breast Cancer | Recurrent Breast Carcinoma | Estrogen Receptor Negative | HER2/Neu Negative | HER2/Neu Positive | Progesterone Receptor Negative | Breast Carcinoma Metastatic in the Brain

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Blood Tests and Questionnaires in Studying Adherence to Preventative Swallowing Exercises in Participants With Metastatic Head and Neck Cancer

Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Stage III Hypopharyngeal Carcinoma AJCC v8 | Stage III Laryngeal Cancer AJCC v8 | Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8 | Stage IV Hypopharyngeal Carcinoma AJCC v8 | Stage IV Laryngeal Cancer... and other conditions

United States
KaliVir Immunotherapeutics

Not yet recruiting

A Study of VET3-TGI in Patients With Solid Tumors (STEALTH-001)

Kidney Cancer | Renal Cell Carcinoma | Cervical Cancer | Mesothelioma | Non-small Cell Lung Cancer | Head and Neck Squamous Cell Carcinoma | Solid Tumor, Adult | Microsatellite Stable Colorectal Cancer | Melanoma Stage IV | Merkel Cell Carcinoma of Skin
Angiochem Inc

No longer available

Expanded Access to ANG1005 for Individual Patients

Anaplastic Astrocytoma | Anaplastic Oligodendroglioma | Leptomeningeal Carcinomatosis | Breast Cancer With Recurrent Brain Metastases

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease

Castleman Disease | Lymphangioleiomyomatosis | Digestive System Carcinoma | Malignant Neoplasm | Recurrent Breast Carcinoma | Recurrent Thyroid Gland Carcinoma | Metastatic Urothelial Carcinoma | Malignant Female Reproductive System Neoplasm | Neurofibromatosis Type 2 | Recurrent Adult Soft Tissue Sarcoma and other conditions

United States
Ohio State University Comprehensive Cancer Center

Completed

Phase 1b Food Based Modulation of Biomarkers in Human Tissues at High-Risk for Oral Cancer.

Tongue Cancer | Salivary Gland Squamous Cell Carcinoma | Stage I Salivary Gland Cancer | Stage I Squamous Cell Carcinoma of the Hypopharynx | Stage I Squamous Cell Carcinoma of the Larynx | Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity | Stage I Squamous Cell Carcinoma of the Nasopharynx and other conditions

United States
Hospital Universitario de Móstoles

Recruiting

Endoscopic Surveillance in Serrated Polyposis Syndrome and Low-risk of Advanced Neoplasia

Colonic Polyp | Colonic Neoplasms | Colonic Cancer | Serrated Polyposis | Serrated Polyp of Colon

Spain
University Hospital, Antwerp

Completed

Dendritic Cell Vaccination for Patients With Solid Tumors

Renal Cell Carcinoma | Glioblastoma | Malignant Mesothelioma | Colorectal Tumors | Breast Cancers | Sarcomas

Belgium
Pfizer

Recruiting

A Study of PF-07820435 as a Single Agent and in Combination in Participants With Advanced Solid Tumors

Melanoma | Neoplasms | Renal Cell Carcinoma | Non-small-cell Lung Cancer | Squamous Cell Carcinoma of the Head and Neck | Urothelial Carcinoma | Colorectal Carcinoma | Ovarian Carcinoma

United States, Japan, Puerto Rico
National Cancer Institute (NCI)
NRG Oncology

Recruiting

Testing the Addition of the AKT Inhibitor, Ipatasertib, to Treatment With the Hormonal Agent Megestrol Acetate for Recurrent or Metastatic Endometrial Cancers

Recurrent Endometrial Endometrioid Adenocarcinoma | Stage IV Uterine Corpus Cancer AJCC v8 | FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma | FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma | Metastatic Endometrial Endometrioid Adenocarcinoma

United States
National Cancer Institute (NCI)

Completed

Temsirolimus and Bevacizumab in Treating Patients With Advanced Endometrial, Ovarian, Liver, Carcinoid, or Islet Cell Cancer

Uterine Carcinosarcoma | Recurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma | Recurrent Uterine Corpus Carcinoma | Ovarian Endometrioid Adenocarcinoma | Ovarian Seromucinous Carcinoma | Endometrial Serous Adenocarcinoma | Lung Carcinoid Tumor | Metastatic... and other conditions

United States, Canada
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Active, not recruiting

Cancer and Blood Pressure Management, CARISMA Study

Metastatic Renal Cell Carcinoma | Chronic Kidney Disease | Stage IV Renal Cell Cancer AJCC v8 | Cardiovascular Disorder | Metastatic Thyroid Gland Medullary Carcinoma | Stage IV Thyroid Gland Medullary Carcinoma AJCC v8 | Stage IVA Thyroid Gland Medullary Carcinoma AJCC v8 | Stage IVB Thyroid Gland... and other conditions

United States
Yale University

Completed

MK-3475 in Melanoma and NSCLC Patients With Brain Metastases

Melanoma | Non-Small Cell Lung Cancer | Brain Metastases

United States
Case Comprehensive Cancer Center
National Cancer Institute (NCI)

Withdrawn

Ovarian Damage in Young Premenopausal Women Undergoing Chemotherapy for Cancer

Lymphoma | Unspecified Childhood Solid Tumor, Protocol Specific | Leukemia | Unspecified Adult Solid Tumor, Protocol Specific | Long-term Effects Secondary to Cancer Therapy in Children | Long-term Effects Secondary to Cancer Therapy in Adults | Sexuality and Reproductive Issues | Sexual Dysfunction...

United States
HRYZ Biotech Co.

Recruiting

HRYZ-T101 Injection for HPV18 Positive Solid Tumor

Cervical Cancer | Head and Neck Squamous Cell Carcinoma | Anal Cancer | Carcinoma of Penis | Carcinoma of Vulva | Carcinoma of Vagina

China
Northwestern University
National Cancer Institute (NCI); Merck Sharp & Dohme LLC

Recruiting

Pembrolizumab and Carboplatin in Treating Patients With Circulating Tumor Cells Positive Metastatic Breast Cancer

Stage IV Breast Cancer | Recurrent Breast Carcinoma | Estrogen Receptor Negative | Estrogen Receptor Positive | HER2/Neu Negative | Progesterone Receptor Negative | Triple-Negative Breast Carcinoma

United States
Ohio State University Comprehensive Cancer Center
American Cancer Society, Inc.; Lance Armstrong Foundation

Completed

Cognitive-Behavioral Intervention for Worry, Uncertainty, and Insomnia for Cancer Survivors (FOCUS)

Depression | Pain | Leukemia | Fatigue | Multiple Myeloma | Insomnia | Pancreatic Cancer | Esophageal Cancer | Lung Cancer | Glioblastoma Multiforme | Sleep Disorders | Uncertainty | Ovarian Neoplasm | Anxiety Disorder | Psychological Intervention | Relapsed Lymphoma | Worry | Cognitive-behavioral Therapy | Stage III or IV Cervical... and other conditions

United States
University of Washington
National Cancer Institute (NCI)

Terminated

Image Guided Hypofractionated Radiation Therapy, Nelfinavir Mesylate, Pembrolizumab, Nivolumab and Atezolizumab in Treating Patients With Advanced Melanoma, Lung, or Kidney Cancer

Stage IV Cutaneous Melanoma AJCC v6 and v7 | Stage IV Renal Cell Cancer AJCC v7 | Recurrent Lung Non-Small Cell Carcinoma | Metastatic Kidney Carcinoma | Stage IV Lung Non-Small Cell Cancer AJCC v7

United States
Ascendis Pharma Oncology Division A/S

Recruiting

A Study of TransCon TLR7/8 Agonist With or Without Pembrolizumab in Patients With Advanced or Metastatic Solid Tumors

Advanced Solid Tumor | Metastatic Solid Tumor | Locally Advanced Solid Tumor | Neoadjuvant Melanoma | Head and Neck Squamous Cell Carcinoma HNSCC | HPV-associated Cancers | Neoadjuvant Cutaneous Squamous Cell Carcinoma (cSCC)

United States, Australia, Spain, Netherlands, Korea, Republic of, Taiwan
Merck Sharp & Dohme LLC

Terminated

Study of Temozolomide in the Treatment of Brain Metastasis From Non-small-cell Lung Cancer (Study P02143)

Carcinoma, Non-Small-Cell Lung | Brain Neoplasms | Metastases, Neoplasm
Aarhus University Hospital
Rigshospitalet, Denmark; Herlev Hospital

Recruiting

TDM for Optimized Outcome in Patients With mRCC.

Kidney Cancer | Renal Cell Carcinoma Metastatic | Drug Toxicity | Drug Side Effect | Drug Mechanism

Denmark
Institute of Cancer Research, United Kingdom
Royal Marsden NHS Foundation Trust; Cambridge University Hospitals NHS Foundation... and other collaborators

Completed

Diffusion-weighted Imaging Study in Cancer of the Ovary (DISCOVAR)

Ovarian Cancer | Peritoneal Metastases

United Kingdom
InSightec

Completed

Focused Ultrasound Surgery in the Treatment of Pain Resulting From Metastatic Bone Tumors With the ExAblate 2100 Conformal Bone System

Pain | Bone Cancer | Bone Metastases

Israel
M.D. Anderson Cancer Center
National Cancer Institute (NCI); Janssen Research & Development, LLC

Active, not recruiting

Daratumumab in Treating Patients With Muscle Invasive Bladder Cancer or Metastatic Kidney Cancer

Clear Cell Renal Cell Carcinoma | Stage IV Renal Cell Cancer AJCC v8 | Bladder Urothelial Carcinoma | Metastatic Kidney Carcinoma | Malignant Urinary System Neoplasm

United States
H. Lee Moffitt Cancer Center and Research Institute

Recruiting

The Pancreas Interception Center (PIC) for Early Detection, Prevention, and Novel Therapeutics

Lynch Syndrome | Pancreatic Ductal Adenocarcinoma | Chronic Pancreatitis | Pancreatic Cyst | Ataxia Telangiectasia | FAP | Peutz-Jeghers Syndrome | PALB2 Gene Mutation | BRCA Mutation | Fatty Pancreas | Genetic Pancreatic Cancer | Genetic Pancreatitis | Familial Atypical Multiple Mole-Melanoma

United States
Pfizer

Completed

A Multicenter Phase 2 Study of CI-1040 in Patients With Advanced Nonsmall-Cell Lung, Breast, Colon and Pancreatic Cancer

Breast Neoplasms | Carcinoma, Non-Small-Cell Lung | Colorectal Neoplasms | Pancreatic Neoplasms

United States
University of Florida
Monteris Medical

Terminated

LITT and Pembrolizumab in Recurrent Brain Metastasis (TORCH)

Melanoma | Primary Mediastinal Large B-Cell Lymphoma | Cervical Cancer | Hepatocellular Carcinoma | Gastric Cancer | Esophageal Cancer | Small-cell Lung Cancer | Head and Neck Squamous Cell Cancer | Urothelial Carcinoma | Classical Hodgkin Lymphoma | Merkel Cell Carcinoma | Brain Metastases, Adult | Renal Cell... and other conditions

United States
IGM Biosciences, Inc.

Recruiting

Phase 1a/1b Study of Aplitabart (IGM-8444) Alone or in Combination in Participants With Relapsed, Refractory, or Newly Diagnosed Cancers

Sarcoma | Acute Myeloid Leukemia | Colorectal Cancer | Solid Tumor | Chronic Lymphocytic Leukemia | Non Hodgkin Lymphoma | Chondrosarcoma | Small Lymphocytic Lymphoma

United States, Korea, Republic of, France, Spain, Australia
Hospital Universitari de Bellvitge
Institut d'Investigació Biomèdica de Bellvitge

Unknown

E6/E7 mRNA Performance to Detect HSIL and Cost-effectiveness Analysis of This Screening Strategy in HIV + MSM (ELAVI-67)

Hiv | Anal Cancer | HPV - Anogenital Human Papilloma Virus Infection | HSIL, High Grade Squamous Intraepithelial Lesions

Spain
Stephen E. Goldstone

Unknown

A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRX™ Anorectal Wand

Anal Cancer | Human Papillomavirus Infection | Human Papilloma Virus | HSIL, High Grade Squamous Intraepithelial Lesions | HPV-Related Squamous Cell Carcinoma | Ain III

United States
Tarveda Therapeutics

Recruiting

PEN-866 in Patients With Advanced Solid Malignancies

Neoplasms | Carcinoma | Small Cell Lung Carcinoma | Gastric Cancer | Pancreatic Adenocarcinoma | Solid Tumor | Gastric Adenocarcinoma | Small-cell Lung Cancer | Advanced Cancer | Pancreatic Ductal Adenocarcinoma | Adenocarcinoma of the Pancreas | Endometrial Adenocarcinoma | Squamous Cell Carcinoma of the Penis | Gastroesophageal... and other conditions

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

PET/CT and Lymph Node Mapping in Finding Lymph Node Metastasis in Patients With High-Risk Endometrial Cancer

Endometrial Clear Cell Adenocarcinoma | Endometrial Serous Adenocarcinoma | Endometrial Mixed Adenocarcinoma | Grade 3 Endometrial Endometrioid Adenocarcinoma | Malignant Mixed Mesodermal (Mullerian) Tumor

United States
University of Oklahoma

Active, not recruiting

Analyzing Clinical Outcomes and Genomic Data of American Indian Patient Population (SCC-ClinO+Ge)

Melanoma | Renal Cell Carcinoma | Nonsmall Cell Lung Cancer | Metastatic Solid Tumor | Gastrointestinal Cancer | Immune Checkpoint Inhibitors | Squamous Cell Carcinoma

United States
Memorial Sloan Kettering Cancer Center
Varian Medical Systems

Recruiting

A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue

Melanoma | Sarcoma | Renal Cell Carcinoma | Pancreatic Cancer | NSCLC | Non Small Cell Lung Cancer | Bladder Cancer | Metastatic Solid Tumor | Gastrointestinal Cancer | Lobular Breast Carcinoma | Invasive Ductal Breast Carcinoma | Gastrointestinal Adenocarcinoma | Invasive Ductal Breast Carcinoma Stage IV | Lobular... and other conditions

United States
Taizhou Hospital

Not yet recruiting

High-dose Furmonertinib Versus Osimertinib in Advanced EGFRm NSCLC Patients With Brain Metastases

Lung Cancer, Nonsmall Cell
Sun Yat-sen University

Recruiting

Cryoablation Combined With Cardonilizumab and Bevacizumab in Hepatocellular Carcinoma With Pulmonary Metastases

Hepatocellular Carcinoma | Pulmonary Metastases | Bevacizumab | Liver Cancer Stage IV | Cryoablation | Cadonilimab

China

Clinical Trials on Ras-mutated Metastatic Colorectal Cancer

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