Clinical Trials on Recurrent MGMT-Methylated Glioblastoma

Total 334 results

Bristol-Myers Squibb

Active, not recruiting

A Study of the Effectiveness and Safety of Nivolumab Compared to Bevacizumab and of Nivolumab With or Without Ipilimumab in Glioblastoma Patients (CheckMate 143)

Recurrent Glioblastoma

Poland, United Kingdom, United States, Spain, Australia, Germany, Italy, Denmark, Belgium, France, Netherlands, Switzerland
TVAX Biomedical

Available

TVI-Brain-1 in Expanded Access Patient

Recurrent Glioblastoma

United States
Darell Bigner
Rockefeller University

Not yet recruiting

D2C7-IT + 2141-V11 Combination Post-rection in rGBM - Phase 1b

Recurrent Glioblastoma IDH Wildtype

United States
Center Trials & Treatment

Withdrawn

Clinical Trial of the Use of the Nasal Spray of Patients With Recurrence of Glioblastoma

Gliosarcoma | Recurrent Glioblastoma | Anaplastic Gliomas

Singapore, Hong Kong
PD Dr. Martin Glas

Unknown

Dovitinib (TKI258) in the Treatment of Patients With Relapsed Glioblastoma (TKI258)

First or Second Recurrence of Glioblastoma

Germany
Sidney Kimmel Comprehensive Cancer Center at Johns...
Bristol-Myers Squibb; National Cancer Institute (NCI)

Completed

Anti-LAG-3 Alone & in Combination w/ Nivolumab Treating Patients w/ Recurrent GBM (Anti-CD137 Arm Closed 10/16/18)

Glioblastoma | Gliosarcoma | Recurrent Brain Neoplasm

United States
Memorial Sloan Kettering Cancer Center

Recruiting

Clindamycin and Triamcinolone in People With Glioblastoma to Prevent Skin-Related Side Effects of Tumor Treating Fields

Glioblastoma | Recurrent Glioblastoma | Skin Toxicity

United States
Grupo Español de Investigación en Neurooncología
Pfizer

Completed

Safety and Efficacy of PF-299804 (Dacomitinib), a Pan-HER Irreversible Inhibitor, in Patients With Recurrent Glioblastoma With EGFR Amplification or Presence of EGFRvIII Mutation. A Phase II CT.

Glioblastoma | Brain Tumor, Recurrent

Spain
Angiochem Inc

Completed

ANG1005 in Patients With Recurrent High-Grade Glioma

Glioma | Glioblastoma | Brain Tumor, Recurrent

United States
Michael Vogelbaum, MD, PhD
National Cancer Institute (NCI)

Terminated

Aminolevulinic Acid in Visualizing a Tumor During Surgery in Patients With Glioblastoma Multiforme

Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Recurrent Adult Brain Tumor

United States
Sidney Kimmel Cancer Center at Thomas Jefferson...
Millennium Pharmaceuticals, Inc.

Completed

Alisertib and Fractionated Stereotactic Radiosurgery in Treating Patients With Recurrent High Grade Gliomas

Adult Anaplastic Astrocytoma | Adult Anaplastic Ependymoma | Adult Anaplastic Oligodendroglioma | Adult Diffuse Astrocytoma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Adult Mixed Glioma | Adult Oligodendroglioma | Adult Pilocytic Astrocytoma | Adult Pineal Gland Astrocytoma | Recurrent... and other conditions

United States
Center Trials & Treatment

No longer available

Expanded Access for Pembrolizumab (MK-3475)

Glioblastoma Multiforme | Melanoma (Skin) | Melanoma Recurrent | Glioma of Brain | Glioblastoma by Gene Expression Profile

Hong Kong, Belarus, Tajikistan, Uzbekistan
Jonsson Comprehensive Cancer Center
National Cancer Institute (NCI)

Completed

Palliative 4pi Radiotherapy in Treating Patients With Recurrent Glioblastoma Multiforme

Glioblastoma | Recurrent Brain Neoplasm

United States
John Sampson
National Cancer Institute (NCI)

Completed

Vaccine Therapy in Treating Patients Undergoing Surgery for Recurrent Glioblastoma Multiforme

Recurrent Central Nervous System Neoplasm

United States
Genexine, Inc.

No longer available

Individual Patient Compassionate Use of GX-I7

Melanoma | Glioblastoma | High Grade Glioma | Recurrent Glioblastoma | Advanced Cancer

Korea, Republic of
Seema Nagpal

Completed

BPM31510 in Treating Patients With Recurrent High-Grade Glioma Previously Treated With Bevacizumab

Glioblastoma | Gliosarcoma | Recurrent Glioblastoma | Astrocytoma of Brain

United States
University of Texas Southwestern Medical Center

Active, not recruiting

Abemaciclib w/Bevacizumab in Recurrent GBM Pts w/Loss of CDKN2A/B or Gain or Amplification of CDK4/6

Glioblastoma | Brain Tumor | GBM | Brain Tumor, Recurrent

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Bafetinib in Treating Patients With Recurrent High-Grade Glioma or Brain Metastases

Adult Anaplastic Astrocytoma | Adult Anaplastic Ependymoma | Adult Anaplastic Oligodendroglioma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Adult Mixed Glioma | Recurrent Adult Brain Tumor | Tumors Metastatic to Brain | Adult Anaplastic Oligoastrocytoma

United States
Novartis Pharmaceuticals

Terminated

Safety and Efficacy of INC280 and Buparlisib (BKM120) in Patients With Recurrent Glioblastoma

c-MET Inhibitor; PI3K Inhibitor, PTEN Mutations, Homozygous Del. of PTEN or PTEN Neg. by IHC, c-Met Ampli. by FISH, INC280, BKM120, Buparlisib; Recurrent GBM

Spain, Switzerland, Germany, United States, Netherlands
Merck Sharp & Dohme LLC

Completed

Study of the Safety and Efficacy of MK-4827 Given With Temozolomide in Participants With Advanced Cancer (MK-4827-014 AM1)

Melanoma | Glioblastoma Multiforme | Recurrence of Solid Tumor
National Cancer Institute (NCI)

Completed

Tipifarnib in Treating Young Patients With Recurrent or Progressive High-Grade Glioma, Medulloblastoma, Primitive Neuroectodermal Tumor, or Brain Stem Glioma

Recurrent Childhood Medulloblastoma | Childhood High-grade Cerebral Astrocytoma | Recurrent Childhood Brain Stem Glioma | Recurrent Childhood Cerebellar Astrocytoma | Recurrent Childhood Cerebral Astrocytoma | Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor | Recurrent Childhood... and other conditions

United States
Binhai Hospital of Fujian Medical University
Shanghai Yuansong Biotechnology Co., LTD

Recruiting

Safety and Tolerability Study of Recombinant L-IFN Adenovirus Injection in Patients With Recurrent Glioblastoma (YSCH-01)

Recurring Glioblastoma

China
Sue O'Dorisio
National Cancer Institute (NCI); Ride for Kids

Withdrawn

Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors

Recurrent Childhood Medulloblastoma | Recurrent Childhood Ependymoma | Untreated Childhood Brain Stem Glioma | Untreated Childhood Medulloblastoma | Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor | Adult Anaplastic Astrocytoma | Adult Anaplastic Ependymoma | Adult Anaplastic Oligodendroglioma and other conditions

United States
Andrew B Lassman, MD
Pfizer; AEterna Zentaris

Completed

Perifosine and Torisel (Temsirolimus) for Recurrent/Progressive Malignant Gliomas

Glioblastoma | Anaplastic Astrocytoma | Anaplastic Oligodendroglioma | Brain Tumor, Recurrent | Mixed Glioma

United States
Sabine Mueller, MD, PhD
National Cancer Institute (NCI); Dana-Farber Cancer Institute; Mithil Prasad... and other collaborators

Recruiting

ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors (PNOC023)

Glioblastoma | Recurrent Ependymoma | CNS Tumor | Diffuse Midline Glioma (DMG) | Recurrent Malignant Central Nervous System Neoplasm | Spinal Cord Glioma | Central Nervous System Tumor | World Health Organization (WHO) Grade III Glioma

United States, Switzerland
Virginia Commonwealth University
National Cancer Institute (NCI)

Active, not recruiting

Sorafenib, Valproic Acid, and Sildenafil in Treating Patients With Recurrent High-Grade Glioma

Glioblastoma | Malignant Glioma | WHO Grade III Glioma | Recurrent Adult Brain Neoplasm

United States
AHS Cancer Control Alberta

Recruiting

Tamoxifen Versus Etoposide After First Recurrence in GBM Patients

Glioblastoma Multiforme

Canada
Sidney Kimmel Comprehensive Cancer Center at Johns...
Bristol-Myers Squibb

Terminated

Biomarker-Driven Therapy Using Immune Activators With Nivolumab in Patients With First Recurrence of Glioblastoma

Glioblastoma | Glioblastoma Multiforme

United States
The Methodist Hospital Research Institute
University of California, Los Angeles

Terminated

Response Monitoring Trial in Patients With Suspected Recurrence of Glioblastoma

Glioma | Glioblastoma | Glioblastoma Multiforme

United States
National Cancer Institute (NCI)

Completed

Aflibercept, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma Multiforme, Gliosarcoma, or Other Malignant Glioma

Adult Anaplastic Astrocytoma | Adult Anaplastic Oligodendroglioma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Adult Mixed Glioma | Recurrent Adult Brain Tumor

United States
Université de Sherbrooke

Recruiting

Intraarterial Carboplatin + Caelyx vs Intraarterial Carboplatin + Etoposide Phosphate for Progressing Glioblastoma

Glioblastoma Multiforme | Relapse

Canada
Arno Therapeutics

Unknown

Study of AR-67 in Adult Patients With Recurrence of Glioblastoma Multiforme (GBM) or Gliosarcoma

Glioblastoma Multiforme | Gliosarcoma | GBM

United States, Canada
Southern Medical University, China

Not yet recruiting

The Effectiveness of HP and TMZ Synergism on Adult Recurrence GBM

Glioblastoma Multiforme
University of Birmingham
University of Leeds; Jazz Pharmaceuticals; The Brain Tumour Charity

Recruiting

ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids (ARISTOCRAT)

Glioblastoma | Brain Tumor | Cannabis | Brain Tumor, Recurrent

United Kingdom
Brain & Spine Surgeons of New York

Terminated

Bevacizumab (Avastin) Into the Tumor Resection Cavity in Subjects With Glioblastoma Multiforme at First Recurrence

Glioblastoma Multiforme

United States
Peregrine Pharmaceuticals

Completed

Dose Confirmation Study of Cotara for the Treatment of Glioblastoma Multiforme at First Relapse

Glioblastoma Multiforme

United States, India
Vanderbilt-Ingram Cancer Center
National Cancer Institute (NCI)

Terminated

3T MRI Biomarkers of Glioma Treatment Response

Adult Anaplastic Astrocytoma | Adult Anaplastic Ependymoma | Adult Anaplastic Oligodendroglioma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Recurrent Adult Brain Tumor

United States
Abramson Cancer Center of the University of Pennsylvania

Withdrawn

Multimodality MRI and Liquid Biopsy in GBM

Glioblastoma Multiforme | Brain Tumor, Recurrent | Brain Tumor, Primary | Brain Tumor, Adult: Glioblastoma

United States
National Cancer Institute (NCI)

Completed

Magnetic Resonance Spectroscopy Imaging in Predicting Response to Vorinostat and Temozolomide in Patients With Recurrent or Progressive Glioblastoma

Depression | Adult Glioblastoma | Recurrent Adult Brain Tumor

United States
National Cancer Institute (NCI)

Terminated

Cilengitide and Sunitinib Malate in Treating Patients With Advanced Solid Tumors or Glioblastoma Multiforme

Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Recurrent Adult Brain Neoplasm | Adult Solid Neoplasm

United States
Ann & Robert H Lurie Children's Hospital of Chicago
Photoelectron Corporation

Completed

A Phase I/II Study of the Photon Radiosurgery System

Glioblastoma Multiforme | Brain Tumor, Recurrent

United States
University of California, Davis
National Cancer Institute (NCI); NovoCure Ltd.

Withdrawn

NovoTTF-100A With Bevacizumab and Carmustine in Treating Patients With Glioblastoma Multiforme in First Relapse

Recurrent Adult Brain Neoplasm | Adult Brain Glioblastoma

United States
AstraZeneca

Recruiting

A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

Recurrent Glioblastoma Multiforme | Brain Neoplasms, Malignant | Primary Glioblastoma Multiforme | Leptomeningeal Disease (LMD)

United States, United Kingdom
National Cancer Institute (NCI)

Active, not recruiting

Vorinostat and Temozolomide in Treating Patients With Malignant Gliomas

Adult Anaplastic Astrocytoma | Adult Anaplastic Oligodendroglioma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Adult Mixed Glioma | Recurrent Adult Brain Neoplasm

United States
Memorial Sloan Kettering Cancer Center
AstraZeneca

Recruiting

Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer

Glioblastoma | Brain Cancer | Metastatic Cancer | Recurrent Glioblastoma | Leptomeningeal Metastasis

United States
University of Washington
National Cancer Institute (NCI)

Terminated

Aminolevulinic Acid During Surgery in Treating Patients With Malignant Brain Tumors

Adult Anaplastic Astrocytoma | Adult Anaplastic Oligodendroglioma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Adult Mixed Glioma | Recurrent Adult Brain Tumor

United States
Constantinos Hadjipanayis
National Cancer Institute (NCI); NX PharmaGen

Withdrawn

More Complete Removal of Malignant Brain Tumors by Fluorescence-Guided Surgery

Glioblastoma | Brain Cancer | Brain Tumors | Brain Tumor, Recurrent | Benign Neoplasms, Brain | Brain Neoplasms, Benign | Brain Neoplasms, Malignant | Brain Tumor, Primary | Intracranial Neoplasms | Neoplasms, Brain | Neoplasms, Intracranial | Primary Brain Neoplasms | Primary Malignant Brain Neoplasms | Primary Malignant... and other conditions

United States
University of Pennsylvania
University of California, San Francisco

Terminated

Autologous T Cells Redirected to EGFRVIII-With a Chimeric Antigen Receptor in Patients With EGFRVIII+ Glioblastoma

Patients With Residual or Reccurent EGFRvIII+ Glioma

United States
University Hospital, Basel, Switzerland

Recruiting

Advanced Diffusion MRI to Differentiate Tumor Recurrence From Pseudoprogression in Patients With Glioblastoma and Brain Metastases (AiD-GLIO)

Glioblastoma (GBM)

Switzerland
National Cancer Institute (NCI)

Completed

Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors

Recurrent Childhood Medulloblastoma | Recurrent Childhood Ependymoma | Childhood Choroid Plexus Tumor | Childhood Craniopharyngioma | Childhood Ependymoblastoma | Childhood Grade I Meningioma | Childhood Grade II Meningioma | Childhood Grade III Meningioma | Childhood High-grade Cerebellar Astrocytoma | Childhood High-grade Cerebral Astrocytoma and other conditions

United States

Clinical Trials on Recurrent MGMT-Methylated Glioblastoma

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