Clinical Trials on Refractory Depression in Czechia

Total 106 results

Charles University, Czech Republic

Recruiting

Pulse Width 0.15ms vs 0.30ms in Electroconvulsive Therapy (PWECT015)

Bipolar Depression | Major Depressive Disorder

Czechia
National Institute of Mental Health, Czech Republic
Czech Health Research Council; Czech Clinical Research Infrastructure Network

Recruiting

Psilocybin Versus Ketamine in Treatment-Resistant Depression (PSIKET_001)

Treatment Resistant Depression

Czechia
National Institute of Mental Health, Czech Republic

Recruiting

Remote Peer Support in Prevention of Postpartum Depression

Postpartum Depression

Czechia
National Institute of Mental Health, Czech Republic

Recruiting

Pregnancy Without Psychosocial Stress

Depression, Postpartum | Depressive Symptoms | Anxiety Disorders and Symptoms

Czechia
Angelini Pharma Česká republika s.r.o.
National Institute of Mental Health (NIMH); Institut biostatistiky a analýz... and other collaborators

Terminated

First choIce Antidepressants: General Practitioner's Treatment Approach in the Czech Republic (FIAT)

Adult Patients | Major Depressive Disorder Co-Occurrent With Anxiety | Newly Diagnosed Depression

Czechia
GH Research Ireland Limited

Recruiting

A Trial of GH001 in Patients With Treatment-resistant Depression

Treatment-resistant Depression

Ireland, Germany, Czechia, Spain, Netherlands, Poland
National Institute of Mental Health, Czech Republic

Completed

Ecologically Valid Virtual Tasks vs Paper-pencil Methods in Cognitive Rehabilitation in Patients With Schizophrenia and Depression

Depression | Schizophrenia | Cognitive Impairment

Czechia
COMPASS Pathways

Completed

Long Term Follow Up Study to COMP 001 And COMP 003 Trials (P-TRD LTFU)

Treatment Resistant Depression

United States, Czechia, Netherlands, United Kingdom, Ireland
Sanofi

Completed

An Eight-week Study to Evaluate the Efficacy and Safety of Saredutant in Patients With Depression

Depressive Disorder

Canada, Germany, Portugal, Estonia, Mexico, Croatia, Chile, Czechia
Sanofi

Completed

A Study of SR58611A in the Prevention of Depression Relapse in Patients With Major Depressive Disorder (CALYPSO)

Depressive Disorder | Major Depression

France, Poland, Romania, Russian Federation, Bulgaria, Serbia, Slovakia, Czech Republic, Mexico, Argentina, Croatia, Finland, South Africa
COMPASS Pathways

Completed

The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant Depression (P-TRD)

Treatment Resistant Depression

United States, Netherlands, Ireland, Germany, United Kingdom, Canada, Czechia, Denmark, Portugal, Spain
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Efficacy, Safety, and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression (TRANSFORM-2)

Treatment-resistant Depression

United States, Poland, Germany, Spain, Czechia
University Hospital, Motol

Completed

Intravenous Continuous LMWH Seems to be Safe Alternative to UFH in VV ECMO Patients

Refractory Respiratory Failure

Czechia
Affectis Pharmaceuticals AG
FGK Clinical Research GmbH

Completed

Cimicoxib for the Treatment of Major Depression (SECIM)

Major Depression

Austria, Czech Republic, Germany
Charles University, Czech Republic
Military University Hospital, Prague

Recruiting

Optimization of Sedation Protocol for Endoscopic Procedures Using Impedance Ventilation Monitor.

Ventilatory Depression | Sedation Complication

Czechia
Institute of Hematology and Blood Transfusion,...

Recruiting

CART19 Cells Effects in Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia and Non-Hodgkin's Lymphoma (UHKT-CAR19-01)

Non-Hodgkin's Lymphoma, Relapsed | Non-Hodgkin's Lymphoma Refractory | Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia

Czechia
Institut de Recherches Internationales Servier
ADIR Association

Completed

Efficacy and Safety of S 47445 Versus Placebo as Adjunctive Treatment in Depressed Patients Not Fully Recovered From Depressive Symptoms With a Current Antidepressant Treatment

Major Depressive Disorder

Bulgaria, Czechia, Finland, Hungary, Russian Federation, Slovakia, Ukraine
Sanofi

Completed

An Eight-week Study Evaluating the Efficacy of a 100mg Dose of Saredutant Once Daily, in Elderly Patients With Major Depressive Disorder

Depressive Disorder

United States, France, Russian Federation, Sweden, Turkey, Czech Republic, Mexico, Croatia
National Institute of Mental Health, Czech Republic

Recruiting

Kogito: App to Reduce Perinatal Psychosocial Stress

Depression, Anxiety | Psychological Stress | Perinatal Problems

Czechia
Intra-Cellular Therapies, Inc.

Completed

Clinical Trial of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder

Major Depressive Disorder

United States, Bulgaria, Czechia, Slovakia, Hungary, India
Neurocrine Biosciences

Completed

Study to Assess the Efficacy and Safety of NBI-1065845 in Adults With Major Depressive Disorder (MDD) (SAVITRI)

Major Depressive Disorder

United States, Czechia, Bulgaria, Poland, Slovakia, Sweden
Sanofi

Completed

An Eight-Week Study to Evaluate the Efficacy and Safety of Saredutant in Patients With Depression

Depressive Disorder

France, Canada, Germany, Portugal, Czech Republic, Mexico, Croatia, Chile
Sándor Beniczky
Hospital del Mar; Centro Hospitalar e Universitário de Coimbra, E.P.E.; Motol... and other collaborators

Active, not recruiting

Clinical Utility of Automated Electric Source Imaging in Presurgical Evaluation (PROMAESIS)

Surgery | Refractory Epilepsy | Electroencephalography | Brain Imaging

Spain, Portugal, Austria, Czechia, Denmark, Germany, Italy, Romania
Janssen-Cilag Ltd.

Active, not recruiting

A Long-Term Extension Study for Participants With Treatment-resistant Major Depressive Disorder Who Are Continuing Esketamine Nasal Spray Treatment (ESCAPE-LTE)

Depressive Disorder, Major

Taiwan, Turkey, Malaysia, Germany, Czechia, Korea, Republic of, Poland, Hungary, Argentina, Belgium, Bulgaria, Finland, Greece, South Africa
Institute for Clinical and Experimental Medicine

Recruiting

Comprehensive Geriatric Assessment in Kidney Transplantation (CoGeriaTx)

Frailty Syndrome | Kidney Transplant; Complications | Depressive Syndrome

Czechia
Eli Lilly and Company

Completed

A Study of Flexible or Fixed Dose LY2216684 as Adjunctive Treatment for Participants With Major Depressive Disorder Who Have Had a Partial Response to Selective Serotonin Reuptake Inhibitor (SSRI) Treatment

Major Depressive Disorder (MDD)

United States, Puerto Rico, Finland, Japan, Slovakia, Czechia, Croatia
Aziende Chimiche Riunite Angelini Francesco S.p.A

Completed

Trazodone Once a Day in Major Depression Disorder

Major Depressive Disorder

Austria, Czech Republic, Italy, Romania, Slovakia, Spain
H. Lundbeck A/S

Completed

Comparison of Vortioxetine and Desvenlafaxine in Adult Patients Suffering From Depression (VIVRE)

Major Depressive Disorder

Spain, Czechia, Slovakia, Estonia, Sweden, Argentina, Belgium, Bulgaria, Latvia, Mexico, Russian Federation, Ukraine
Shire

Completed

Efficacy and Safety Study of SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder

Major Depressive Disorder

United States, Germany, Sweden, Poland, South Africa, Belgium, Czechia, Estonia, Finland, Hungary, Romania
AbbVie

Completed

The Objective of This Study is to Evaluate the Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD) Who Have Had an Inadequate Response to Antidepressants Alone

Major Depressive Disorder

United States, Canada, Czechia, Finland, Poland, Puerto Rico, Serbia, Slovakia
Intra-Cellular Therapies, Inc.

Enrolling by invitation

An Open-label Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder

Major Depressive Disorder

United States, Bulgaria, Czechia, Slovakia, Germany, Hungary, Poland, Finland, India, Korea, Republic of, Sweden
Eli Lilly and Company
Boehringer Ingelheim

Completed

A Randomized Double Blind Study Evaluating Duloxetine in Outpatients With MDD and Pain

Depressive Disorder, Major

Belgium, Germany, France, Slovakia, Czech Republic, Finland
Janssen Research & Development, LLC

Completed

A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant and Long-term Safety Extension Treatment With Seltorexant

Depressive Disorder, Major

United States, Taiwan, Czechia, Spain, Mexico, South Africa, Colombia, Russian Federation, Brazil, Bulgaria, Sweden
Boehringer Ingelheim

Completed

A Study to Test the Effect of Different Doses of BI 1358894 and Quetiapine in People With Depression

Depressive Disorder, Major

Spain, United States, Canada, Germany, Japan, Argentina, Hungary, France, Australia, Bulgaria, Czechia, Poland, Russian Federation, Slovakia
NovaShunt AG

Completed

A Feasibility Study of the Automated Fluid Shunt (AFS) for Automated Ascites Removal

Refractory Ascites

Czech Republic
Shire

Terminated

SPD489 Adult Major Depressive Disorder (MDD) Open-label Safety and Tolerability Rollover Extension Study

Major Depressive Disorder

United States, Spain, Germany, Puerto Rico, Canada, Estonia, South Africa, Czechia, Finland, Chile, Hungary, Mexico, Poland, Romania
Janssen-Cilag International NV

Completed

A Long-term Comparison of Esketamine Nasal Spray Versus Quetiapine Extended Release, Both in Combination With a Selective Serotonin Reuptake Inhibitor/Serotonin-Norepinephrine Reuptake Inhibitor, in Participants With Treatment Resistant Major Depressive Disorder (ESCAPE-TRD)

Depressive Disorder, Major

Israel, Hungary, Korea, Republic of, Taiwan, Portugal, Turkey, Germany, Malaysia, Denmark, Bulgaria, Czechia, Belgium, Poland, Brazil, Netherlands, Argentina, Finland, Greece, South Africa, Austria, Kazakhstan, Norway, Sweden, United...
AstraZeneca
Targacept Inc.

Completed

A Study to Assess the Efficacy and Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder

Depression | Major Depressive Disorder

Sweden, Czech Republic, Poland, Germany, Estonia, Latvia, Lithuania, Finland, France, Hungary
H. Lundbeck A/S

Completed

Dose-finding Study With Lu AA24530 in Major Depressive Disorder

Major Depressive Disorder

Ukraine, Lithuania, France, Austria, Russian Federation, Australia, Belgium, Canada, Czech Republic, Finland, India, Korea, Republic of, Malaysia, Norway, Philippines, Serbia, Sweden
Janssen Research & Development, LLC

Completed

A Study of Seltorexant Compared to Quetiapine XR as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy

Depressive Disorder, Major

United States, Belgium, Czechia, Ukraine, Poland, Malaysia, Serbia, Bulgaria, Argentina, Lithuania, Slovakia, Russian Federation, Canada, United Kingdom, Latvia
Janssen Research & Development, LLC

Recruiting

A Study of Aticaprant in Adult and Elderly Participants With Major Depressive Disorder (MDD) (VENTURA-LT)

Depressive Disorder, Major

United States, Korea, Republic of, Taiwan, Slovakia, Spain, Bulgaria, Poland, Belgium, Argentina, Czechia, Hungary, South Africa, Sweden, Italy, France, Australia, China, Brazil, Portugal
AstraZeneca

Completed

Efficacy of Seroquel SR in Combination With an Antidepressant in Treatment of Major Depressive Disorder (ONYX)

Major Depressive Disorder

Sweden, Czech Republic, France, Germany, Poland, Romania, Finland, Norway, Belgium, Canada, Australia, South Africa
Takeda
H. Lundbeck A/S

Completed

Efficacy Study of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder

Major Depressive Disorder

France, Ukraine, Germany, Malaysia, South Africa, Korea, Republic of, Russian Federation, Czech Republic, Lithuania, United Kingdom, Latvia, Australia, Netherlands, Poland, Taiwan
Janssen Research & Development, LLC

Completed

54135419SUI3002: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for Suicide (Aspire II)

Depressive Disorder, Major

United States, Belgium, Canada, Poland, France, Spain, Brazil, Lithuania, Czechia, Austria, Argentina, Turkey
Sunovion

Completed

Lurasidone - A 6-week Study of Patients With Bipolar I Depression (Add-on)

Bipolar Depression

United States, Czech Republic, India, France, Germany, Poland, Romania, Russian Federation, South Africa, Ukraine
Sunovion

Completed

Lurasidone - A 6-week Study of Patients With Bipolar I Depression (Monotherapy)

Bipolar Depression

United States, Czech Republic, India, France, Romania, Russian Federation, South Africa, Ukraine
Janssen Research & Development, LLC

Completed

A Long-term Safety Study of Esketamine Nasal Spray in Treatment-resistant Depression (SUSTAIN-3)

Depressive Disorder, Treatment-Resistant

United States, France, Poland, United Kingdom, Belgium, Germany, Taiwan, Spain, Argentina, Mexico, Bulgaria, Malaysia, South Africa, Turkey, Canada, Korea, Republic of, Brazil, Estonia, Hungary, Lithuania, Slovakia, Sweden, Czechia, A... and more
Sunovion

Completed

Lurasidone HCI - A 6-week Phase 3 Study of Patients With Bipolar I Depression (PREVAIL3)

Bipolar Depression

United States, Canada, Colombia, Czech Republic, India, Japan, Lithuania, Peru, Slovakia, Ukraine
Abbott Medical Devices

Completed

HeartMate 3 CE Mark Study Long Term Follow-up (HM3 CE LTFU)

Advanced Refractory Left Ventricular Heart Failure

Germany, Canada, Austria, Czechia, Kazakhstan, Australia
Sunovion

Completed

Lurasidone - A 24-week Extension Study of Patients With Bipolar I Depression

Bipolar Depression

United States, Canada, Czech Republic, India, Lithuania, Peru, South Africa, France, Poland, Romania, Russian Federation, Ukraine, Colombia, Slovakia, Japan

Clinical Trials on Refractory Depression in Czechia

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