Clinical Trials on Refractory Pains in United Kingdom

Total 9335 results

Barts & The London NHS Trust

Not yet recruiting

Assessing the Safety and Effectiveness of Intracoronary Stem Cells in Patients With Refractory Angina (RegenCobra)

Refractory Angina | Refractory Angina Pectoris

United Kingdom
Guy's and St Thomas' NHS Foundation Trust

Unknown

Identifying Biomarkers and Changes in Cerebrospinal Fluid Collected Pre and Post Spinal Cord Stimulation in Subjects Suffering From Chronic Refractory Pain Conditions (CSF-STIM)

Neuropathic Pain

United Kingdom
Guy's and St Thomas' NHS Foundation Trust
King's College London; University of Oxford; University of Liverpool; National... and other collaborators

Unknown

Sham-Controlled RCT on 10kHz High-Frequency Spinal Cord Stimulation for Chronic Neuropathic Low Back Pain (Modulate-LBP) (Modulate-LBP)

Chronic Low Back Pain | Neuropathic Pain | Refractory Pain

United Kingdom
Royal Marsden NHS Foundation Trust
AstraZeneca; Cancer Research UK; RM/ICR Biomedical Research Centre

Active, not recruiting

Phase I Study to Assess Safety of AZD6738 Alone and in Combination With Radiotherapy in Patients With Solid Tumours (Patriot)

Solid Tumour Refractory to Conventional Treatment

United Kingdom
London North West Healthcare NHS Trust

Unknown

Bowel Preparation and Prokinetics in Capsule Endoscopy

Gastrointestinal Hemorrhage | Small Bowel Disease | Refractory Anemia

United Kingdom
Imperial College London
National Institute for Health Research, United Kingdom

Completed

Lipoprotein Apheresis in Refractory Angina Study

Refractory Angina | Raised Lipoprotein(a)>50mg/dL or >500mg/L

United Kingdom
Imperial College London
Guy's and St Thomas' NHS Foundation Trust; Liverpool University Hospitals NHS... and other collaborators

Recruiting

Coronary Sinus Reducer Implantation in Patients With Ischaemia and Non-obstructed Coronary Arteries and Coronary Microvascular Dysfunction. (REMEDY-PILOT)

Coronary Disease | Angina Pectoris | Refractory Angina | Microvascular Angina | Microvascular Coronary Artery Disease

United Kingdom
Gilead Sciences

Completed

Study to Assess the Long-term Safety and Efficacy of Tirabrutinib in Adults With Relapsed/Refractory B-cell Malignancies

Relapsed/Refractory B-cell Malignancies

France, United Kingdom
Clavis Pharma
Syneos Health; Theradex; CardiaBase; Learn & Confirm

Completed

The Pharmacokinetics and Cardiac Properties of Elacytarabine (CP-4055)

Relapsed/Refractory AML

United Kingdom, Spain
Lupin Ltd.

Completed

A Study of LNP3794 in Subjects With NRAS/KRAS Mutated Advanced or Metastatic Refractory Solid Tumors

NRAS/KRAS Mutated Advanced or Metastatic Refractory Solid Tumors

United Kingdom, Netherlands, Belgium
Imperial College London
Medical Research Council; Imperial College Healthcare Nissen Fund

Recruiting

Coronary Sinus Reducer Objective Impact on Symptoms, MRI Ischaemia and Microvascular Resistance (ORBITA-COSMIC)

Refractory Angina

United Kingdom
Skyline Diagnostics BV
Illumina, Inc.

Terminated

Accuracy Testing of the Chromosomal Aberration and Gene Mutation Markers of the AMLProfiler

Acute Myeloid Leukemia (AML) | Acute Promyelocytic Leukemia (APL) | Refractory Anemia With Excess of Blasts (RAEB)

United States, Germany, Netherlands, United Kingdom
San Diego Hospice & Palliative Care

Withdrawn

Intravenous (IV) Lidocaine for Opioid-refractory Pain

Neoplasms | Pain

United States
Neovasc Inc.

Completed

Coronary Sinus Reducer for Treatment of Refractory Angina - COSIRA (COSIRA)

Refractory Angina

United Kingdom, Canada, Belgium, Denmark, Netherlands, Sweden
Great Ormond Street Hospital for Children NHS Foundation...

Recruiting

MELD as an Adjunct for SEEG Trajectories (MAST)

Epilepsy | Epilepsy, Focal | Epilepsy, Refractory

United Kingdom
University College London Hospitals

Terminated

Intermittent Fasting in Refractory Epilepsy

Epilepsy

United Kingdom
Great Ormond Street Hospital for Children NHS Foundation...

Active, not recruiting

Novel Network Analysis of Intracranial Stereoelectroencephalography (NNAIS)

Epilepsies, Partial | Intractable Epilepsy | Focal Epilepsy | Refractory Epilepsy | Epilepsy Intractable | Epilepsy in Children | Epilepsy, Focal

United Kingdom
Justin Parker Neurological Institute

Completed

Prospective Randomized Feasibility Study Comparing Manual vs. Automatic Position-Adaptive Spinal Cord Stimulation With Surgical Leads (RestoreSensor)

Chronic Refractory Low Back and Leg Pain

United States
Afferent Pharmaceuticals, Inc.

Completed

Effect of Gefapixant (AF-219/MK-7264) on Cough Reflex Sensitivity (MK-7264-015)

Refractory Chronic Cough

United Kingdom
Autolus Limited

Recruiting

A Study of CD19 Targeted CAR T Cell Therapy in Pediatric Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukaemia (B ALL) and Aggressive Mature B-cell Non-Hodgkin Lymphoma (B NHL)

Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia | Relapsed or Refractory B Cell Non-Hodgkin Lymphoma

United Kingdom
Sequana Medical N.V.

Completed

ALFApump System Versus Standard of Care in Ascites Treatment

Refractory or Recurrent Ascites

Spain, United Kingdom, Italy, France, Austria
Stichting Hemato-Oncologie voor Volwassenen Nederland

Completed

Cytarabine and Daunorubicin With or Without Gemtuzumab Ozogamicin in Treating Older Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes

Myelodysplastic Syndromes | Leukemia

United Kingdom
Cancer Research UK

Completed

A Phase I Trial of Anti-GD2 T-cells (1RG-CART)

Relapsed or Refractory Neuroblastoma

United Kingdom
National Cancer Institute (NCI)

Completed

Lenalidomide in Treating Young Patients With Relapsed or Refractory Solid Tumors or Myelodysplastic Syndromes

Unspecified Childhood Solid Tumor, Protocol Specific | Childhood Myelodysplastic Syndromes | Previously Treated Myelodysplastic Syndromes | Secondary Myelodysplastic Syndromes | de Novo Myelodysplastic Syndromes | Refractory Anemia | Refractory Anemia With Excess Blasts | Refractory Cytopenia With... and other conditions

United States
MedtronicNeuro

Completed

Restore Claims Characterization Study

Chronic Refractory Pain Associated With Failed Back Surgery Syndrome, Epidural Fibrosis, Peripheral Causalgia, Complex Regional Pain Syndrome

United States
Boston Scientific Corporation

Completed

Bion Occipital Nerve Stimulation (ONS) Compassionate Use Study

Chronic, Medically Refractory Headache

United States
Institute of Cancer Research, United Kingdom
Royal Marsden NHS Foundation Trust; Nottingham University Hospitals NHS Trust; Barts & The London NHS Trust and other collaborators

Recruiting

The BARCODE 2 Study - The Use of Genetic Profiling to Guide Prostate Cancer Treatment (BARCODE2)

Hormone Refractory Prostate Cancer

United Kingdom
Great Ormond Street Hospital for Children NHS Foundation...
Medical Research Council; UCL Great Ormond Street Institute of Child Health

Recruiting

Base Edited CAR7 T Cells to Treat T Cell Malignancies (TvT CAR7) (TvT CAR7)

Relapsed/Refractory T-cell Acute Lymphoid Leukaemia

United Kingdom
Teesside University
Prof Denis Martin; Prof Cormac Ryan; Gail Sowden; Prof Lorimer Moseley; Dr Jonathan...

Completed

An Evaluation of a Public Health Campaign Related to Persistent Pain in the United Kingdom

Arthritis | Back Pain | Musculoskeletal Pain | Chronic Pain | Pain, Chronic | Pain, Back

United Kingdom
National Cancer Institute (NCI)

Completed

Tipifarnib in Treating Patients With Myelodysplastic Syndromes

Chronic Myelomonocytic Leukemia | Previously Treated Myelodysplastic Syndromes | de Novo Myelodysplastic Syndromes | Refractory Anemia | Refractory Anemia With Excess Blasts | Refractory Cytopenia With Multilineage Dysplasia | Refractory Anemia With Excess Blasts in Transformation | Refractory Anemia...

United States
Barts & The London NHS Trust
Boston Scientific Corporation

Not yet recruiting

Evaluating the Effect of Spinal Cord Stimulation Frequency on Fast-Acting Sub-perception Therapy (FAST) for Chronic Pain (CHRONOS)

Neuropathic Low Back Pain

United Kingdom
University of Birmingham
Pfizer; Bloodwise

Completed

Avelumab in Relapsed and Refractory Peripheral T-cell Lymphoma (AVAIL-T)

T-Cell Lymphoma Relapsed | T-Cell Lymphoma Refractory

United Kingdom
Case Comprehensive Cancer Center

Completed

Differentiation Therapy With Decitabine in Treating Patients With Myelodysplastic Syndrome

Myelodysplastic Syndromes | Thrombocytopenia | Chronic Myelomonocytic Leukemia | de Novo Myelodysplastic Syndromes | Refractory Anemia | Refractory Anemia With Excess Blasts | Refractory Cytopenia With Multilineage Dysplasia | Refractory Anemia With Ringed Sideroblasts

United States
Teesside University

Unknown

A Comparison of Two Self-management Programmes for Patients With Back Pain

Lower Back Pain Chronic

United Kingdom
Edinburgh Napier University
Scottish Hospital Endowments Research Trust; Pacla Medical Ltd

Completed

Investigating the Effects of a Spinal Mobilisation Intervention in People With Lower Back Pain

Lower Back Pain

United Kingdom
Aarogyam UK
Brunel University

Completed

Effectiveness of Yoga@Work to Reduce Head and Muscle Pain in Office Workers

Musculoskeletal Pain | Headache | Cervical Pain

United Kingdom
King's College London

Completed

A Trial of Brief Physiotherapy Informed by Acceptance and Commitment Therapy for Chronic Low Back Pain: the PACT Study (PACT)

Chronic Low Back Pain

United Kingdom
Charlotte Morgan

Completed

Case Series Evaluation of Psychodynamic Interpersonal Therapy in Chronic Low Back Pain

Chronic Low Back Pain

United Kingdom
Boston Children's Hospital

Completed

Pilot of Abatacept-based Immunosuppression for Prevention of Acute GvHD During Unrelated Donor HCT

AML | ALL | Biphenotypic Leukemia | Refractory Anemia | Refractory Cytopenia With Multilineage Dysplasia | Refractory Anemia With Ringed Sideroblasts | Undifferentiated Leukemia | Ref. Cytopenia w Multilineage Dysplasia & Ringed Sideroblasts | Refractory Anemia With Excess Blasts-1 (5-10% Blasts) | Refractory... and other conditions

United States
Queen Mary University of London
Barts & The London NHS Trust

Recruiting

Investigate and Predict Aortic & Thoracic Surgery Persistenet Postsurgical Pain (ImPARTonPPP)

Persistent Postsurgical Pain

United Kingdom
University College of Osteopathy
Osteopathic Foundation

Completed

Osteopathic Single CAse Research for Patients With Chronic Low Back Pain (OSCAR)

Chronic Low-back Pain

United Kingdom
East and North Hertfordshire NHS Trust
National Institute for Health Research, United Kingdom; Manuka Doctor UK Ltd

Recruiting

HONEY for the Treatment of POst-Tonsillectomy Pain (HONEY-POT)

Analgesia | Post Surgical Pain

United Kingdom
Aarogyam UK
Brunel University

Completed

Yoga@Work for Reducing Musculoskeletal Pain in Neck and Shoulder

Musculoskeletal Pain | Neck Pain | Shoulder Pain

United Kingdom
Barts & The London NHS Trust
Mainstay Medical

Recruiting

Multifidus PET Scan Study (MUST)

Low Back Pain

United Kingdom
Mundipharma Research Limited

Terminated

A Study to Assess the Safety and Tolerability of Oxycodone Hydrochloride 50mg/mL Administered as an Infusion

Severe Caner Pain

United Kingdom
Barts & The London NHS Trust
Boston Scientific Corporation

Recruiting

High Frequency (1000Hz) Spinal Cord Stimulation in Neuropathic Pain Patients With Virgin Back

Low Back Pain | Neuropathic Pain

United Kingdom
AstraZeneca

Completed

Determine the Effect of AZD3161,Injected Intradermally, on Quantitative Sensory Testing Variables in Normal and Ultraviolet-C (UVC) Exposed Skin in Healthy Volunteers

Nociceptive Pain | Peripheral Neuropathic Pain

United Kingdom
Guy's and St Thomas' NHS Foundation Trust
University of Parma

Unknown

Genetic Predictors of Responsiveness to Radiofrequency Denervation in Chronic Low Back Pain

Chronic Low Back Pain

United Kingdom
University of Manchester

Completed

Effects of a Mulligan Mobilisation in the Lumbar Flexion Range of Asymptomatic Subjects (Mulligan)

Low Back Pain

United Kingdom
Imperial College London

Recruiting

Preliminary Assessment of Safety and Tolerability of Dostarlimab in Combination Antiretroviral Therapy (cART) Refractory HIV Associated Kaposi Sarcoma (STARKAP)

Refractory HIV Associated Kaposi Sarcoma

United Kingdom

Clinical Trials on Refractory Pains in United Kingdom

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