Clinical Trials on Refractory Childhood Malignant Germ Cell Neoplasm

Total 9867 results

Martin, Paul
National Cancer Institute (NCI)

Completed

Palifermin in Preventing Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer

Primary Myelofibrosis | Stage I Multiple Myeloma | Stage II Multiple Myeloma | Stage III Multiple Myeloma | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma and other conditions

United States
M.D. Anderson Cancer Center

Active, not recruiting

Decitabine, Venetoclax, and Ponatinib for the Treatment of Philadelphia Chromosome-Positive Acute Myeloid Leukemia or Myeloid Blast Phase or Accelerated Phase Chronic Myelogenous Leukemia

Acute Myeloid Leukemia | Recurrent Acute Myeloid Leukemia | Refractory Acute Myeloid Leukemia | Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Accelerated Phase...

United States
Novartis Pharmaceuticals

Active, not recruiting

Study of Safety and Efficacy of DKY709 Alone or in Combination With PDR001 in Patients With Advanced Solid Tumors.

Melanoma | Carcinoma, Non-Small-Cell Lung | Nasopharyngeal Carcinoma | Triple Negative Breast Cancer | Microsatellite Stable Colorectal Cancer

United States, Taiwan, Spain, Germany, Japan, Hong Kong
National Cancer Institute (NCI)

Completed

Eligibility Screening for a NCI Pediatric Oncology Branch Research Study

Osteosarcoma | Acute Lymphoblastic Leukemia | Ewing Sarcoma | Neurofibromatosis Type 1 | Neuroblastoma

United States
Universitätsklinikum Hamburg-Eppendorf

Completed

Psychosocial Situation of Children With Rare Solid Abdominal Tumors and Their Families (PsyRareCare)

Neuroblastoma | Hepatoblastoma | Nephroblastoma

Germany
Icahn School of Medicine at Mount Sinai
Patient-Centered Outcomes Research Institute

Completed

Improving Goals of Care Discussion in Advanced Cancer Patients

Melanoma | Glioblastoma | Colorectal Cancer | Cancer of Pancreas | Cancer of Stomach | Head or Neck Cancer | Stage III | Esophageal | Stage IV | Lung Cancers | Pancreatic Cancers | Primary Stage IV Hepatobiliary

United States
Dana-Farber Cancer Institute
NH TherAguix SAS

Recruiting

Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases

Melanoma | Breast Cancer | Colorectal Cancer | Lung Cancer | Brain Cancer | Brain Tumor | HER2-positive Breast Cancer | Gastrointestinal Cancer | Brain Metastases | SRS | SRT | Whole Brain Radiation | Stereotactic Radiation | AGuIX | Nanoparticle | Cystic

United States
Dr Jean Yannis PERENTES

Recruiting

Treatment Pleural Carcinosis of Pressurized IntraThoracic Hyperthermic Aerosol Cisplatin Administration (PITHAC)

Carcinoma, Non-Small-Cell Lung | Gastric Cancer | Esophageal Cancer | Ovarian Cancer | Mesothelioma, Malignant | Carcinoma Breast Stage IV

Switzerland
Gynecologic Oncology Group
National Cancer Institute (NCI)

Terminated

Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Stage III Ovarian Cancer

Ovarian Clear Cell Cystadenocarcinoma | Ovarian Endometrioid Adenocarcinoma | Ovarian Serous Cystadenocarcinoma | Primary Peritoneal Carcinoma | Malignant Ovarian Mixed Epithelial Tumor | Ovarian Mucinous Cystadenocarcinoma | Undifferentiated Ovarian Carcinoma | Stage III Ovarian Cancer

United States
Hoffmann-La Roche

Active, not recruiting

Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions) (STARTRK-2)

Melanoma | Renal Cell Carcinoma | Adult Solid Tumor | Breast Cancer | Head and Neck Neoplasms | Colorectal Cancer | Pancreatic Cancer | Ovarian Cancer | Non-Small Cell Lung Cancer | Neuroendocrine Tumors | Lymphoma, Large-Cell, Anaplastic | Cholangiocarcinoma | Papillary Thyroid Cancer | Sarcomas | Salivary Gland Cancers and other conditions

United States, China, Korea, Republic of, Australia, Taiwan, France, Spain, United Kingdom, Hong Kong, Belgium, Italy, Germany, Japan, Singapore, Netherlands, Poland
Sanjiv Sam Gambhir
National Cancer Institute (NCI)

Completed

18F-FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy

Unspecified Adult Solid Tumor, Protocol Specific | Recurrent Pancreatic Cancer | Stage IV Pancreatic Cancer | Male Breast Cancer | Stage IV Breast Cancer | Stage IIIA Non-small Cell Lung Cancer | Stage IIIB Non-small Cell Lung Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Tongue Cancer | Stage... and other conditions

United States
Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

Gestional Trophoblastic Neoplasia Ultrasound Assessment: Titanium Study (TITANIUM)

Describe Typical Gray Scale/Color Doppler Ultrasound Features of Gestational Trophoblastic Neoplasia at the US Examination | To Assess if There Are Differences at the Baseline US Scan Between Low-risk and High-risk Patients | To Identify Ultrasound Predictors of Resistance to First-line... and other conditions

Italy
Second Affiliated Hospital, School of Medicine,...

Recruiting

A Prospective Study to Evaluate Clinical Outcomes in Anti-LGI1 Encephalitis

Autoimmune Encephalitis | Leucine-Rich Glioma Inactivated 1 Autoimmune Encephalitis

China
UCB Biopharma SRL

Terminated

A Study to Test the Efficacy, Safety, and Pharmacokinetics of Rozanolixizumab in Adult Study Participants With Leucine-Rich Glioma Inactivated 1 Autoimmune Encephalitis

Leucine-Rich Glioma Inactivated 1 Autoimmune Encephalitis

United States, Australia, Belgium, France, Germany, Italy, Netherlands, Spain, United Kingdom
Rutgers, The State University of New Jersey
National Cancer Institute (NCI); University of Virginia

Completed

Interactive Tailored Website to Promote Sun Protection and Skin Self-Check Behaviors in Patients With Melanoma

Stage IIIB Skin Melanoma | Stage IIIC Skin Melanoma | Stage III Skin Melanoma | Stage IIA Skin Melanoma | Stage IIB Skin Melanoma | Stage IIC Skin Melanoma | Stage IIIA Skin Melanoma | Stage IA Skin Melanoma | Stage IB Skin Melanoma | Stage 0 Skin Melanoma | Stage I Skin Melanoma | Stage II Skin Melanoma

United States
National Cancer Institute (NCI)

Completed

Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer

Metastatic Squamous Neck Cancer With Occult Primary | Small Intestine Lymphoma | Recurrent Pancreatic Cancer | Stage IV Pancreatic Cancer | Gastrointestinal Stromal Tumor | Metastatic Gastrointestinal Carcinoid Tumor | Recurrent Gastrointestinal Carcinoid Tumor | Tongue Cancer | Stage IV Colon Cancer | Stage IV Rectal Cancer and other conditions

United States
Leaf Vertical Inc.

Unknown

A Study of the Efficacy of Cannabidiol in Patients With Multiple Myeloma, Glioblastoma Multiforme, and GI Malignancies

Glioblastoma Multiforme | Cancer of Liver | Cancer of Pancreas | Cancer of Colon | Myeloma Multiple | Cancer of Rectum | Cancer, Gall Bladder

United States
Pfizer
Children's Oncology Group (COG)

Active, not recruiting

Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

Ewing Sarcoma | Medulloblastoma | Rhabdoid Tumor | Neuroblastoma | Solid Tumors | Rhabdomyosarcoma | Diffuse Intrinsic Pontine Glioma

United States, Canada, India, Spain, United Kingdom, Belgium, Hungary, Brazil, Slovakia, Poland, Argentina, Bulgaria, Korea, Republic of, Czechia, Germany, Israel, Netherlands, France, Italy, Sweden, Turkey
M.D. Anderson Cancer Center

Recruiting

Immune Related Toxicity and Symptom Burden in Chronic Cancer Survivors With Melanoma Receiving Adjuvant Immunotherapy With Immune Checkpoint Inhibitors

Clinical Stage III Cutaneous Melanoma AJCC v8 | Pathologic Stage IIIB Cutaneous Melanoma AJCC v8 | Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 | Pathologic Stage IIID Cutaneous Melanoma AJCC v8 | Pathologic Stage III Cutaneous Melanoma AJCC v8 | Pathologic Stage IIIA Cutaneous Melanoma... and other conditions

United States
Massachusetts General Hospital
Dana-Farber Cancer Institute

Recruiting

Infliximab for Treatment of Immune Checkpoint Inhibitor Colitis

Melanoma Stage IV | Melanoma Stage III | Drug Toxicity | Immune-related Adverse Event | Skin Cancer Stage III | Skin Cancer Stage IV | Drug-Induced Colitis

United States
National Cancer Institute (NCI)

Recruiting

Enasidenib in IDH2-Mutated Malignant Sinonasal and Skull Base Tumors

Locally Advanced Chondrosarcoma | Metastatic Chondrosarcoma | Metastatic Sinonasal Adenocarcinoma | Locally Advanced Sinonasal Adenocarcinoma | Metastatic Large-cell Neuroendocrine Carcinoma | Locally Advanced Large-cell Neuroendocrine Carcinoma | Metastatic Olfactory Neuroblastoma | Locally Advanced... and other conditions

United States
AC Camargo Cancer Center

Recruiting

Everolimus 5 mg vs 10 mg/Daily for Patients With Neuroendocrine Tumors (EVENET)

Progression | Neuroendocrine Tumors | Neuroendocrine Tumor of the Lung | Neuroendocrine Tumor Grade 2 | Neuroendocrine Tumor Grade 1 | Neuroendocrine Tumor of Pancreas | Neuroendocrine Tumor Carcinoid

Brazil
Kaiser Permanente
National Cancer Institute (NCI); University of Washington; University of Texas...

Completed

Self-Testing Options in the Era of Primary HPV Screening for Cervical Cancer Trial (STEP)

Neoplasms | Urogenital Neoplasms | Neoplasms by Site | Cervical Cancer | Uterine Neoplasms | Genital Neoplasms, Female | Uterine Cervical Diseases | Uterine Diseases | HPV-Related Malignancy | HPV Infection | HPV-Related Cervical Carcinoma | Human Papilloma Virus | Uterine Cervical Neoplasm | Cervical Dysplasia

United States
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Traumeel® S in Preventing and Treating Mucositis in Young Patients Undergoing Stem Cell Transplantation

Sarcoma | Lymphoma | Kidney Cancer | Leukemia | Neuroblastoma | Oral Complications

United States, Israel, Australia, Canada
Fred Hutchinson Cancer Center

Completed

Donor Bone Marrow Transplant in Treating Young Patients With Cancer or a Non-Cancerous Disease

Sarcoma | Lymphoma | Kidney Cancer | Myelodysplastic Syndromes | Leukemia | Neuroblastoma

United States
Merck Sharp & Dohme LLC

Recruiting

Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)

Von Hippel-Lindau Disease | Pancreatic Neuroendocrine Tumor | Pheochromocytoma/Paraganglioma | Advanced Gastrointestinal Stromal Tumor | HIF-2α Mutated Cancers

Canada, United States, Denmark, France, Germany, Hungary, Italy, Russian Federation, Spain, Sweden, Turkey, Israel, United Kingdom, Netherlands, Australia, China, Singapore, Japan
Taipei Veterans General Hospital, Taiwan

Unknown

Evaluation of Acupuncture Effects for Complications After Surgery of Cerebellopontine Angle Tumor in Skull Base

Quality of Life | Acupuncture | Neuromuscular Blockade | Complication of Treatment | Tumor, Brain | Skull Base Tumor | Cerebellopontine Angle Tumor

Taiwan
Washington University School of Medicine

Withdrawn

Erlotinib in Combination With Temozolomide in Treating Relapsed/Recurrent/Refractory Pediatric Solid Tumors

Glioma | Osteosarcoma | Ependymoma | Medulloblastoma | Rhabdomyosarcoma | Wilms Tumor | Neuroectodermal Tumor | Ewing's Sarcoma
Stanford University
VA Palo Alto Health Care System

Completed

Engagement of Patients With Advanced Cancer (EPAC)

Melanoma | Kidney Cancer | Testicular Neoplasms | Head and Neck Neoplasms | Gastric Cancer | Prostate Cancer | Glioblastoma Multiforme | Advanced Cancer | Colon Cancer | Liver Cancer | End of Life | Cancer of Unknown Origin | Lung Neoplasm | Rectum Cancer
University Hospital, Basel, Switzerland
University Hospital, Zürich; University Hospital Freiburg; Krebsforschung Schweiz... and other collaborators

Recruiting

177Lu-PP-F11N for Receptor Targeted Therapy and Imaging of Metastatic Thyroid Cancer. (Lumed)

Thyroid Cancer, Medullary | Neuroendocrine Tumor of the Lung Grade 1 and 2 | Neuroendocrine Tumor of the Thymus Grade 1 and 2 | Neuroendocrine Tumor GEP Grade 1-3

Switzerland
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Vinblastine and Carboplatin in Treating Young Patients With Newly Diagnosed or Recurrent Low-Grade Glioma

Brain and Central Nervous System Tumors | Neurofibromatosis Type 1

Canada, United States
NiKang Therapeutics, Inc.

Recruiting

A Study With NKT3447 for Adults With Advanced/Metastatic Solid Tumors

Small Cell Lung Carcinoma | Gastric Cancer | Ovarian Neoplasms | Ovarian Cancer | Solid Tumor | Endometrial Neoplasms | Triple Negative Breast Cancer | Triple Negative Breast Neoplasms | Advanced Solid Tumor | Endometrial Cancer | Small-cell Lung Cancer | Platinum-resistant Ovarian Cancer | Ovarian Carcinoma | Solid... and other conditions

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Terminated

Therapeutic Allogeneic Lymphocytes and Aldesleukin in Treating Patients With High-Risk or Recurrent Myeloid Leukemia After Undergoing Donor Stem Cell Transplant

Recurrent Adult Acute Myeloid Leukemia | Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Adult Acute Myeloid Leukemia With Del(5q) | Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Adult... and other conditions

United States
University of California, San Francisco

Terminated

Capmatinib, Ceritinib, Regorafenib, or Entrectinib in Treating Patients With BRAF/NRAS Wild-Type Stage III-IV Melanoma

ALK Fusion Protein Expression | Stage III Cutaneous Melanoma | Stage IIIA Cutaneous Melanoma | Stage IIIB Cutaneous Melanoma | Stage IIIC Cutaneous Melanoma | Stage IV Cutaneous Melanoma | ROS1 Fusion Positive | BRAF wt Allele | Invasive Skin Melanoma | MET Fusion Gene Positive | NRAS wt Allele | NTRK1 Fusion... and other conditions

United States
Masonic Cancer Center, University of Minnesota

Terminated

MT2004-30: Tomotherapy for Solid Tumors

Sarcoma | Kidney Cancer | Brain and Central Nervous System Tumors | Retinoblastoma | Liver Cancer

United States
Massachusetts Eye and Ear Infirmary
Oregon Health and Science University; National Institute on Deafness and Other... and other collaborators

Enrolling by invitation

Analysis of Vestibular Compensation Following Clinical Intervention for Vestibular Schwannoma

Migraine | Dizziness | Motion Sickness | Vestibular Migraine | Vestibular Schwannoma | Vestibular Disorder

United States
Dana-Farber Cancer Institute

Recruiting

Serial MRI Scans During Radiation Therapy (RELAY)

MRI | Glioblastoma | Esophageal Cancer | Prostate Cancer | Vulvar Cancer | Magnetic Resonance Imaging | Radiotherapy | Pediatric Glioblastoma Multiforme

United States
National Cancer Institute (NCI)

Terminated

Monoclonal Antibody Therapy in Treating Patients With Ovarian Epithelial Cancer, Melanoma, Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Non-Small Cell Lung Cancer

Recurrent Adult Acute Myeloid Leukemia | Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) | Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) | Previously Treated Myelodysplastic... and other conditions

United States
National Cancer Institute (NCI)

Completed

Sorafenib Tosylate in Treating Patients With Metastatic, Locally Advanced, or Recurrent Medullary Thyroid Cancer

Multiple Endocrine Neoplasia Type 2A | Multiple Endocrine Neoplasia Type 2B | Recurrent Thyroid Gland Medullary Carcinoma | Hereditary Thyroid Gland Medullary Carcinoma | Locally Advanced Thyroid Gland Medullary Carcinoma | Sporadic Thyroid Gland Medullary Carcinoma | Stage III Thyroid Gland Medullary... and other conditions

United States
University of British Columbia

Recruiting

Polyomic Biomarker Verification in Adult Chronic Graft-Versus-Host Disease (ABLE3.0/CTTC2201)

Leukemia | Allogeneic Hematopoietic Stem Cell Transplantation | Blood Cancer | Chronic Graft-versus-Host-Disease | Non-Malignant Hematologic and Lymphocytic Disorder

United States, Canada
Shenzhen Second People's Hospital
Shenzhen Institute for Innovation and Translational Medicine

Unknown

T Cell Receptor-transduced T Cells Targeting NY-ESO-1 for Treatment of Patients With NY-ESO-1- Expressing Malignancies

Melanoma | Breast Cancer | Multiple Myeloma | Ovarian Cancer | Lung Cancer | Neuroblastoma | Bladder Carcinoma | Synovial Sarcoma | Esophagus Carcinoma | Other Metastatic Solid Cancers

China
Weill Medical College of Cornell University
Novartis Pharmaceuticals

Recruiting

68-Ga DOTATATE PET/MRI in the Diagnosis and Management of Somatostatin Receptor Positive CNS Tumors. (DOMINO-START)

Pituitary Adenoma | Medulloblastoma | Meningioma | Esthesioneuroblastoma | Paraganglioma | CNS Tumors | Hemangioblastoma

United States
Massachusetts Eye and Ear Infirmary
Massachusetts General Hospital; United States Department of Defense

Recruiting

Study of Aspirin in Patients With Vestibular Schwannoma

Neurofibromatosis 2 | Vestibular Schwannoma | Acoustic Neuroma

United States
National Cancer Institute (NCI)

Completed

Tanespimycin in Treating Patients With Inoperable Locoregionally Advanced or Metastatic Thyroid Cancer

Recurrent Thyroid Cancer | Stage IV Follicular Thyroid Cancer | Stage IV Papillary Thyroid Cancer | Thyroid Gland Medullary Carcinoma

United States
Emory University
National Institute on Deafness and Other Communication Disorders (NIDCD)

Completed

Recovery of Visual Acuity in People With Vestibular Deficits

Vestibular Schwannoma | Vestibular Neuronitis | Vestibular Neuronitis, Bilateral

United States
University of Chicago
National Cancer Institute (NCI)

Recruiting

Intensity Modulated Total Marrow Irradiation, Fludarabine Phosphate, and Melphalan in Treating Patients With Relapsed Hematologic Cancers Undergoing a Second Donor Stem Cell Transplant

Previously Treated Myelodysplastic Syndrome | Recurrent Adult Acute Myeloid Leukemia | Recurrent Adult Acute Lymphoblastic Leukemia | Recurrent Hematologic Malignancy

United States
Cancer Trials Ireland

Completed

Study of Blood Samples From Patients With Malignant Melanoma, Metastatic Breast Cancer, Advanced Lung Cancer, Pancreatic Cancer, or Colorectal Cancer.

Breast Cancer | Colorectal Cancer | Pancreatic Cancer | Lung Cancer | Melanoma (Skin)

Ireland
National Cancer Institute (NCI)

Completed

Bevacizumab, Fluorouracil, and Hydroxyurea Plus Radiation Therapy in Treating Patients With Advanced Head and Neck Cancer

Recurrent Metastatic Squamous Neck Cancer With Occult Primary | Recurrent Salivary Gland Cancer | Recurrent Squamous Cell Carcinoma of the Hypopharynx | Recurrent Squamous Cell Carcinoma of the Larynx | Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity | Recurrent Squamous Cell Carcinoma... and other conditions

United States
Washington University School of Medicine

Completed

Auditory Nerve Test System During Vestibular Schwannoma Resection (ANTS)

Sensorineural Hearing Loss | Skull Base Neoplasms | Vestibular Schwannoma | Acoustic Neuroma | Asymmetric Sensorineural Hearing Loss | Cochlear Nerve Damage | Cochlear Nerve Deafness | Auditory; Nerve

United States
Vanderbilt University
National Cancer Institute (NCI)

Withdrawn

Early Enteral Tube Feedings in Children Receiving Chemo for AML/MDS & High Risk Solid Tumors

Sarcoma | Kidney Cancer | Leukemia | Solid Tumor | Brain and Central Nervous System Tumors | Neuroblastoma | Liver Cancer

Clinical Trials on Refractory Childhood Malignant Germ Cell Neoplasm

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