Clinical Trials on Renal Impairments

Total 12544 results

Astellas Pharma Global Development, Inc.

Completed

A Study About How ASP5354 Affects the Body in Healthy Adults and in Adults Whose Kidneys do Not Work Well

Renal Impairment | Healthy Volunteers

United States, Japan
Astellas Pharma Global Development, Inc.

Completed

A Study to Investigate the Effect of Renal Impairment on the Safety and Tolerability of Fezolinetant Compared to Participants With Normal Renal Function

Renal Impairment | Healthy Volunteers

United States
Pfizer

Completed

Renal Impairment Study of PF-06700841

Renal Impairment | Healthy Volunteer

United States
Millennium Pharmaceuticals, Inc.

Completed

A Study of Mobocertinib Capsules in People With Severe Kidney Problems and People With Healthy Kidneys

Renal Impairment | Healthy Volunteers

United States
University of Texas Southwestern Medical Center

Completed

Neuromuscular Blockade in Patients With Severe Renal Impairment

Renal Impairment | Neuromuscular Blockade

United States
Mayo Clinic

Completed

Study to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical Systolic Cardiomyopathy (Aim2) (Aim2)

Renal Impairment | Cardiomyopathy

United States
CTI BioPharma
SGS S.A.

Completed

PK of Pacritinib in Patients With Mild, Moderate, Severe Renal Impairment and ESRD Compared to Healthy Subjects

Myelofibrosis

Moldova, Republic of, Germany, Romania
Bayer

Completed

A Study to Learn How the Study Treatment BAY1753011 Moves Into, Through and Out of the Body, How it Works, How Safe it is, and How it Affects the Body When Given Once as Tablet in Male and Female Participants With Reduced Kidney Function Compared to Matched Participants With Normal Kidney Function

Renal Impairment | Congestive Heart Failure

Germany
Massachusetts General Hospital

Completed

The CASABLANCA Study: Catheter Sampled Blood Archive in Cardiovascular Diseases (CASABLANCA)

Atherosclerosis | Renal Impairment | Contrast Induced Nephropathy

United States
Takeda

Completed

Effect of Febuxostat on Renal Function in Patients With Gout and Moderate to Severe Renal Impairment

Renal Impairment

United States
University of Pennsylvania

Withdrawn

LDX for the Treatment of Cognitive Functioning Issues in Women Post-Oophorectomy (LDX)

Cognitive Impairments | RRSO

United States
Bayer

Completed

Clinical Study to Evaluate the Pharmacokinetics, Safety, Tolerability and Pharmacodynamic Effects of a Single Oral 10 mg BAY1101042 Tablet Dose in Men and Woman With Renal Impairment and in Healthy Subjects

Renal Impairment

Germany
Merck Sharp & Dohme LLC

Completed

A Study of Belzutifan (MK-6482) in Participants With Renal Impairment (MK-6482-021)

End Stage Renal Disease | Renal Impairment

United States
Vertex Pharmaceuticals Incorporated

Completed

Evaluation of the Pharmacokinetics and Safety of VX-548 in Participants With Renal Impairment

Pain

United States
Austin Health

Completed

Bicarbonate and Lipocalin in Systemic Inflammatory Response Syndrome (SIRS) Study (BLISS)

Systemic Inflammatory Response Syndrome | Renal Impairment | Oliguria

Australia
Bournemouth University
Dorset HealthCare University NHS Foundation Trust

Completed

The Effect of Vegetable Oil on Cognitive Functions of MCI Patients (DICe)

Metabolic Ketosis | Cognitive Impairments, Mild

United Kingdom
Marco Antonio Alvarez Gonzalez
Complejo Hospitalario de Navarra; Althaia Xarxa Assistencial Universitària...

Recruiting

Bowel Cleansing With Renal Impairment (BC-RIMP)

Renal Impairment | Adverse Effects of Medical Drugs

Spain
Northwestern University
National Cancer Institute (NCI)

Completed

The "Light for the Brain" Study

Depression | Quality of Life | Fatigue | Sleep | Hematopoietic Stem Cell Transplantation | Cognitive Impairments

United States
GlaxoSmithKline

Completed

Study to Assess the Safety and PK of GSK573719 and GSK573719/GW642444(VI) Combination in Healthy Subjects and Subjects With Severe Renal Impairment

Pulmonary Disease, Chronic Obstructive

Czechia, Hungary
Boehringer Ingelheim

Completed

Safety and Efficacy in Type 2 Diabetic Patients With Severe Chronic Renal Impairment, 5 mg BI 1356 (Linagliptin) vs. Placebo, Insulin Background Inclusive

Diabetes Mellitus, Type 2

United States, Australia, Hong Kong, Israel, New Zealand, Ukraine
Celgene

Not yet recruiting

A Study to Evaluate the Drug Levels of Mezigdomide in Adult Participants With Renal Impairment

Renal Impairment

United States
Acrotech Biopharma Inc.
Axis Clinicals Limited

Terminated

To Evaluate Safety and Pharmacokinetics of Belinostat in Patients Who Have Mild, Moderate and Severe Renal Impairment.

Relapsed/Refractory Solid Tumors/Hematological Malignancies

United States
Janssen R&D Ireland

Withdrawn

An Efficacy, Safety, Tolerability and Pharmacokinetics Study of 12 Weeks Treatment With Simeprevir and Daclatasvir in Participants With Chronic Hepatitis C Virus Genotype 1b or 4 Infection and Either Severe Renal Impairment or End-stage Renal Disease on Hemodialysis.

Renal Impairment | End-stage Renal Disease

France, Spain
Pfizer

Completed

A Study To Investigate The Pharmacokinetics, Safety And Tolerability Of An Intravenous And Oral Form Of A Compound In Subjects With Varying Degrees Of Renal Impairment And Normal Renal Function

Pneumonia

Belgium, United States
Pfizer

Completed

Renal Impairment Study of PF-07321332 Boosted With Ritonavir in Adult Participants With Renal Impairment and in Healthy Participants With Normal Renal Function.

Renal Impairment

United States
Daiichi Sankyo Co., Ltd.

Completed

Safety and Pharmacokinetics Study of DU-176b Administered to Non-valvular Atrial Fibrillation With Severe Renal Impairment

Non-valvular Atrial Fibrillation

Japan
The University of Hong Kong
Haven of Hope Hospital; The Social Innovation and Entrepreneurship Development...

Completed

Tablet-based Interactive Games in Elderly With Cognitive Impairment and Persons With Intellectual Disability

Intellectual Disability | Technology | Cognitive Impairments

Hong Kong
Bayer

Completed

Study to Assess the Safety, Tolerability, Effects on the Body, Absorption, Distribution and Elimination of 25 mg BAY2433334 in Renal Impairment Including Renal Replacement Therapy ("Dialysis")

Prevention of Thromboembolic Events

Germany
VA Office of Research and Development

Completed

Cognitive Impairment in Kidney Disease

Kidney Insufficiency, Chronic

United States
Barts & The London NHS Trust

Unknown

Development of a Biomarker Panel for the Earlier Prediction of Acute Kidney Injury in Patients With Diabetes (BIOMARKERS)

Diabetes Mellitus | Renal Impairment

United Kingdom
Massachusetts General Hospital

Withdrawn

Calcium, Phosphate, Renal Impairment and Coronary Artery Disease in the Cardio-renal Syndrome, The CAPRICORN-CRS Study (CAPRICORN)

Heart Failure

United States
NRG Oncology
National Cancer Institute (NCI)

Recruiting

Cognitive Training for Cancer Related Cognitive Impairment in Breast Cancer Survivors

Breast Cancer | Cognitive Impairments

United States
Bayer

Withdrawn

A Study to Learn How the Study Treatment BAY2395840 Moves Into, Through and Out of the Body, How Safe it is, and How it Affects the Body in Participants With Moderate Reduced Kidney Function and in Healthy Male and Female Participants With Normal Kidney Function

Renal Impairment | Healthy Volunteers | Diabetic Neuropathic Pain

United States
AstraZeneca

Completed

A Study of Fostamatinib in Subjects With Impaired Kidney Function

Rheumatoid Arthritis | Renal Impairment

United States
Pfizer

Completed

STUDY OF PF-06882961 IN PARTICIPANTS WITH TYPE 2 DIABETES MELLITUS WITH VARYING DEGREES OF RENAL IMPAIRMENT AND PARTICIPANTS WITHOUT RENAL IMPAIRMENT

Healthy | Diabetes Mellitus, Type 2 | Renal Impairment

United States
Novo Nordisk A/S

Completed

Effect of Renal Impairment on the Pharmacokinetics of NN9535

Diabetes Mellitus, Type 2 | Diabetes | Renal Impairment

United States
GlaxoSmithKline

Completed

A Study of the Efficacy and Safety of Albiglutide in Subjects With Type 2 Diabetes With Renal Impairment.

Diabetes Mellitus, Type 2

United States, Germany, Peru, Israel, Taiwan, Australia, Russian Federation, United Kingdom, Korea, Republic of, Spain, Brazil, Colombia, India, Philippines, South Africa
Bayer

Completed

A Study to Learn How the Study Treatment BAY3283142 Taken as Single Dose by Mouth Moves Into, Through, and Out of the Body, How Safe it is, and How it Affects the Body in Participants With Reduced Kidney Function Compared to Participants With Normal Kidney Function of Similar Age, Gender, and Weight

Renal Impairment | Chronic Kidney Disease | Healthy Volunteers

Germany
Ganzhou Hemay Pharmaceutical Co., Ltd

Not yet recruiting

To Evaluate the Pharmacokinetics of Hemay005 Tablets in Patients With Renal Impairment

Psoriasis
Ottawa Hospital Research Institute
Canadian Institutes of Health Research (CIHR)

Unknown

Renal Hypothermia During Partial Nephrectomy

Kidney Cancer | Kidney Diseases | Urologic Diseases | Cancer | Renal Impairment | Hypothermia

Canada
GE Healthcare

Completed

Renal Effects of Two Iodinated Contrast Media in Patients at Risk Undergoing Coronary Angiography

Coronary Artery Disease | Renal Impairment

Sweden
Fondazione Don Carlo Gnocchi Onlus
University of Milano Bicocca

Completed

ABILITY - TelerehABILITation: TechnologY-enhanced Multi-domain at Home Continuum of Care Program

Dementia | Alzheimer Disease | Cognitive Impairments
Team Foods Colombia S.A.
Biopolis S.L.

Unknown

Study to Evaluate the Effect of a Vegetal Oil on Cognitive Impairment

Alzheimer Disease | Cognitive Impairments

Spain
Natalie Garratt

Completed

The Kidney and The Brain Study - Assessment of Cognitive Impairment in Advanced CKD

Chronic Kidney Diseases | Cognitive Impairment | Dementia | End Stage Renal Disease | Hemodialysis Complication | Renal Transplant | Peritoneal Dialysis Complication

United Kingdom
Chiesi Farmaceutici S.p.A.

Completed

PK of CHF6001 in Subjects With Mild, Moderate and Severe Renal Impairment vs. Healthy Volunteers

Chronic Obstructive Pulmonary Disease

Bulgaria
Hoffmann-La Roche

Completed

A Study of RO4998452 in Type 2 Diabetes Patients With Varying Degrees of Renal Impairment

Diabetes Mellitus Type 2

United States, Russian Federation
AstraZeneca
Bristol-Myers Squibb

Completed

Treatment Effect of Saxagliptin Compared With Placebo in Patients With Type 2 Diabetes and Renal Impairment

Type 2 Diabetes

Croatia, United States, Bulgaria, Czech Republic, Poland, Russian Federation, Belarus, Estonia, Germany, Hungary, Latvia, Lithuania, Romania, Ukraine
University of Vermont
Medical University of South Carolina; University of Washington; University of...

Active, not recruiting

Communication During Hospitalization About Resuscitation Trial (CHART)

End Stage Renal Disease | Severe Life-limiting COPD | Severe Life-limiting Heart Failure | Severe Life-limiting Cirrhosis | Severe Life-limiting Malignancy | Severe Functional Impairment

United States
Merck Sharp & Dohme LLC

Completed

A Study to Assess Pharmacokinetics (PK) of Preladenant in Participants With Chronic Renal Impairment (CRI) (P06512)

Parkinson Disease
Merck Sharp & Dohme LLC
Pfizer

Completed

Effect of Renal Impairment on the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Ertugliflozin in Participants With Type 2 Diabetes Mellitus (MK-8835-009)

Type 2 Diabetes Mellitus | Renal Impairment

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