Clinical Trials on Safety and Pharmacokinetics in United States

Total 161421 results

Hillier, Sharon, PhD
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Safety and Pharmacokinetics of Two Vaginal Film Formulations Containing the Integrase Inhibitor MK-2048 (FAME103)

Pharmacokinetics | Safety

United States
Pennington Biomedical Research Center
Louisiana Clinical and Translational Science Center

Completed

Safety and Pharmacokinetics of an Extract of Naringenin (Citrus)

Pharmacokinetics | Safety Issues

United States
Altasciences Company Inc.

Completed

Single Ascending Doses of Kratom in Healthy Nondependent Adults With Opioid Experience

Pharmacokinetics | Pharmacodynamics | Safety

United States
Usona Institute

Completed

Pharmacokinetics, Safety, and Tolerability of Intramuscular 5-MeO-DMT in Healthy Volunteers

Pharmacokinetics | Tolerability | Safety

United States
AstraZeneca

Completed

A Study to Assess the Pharmacokinetics and Safety of Single Doses of Anifrolumab in Healthy Subjects

Healthy Subjects | Pharmacokinetics | Safety

United States
Nanjing Immunophage Biotech Co., Ltd

Recruiting

IPG7236 in Patients With Advanced Solid Tumors

Pharmacokinetics | Safety Issues | Tolerability

United States
Takeda

Terminated

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MLN3126 in Healthy Japanese and Non-Japanese Participants

Pharmacokinetics | Pharmacodynamics | Tolerability | Safety

United States
AstraZeneca

Completed

A Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD7503 in Healthy Participants

Pharmacokinetics | Healthy Participants | Tolerability | Safety

United States
Jupiter Orphan Therapeutics Inc.
National Institute on Aging (NIA)

Completed

JOTROL PK, Safety, and Food Effect Assessment

Pharmacokinetics | Food-drug Interaction | Safety

United States
Daiichi Sankyo, Inc.

Completed

Single Ascending Dose Study Using DS-1971 to Assess Safety, Tolerability, and Pharmacokinetics in Healthy Participants.

Pharmacokinetics | Tolerability | Safety

United Kingdom
Heptares Therapeutics Limited

Completed

Pharmacokinetics of Oral Capsule in Healthy Japanese vs. Caucasian Subjects (HTL0018318)

Pharmacokinetics | Safety Issues

United Kingdom
Shire

Completed

A Double-Blind Multi-Dose Tolerability and Pharmacokinetic Study of Teduglutide

Pharmacokinetics and Safety of Elevated Doses

United States
Celgene

Completed

A Phase 1 Open-Label Study to Evaluate the Metabolism and Excretion of CC-223 and the Effect of Food on the Pharmacokinetics of CC-223 in Healthy Male Adult Subjects (AME/FE)

Safety and Pharmacokinetics in Healthy Volunteer Subjects

United States
University of Kansas Medical Center
Thomas Jefferson University

Completed

Evaluation of Intravenous Ascorbic Acid

Safety and Pharmacokinetics of Intravenous Ascorbate

United States
Yiling Pharmaceutical Inc.

Completed

A Phase I Pharmacokinetics Study for KT07 Capsule

Pharmacokinetics | Healthy Adult Subjects | Safety and Tolerability

United States
e-Therapeutics PLC

Completed

Assessment of Single Doses of Oral Dexanabinol in Healthy Subjects

Cancer | Pharmacokinetics | Tolerability | Safety

United Kingdom
AstraZeneca

Completed

A Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD9977 After Single Ascending Doses to Healthy Males

Healthy Subjects | Pharmacokinetics | Tolerability | Safety

United Kingdom
Astellas Pharma Europe B.V.

Completed

A Clinical Trial to Investigate Safety and Tolerability of ASP7962 in Healthy Humans

Tolerability | Safety | Pharmacokinetics of ASP7962

United Kingdom
AstraZeneca

Completed

Single + Multiple Ascending Dose and Food Effect Study of AZD7986 in Healthy Volunteers, PK, PD and Safety Study

Safety, Pharmacokinetics, Pharmacodynamics, Food Effect

United Kingdom
Actelion

Completed

Study of Selexipag and Its Metabolite ACT-333679 on Cardiac Repolarization in Healthy Male and Female Subjects

Pharmacokinetics | Tolerability | Safety | Cardiodynamics

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

Study of the Pharmacokinetics of Isavuconazole in Healthy Non-Elderly and Elderly Male and Female Subjects

Healthy Volunteers | Pharmacokinetics of Isavuconazole | Safety and Tolerability in Elderly

United States
Pfizer

Completed

Evaluating QTc, PK, Safety of Gemtuzumab Ozogamicin (GO) in Patients With CD33+ R/R AML

Pharmacokinetics | Safety | ECG

Canada, Spain, United States, Hungary, Poland, United Kingdom
AstraZeneca

Withdrawn

A Study to Compare the Pharmacokinetics of Different Formulations of AZD9977 and the Influence of Food in Healthy Male Subjects

Healthy Male Subjects | Pharmacokinetics | Safety | Food Effect

United Kingdom
AstraZeneca

Completed

Comparison of Two Formulations of AZD5363 and the Effect of Food on Pharmacokinetic Exposure, Safety and Tolerability (OAK)

Safety and Tolerability, | Advanced Solid Malignancy, | Pharmacokinetics, Pharmacodynamics, | Tumour Response,

United Kingdom, Netherlands
AstraZeneca

Completed

To Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Ascending Doses of Inhaled AZD7594

Pharmacokinetics | Safety | Pharmacodynamics of AZD7594

United Kingdom
University of Minnesota
Paralyzed Veterans of America Research Foundation

Completed

Dose Escalation Study of Intravenous Baclofen in Healthy Adult Volunteers

Safety and Pharmacokinetics of Intravenous Baclofen

United States
International Partnership for Microbicides, Inc.
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

PK, Safety Study of 90-Day Use of Vaginal Rings Containing Dapivirine and Levonorgestrel

Bleeding | Pharmacokinetics | Safety Issues

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

A Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of Methotrexate

Healthy Subjects | Pharmacokinetics of Isavuconazole | Pharmacokinetics of Methotrexate | Pharmacokinetics of 7-hydroxymethotrexate

United States
Sharon Hillier
National Cancer Institute (NCI)

Completed

Safety and Acceptability of Q GRFT Nasal Spray for COVID-19 Prophylaxis

COVID-19 | Pharmacokinetics | Safety

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

Drug Interaction Study of Isavuconazole and Methadone

Healthy Volunteers | Pharmacokinetics of Isavuconazole | Pharmacokinetics of Methadone

United States
Astellas Pharma Inc
Basilea Pharmaceutica

Completed

Drug Interaction Study of Isavuconazole and Midazolam

Healthy Volunteers | Pharmacokinetics of Isavuconazole | Pharmacokinetics of Midazolam

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

Drug Interaction Study of Isavuconazole and Digoxin

Healthy Volunteers | Pharmacokinetics of Isavuconazole | Pharmacokinetics of Digoxin

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

Drug Interaction Study of Multiple Doses of Isavuconazole and a Single Dose of Bupropion

Healthy Volunteers | Pharmacokinetics of Isavuconazole | Pharmacokinetics of Bupropion

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

A Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of a Single Dose of Sirolimus in Healthy Subjects

Healthy Subjects | Pharmacokinetics of Isavuconazole | Pharmacokinetics of Sirolimus

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

Drug Interaction Study of Multiple Doses of Isavuconazole and Single Dose of Atorvastatin

Healthy Volunteers | Pharmacokinetics of Isavuconazole | Pharmacokinetics of Atorvastatin

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

A Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of Repaglinide and Caffeine

Healthy Subjects | Pharmacokinetics of Caffeine | Pharmacokinetics of Repaglinide

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

A Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of Metformin

Healthy Subjects | Pharmacokinetics of Isavuconazole | Pharmacokinetics of Metformin

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

A Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of a Single Dose of Prednisone in Healthy Adult Subjects

Healthy Subjects | Pharmacokinetics of Isavuconazole | Pharmacokinetics of Prednisolone

United States
Astellas Pharma Inc
Basilea Pharmaceutica International Ltd

Completed

Drug Interaction Study of Isavuconazole and Tacrolimus

Healthy Volunteers | Pharmacokinetics of Isavuconazole | Pharmacokinetics of Tacrolimus

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

Drug Interaction Study of Multiple Doses of Isavuconazole and Single Dose of Dextromethorphan in Healthy Adult Subjects

Healthy Adult Volunteers | Pharmacokinetics of Isavuconazole | Pharmacokinetics of Dextromethorphan

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

Drug-drug Interaction Study Between Lopinavir/Ritonavir and Isavuconazole

Healthy Volunteers | Pharmacokinetics of Isavuconazole | Pharmacokinetics of Lopinavir/Ritonavir

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

A Study to Assess the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of a Single Dose of Mycophenolate Mofetil in Healthy Adult Subjects

Healthy Subjects | Pharmacokinetics of Isavuconazole | Pharmacokinetics of Plasma Mycophenolic Acid (MPA) | Pharmacokinetics of Plasma Phenolic Glucuronide of MPA (MPAG)

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

Drug Interaction Study of the Effect of Ketoconazole at Steady State on the Pharmacokinetics of a Single Dose of Isavuconazole in Healthy Adult Subjects

Healthy Adult Volunteers | Pharmacokinetics of Isavuconazole | Pharmacokinetics of Ketoconazole

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

Drug Interaction Study of Isavuconazole and Oral Contraceptive Containing Ethinyl Estradiol and Norethindrone

Healthy Volunteers | Pharmacokinetics of Isavuconazole | Pharmacokinetics of Ethinyl Estradiol and Norethindrone

United States
XBiotech, Inc.

Active, not recruiting

Hutrukin to Analyze Safety and PK in Healthy Volunteers

Pharmacokinetics

United States
Alumis Inc

Completed

Relative Bioavailability of ESK-001 Tablet Versus Liquid in Healthy Participants

Pharmacokinetics

United States
BHB Therapeutics, Ireland LTD
Mérieux NutriSciences Biofortis

Completed

Pharmacokinetics of C6 Ketone Di-ester

Pharmacokinetics

United States
Daiichi Sankyo, Inc.

Completed

Pharmacokinetics (PK) Drug Interaction Study of Milademetan and Itraconazole or Posaconazole in Healthy Participants

Pharmacokinetics

United States
University of Texas Southwestern Medical Center
McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.; American College of Medical Toxicology

Withdrawn

A Randomized Crossover Study to Determine the Pharmacokinetics of Intranasally Administered Acetaminophen in Healthy Adults

Pharmacokinetics

United States
McGuff Pharmaceuticals, Inc.

Completed

A Pharmacokinetics Study of Intravenous Ascorbic Acid

Pharmacokinetics

United States

Clinical Trials on Safety and Pharmacokinetics in United States

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