Clinical Trials on Severe Malaria

Total 5051 results

Centre de Recherche Médicale de Lambaréné
Institute of Tropical Medicine, University of Tuebingen

Not yet recruiting

A Crossover Bioavailability Clinical Trial of Parenteral Pyronaridine and Artesunate

Severe Malarial Treatment

Gabon
University of Oxford

Completed

Evaluation of Volume Status, Haemodynamics and Microcirculatory Flow in Adult Patients With Severe Falciparum Malaria (PRiSM)

Severe Falciparum Malaria

Bangladesh
Novartis Pharmaceuticals
Wellcome Trust; European and Developing Countries Clinical Trials Partnership...

Recruiting

To Evaluate Efficacy, Safety, Tolerability and PK of Intravenous Cipargamin in Participants With Severe Plasmodium Falciparum Malaria

Severe Malaria

Burkina Faso, India, Rwanda, Congo, The Democratic Republic of the, Gabon, Nigeria, Côte D'Ivoire, Kenya, Uganda
Menzies School of Health Research
National Health and Medical Research Council, Australia; Wellcome Trust

Suspended

Safety and Preliminary Efficacy of L-arginine in Severe Falciparum Malaria (ARGISM)

Severe Falciparum Malaria

Indonesia
Institute of Tropical Medicine, Belgium
KU Leuven; Leiden University Medical Center; Barcelona Institute for Global Health and other collaborators

Recruiting

Host Immune and Metabolic Determinants of Sexual Conversion in Plasmodium Parasites IMMETASEX (IMMETASEX)

Uncomplicated Malaria | Severe Malaria | Asyptomatic Plasmodium Infection

Mozambique, Belgium, Burkina Faso
Dr Fabrice BRUNEEL

Completed

Very Severe Malaria Treated by Intravenous Artesunate (Palustar)

Severe Malaria

France
National Institute of Allergy and Infectious Diseases...

Completed

Evaluation of Oral Activated Charcoal on Antimalarial Drug's Ability to Kill Parasites in Malian Children With Malaria

Malaria | Severe Malaria

Mali
Makerere University

Unknown

Pharmacokinetics and Pharmacodynamics of Intravenous Artesunate for Severe Malaria Treatment

Severe Malaria

Uganda
University of Oxford
University of Kinshasa; Mahidol Oxford Tropical Medicine Research Unit

Completed

Lung Ultrasound in Children With Severe Malaria (LUSiSM)

Severe Malaria

Congo, The Democratic Republic of the
Swiss Tropical & Public Health Institute
Makerere University; Kinshasa School of Public Health; Clinton Health Access... and other collaborators

Completed

Monitoring of Molecular Markers of Artemisinin Resistance Through Repeated Cross-sectional Assessments in DR Congo, Nigeria and Uganda (Caramal DRM)

Severe Malaria

Congo, The Democratic Republic of the, Nigeria, Uganda
Swiss Tropical & Public Health Institute
Medicines for Malaria Venture

Completed

Malaria Treatment With Injectable ArteSunate (MATIAS)

Severe Malaria

Congo, The Democratic Republic of the
National Institute of Allergy and Infectious Diseases...

Completed

Severe Malaria and Anti-malarial Drug Resistance in Cambodia

Malaria | Severe Malaria | Antimalarial Drug Resistance

Cambodia
University of Oxford
Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.; National Institute... and other collaborators

Completed

Study to Compare Feasibility of 1-step Injectable Artesunate vs. Conventional 2-step Injectable Artesunate (1STEP-AS)

Severe Malaria

Congo, The Democratic Republic of the
University Health Network, Toronto
University of Toronto; Makerere University

Completed

Inhaled Nitric Oxide for the Adjunctive Therapy of Severe Malaria: a Randomized Controlled Trial

Severe Malaria

Uganda
Epicentre
University of Cape Town; Malaria Research and Training Center, Bamako, Mali

Completed

Efficacy and Bio-availability of Artemether-Lumefantrine in Severely Malnourished Children (MAL-NUT)

Malaria | Severe Acute Malnutrition

Mali, Niger
University of Ibadan
Shin Poong Pharm Co Ltd 161 yoksam-ro, Gangnam-Gu Seoul 135-925, Korea; Institute...

Completed

Efficacy and Safety of Pyronaridine-Artesunate Versus Artemether-Lumefantrine

Plasmodium Falciparum Malaria | Uncomplicated Malaria | Malaria Fever

Nigeria
University of Oxford
Chittagong Medical College and Hospital

Completed

Severe and Cerebral Malaria Investigated Through Host Metabolomics

Severe Malaria

Bangladesh
Epicentre
Medecins Sans Frontieres, Spain

Withdrawn

Efficacy of Artesunate-amodiaquine (AS-AQ) in Children With Malaria and Severe Acute Malnutrition, Madaoua, Niger 2010

Child | Malnutrition | Malaria, Falciparum

Niger
Johns Hopkins Bloomberg School of Public Health
Johns Hopkins University; University of Maryland; University of California, San... and other collaborators

Recruiting

Platelet-Directed Whole Blood Transfusion Strategy for Malaria (PLATFORM)

Thrombocytopenia | Severe Malaria

United States, Zambia
LG Life Sciences

Unknown

Clinical Study to Evaluate the Efficacy and Safety of YVOIRE® Contour Compared With Restylane SubQ™ Injected Into the Anteromedial Malar Region

Normal, Healthy Adults With Moderate, Severe, or Very Severe Volume Loss of Anteromedial Malar Region

Korea, Republic of
GlaxoSmithKline

Completed

Immunogenicity and Safety Study of GSK Biologicals' Candidate Malaria Vaccine Given at 6, 7.5 and 9 Months of Age in Co-administration With Measles, Rubella and Yellow Fever (YF) Vaccines Followed by a Booster of the Malaria Vaccine.

Malaria | Malaria Vaccines

Ghana
Centers for Disease Control and Prevention

Completed

Non-malarial Febrile Illness in Children in Areas of Perennial Malaria Transmission

Malaria | Non-malarial Febrile Illness

Tanzania
University of British Columbia
Mahidol Oxford Tropical Medicine Research Unit; Kinshasa Medical Oxford Research...

Recruiting

Effect of Paracetamol on Kidney Function in Severe Malaria (PROTECtS)

Acute Kidney Injury | Malaria,Falciparum | Severe Malaria | Paracetamol

Congo, The Democratic Republic of the
National Institute of Allergy and Infectious Diseases...

Completed

Examination of Protective Factors Against Severe Malaria

Malaria | Severe Malaria

Mali
Malaria Vaccine and Drug Development Center
Fundacion Clinica Valle del Lili

Completed

Evaluation of Reproducibility of a Sporozoite Challenge Model for Plasmodium Vivax in Human Volunteers

MALARIA | Chills | FEVER | ANEMIA | Sweating Fever

Colombia
Karolinska Institutet
University of Dschang

Recruiting

Association of Diabetes and Metabolic Syndrome With Severe Malaria in Cameroon

Obesity | Diabetes Mellitus, Type 2 | Metabolic Syndrome | Malaria,Falciparum | Severe Malaria

Cameroon
Institute of Tropical Medicine, Belgium
KU Leuven; Institut National de Recherche Biomédicale. Kinshasa, République... and other collaborators

Completed

Clinical Decision Support in Non-typhoidal Salmonella Bloodstream Infections in Children (DeNTS)

Bloodstream Infection | Malaria,Falciparum | Severe Malaria | Salmonella Bacteremia

Belgium
Sanofi Pasteur, a Sanofi Company

Completed

Immunogenicity and Safety of a Tetravalent Dengue Vaccine Booster Injection in Subjects Who Previously Completed a 3-dose Schedule

Dengue Fever | Dengue Hemorrhagic Fever

Singapore
Sanofi Pasteur, a Sanofi Company
United States Department of Defense

Completed

Immunologic Mechanisms of Immune Interference and/or Cross-Neutralizing Immunity After CYD Tetravalent Dengue Vaccine

Dengue | Dengue Fever | Dengue Hemorrhagic Fever

United States
Foundation for Innovative New Diagnostics, Switzerland
National Institute of Malaria Research, New Delhi, India

Completed

Clinical Evaluation of the STANDARD™ Q Malaria/CRP Duo Test

Fever Malaria

India
Université de Parakou
University of Copenhagen; Hôpital Cochin; University of Ghana; Institut de Recherche... and other collaborators

Completed

Impact of Seasonal Malaria Chemoprevention on Immunity Against Malaria Among Children in Northern Benin (ISAMIMA)

Determine the Impact of Treatment on the Acquisition of Anti-malarial Antibodies in Children Before, During and After the Intervention | Determine the Prevalence of Malarial Infection in Children Before, During and After Seasonal Malaria Chemoprevention

Benin
National Malaria Control Programme, Madagascar
Sanofi; Population Services International; Institut Pasteur de Madagascar; Reggio... and other collaborators

Completed

ACT for the Home Management in Malagasy Children

Fever | Suspected Malaria

France
Lihir Medical Centre

Withdrawn

Prednisone Plus Chloroquine for the Treatment of Hyper-reactive Malarial Splenomegaly (LiHMS)

Malaria | Anaemia | Hyper-reactive Malarial Splenomegaly

Papua New Guinea
National Institute of Allergy and Infectious Diseases...
Johns Hopkins Bloomberg School of Public Health

Completed

Safety of and Immune Response to Two Different Dengue Virus Vaccines in Individuals Previously Immunized Against Dengue Virus

Dengue Hemorrhagic Fever

United States
Sanofi Pasteur, a Sanofi Company

Completed

Study of a Booster Injection of Pentaxim™ Vaccine Administered With Dengue Vaccine in Healthy Toddlers

Dengue | Dengue Hemorrhagic Fever

Mexico
Sanofi Pasteur, a Sanofi Company

Completed

Study of CYD Dengue Vaccine in Healthy Children and Adolescents in South America

Dengue | Dengue Hemorrhagic Fever

Brazil
Mahidol University

Completed

Pharmacokinetics and Pharmacodynamics of Ivermectin in Pediatric Dengue Patients (PKIDEN)

Dengue Hemorrhagic Fever

Thailand
LG Life Sciences

Completed

Extension Clinical Study to Evaluate the Long-term Efficacy and Safety of Repeat Treatment of YVOIRE Contour Injected Into the Anteromedial Malar Region in Subjects Who Have Completed the LG-HACL014 Study

Normal, Healthy Adults With Moderate, Severe, or Very Severe Volume Loss of Anteromedial Malar Region Who Have Completed the LG-HACL014 Study

Korea, Republic of
Sanofi Pasteur, a Sanofi Company

Completed

Immune Response to Different Schedules of a Tetravalent Dengue Vaccine Given With or Without Yellow Fever Vaccine

Yellow Fever | Dengue | Dengue Fever | Dengue Hemorrhagic Fever

United States
Kamuzu University of Health Sciences
London School of Hygiene and Tropical Medicine; University of Bergen; The Research... and other collaborators

Unknown

Delivery of Malaria Chemoprevention in the Post-discharge Management of Children With Severe Anaemia in Malawi (PMC)

Malaria | Severe Anemia

Malawi
Liverpool School of Tropical Medicine
The Research Council of Norway; Makerere University; Kenya Medical Research Institute

Completed

Post-discharge Malaria Chemoprevention(PMC) Study (PMC)

Malaria | Severe Anemia

Uganda, Kenya
Sanofi Pasteur, a Sanofi Company

Completed

Study of a Novel Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 14 Years in Asia

Dengue | Dengue Fever | Dengue Hemorrhagic Fever

Indonesia, Philippines, Malaysia, Thailand, Vietnam
Sanofi Pasteur, a Sanofi Company

Completed

Study of a Tetravalent Dengue Vaccine in Healthy Adults in Australia

Dengue Fever | Dengue Hemorrhagic Fever

Australia
Sanofi Pasteur, a Sanofi Company

Completed

Association of Host Genetics With Vaccine Efficacy and Study of Immune Correlates of Risk From a Tetravalent Dengue Vaccine

Dengue Fever | Dengue Haemorrhagic Fever

Thailand
Sanofi Pasteur, a Sanofi Company

Completed

Study of a Tetravalent Dengue Vaccine in Healthy Adult Subjects Aged 18 to 45 Years in India

Dengue | Dengue Fever | Dengue Hemorrhagic Fever

India
Sanofi Pasteur, a Sanofi Company

Completed

Long-Term Study of Hospitalized Dengue & Safety in Thai Children Included in a Tetravalent Dengue Vaccine Efficacy Study

Dengue | Dengue Fever | Dengue Hemorrhagic Fever

Thailand
Sanofi Pasteur, a Sanofi Company

Terminated

Study of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Adacel® in Healthy Subjects

Dengue Fever | Dengue Hemorrhagic Fever

Philippines
Sanofi

Completed

Study of a Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 11 Years in Malaysia

Dengue Fever | Dengue Hemorrhagic Fever

Malaysia
Sanofi Pasteur, a Sanofi Company

Completed

Study of a Novel Tetravalent Dengue Vaccine in Healthy Children and Adolescents Aged 9 to 16 Years in Latin America

Dengue | Dengue Fever | Dengue Hemorrhagic Fever

Colombia, Puerto Rico, Brazil, Honduras, Mexico
U.S. Army Medical Research and Development Command
GlaxoSmithKline

Completed

A Study of Two Doses of WRAIR Dengue Vaccine Administered Six Months Apart to Healthy Adults and Children

Dengue Fever | Dengue Hemorrhagic Fever | Dengue Shock Syndrome

Puerto Rico

Clinical Trials on Severe Malaria

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Uganda

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations