Clinical Trials on Severe Malaria

Total 5056 results

Kamuzu University of Health Sciences
Boston University; Michigan State University; Ministry of Health, Malawi

Not yet recruiting

The Impact RTS,S/AS01 Vaccine in School Aged Children RTS,S/AS01 Malaria Vaccine in School Aged Children

Malaria,Falciparum
Radboud University Medical Center
London School of Hygiene and Tropical Medicine; Malaria Research and Training...

Not yet recruiting

Safety, Pharmacokinetics, and Plasmodium Falciparum Transmission-reducing Activity of Monoclonal Antibody TB31F in Mali

Malaria,Falciparum
University of Oxford

Recruiting

A Study of the Plasmodium Falciparum Malaria Vaccine Candidate Pfs48/45 in Matrix-M Adjuvant in the UK

Malaria | Plasmodium Falciparum

United Kingdom
Sanaria Inc.
Swiss Tropical & Public Health Institute; Ifakara Health Institute; Medical Care...

Completed

Study to Evaluate Safety, Immunogenicity and Efficacy of PfSPZ Vaccine in HIV Negative and HIV Positive Tanzanian Adults

Malaria | Malaria,Falciparum

Tanzania
sigma-tau i.f.r. S.p.A.

Completed

A Pharmacokinetic/Pharmacodynamic Study of Eurartesim Dispersible Formulation in Infants With P.Falciparum Malaria

Malaria,Falciparum

Burkina Faso, Congo, The Democratic Republic of the, Gambia, Mozambique, Tanzania
PATH
Tulane University; Ministry of Health, Zambia; Macha Research Trust, Zambia

Active, not recruiting

Attractive Targeted Sugar Bait Phase III Trial in Zambia

Malaria | Malaria,Falciparum | Vector-Borne Transmission of Infection

Zambia
Sanofi
Medicines for Malaria Venture

Completed

Study to Investigate the Clinical and Parasiticidal Activity and Pharmacokinetics of Different Doses of Artefenomel and Ferroquine in Patients With Uncomplicated Plasmodium Falciparum Malaria

Plasmodium Falciparum Infection

Benin, Burkina Faso, Gabon, Kenya, Uganda
National Institute for Medical Research, Tanzania
Universiteit Antwerpen

Unknown

Effectiveness and Safety of Intermittent Preventive Treatment for Malaria Using Either Dihydroartemisinin-piperaquine or Artesunate-amodiaquine in Reducing Malaria Related Morbidities and Improving Cognitive Ability in School-aged Children in Tanzania (InSMART-school)

Anemia | Malaria,Falciparum

Tanzania
Foundation for Innovative New Diagnostics, Switzerland
World Health Organization; World Bank; UNICEF; United Nations Development Programme

Unknown

Malaria Rapid Diagnostic Tests (RDTs) in Pregnancy: Detection of Placental Malaria

Malaria | Malaria in Pregnancy | Placental Malaria

Burkina Faso, Uganda
Malaria Consortium

Not yet recruiting

Seasonal Malaria Chemoprevention Rapid Assessment Study Mozambique

Malaria,Falciparum | Chemoprevention
Novartis

Completed

Efficacy and Safety of the Pediatric Formulation of Artemether- Lumefantrine in Children With Uncomplicated P. Falciparum Malaria.

Malaria | Falciparum

Benin, Kenya, Mali, Mozambique, Tanzania
University of Oxford
PATH

Not yet recruiting

Southeast Asia Dose Optimization of Tafenoquine (SEADOT)

Plasmodium Vivax Malaria

Cambodia, Lao People's Democratic Republic, Thailand, Vietnam
University of California, San Francisco
Institut de Recherche en Sciences de la Sante, Burkina Faso

Completed

Association Between Drug Levels, Malaria, and Antimalarial Resistance in the Setting of Seasonal Malaria Chemoprevention (DRUMARS)

Malaria,Falciparum

Burkina Faso
National Institute of Allergy and Infectious Diseases...

Completed

ICC-1132 - Candidate Vaccine Against P Falciparum Malaria

Plasmodium Falciparum Malaria

United States
Sanofi
Medicines for Malaria Venture

Terminated

To Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of a Single Dose Regimen of Ferroquine and Artefenomel in Adults and Children With Uncomplicated Plasmodium Falciparum Malaria (FALCI)

Plasmodium Falciparum Infection

Benin, Burkina Faso, Gabon, Kenya, Mozambique, Uganda, Vietnam
National Institute of Allergy and Infectious Diseases...

Completed

Malaria Incidence in Infants in Bancoumana, Mali

Anemia | Malaria Infection | Malaria Incidence

United States
University of Maryland, Baltimore
National Institute of Allergy and Infectious Diseases (NIAID); Michigan State... and other collaborators

Completed

Malawi International Center of Excellence in Malaria Research School-based Cohort

Anemia | Malaria | Malaria,Falciparum
Medicines for Malaria Venture
QIMR Berghofer Medical Research Institute; Children's Health Queensland Hospital... and other collaborators

Completed

Pyronaridine in Healthy Adult Participants Infected With Blood Stage Malaria

Protozoan Infections | Malaria | Parasitemia | Malaria,Falciparum | Parasitic Disease | Malaria Recrudescence

Australia
Liverpool School of Tropical Medicine
Kamuzu University of Health Sciences

Not yet recruiting

Preventing Malaria in School Children to Protect the Whole Community in Rural Blantyre District, Malawi

Malaria,Falciparum | Anemia in Children
University of Maryland, Baltimore
Kamuzu University of Health Sciences; Doris Duke Charitable Foundation

Completed

Comparing Chemoprevention Drugs for School-based Malaria Control

Malaria,Falciparum | Anemia in Children

Malawi
Research Institute for Tropical Medicine, Philippines
World Health Organization

Completed

TES of Chloroquine for Pv in the Philippines in 2016 (TES)

Malaria | Vivax Malaria | Recrudescence
DBL -Institute for Health Research and Development
London School of Hygiene and Tropical Medicine; Ministry of Health, Uganda; Artemisinin-based...

Completed

Introducing Rapid Diagnostic Tests Into the Private Health Sector

Fever | Malaria | Diagnosis | Referral

Uganda
University of Oxford
Mahidol University; National Malaria and Leishmaniasis Control Program, Afghanistan

Completed

Estimating the Risk of Plasmodium Vivax Relapses in Afghanistan (VRA)

Vivax Malaria

Afghanistan
Pfizer
London School of Hygiene and Tropical Medicine; Medicines for Malaria Venture

Terminated

Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa

Intermittent Preventive Treatment In Pregnancy (IPTp)

Malawi, Benin, Kenya, Tanzania, Uganda
University of Maryland, Baltimore
Kamuzu University of Health Sciences; Doris Duke Charitable Foundation

Completed

Comparing Chemoprevention Approaches for School-based Malaria Control

Malaria,Falciparum | Anemia in Children

Malawi
University of Oxford

Recruiting

A Study to Compare Two Dosing Regimens for a New Malaria Vaccine

Infections | Vector Borne Diseases | Protozoan Infections | Malaria | Malaria,Falciparum | Parasitic Disease

United Kingdom
Armed Forces Research Institute of Medical Sciences...
University of North Carolina, Chapel Hill

Recruiting

Biomarkers of P. Vivax Relapse

Malaria | Vivax Malaria | Relapse | CYP2D6 Polymorphism

Thailand
Foundation for Innovative New Diagnostics, Switzerland
Makerere University; Ministry of Public Health, Democratic Republic of the...

Withdrawn

Prospective Evaluation of an RDT to Screen for Gambiense HAT and Diagnose P. Falciparum Malaria

Human African Trypanosomiasis
University Health Network, Toronto
University of Toronto

Completed

The Cytoadherence in Pediatric Malaria (CPM) Study (CPM)

Plasmodium Falciparum Malaria

Uganda
Royal Tropical Institute
Imperial College London; World Health Organization; Medical Research Council... and other collaborators

Completed

Community-based Screening and Treatment of Malaria in Pregnancy: a Cluster-randomized Trial (COSMIC)

Small for Gestational Age (Disorder) | Malaria, Antepartum | Maternal Malaria During Pregnancy - Baby Not Yet Delivered

Benin, Burkina Faso, Gambia
Leiden University Medical Center

Recruiting

Coadministration of GA2 Sporozoites With Adjuvants (CoGA)

Malaria,Falciparum

Netherlands
University of California, San Francisco
National Institute of Allergy and Infectious Diseases (NIAID); Stanford University and other collaborators

Not yet recruiting

FocaL Mass Drug Administration for Vivax Malaria Elimination (FLAME)

Malaria | Malaria, Vivax

Peru
GlaxoSmithKline
The PATH Malaria Vaccine Initiative (MVI)

Recruiting

Epidemiology Study of Malaria Transmission Intensity in Sub-Saharan Africa

Malaria | Malaria Vaccines

Burkina Faso, Ghana, Kenya, Malawi, Senegal, Tanzania
University of Oxford

Active, not recruiting

Safety and Immunogenicity of Pvs25-IMX313/Matrix-M1 Vaccine

Malaria, Vivax

United Kingdom
University of Oxford

Completed

Malaria Vaccine Safety and Immunogenicity Study in Healthy Adults (RTSS)

Malaria Vaccine

Thailand
U.S. Army Medical Research and Development Command
GlaxoSmithKline; United States Agency for International Development (USAID); Walter... and other collaborators

Completed

Double-blind, Randomized, Controlled Study of Safety, Immunogenicity and Efficacy of a Candidate Malaria Vaccine

Malaria, Falciparum

Kenya
Obafemi Awolowo University
University of Copenhagen; European and Developing Countries Clinical Trials... and other collaborators

Unknown

Assessing to What Extent Dhps-431V Mutation May Influence the Protective Efficacy of IPTp-SP (DEEM-FIT)

Pregnancy Malaria

Nigeria
PATH
Tulane University; Ministry of Health, Zambia; Minister of Community Development...

Completed

Mass Drug Administration With Dihydroartemisinin + Piperaquine for Reducing Malaria in Southern Zambia

Malaria | Malaria, Falciparum

Zambia
GlaxoSmithKline
Medicines for Malaria Venture

Completed

Efficacy and Safety Study of Tafenoquine (TQ) Co-administered With Dihydroartemisinin-piperaquine (DHA-PQP) for the Radical Cure of Plasmodium Vivax (P. Vivax) Malaria

Malaria, Vivax

Indonesia
Alfasigma S.p.A.

Terminated

Eurartesim® in Patients With Imported Uncomplicated Plasmodium Vivax Malaria

Malaria, Vivax

Switzerland, France, Germany, Israel, Italy, Netherlands, Spain
GlaxoSmithKline
Medicines for Malaria Venture

Completed

Assessment of Any Potential Retinal Effects of Tafenoquine (TQ)

Malaria, Vivax

United States
GlaxoSmithKline
Medicines for Malaria Venture

Completed

A Study to Evaluate the Pharmacokinetics of a Single Dose of Tafenoquine Co-administered With Either Artemether + Lumefantrine or Dihydroartemisinin + Piperaquine Tetraphosphate

Malaria, Vivax

United States
National Institute of Allergy and Infectious Diseases...

Completed

Malaria Vaccine for Children in Mali

Malaria | Malaria Infection

Mali
GlaxoSmithKline

Completed

Chlorproguanil-Dapsone-Artesunate (CDA) Versus Chlorproguanil-Dapsone (LAPDAP) For Uncomplicated Malaria

Malaria, Falciparum

Ghana, Mali, Burkina Faso, Nigeria
Epicentre
Medecins Sans Frontieres, Netherlands

Completed

Time to Become Negative of Three Rapid Diagnostic Tests for Malaria

Malaria, Falciparum

Uganda
London School of Hygiene and Tropical Medicine
Universitas Sumatera Utara

Completed

Artemisinin-based Combination Therapy for Treatment of Plasmodium Falciparum Malaria in North Sumatera, Indonesia

Malaria, Falciparum

Indonesia
Centre Muraz
Institute of Tropical Medicine, Belgium

Completed

Amodiaquine+Artesunate for Uncomplicated Malaria Treatment (ASAQ-MAL)

Uncomplicated Malaria

Burkina Faso
Pfizer

Completed

Azithromycin Plus Chloroquine Versus Artemether-Lumefantrine For The Treatment Of Uncomplicated P. Falciparum Malaria In Children In Africa

Malaria, Falciparum

Burkina Faso, Kenya, Mali, Ghana, Côte D'Ivoire
U.S. Army Medical Research and Development Command
GlaxoSmithKline

Completed

Safety and Preliminary Efficacy of the Malaria Vaccine Candidates Falciparum Merozoite Protein-1 (FMP1) and SmithKlineBeecham (SKBB) Candidate Malaria Vaccine RTS,S (MAL019)

Malaria, Falciparum

United States
University of California, San Francisco
Mahidol University; Holley-Cotec Pharmaceuticals Co., LTD.

Completed

Pharmacokinetics of Dihydroartemisinin-Piperaquine in the Treatment of Uncomplicated Malaria in Children in Burkina Faso

Uncomplicated Malaria

Clinical Trials on Severe Malaria

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