Clinical Trials on Sickle Cell Anaemia

Total 35724 results

Assistance Publique - Hôpitaux de Paris

Recruiting

Observational Prospective Study Measuring the Impact of the Use of a Hypnotic Script Associated With Virtual Reality on the Pain of the Child's Sickle Cell During a Vaso-occlusive Crisis (DREPAReV)

Sickle Cell Disease

France
Hoffmann-La Roche

Recruiting

A Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics and Efficacy of Crovalimab for the Management of Acute Uncomplicated Vaso-Occlusive Episodes (VOE) in Participants With Sickle Cell Disease (SCD). (CROSSWALK-a)

Sickle Cell Disease

United States, Brazil, Italy, Spain, Kenya, Netherlands, United Kingdom, France, South Africa
University of Florida
National Institute of Nursing Research (NINR)

Recruiting

A Stress and Pain Self-management m-Health App for Adult Outpatients With Sickle Cell Disease

Sickle Cell Disease

United States
bluebird bio

Recruiting

A Study Evaluating Gene Therapy With BB305 Lentiviral Vector in Sickle Cell Disease

Sickle Cell Disease

United States
University of Chicago

Recruiting

Haploidentical Hematopoietic Stem Cell Transplantation (HSCT) for Patients With Severe Sickle Cell Disease

Sickle Cell Disease

United States
Boston Children's Hospital
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

A Pilot Study on Neuroimaging in SCD: Part of The Boston Consortium to Cure Sickle Cell Disease

Sickle Cell Disease

United States
Gladwin, Mark, MD
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Sickle Cell Disease and CardiovAscular Risk - Red Cell Exchange Trial (SCD-CARRE) (SCD-CARRE)

Sickle Cell Disease

United States, France, Brazil
EpiDestiny, Inc.
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health...

Recruiting

A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Disease

Sickle Cell Disease

United States
University Hospital Heidelberg
Charite University, Berlin, Germany; Pfizer; German Cancer Research Center; Johann... and other collaborators

Recruiting

Sickle-cell Disease Registry of the GPOH (SichReg)

Sickle Cell Disease

Germany
City of Hope Medical Center

Recruiting

Haploidentical Transplantation With Pre-Transplant Immunosuppressive Therapy for Patients With Sickle Cell Disease

Sickle Cell Disease

United States
David Williams

Active, not recruiting

Gene Transfer for Sickle Cell Disease

Sickle Cell Disease

United States
Vifor (International) Inc.
Fortrea

Completed

Study to Assess Efficacy and Safety of VIT-2763 (Vamifeport) in Subjects With Sickle Cell Disease (ViSionSerenity)

Sickle Cell Disease

United States, France, Greece, Lebanon, United Kingdom
St. Jude Children's Research Hospital

Active, not recruiting

Exploring Adherence Monitoring in Sickle Cell Disease

Sickle Cell Disease

United States
Pfizer

Terminated

Voxelotor Neurocognitive Function Study

Sickle Cell Disease

United States
Medical College of Wisconsin
National Heart, Lung, and Blood Institute (NHLBI); Dana-Farber Cancer Institute and other collaborators

Completed

Bone Marrow Transplantation vs Standard of Care in Patients With Severe Sickle Cell Disease (BMT CTN 1503) (STRIDE2)

Sickle Cell Disease

United States
Children's Hospital Medical Center, Cincinnati

Terminated

Gene Transfer for Patients With Sickle Cell Disease

Anemia, Sickle Cell

United States
Hospital Universitari Vall d'Hebron Research Institute

Active, not recruiting

GenoMed4ALL: Improving SCD Classification and Prognosis by AI (GenoMed4ALL)

Sickle Cell Disorders

Spain, Netherlands, France, Italy
Pfizer
Pfizer

Available

Expanded Access Protocol for Adults and Pediatric Patients With Sickle Cell Disease Who Have No Alternative Treatment Options

Sickle Cell Disease

United States, Brazil
Pfizer

Active, not recruiting

Study to Assess the Effect of Long-term Treatment With Voxelotor in Participants Who Have Completed Treatment in Study GBT440-031 (034OLE)

Sickle Cell Disease

United States, Lebanon, United Kingdom, Oman, Turkey, Canada, Egypt, Kenya, France, Italy, Netherlands
New York Medical College
Washington University School of Medicine; University of California, Los Angeles and other collaborators

Active, not recruiting

Haplo T-Cell Depleted Transplantation in High-Risk Sickle Cell Disease (HaploSCD)

Sickle Cell Disease

United States
bluebird bio

Completed

A Study Evaluating the Safety and Efficacy of bb1111 in Severe Sickle Cell Disease

Sickle Cell Disease

United States
St. Jude Children's Research Hospital
National Heart, Lung, and Blood Institute (NHLBI)

Active, not recruiting

Sickle Cell Disease and the Genomic and Gene Therapy Needs of Stakeholders

Sickle Cell Disease

United States
Ensoma
bluebird bio

Terminated

Study of MGTA-145 and Plerixafor in Patients With Sickle Cell Disease

Sickle Cell Disease

United States
Ain Shams University

Completed

Glutamine Role in Preventing Vaso-occlusive Crisis Among SCD Patients (Glu_SCD_Egy)

Sickle Cell Disease

Egypt
Medical College of Wisconsin
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute... and other collaborators

Active, not recruiting

Haploidentical Bone Marrow Transplantation in Sickle Cell Patients (BMTCTN1507)

Sickle Cell Disease

United States
Children's Hospital Medical Center, Cincinnati
Bristol-Myers Squibb

Active, not recruiting

Realizing Effectiveness Across Continents With Hydroxyurea (REACH) (REACH)

Sickle Cell Disease

Angola, Congo, The Democratic Republic of the, Kenya, Uganda
Seattle Children's Hospital
The Hospital for Sick Children; Northwestern University; Emory University; University... and other collaborators

Completed

iCanCope With Sickle Cell Pain

Sickle Cell Disease

United States, Canada
St. Jude Children's Research Hospital
National Heart, Lung, and Blood Institute (NHLBI); University of Memphis; RTI...

Completed

Integration of mHEALTH Into the Care of Patients With Sickle Cell Disease to Increase Hydroxyurea Utilization

Sickle Cell Disease

United States
Pfizer

Terminated

Dose Escalation Study to Evaluate the Safety, Tolerability, PK and PD of Voxelotor in Patients With SCD

Sickle Cell Disease

United Kingdom
Sangamo Therapeutics

Active, not recruiting

A Study to Assess the Safety, Tolerability, and Efficacy of BIVV003 for Autologous Hematopoietic Stem Cell Transplantation in Patients With Severe Sickle Cell Disease

Sickle Cell Disease

United States
Memorial Sloan Kettering Cancer Center
Sanofi; Duke University; Weill Medical College of Cornell University; New York...

Active, not recruiting

Escalation of Plerixafor for Mobilization of CD34+ Hematopoietic Progenitor Cells and Evaluation of Globin Gene Transfer in Patients With Sickle Cell Disease

Sickle Cell Disease

United States
Duke University
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health...

Completed

Improving Sickle Cell Disease (SCD) Care Using Web-based Guidelines

Sickle Cell Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)
St. Jude Children's Research Hospital

Completed

Peripheral Blood Stem Cell Collection for Sickle Cell Disease (SCD) Patients

Sickle Cell Disease

United States
CSL Behring

Completed

Safety of Single Doses of CSL889 in Adult Patients With Sickle Cell Disease

Sickle Cell Disease

United States, United Kingdom, Netherlands
St. Jude Children's Research Hospital

Suspended

Reduced Intensity Transplantation for Severe Sickle Cell Disease

Sickle Cell Disease

United States
Pfizer

Completed

Study to Evaluate the Effect of Voxelotor Administered Orally to Patients With Sickle Cell Disease (GBT_HOPE) (GBT_HOPE)

Sickle Cell Disease

United States, Italy, France, United Kingdom, Netherlands, Turkey, Egypt, Canada, Jamaica, Kenya, Lebanon, Oman
Cyclerion Therapeutics

Completed

A Study of the Effect of IW-1701 (Olinciguat), a Stimulator of Soluble Guanylate Cyclase (sGC), on Patients With Sickle Cell Disease (SCD) (STRONG SCD)

Sickle Cell Disease

United States, United Kingdom, Lebanon
Duke University
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Comparing Individualized vs. Weight Based Protocols to Treat Vaso-Occlusive Episodes in Sickle Cell Disease (COMPARE-VOE)

Sickle Cell Disease

United States
Ain Shams University

Completed

Endothelial Monocyte-activating Polypeptide-II in Egyptian Sickle Patients

Sickle Cell Disease
Novartis Pharmaceuticals

Completed

Patient Characteristics and Treatment Patterns From Early Crizanlizumab Use in Real-world Setting: Preliminary Analysis From Select Sickle Cell Centers

Sickle Cell Disease

United States
Assistance Publique - Hôpitaux de Paris

Completed

Evaluation of the Lung Capillary Blood Volume in Children With Sickle Cell Disease (VOLCADREP)

Sickle Cell Disease

France
ADDMEDICA SASA

Completed

Acceptability of a New Paediatric Formulation of Hydroxycarbamide in Children With Sickle Cell Disease.

Sickle Cell Disease

France
Wake Forest University Health Sciences
Emory University; Children's Healthcare of Atlanta

Completed

High Dose Vitamin D for Sickle Cell Disease (SCD-VitD)

Sickle Cell Disease

United States
Kathleen Dorritie

Terminated

Stem Cell Transplant in Patients With Severe Sickle Cell Disease

Sickle Cell Disease

United States
Johns Hopkins University

Completed

Assessing the Safety of Buprenorphine in People With Sickle Cell Disease

Sickle Cell Disease

United States
Medical University of South Carolina

Completed

SMYLS: A Self-management Program for Youth Living With Sickle Cell Disease

Sickle Cell Disease

United States
Children's National Research Institute

Completed

Hydroxyurea and Transfusion (HAT)

Sickle Cell Disease

United States
Fondation Ophtalmologique Adolphe de Rothschild

Completed

Implications of a Paediatrician-psychologist Tandem for Sickle Cell Disease Care and Impact on Cognitive Functioning

Sickle Cell Disease
Baxalta now part of Shire

Terminated

Evaluation of Different Dose Regimens of Aes-103 Given for 28 Days to Subjects With Stable Sickle Cell Disease

Sickle Cell Disease

United Kingdom
Baxalta now part of Shire
National Heart, Lung, and Blood Institute (NHLBI); SAIC-Frederick, Inc.; Cato... and other collaborators

Completed

A Single Dose Study of the Safety, Blood Levels and Biological Effects of Aes-103 Compared to Placebo in Subjects With Stable Sickle Cell Disease

Sickle Cell Disease

United States

Clinical Trials on Sickle Cell Anaemia

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