Clinical Trials on Single-Gene Defects in South Africa
Total 315 results
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GLYCAR SA (Pty) LtdRecruitingCardiac Anomaly | Cardiac Defect | Pericardial DefectSouth Africa
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Ocular Therapeutix, Inc.Completed
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Abbott Medical DevicesCompletedMembranous Ventricular Septal DefectsUnited States
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Medical University of South CarolinaAmerican Heart AssociationCompletedSingle Ventricle Heart Disease After Fontan SurgeryUnited States
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Abbott Medical DevicesCompletedHeart Septal Defects, VentricularUnited States
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Cryonove PharmaCEISO; Dermatech; Sefako Makgatho Health Sciences UniversityCompletedSolar Lentigo | Post-inflammatory Hyperpigmentation | Senile LentigoSouth Africa
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Cryonove PharmaCEISO; Dermatech; Sefako Makgatho Health Sciences UniversityNot yet recruitingSolar Lentigo | Post Inflammatory Hyperpigmentation | Senile LentigoSouth Africa
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Abbott Medical DevicesActive, not recruitingVentricular Septal DefectsUnited States, Canada
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HealthCore-NERINational Heart, Lung, and Blood Institute (NHLBI); Pediatric Heart NetworkCompletedHeart Defects, CongenitalUnited States, Canada
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University of HoustonMichigan State University; Bar-Ilan University, Israel; University of the Free...CompletedHIV Affected Children (Single and/or Double Orphans)South Africa
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Abbott Medical DevicesCompletedAtrial Septal DefectUnited States
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National Heart, Lung, and Blood Institute (NHLBI)Pediatric Heart NetworkCompletedHeart Defects, Congenital | Heart Failure, CongestiveUnited States, Canada
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Mezzion Pharma Co. LtdRecruitingSingle Ventricle Heart DiseaseUnited States
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Anna ErenbourgSheba Medical Center; San Salvatore Hospital of L'Aquila; Vittore Buzzi Children... and other collaboratorsRecruitingCongenital Heart Defect | Cardiac FunctionIsrael, Australia, Italy, Mayotte, Poland
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Mezzion Pharma Co. LtdNational Heart, Lung, and Blood Institute (NHLBI)UnknownSingle Ventricle Heart DiseaseUnited States, Canada
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Mezzion Pharma Co. LtdNational Heart, Lung, and Blood Institute (NHLBI)CompletedSingle Ventricle Heart DiseaseUnited States, Korea, Republic of, Canada
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Mezzion Pharma Co. LtdNational Heart, Lung, and Blood Institute (NHLBI)UnknownFunctional Single Ventricle Heart DiseaseUnited States, Korea, Republic of, Canada
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Prisma Health-UpstateIpsenRecruitingSolid Tumor | ARID1A Gene MutationUnited States
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BioMed Valley Discoveries, IncTerminatedAdvanced Solid Tumor | MAP2K1 Gene Mutation | BRAF Gene Mutation | MEK Mutation | BRAF Gene Alteration | MEK Alteration | MAP2K1 Gene Alteration | MAP2K2 Gene Mutation | MAP2K2 Gene AlterationUnited States
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University of Cape TownMedical Research Council, South AfricaCompletedDrug-Induced Liver InjurySouth Africa
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Nested Therapeutics, IncRecruitingGlioma | Melanoma | NSCLC | Oncology | Solid Tumor, Adult | MEK Mutation | RAF Gene Mutation | Ras (KRAS or NRAS) Gene Mutation | MAPK Pathway Gene MutationAustralia
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atHeart MedicalRecruitingHeart Diseases | Cardiovascular Diseases | Congenital Abnormalities | Heart Septal Defects, Atrial | Heart Defects, Congenital | Cardiovascular Abnormalities | Heart Septal DefectUnited States, France
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Southwest Oncology GroupNational Cancer Institute (NCI)CompletedBRCA1 Gene Mutation | BRCA2 Gene Mutation | Recurrent Squamous Cell Lung Carcinoma | Stage IV Squamous Cell Lung Carcinoma AJCC v7 | BRIP1 Gene Mutation | PALB2 Gene Mutation | ATM Gene Mutation | ATR Gene Mutation | CHEK2 Gene Mutation | NBN Gene Mutation | RAD51 Gene Mutation | CHEK1 Gene Mutation | FANCA Gene... and other conditionsUnited States, Canada
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Christoph P Hornik, MD MPHEunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaboratorsCompletedCongenital Heart DiseaseUnited States
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St Vincent's Hospital, SydneyTerminatedSolid Tumor | Androgen Receptor Gene OverexpressionAustralia
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BioMarin PharmaceuticalActive, not recruitingHemophilia A | Gene Therapy | Blood Disorder | Clotting DisordersTaiwan, Korea, Republic of, United Kingdom, South Africa
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Relay Therapeutics, Inc.Active, not recruitingCholangiocarcinoma | Intrahepatic Cholangiocarcinoma | FGFR2 Gene Mutation | FGFR2 Amplification | FGFR2 Gene Fusion/Rearrangement | FGFR2 Gene Translocation | FGFR2 Gene Activation | Other Solid Tumors, AdultUnited States, France, Italy, United Kingdom, Korea, Republic of, Spain, Taiwan, Sweden, Germany, Netherlands, Singapore, Australia, Hong Kong
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Merrimack PharmaceuticalsCompletedHER-2 Gene AmplificationUnited States
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Sheffield Children's NHS Foundation TrustWithdrawnGene Expression Profiles in CML Non-respondersUnited Kingdom
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ChimerixTerminatedProtein Losing EnteropathyUnited States
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Sheffield Hallam UniversityUnknownModulation of Cognitive Flexibility by Transcranial Direct Current Stimulation, Tyrosine Administration and Polymorphisms in the COMT GeneUnited Kingdom
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AstraZenecaCompletedInvestigation of Platelet Aggregation in Paediatric Patients With Sickle Cell DiseaseUnited States, Canada, United Kingdom, South Africa, Lebanon, Kenya
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National and Kapodistrian University of AthensRecruitingForamen Ovale, Patent | Metal Allergy | Nickel Sensitivity | Dermatitis Contact IrritantGreece
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Southwest Oncology GroupNational Cancer Institute (NCI)CompletedRecurrent Squamous Cell Lung Carcinoma | Stage IV Squamous Cell Lung Carcinoma AJCC v7 | FGFR1 Gene Amplification | FGFR2 Gene Amplification | FGFR2 Gene Mutation | FGFR3 Gene Mutation | FGFR1 Gene Mutation | FGFR3 Gene AmplificationUnited States, Canada
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QED Therapeutics, Inc.Helsinn Healthcare SATerminatedFGFR2 Gene Mutation | Advanced CholangiocarcinomaKorea, Republic of, United States, Belgium, Spain, Taiwan, China, United Kingdom, France, Canada, Germany, Thailand, Italy, Portugal, Australia, Puerto Rico
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Medical University of South CarolinaCompletedGrowth Failure | Congenital Heart DefectsUnited States
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Novartis PharmaceuticalsCompletedSickle Cell AnemiaTurkey, United States, Germany, Canada, United Kingdom, Israel, South Africa
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Taiho Oncology, Inc.Active, not recruitingAdvanced Cholangiocarcinoma | FGFR2 Gene RearrangementsUnited States, Spain, United Kingdom, Australia, Taiwan, Italy, France, Korea, Republic of, Belgium, Japan, Thailand, Germany, Brazil, Peru, Portugal, Argentina, Hong Kong, Mexico, Netherlands, Poland
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University of UtahNational Heart, Lung, and Blood Institute (NHLBI); Pediatric Heart NetworkTerminatedHeart Defects, Congenital | Heart Septal Defects, Ventricular | Heart Failure, CongestiveUnited States, Canada
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SanofiBristol-Myers SquibbCompletedHeart Defects, CongenitalFrance, Canada, Brazil, Poland, Russian Federation, Germany, Italy, Netherlands, Portugal, Spain, Sweden, India, Malaysia, Singapore, Taiwan, Belgium, Mexico, Argentina, Denmark, Egypt, Finland, Hungary, Israel, Norway, Korea, Republic of, Hong Kong and more
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BayerRecruitingLocally Advanced or Metastatic Solid Tumor Harboring an NTRK Gene FusionUnited States, Austria, Denmark, Germany, Italy, Norway, Spain, United Kingdom, Brazil, Russian Federation, Switzerland, Taiwan, Canada, China, Australia, Greece, Belgium, Sweden, Korea, Republic of, France, Argentina, Finland, Ireland and more
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Southwest Oncology GroupNational Cancer Institute (NCI)CompletedCCND1 Gene Amplification | CCND2 Gene Amplification | CCND3 Gene Amplification | CDK4 Gene Amplification | Recurrent Squamous Cell Lung Carcinoma | Stage IV Squamous Cell Lung Carcinoma AJCC v7United States
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The University of New South WalesCompletedEffects on LearningAustralia
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PfizerMedivation, Inc.CompletedBreast Neoplasms | BRCA 1 Gene Mutation | BRCA 2 Gene MutationKorea, Republic of, United States, Australia, Spain, Belgium, France, Ireland, Taiwan, Poland, Germany, Israel, Brazil, United Kingdom, Italy, Russian Federation, Ukraine
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Glaukos CorporationCompletedGlaucoma Open-angleUnited States
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Vistakon PharmaceuticalsCompletedOcular Hypertension | Open-angle GlaucomaUnited States
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ShireCompleted
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PolyActiva Pty LtdActive, not recruitingOpen Angle GlaucomaAustralia, New Zealand
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Alcon ResearchCompletedOpen-angle Glaucoma | Oular HypertensionUnited States
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Recursion Pharmaceuticals Inc.RecruitingSolid Tumor | APC Gene Mutation | AXIN1 Gene MutationUnited States