Clinical Trials on Spinal Muscular Atrophy (SMA)

Total 2755 results

Asan Medical Center

Active, not recruiting

Sarcopenia and Outcomes of Neuroplasty in Lumbar Spinal Stenosis

Sarcopenia | Lumbar Spinal Stenosis | Neurogenic Claudication

Korea, Republic of
University of Sao Paulo

Completed

Leucine Supplementation and Skeletal Muscle Disuse

Disuse Atrophy

Brazil
University of Sao Paulo General Hospital
Agência Brasileira de Desenvolvimento Industrial (Brazilian Agency For Industrial...

Not yet recruiting

Pilot Study for Peripheral Neuromuscular Electrical Stimulation of the Quadriceps Muscle

Brain Injuries | Spinal Cord Injuries | Muscle Atrophy

Brazil
Duke University
CReATe Consortium (funded by NIH/NCATS/NINDS)

Completed

Study of ALS Reversals 2: Genetic Analyses (StAR2)

Amyotrophic Lateral Sclerosis | Progressive Muscular Atrophy

United States
Centre Hospitalier Universitaire, Amiens

Recruiting

Exploratory Study of Respiratory Bacterial Infections or Superinfections and Colonizations in Patients With Spinal Muscular Atrophy Under NIV (AVNIR)

Spinal Muscular Atrophy | Non Invasive Ventilation | Respiratory Bacterial Infection

France
LMU Klinikum

Completed

Musculoskeletal Nociceptive Pain in Participants With Neuromuscular Disorders

Healthy | Myotonic Dystrophy Type 2 | Pompe Disease (Late-onset) | Spinal Muscular Atrophy Type 3 | Myotonic Dystrophy Type 1 (DM1) | Facioscapulohumeral Muscular Dystrophy 1 | Inclusion Body Myositis, Sporadic

Germany
University of Oklahoma

Completed

Effects of Power Mobility on Young Children With Severe Motor Impairments

Cerebral Palsy | Spinal Muscular Atrophy | Arthrogryposis | Other Central Nervous System or Musculoskeletal Disorders

United States
University of Birmingham
University of Nottingham; Biotechnology and Biological Sciences Research Council

Completed

Preventing Bed-rest Induced Muscle Loss in the Elderly

Sarcopenia | Muscle Loss | Prehabilitation | Disuse Atrophy | Protein Metabolism

United Kingdom
University of Alberta
McGill University; University of Toronto; Laval University; Simon Fraser University

Recruiting

Comprehensive Analysis Platform To Understand, Remedy and Eliminate ALS (CAPTURE ALS)

Amyotrophic Lateral Sclerosis | Primary Lateral Sclerosis | Frontotemporal Degeneration | Progressive Muscular Atrophy

Canada
University of Miami
Florida

Recruiting

Study Testing Benefits of Ursolic Acid (UA) as a Countermeasure To Myopenia and Insulin Resistance in Chronic Spinal Cord Injury (SCI)

Insulin Resistance | Spinal Cord Injuries | Tetraplegia | Muscle Loss | Paraplegia | Atrophy, Muscular

United States
Duke University
UCB Pharma

Completed

Levetiracetam for Cramps, Spasticity and Neuroprotection in Motor Neuron Disease

Motor Neuron Disease | Amyotrophic Lateral Sclerosis | Primary Lateral Sclerosis | Progressive Muscular Atrophy

United States
McMaster University

Active, not recruiting

Dynamic Proteomics and Integrated Rates of Muscle Protein Synthesis During an Acute Period of Loading and Unloading (HYPAT)

Hypertrophy | Exercise | Proteomics | Atrophy, Disuse

Canada
LMU Klinikum

Recruiting

Pompe & Pain - Study to Assess Nociceptive Pain in Adult Patients With Pompe Disease

Pompe Disease (Late-onset) | FSHD | Spinal Muscular Atrophy Type 3 | Inclusion Body Myositis

Germany
Stem Cells Arabia

Unknown

Autologous Bone Marrow-Derived Stem Cell Therapy for Motor Neuron Disease

Motor Neuron Disease | Amyotrophic Lateral Sclerosis | Primary Lateral Sclerosis | Progressive Muscular Atrophy | Progressive Bulbar Palsies
Ohio State University

Completed

Metabolic Health in Individuals With Spinal Cord Injury (SCI) (SCI)

Spinal Cord Injuries | Metabolic Disease | Skeletal Muscle Atrophy

United States
Maastricht University Medical Center

Terminated

Neuromuscular Electrical Stimulation During Immobilization Due to Ankle Fractures (ANKL-ES)

Immobilization | Muscle Disuse Atrophy

Netherlands
Thomas Jefferson University

Recruiting

NuroSleeve Powered Brace & Stimulation System to Restore Arm Function

Stroke | Cerebral Palsy | Amyotrophic Lateral Sclerosis | Muscular Dystrophies | Spinal Cord Injuries | Hemiparesis | Spinal Muscular Atrophy | Quadriplegia | Arthrogryposis | Neurologic Diseases | Charcot-Marie-Tooth | Weakness of Extremities as Sequela of Stroke | Weakness Due to Upper Motor Neuron Dysfunction | Arm Paralysis

United States
Johns Hopkins University
Massachusetts General Hospital; Washington University School of Medicine; Emory... and other collaborators

Completed

Answer ALS: Individualized Initiative for ALS Discovery (AnswerALS)

Motor Neuron Disease | Amyotrophic Lateral Sclerosis | Primary Lateral Sclerosis | Progressive Muscular Atrophy | Healthy Controls | Flail Arm ALS | Monomelic Amyotrophy | Asymptomatic ALS Gene Carriers

United States
University of Michigan
National Institute of Neurological Disorders and Stroke (NINDS)

Completed

PET Imaging Study of Neurochemical and Autonomic Disorders in Multiple System Atrophy (MSA)

Multiple System Atrophy - Parkinsonian Subtype (MSA-P) | Multiple System Atrophy - Cerebellar Subtype (MSA-C)

United States
Maastricht University Medical Center

Completed

Immobilization and Protein Supplementation (IM-PRO) (IM-PRO)

Aging | Disuse Atrophy

Netherlands
Chang Gung University

Completed

The Investigation of the Pre-movement Facilitation of Agonist-antagonist Muscles and the Effect of the Feedforward Rehabilitation in Individuals With Hypermetria

Spinocerebellar Atrophy (SCA)

Taiwan
Bispebjerg Hospital

Recruiting

The Impact of Bed Rest, Aging and NMES on Skeletal Muscle

Muscle Function | Neuromuscular Electrical Stimulation | Disuse Atrophy (Muscle) of Lower Extremities | Myofibrillar Protein Synthesis

Denmark
National Institutes of Health Clinical Center (CC)

Recruiting

Evaluating Long-term Use of a Pediatric Robotic Exoskeleton (P.REX/Agilik) to Improve Gait in Children With Movement Disorders

Cerebral Palsy | Muscular Dystrophy | Spina Bifida | Incomplete Spinal Cord Injury

United States
National Institutes of Health Clinical Center (CC)

Recruiting

Evaluating a New Knee-Ankle-Foot Brace to Improve Gait in Children With Movement Disorders

Cerebral Palsy | Muscular Dystrophy | Spina Bifida | Incomplete Spinal Cord Injury

United States
The Hong Kong Polytechnic University

Completed

A BHI to Increase Hope Level and Stress Level of Parents With a CMC

Endocrine System Diseases | Muscular Atrophy, Spinal | Child With Cancer | Child With Cerebral Palsy

China
Maastricht University Medical Center

Completed

Electrical Stimulation During Immobilization (ESDIM)

Immobilization | Neuromuscular Electrical Stimulation | Disuse Atrophy

Netherlands
University of Dublin, Trinity College
Motor Neurone Disease Association, UK; Irish Research Council, IE; Thierry Latran... and other collaborators

Recruiting

Non-invasive Spinal, Cortical, and Sensorimotor Biomarkers in Motor Neurone Disease

Multiple Sclerosis | Primary Lateral Sclerosis | Postpoliomyelitis Syndrome | Motor Neuron Disease, Amyotrophic Lateral Sclerosis | Motor Neuron Disease Progressive Spinal Muscle Atrophy

Ireland
CENTOGENE GmbH Rostock

Completed

Biomarker for Duchenne Muscular Dystrophy (BioDuchenne)

Scoliosis | Muscular Atrophy | Duchenne Muscular Dystrophy | Lordosis | Muscular Weakness | Increased Lordosis/Scoliosis | Hyporeflexia | Red-Green Color Blindness

Egypt, India, Albania, Pakistan, Georgia, Lebanon, Romania, Sri Lanka
Bio-Medical Research, Ltd.
Liverpool University Hospitals NHS Foundation Trust

Completed

Effects of Kneehab 12-week Peri-operative Total Knee Arthroplasty (KneehabTKA)

Knee Osteoarthritis | Disuse Atrophy

United Kingdom
Rigshospitalet, Denmark

Completed

MRI in Patients With Kennedy Disease

Bulbo-Spinal Atrophy, X-Linked | Kennedy Disease

Denmark
University of Zurich
Foundation Wings For Life

Completed

Plasticity of Grey and White Matter in Response to Motor Skill Training in Healthy Individuals and Those With Spinal Cord Injury

Investigating Spinal Atrophy in Patients With Spinal Injury

Switzerland
University of Sao Paulo General Hospital

Recruiting

Protein Intake Plus Neuromuscular Electrical Stimulation on Muscle Mass in Hospitalized Elderly

Atrophy, Muscular

Brazil
GlaxoSmithKline

Completed

A Clinical Study to Assess the Safety, Tolerability and Pharmacokinetics of Oral SRT2104 Capsules Administered to Healthy Elderly Subjects for 28 Days

Atrophy, Muscular

United Kingdom
University of Miami
National Institute of Neurological Disorders and Stroke (NINDS); National Institutes...

Active, not recruiting

TRIAL READY (Clinical Trial Readiness)

Amyotrophic Lateral Sclerosis | Primary Lateral Sclerosis | Frontotemporal Dementia | Progressive Muscular Atrophy | ALS-Frontotemporal Dementia

United States
University of Alberta

Withdrawn

Digital Smartwatch Measurements as Potential Biomarkers for Remote Disease Tracking in ALS

Healthy | Amyotrophic Lateral Sclerosis | Primary Lateral Sclerosis | Frontotemporal Dementia | Muscular Atrophy, Progressive

Canada
University of Rzeszow

Completed

Effectiveness of Spa Treatment, Outpatient Physiotherapy and no Physiotherapy in Spine Osteoarthritis

Spine Osteoarthritis | Spa Resorts

Poland
University of South Florida
University of Miami; National Institutes of Health (NIH); University of Kansas

Completed

A Patient Centric Motor Neuron Disease Activities of Daily Living Scale

Amyotrophic Lateral Sclerosis | Primary Lateral Sclerosis | Progressive Muscular Atrophy | Hereditary Spastic Paraplegia
University of Miami
National Institute of Neurological Disorders and Stroke (NINDS); National Institutes... and other collaborators

Recruiting

Clinical Procedures to Support Research in ALS (CAPTURE-ALS)

Amyotrophic Lateral Sclerosis | Primary Lateral Sclerosis | Progressive Muscular Atrophy | ALS-Frontotemporal Dementia

United States
All India Institute of Medical Sciences, New Delhi

Recruiting

Cervical Fixation Surgery Cervical Collar for Management of Hirayama Disease: A Randomized Study

Hirayama Disease

India
Hospices Civils de Lyon

Completed

Sarcopenia in Axial and Peripheral Spondyloarthropathies (SASPAR)

Sarcopenia | Spondylarthropathy

France
Hasselt University
Jessa Hospital; Sint-Trudo Hospital; Sint-Franciscus Ziekenhuis

Suspended

Extreme Lateral Interbody FusionFUSION (XLIF) Versus Posterior Lumbar Interbody Fusion (PLIF) (XLIF)

Atrophy | Muscle Damage | Degenerative Diseases, Spinal Cord

Belgium
GlaxoSmithKline

Withdrawn

A Clinical Study to Assess the Effects of SRT2104 Upon Immobilization-Induced Skeletal Muscle Atrophy in Healthy Human Volunteers

Healthy Volunteer | Atrophy, Muscular
University of Rochester

Completed

Study of Muscle Wasting and Altered Metabolism in Patients With Myotonic Dystrophy

Myotonic Muscular Dystrophy
University of Exeter

Completed

Energy Balance in Extreme Environments: Finding the EI Limit (StOMPE)

Energy Expenditure | Energy Intake | Atrophy, Muscular

United Kingdom
University of Texas Southwestern Medical Center

Recruiting

Multiple System Atrophy Multidisciplinary Clinic

Multiple System Atrophy (MSA)

United States
Kessler Foundation
The Craig H. Neilsen Foundation

Unknown

Activity Dependent Rehabilitation Model to Improve Bone and Muscle Outcomes

Skeletal Muscle Hypertrophy | Nervous System | Atrophy, Disuse | Disuse Osteoporosis | Structural; Marker

United States
Ono Pharmaceutical Co. Ltd

Recruiting

A Phase 2 Study of ONO-2808 in Patients With Multiple System Atrophy

Multiple System Atrophy (MSA)

United States
Biohaven Pharmaceuticals, Inc.

No longer available

Expanded Access Protocol of Verdiperstat in Patients With Multiple System Atrophy (MSA)

Multiple System Atrophy (MSA)

United States
University Hospital, Bordeaux

Completed

Oligomeric Alpha-synuclein in Multiple System Atrophy (BIOAMS)

Multiple System Atrophy (MSA)

France
AstraZeneca

Completed

AZD3241 PET MSA Trial, Phase 2, Randomized,12 Week Safety and Tolerability Trial With PET in MSA Patients

Multiple System Atrophy, MSA

United States, Finland, Austria, France, Sweden, United Kingdom, Italy

Clinical Trials on Spinal Muscular Atrophy (SMA)

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