Clinical Trials on Structural Barriers

Total 292 results

University of Southern Denmark
Hospital of South West Jutland

Not yet recruiting

Comparison of Three Different Antibiotic Treatments Against Recurrent Urinary Tract Infections in Catheterized Patients

Recurrent Urinary Tract Infections | Antibiotic Treatment | Chronic Urinary-catheter-carrier | Biofilm Infection | Replacement of Urinary Catheter
Groupe Maladies hémorragiques de Bretagne

Completed

Genetic Factors of the Desmopressin Response in Carriers of Hemophilia A (GIDEHAC)

Factor VIII Deficiency | Desmopressin | Carrier of Hemophilia A

France
Radboud University Medical Center

Unknown

Muscle Relaxation in Myopathies With Positive Muscle Phenomena

Myotonic Dystrophy Type 2 | McArdle Disease | Nemaline Myopathy Type 6
Alnylam Pharmaceuticals

Recruiting

Observational Study of Neurofilament Light Chain (NfL) as a Biomarker in Asymptomatic Carriers of the Transthyretin (TTR) Variants and Patients With Hereditary Transthyretin-mediated (hATTR) Amyloidosis With Polyneuropathy

Hereditary Amyloidosis, Transthyretin-Related | Asymptomatic Carrier State

France
Hospital Rudolfstiftung
Oesterreichische Muskelforschung

Completed

Myocardial Involvement in Carriers of Duchenne Muscular Dystrophy: An MRI-study

Carrier of Duchenne Muscular Dystrophy

Austria
Cumberland Pharmaceuticals

Completed

Telavancin Observational Use Registry (TOUR) (TOUR)

Complicated Skin and Skin Structure Infections | Hospital Acquired Bacterial Pneumonia | Ventilator Associated Bacterial Pneumonia | Gram Positive Infection

United States
Pfizer

Completed

Study Evaluating The Safety And Effectiveness In Subjects With Tigecycline Treatment

Complicated Skin and Skin Structure Infections | Complicated Intra-abdominal Infections | Community-Acquired Bacterial Pneumonia

Korea, Republic of
Melinta Therapeutics, Inc.

Completed

Safety and Efficacy Study of a Fluoroquinolone to Treat Complicated Skin Infections

Staphylococcal Skin Infections | Bacterial Skin Diseases | Skin Structure Infections

United States, Puerto Rico
Lei Li

Recruiting

Genetic Mutation in Epithelial Ovarian Cancer

Epithelial Ovarian Cancer | Microsatellite Instability | PD-L1 | Nucleotide Variant | Copy Number Variation | Insertion-deletion Variation | Genomic Structural Variation | Total Mutation Burden | PD-1

China
Scripps Health
J. Craig Venter Institute

Completed

Biomarker Monitoring in TP53 Mutation Carriers

Li-Fraumeni Syndrome | Hereditary Cancer Syndromes | TP53 Gene Germline Mutation Carrier

United States
University of L'Aquila

Unknown

Evaluation of Menses in Congenital Bleeding Disorders (MEVA-3)

Von Willebrand Disease | Congenital Coagulation Factors Deficiency | Haemophilia Carriers

Italy
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

mTORC1/2 Inhibitor AZD2014 or the Oral AKT Inhibitor AZD5363 for Recurrent Endometrial and Ovarian

Recurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma | Recurrent Uterine Corpus Carcinoma | Endometrial Adenocarcinoma | Recurrent Breast Carcinoma | Estrogen Receptor Negative | HER2/Neu Negative | Progesterone Receptor Negative | Triple-Negative Breast... and other conditions

United States
Natera, Inc.

Withdrawn

Multi-disease Carrier Screening Test Validation

Genetic Testing | Spinal Muscular Atrophy (SMA) | Carrier Screening

United States
First Affiliated Hospital Xi'an Jiaotong University
General Hospital of Ningxia Medical University; Second Affiliated Hospital... and other collaborators

Not yet recruiting

Prognosis Prediction System of Patients With Cardiovascular and Cerebrovascular Diseases Based on Multi-omics (PROSPECT)

Coronary Artery Disease | Hypertension | Arrhythmias, Cardiac | Heart Valve Diseases | Brain Neoplasms | Myocarditis | Cardiomyopathies | Aortic Dissection | Structural Heart Disease | Heart Neoplasms | Ischemic Cerebrovascular Disease | Hemorrhagic Cerebrovascular Disease

China
AbbVie

Completed

Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections in Children, Known or Suspected to be Caused by Susceptible Gram-positive Organisms, Including MRSA

Bacterial Infections | Staphylococcal Skin Infections | Methicillin-Resistant Staphylococcus Aureus

United States, Bulgaria, Chile, Colombia, Georgia, Greece, Guatemala, Latvia, Mexico, Panama, Spain, Ukraine
Catholic University of the Sacred Heart

Unknown

Study With Trabectedin in BRCA1 and BRCA2 Mutation Carrier and BRCAness Phenotype Ovarian Cancer (MITO15)

BRCA1 and BRCA2 Mutation Carrier and BRCAness Phenotype

Italy
Seng Gee Lim
Roche Pharma AG

Unknown

Peg-interferon for Inactive Chronic Hepatitis B Carriers (INACTIVE)

Chronic Hepatitis, B Virus | Carrier of Viral Hepatitis Type B

Singapore
Peking University First Hospital
Chinese Academy of Sciences

Recruiting

MRI Study of Blood-brain Barrier Function in CADASIL

Cadasil | Blood Brain Barrier Defect

China
Cubist Pharmaceuticals LLC

Terminated

Study of Daptomycin Safety and Efficacy for Complicated Skin and Skin Structure Infections (cSSSI) and Bacteremia in Renal Impairment (RENSE)

Renal Impairment | Complicated Skin and Skin Structure Infections | S. Aureus Bacteremia

United States
Novartis

Terminated

Safety and Efficacy of Daptomycin for the Treatment of Complicated Skin and Skin-structure Infections

Staphylococcal Skin Infections

Italy
Hospital Ruber Internacional

Recruiting

Galactose Supplementation for the Treatment of MOGHE (GATE)

Refractory Epilepsy | SLC35A2-CDG - Solute Carrier Family 35 Member A2 Congenital Disorder of Glycosylation

Spain
Laurent Servais
SYSNAV

Recruiting

Assessments in Patients With Muscular Pathology and in Control Subjects : The ActiLiège Next Study

Duchenne Muscular Dystrophy | Myotonic Dystrophy 1 | Congenital Muscular Dystrophy | Centronuclear Myopathy | Charcot-Marie-Tooth | Fascioscapulohumeral Muscular Dystrophy

Belgium
Federal University of Juiz de Fora
Fundação de Amparo à Pesquisa do estado de Minas Gerais

Unknown

Effects of Supplementation of Vitamin D in Patients With Crohn's Disease

Fatigue | Muscle Weakness | Vitamin D Deficiency | Sarcopenia | Crohn Disease | Disorder of Bone Density and Structure, Unspecified

Brazil
Hywel Dda Health Board
Swansea University; National Institute for Health Research, United Kingdom; Abertawe...

Completed

New Markers to Measure Clotting in Patients With the Obstructive Sleep Apnoea Hypopnoea Syndrome

Obstructive Sleep Apnoea Hypopnoea Syndrome | Biomarkers of Fibrin Clot Structure | Biomarkers of Vascular Endothelial Injury

United Kingdom
National Institute of Allergy and Infectious Diseases...

Recruiting

A Phase 1b/2 Trial of the Safety and Microbiological Activity of Bacteriophage Therapy in Cystic Fibrosis Subjects Colonized With Pseudomonas Aeruginosa

Cystic Fibrosis | Bacterial Disease Carrier

United States
National Cancer Institute (NCI)

Completed

Veliparib in Treating Patients With Malignant Solid Tumors That Do Not Respond to Previous Therapy

Recurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma | Breast Carcinoma | Ovarian Carcinoma | Pancreatic Carcinoma | Prostate Carcinoma | Recurrent Breast Carcinoma | Estrogen Receptor Negative | HER2/Neu Negative | Progesterone Receptor Negative | Triple-Negative... and other conditions

United States
St George's, University of London
Assistance Publique - Hôpitaux de Paris; MRC/UVRI and LSHTM Uganda Research... and other collaborators

Recruiting

Serocorrelate of Protection Against GBS (PREPARE WP3)

Group B Streptococcus Carrier in Childbirth | Group B Streptococcal Infection, Late-Onset | Group B Streptococcal Infection, Early-Onset | Group B Streptococcus Neonatal Sepsis | Group B Strep Infection

France, Italy, Malawi, Netherlands, Uganda, United Kingdom
Western Sydney Local Health District

Recruiting

Catheter Ablation Versus Anti-arrhythmic Drugs for Ventricular Tachycardia (CAAD-VT)

Ventricular Tachycardia | Cardiomyopathy, Dilated | Heart Disease Structural Disorder | Sarcoidosis | Cardiomyopathy, Hypertrophic | Cardiomyopathy, Familial | Cardiomyopathy Ischemic | Arrhythmogenic Right Ventricular Cardiomyopathy 1 | Arrhythmogenic Left Ventricular Cardiomyopathy

Australia
University of Bergen
Haukeland University Hospital

Completed

Growth, Health and Development in Children Born Extremely Preterm (PEP11)

Neurobehavioral Manifestations | Lung Diseases, Obstructive | Cognition Disorders | Infant, Extremely Low Birth Weight | Disorder of Bone Density and Structure, Unspecified

Norway
Amsterdam UMC, location VUmc
MRIguidance B.V.

Completed

MRI-based Synthetic CT Images of the Head and Neck

Sinusitis | Hearing Loss | Head and Neck Tumor | Cholesteatoma | Imaging of Bony Structures of the Head (Various Conditions)

Netherlands
St George's, University of London
MRC/UVRI and LSHTM Uganda Research Unit; MU-JHU CARE

Active, not recruiting

Serosurveillance Study of Maternally Derived Anti-GBS Antibody (ProGreSs)

Group B Streptococcus Carrier in Childbirth | Group B Streptococcal Infection, Late-Onset | Group B Streptococcal Infection, Early-Onset | Group B Streptococcus Neonatal Sepsis | Group B Strep Infection

Uganda
St George's, University of London
MRC/UVRI and LSHTM Uganda Research Unit; MU-JHU CARE

Completed

Maternal, Neonatal and Infant Outcomes at Kawempe National Referral Hospital (PREPARE)

Group B Streptococcus Carrier in Childbirth | Group B Streptococcal Infection, Late-Onset | Group B Streptococcal Infection, Early-Onset | Group B Streptococcus Neonatal Sepsis | Group B Strep Infection

Uganda
Institut Bergonié
Boehringer Ingelheim

Not yet recruiting

Targeting MDMD and PD1 in Tumors With Tertiary Lymphoid Structures (EMPIRE)

Colorectal Cancer | Non Small Cell Lung Cancer | Triple Negative Breast Cancer | Biliary Tract Cancer | Adult Soft Tissue Sarcoma

France
Washington University School of Medicine
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D) (Metabrain)

Inflammation | Insulin Resistance | Type 2 Diabetes Mellitus in Obese | Obesity, Childhood | Type2 Diabetes | Cognitive Decline | Dysglycemia | Overweight, Childhood | Brain Structure | Microvascular Complications | Diabetes in Adolescence

United States
University of Alberta

Withdrawn

Initiation of Resuscitation While Attached to the Cord With Congenital Heart Disease (INSPIRE-CHD)

Hypoplastic Left Heart Syndrome | Congenital Heart Defect | TGA - Transposition of Great Arteries | Congential Absence of Heart Structure | Congenital Malformation of Heart, Unspecified | Hypoplastic Right Heart Syndrome | Congential Malformations of Aortic Valve | Congential Malformations of Great...

Canada
University of California, San Francisco

Terminated

BIIB092 in Primary Tauopathies: CBS, nfvPPA, sMAPT, and TES (TauBasket)

Nonfluent Aphasia, Progressive | Primary Tauopathies | Corticobasal Degeneration Syndrome | Frontotemporal Lobar Degeneration With Tau Inclusions | MAPT Mutation Carriers, Symptomatic | Traumatic Encephalopathy Syndrome

United States
SCARE (Study group for carbapenem resistance)

Unknown

Development of Risk Score Model and Decision Tree Algorithm for Predicting Infections With CRKp in Colonized Patients (DETERMINE)

Central Nervous System Infections | Pneumonia, Bacterial | Urinary Tract Infections | Intra-abdominal Infection | Osteomyelitis | Bloodstream Infection | Acute Bacterial Skin and Skin Structure Infection

Turkey
Henry Ford Health System

Terminated

Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients (STOP-NT)

Bacteremia | Endocarditis | Acute Bacterial Skin and Skin Structure Infections | Health Care Associated Pneumonia | Osteomyelitis/Septic Arthritis

United States
National Cancer Institute (NCI)

Terminated

Veliparib, Oxaliplatin, and Capecitabine in Treating Patients With Advanced Solid Tumors

Unspecified Adult Solid Tumor, Protocol Specific | Adenocarcinoma of the Pancreas | Recurrent Pancreatic Cancer | Stage IV Pancreatic Cancer | Stage IV Breast Cancer | Stage IV Ovarian Epithelial Cancer | Stage IV Ovarian Germ Cell Tumor | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB... and other conditions

United States
Johns Hopkins University
National Cancer Institute (NCI); National Institutes of Health (NIH); ChiRhoClin...

Recruiting

The Cancer of the Pancreas Screening-5 CAPS5)Study (CAPS5)

Lynch Syndrome | Pancreas Cancer | Gene Mutation | Peutz-Jeghers Syndrome (PJS) | Germline Mutation Carrier

United States
McGill University Health Centre/Research Institute...

Recruiting

Longitudinal Natural History Study of Patients With Peroxisome Biogenesis Disorders (PBD)

Peroxisome Biogenesis Disorder | Zellweger Spectrum Disorder | RCDP - Rhizomelic Chondrodysplasia Punctata | D-Bifunctional Protein Deficiency | Alpha-Methylacyl-CoA Racemase Deficiency | Peroxisomal Acyl-CoA Oxidase Deficiency | Peroxisomal Acyl-CoA Oxidase 2 Deficiency | ATP Binding Cassette Subfamily... and other conditions

Canada
Daniel Benjamin
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care (PTN_POPS)

Heart Failure | Epilepsy | Pain | Pneumonia | Sepsis | Inflammation | Hypertension | Chronic Kidney Diseases | Hemophilia | Schizophrenia | Central Nervous System Infections | Nosocomial Pneumonia | Insomnia | Anxiety | Bipolar Disorder | Neutropenia | Staphylococcal Infections | Bradycardia | Seizures | Urinary Tract Infections | Pulmonary... and other conditions

United States, Canada, United Kingdom, Israel, Singapore

Clinical Trials on Structural Barriers

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CROs in Peru

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