Clinical Trials on Transfusion; Maternofetal

Total 401 results

Tampere University Hospital

Withdrawn

ROTEM-guided Transfusion Protocol in Attempt to Reduce Blood Transfusions in Major Oncological Surgery (ROTEM-SUR)

Blood Loss, Surgical | Coagulation Defect; Acquired | Blood Loss Requiring Transfusion

Finland
Novartis Pharmaceuticals

Withdrawn

Deferasirox BID (Twice a Day) in Transfusion Dependent Thalassemia Patients With Inadequate Response to High Doses

Focus on Transfusion Dependent Thalassemia Patients Who Are Inadequate Responders to Deferasirox > 35mg/kgQD
Centre Hospitalier Universitaire de Nice

Completed

Continous Renal Replacement Therapy With the CARPEDIEM® in a French National Cohort of 25 Neonates and Small Infants

Kidney Diseases | Sepsis | Pulmonary Disease | Hypoxic-Ischemic Encephalopathy | Cardiac Disease | Metabolic Disease | Twin to Twin Transfusion Syndrome

France
University of Campania "Luigi Vanvitelli"

Completed

Endocrine Function During Deferasirox Therapy

Iron Overload | Endocrine; Complications | Transfusion-dependent Thalassemia

Italy
Diskapi Teaching and Research Hospital
Turkish Society of Anesthesiology and Reanimation

Completed

Investigation of the Transfusion Practices in Surgical Patients in Turkey (CeKATU)

Anemia | Surgery | Coagulation Disorder | Blood Loss, Surgical | Blood Transfusion | Blood Loss Anemia

Turkey
Sunnybrook Health Sciences Centre
Princess Margaret Hospital, Canada; Juravinski Cancer Center

Unknown

Red Blood Cell Transfusion Thresholds and QOL in MDS (EnhanceRBC)

Quality of Life | Myelodysplastic Syndromes (MDS) | Red Blood Cell (RBC) Transfusions

Canada
Novartis Pharmaceuticals

Completed

Efficacy and Safety of Deferasirox in Patients With Myelodysplastic Syndrome and Transfusion-dependent Iron Overload

Myelodysplastic Syndromes | Transfusion Dependent Iron Overload

Germany
Children's Hospital of Chongqing Medical University

Recruiting

Hepatitis B Vaccination After Neonatal Surgery

Hepatitis B Virus Infection | Hepatitis B Vaccine Adverse Reaction | Blood Transfusion Complication | Vaccination Reaction | Digestive System Disorders of Fetus and Newborn

China
Regeneron Pharmaceuticals

Not yet recruiting

A Study to Test the Safety, Tolerability, and Efficacy of an Antibody, REGN7999, Injected Under the Skin for the Treatment of Iron Overload in Adult Participants With Non-Transfusion Dependent β-thalassemia, Using MRI Scans to Measure Iron Levels in the Body (FERVENT-1)

Non-transfusion Dependent Beta-thalassemia (NTDT)
Hospital Universitari de Bellvitge

Completed

Implementation of a Patient Blood Management Program in Gastric Cancer Surgery (IPAT)

Gastric Cancer | Surgery--Complications | Anemia, Iron Deficiency | Transfusion Related Complication
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Transfusion Safety Study (TSS)

HIV Infections | Acquired Immunodeficiency Syndrome | Blood Transfusion
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Effectiveness of AIDS Antibody Screening

HIV Infections | Acquired Immunodeficiency Syndrome | Blood Transfusion
University Hospital, Montpellier

Completed

SvO2 Trigger in Transfusion Strategy After Cardiac Surgery (ReTSEACS)

Undergoing Nonemergent Cardiac Surgery | Central Venous Catheter on the Superior Vena Cava (to Perform ScVO2 Measure) | Anemia (<9g/dL) Requiring Blood Transfusion | Hemodynamic and Respiratory Stability | Bleeding Graded as Insignificant, Mild, Moderate of Universal Definition of Perioperative...

France
Novartis Pharmaceuticals

Completed

A Protocol to Allow Treatment With ICL670 for Patients With or at Risk of Life-threatening Complications of Transfusional Iron Overload Who Are Unable to Tolerate Other Iron Chelators Because of Documented Severe Toxicity

Transfusional Iron Overload

United States, Greece, Italy
Novartis Pharmaceuticals

Completed

Observation of Patients With Transfusional Hemosiderosis Treatment With Deferasirox

Transfusional Hemosiderosis

Egypt, Spain, United Kingdom, Jordan
National Heart, Lung, and Blood Institute (NHLBI)

Completed

HIV Diversity and Pathogenesis in Donor-Recipient Clusters

HIV Infections | Acquired Immunodeficiency Syndrome | Blood Transfusion | Blood Donors
Novartis Pharmaceuticals

Terminated

Safety and Efficacy of Deferasirox in Combination With Desferoxamine in β-thalassaemia Patients With Severe Cardiac Iron Overload

Cardiac Iron Overload | Transfusion-dependent β-thalassemia Patients

Greece
Angel Augusto Perez Calatayud
Grupo Mexicano para el Estudio de la Medicina Intensiva

Completed

Patient Blood Management for Massive Obstetric Hemorrhage

Post Partum Hemorrhage | Transfusion Related Complication | Fibrinogenolysis; Hemorrhage | Fibrinogen; Deficiency, Acquired | Massive Hemorrhage

Mexico
University Health Network, Toronto

Completed

MR Imaging of Diffuse Myocardial Fibrosis in Transfusion-Dependent Anemias (MAFIO)

Thalassemia Major | Chronic Blood Transfusion Related Iron Overload

Canada
University of California, San Francisco

Terminated

Pilot Trial of Clofarabine Added to Standard Busulfan and Fludarabine for Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation

Myeloid Malignancy | Metabolic Disease | Bone Marrow Failure Syndrome | Transfusion-dependent Red Blood Cell (RBC) Defect | Congenital Immunodeficiency | Severe Immune Dysregulation

United States
Instituto de Investigación Hospital Universitario...

Completed

Complications Associated With Intraoperative Hypothermia.

Hypothermia | Hemorrhage, Postpartum | Transfusion-dependent Anemia | Infection Surgical Wound

Spain
Juan Blanco Morillo
Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca

Completed

Haemo-autologous Antegrade Repriming (HAR) as Minimum Impact Perfusion Strategy for Cardiopulmonary Bypass (HARjbm1)

Embolism, Air | Anemia | Cardiac Disease | Valve Anomalies | Extracorporeal Circulation; Complications | Transfusion | Cognitive; Disorder, Due to General Medical Condition

Spain
Silence Therapeutics plc

Withdrawn

Study in Beta-thalassaemia or Myelodysplastic Syndrome Patients to Investigate the Safety and Tolerability of SLN124

Non-transfusion-dependent Thalassemia | Low Risk Myelodysplastic Syndrome

United Kingdom, Bulgaria
Novartis Pharmaceuticals

Completed

Palatability and Tolerability of Deferasirox Taken With Meals, With Different Liquids or Crushed and Added to Food

Transfusional Hemosiderosis

United States
Children's Hospital Los Angeles
Novartis Pharmaceuticals

Terminated

Clinical Importance of Treating Iron Overload in Sickle Cell Disease

Anemia, Sickle Cell | Transfusion Hemosiderosis

United States
Novartis Pharmaceuticals

Terminated

Myelodysplastic Syndrome (MDS) Gastrointestinal (GI) Tolerability Study (MACS1574)

Myelodysplastic Syndrome | Transfusional Iron Overload

Spain, France, Italy, South Africa
Novartis Pharmaceuticals

Completed

Efficacy and Safety of Deferasirox in Patients With Chronic Anemia and Transfusional Hemosiderosis

Transfusional Hemosiderosis | Chronic Anemia

Japan, Turkey, Spain, Poland, Singapore
Sheba Medical Center
Hadassah Medical Organization; Kaplan Medical Center; Tel Aviv Medical Center; Ziv...

Completed

Effect of Deferiprone on Oxidative-Stress and Iron-Overload in Low Risk Transfusion-Dependent MDS Patients

Myelodysplastic Syndrome With Low-grade Lesions | Iron Overload Due to Repeated Red Blood Cell Transfusions

Israel
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Viral Activation Transfusion Study (VATS)

HIV Infections | Acquired Immunodeficiency Syndrome | Cytomegalovirus Infections | Blood Transfusion
Silence Therapeutics plc

Completed

A Study Investigate the Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Response of SLN124 in Adults With Alpha/Beta-thalassaemia and Very Low- and Low-risk Myelodysplastic Syndrome

Non-transfusion-dependent Thalassemia | Low Risk Myelodysplastic Syndrome | Very-Low Risk Myelodysplastic Syndrome

Thailand, Israel, Jordan, United Kingdom, Germany, Italy, Malaysia
St Vincent's Hospital, Sydney

Completed

Blood Management During ECMO for Cardiac Support (OBLEX)

Hemorrhage | Embolism | Venous Thrombosis | Arrhythmias, Cardiac | Shock, Cardiogenic | Blood Transfusion | Death, Sudden, Cardiac | Disseminated Intravascular Coagulation | HEART ARREST

Australia
Boston Children's Hospital
Novartis

Completed

Pilot Study for Patients With Poor Response to Deferasirox

Sickle Cell Disease | Thalassemia Major | Transfusion-dependent Hemachromatosis

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Retrovirus Epidemiology Donor Study I (REDS I)

HIV Infections | Acquired Immunodeficiency Syndrome | Retroviridae Infections | Blood Transfusion | HIV-1 | Blood Donors | HIV-2 | HTLV-I | HTLV-II
Xiaoping Fan. MD
Jie He.MD; Shihao Cai.MD; Wenda Gu.PhD; Haijiang Guo.PhD; Liang Hong. MD; Ruixing Fan... and other collaborators

Unknown

A Comparative Study of Different Hypothermic Circulatory Arrest Strategies on Aortic Surgery.

Aneurysm | Blood Transfusion | Dialysis | Neurological Disorder | Morality | Endoleak | Operation Time | Hospital Stay | Hypothermic Circulatory Arrest Time | Aortic-cross Clamping Time | Cardiopulmonary Bypass Time | Re-Thoracotomy | ICU Stay | Mechanical Ventilation Time

China
Medical College of Wisconsin
National Heart, Lung, and Blood Institute (NHLBI); University of Wisconsin,... and other collaborators

Recruiting

Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise

Sudden Infant Death | Congenital Heart Disease | Pregnancy Loss | Gastroschisis | Fetal Death | Brugada Syndrome | High Risk Pregnancy | Stillbirth | Long QT Syndrome | Fetal Demise | Birth Defect | Twin Monochorionic Monoamniotic Placenta | Twin Twin Transfusion Syndrome | Fetal Hydrops | Fetal Arrhythmia | Intrauterine... and other conditions

United States
Shire

Terminated

Safety, Efficacy and Pharmacokinetics of an Oral Iron Chelator Given for a Year to Pediatric Patients With Iron Overload

Beta-Thalassemia | Transfusional Iron Overload

United States, Lebanon, Canada, Italy, Turkey
Shire

Completed

Safety and Pharmacodynamic Study of an Oral Iron Chelator Given for 6 Months to Patients With Iron Overload

Beta-thalassemia | Transfusional Iron Overload

United States, United Kingdom, Italy, Thailand, Turkey
FerroKin BioSciences, Inc.

Completed

Safety and Pharmacokinetic Study of Escalating Multiple Doses of an Iron Chelator in Patients With Iron Overload

Beta-thalassemia | Transfusional Iron Overload

United States, Australia, Thailand
Novartis Pharmaceuticals

Completed

An Extension Study of Iron Chelation Therapy With Deferasirox (ICL670) in β-thalassemia Patients With Transfusional Iron Overload

Transfusional Iron Overload in β-thalassemia

United States, Greece, Argentina, Germany, Belgium, Italy, United Kingdom, France, Tunisia, Canada, Turkey, Brazil
Novartis Pharmaceuticals

Completed

Phase I Study to Examine the Effect of Deferasirox on Renal Hemodynamics in β-thalassemia Patients With Transfusional Iron Overload

Transfusional Iron Overload | β-thalassemia

Italy
Children's Hospital of Philadelphia
Ann & Robert H Lurie Children's Hospital of Chicago; The Cooley's Anemia Foundation...

Completed

Combination Deferasirox and Deferiprone for Severe Iron Overload in Thalassemia

Thalassemia Major With Severe Transfusional Iron Overload

United States
Sunnybrook Health Sciences Centre
Ontario Ministry of Health and Long Term Care; Sault Area Hospital; Scarborough... and other collaborators

Completed

Ontario ICU Clinical Best Practices Demonstration Project

Catheter Related Blood Stream Infections | Ventilator Acquired Pneumonia | Pressure Ulcer Prophylaxis | DVT Prophylaxis | Restrictive Blood Transfusion Strategy | Daily Spontaeous Breathing Trials

Canada
Novartis Pharmaceuticals

Completed

A 4-year Extension Study to Core 1-year Study of Iron Chelation Therapy With Deferasirox in β-thalassemia Major Pediatric Patients With Transfusional Iron Overload.

Transfusional Iron Overload | β-thalassemia Major | Pediatric Rare Anemia

Italy, France
The University of Texas Health Science Center at...
National Heart, Lung, and Blood Institute (NHLBI)

Completed

KSHV Infection in Blood Donors From Texas

HIV Infections | Acquired Immunodeficiency Syndrome | Sarcoma, Kaposi | Blood Transfusion | Blood Donors | Herpesvirus, Kaposi Sarcoma-Associated
Talaris Therapeutics Inc.
Duke University

Withdrawn

Phase I/II Pilot Study of Mixed Chimerism to Treat Hemoglobinopathies

Anemia, Sickle Cell | Thalassemia | Beta-Thalassemia | Bone Marrow Failure Syndromes | Diamond-Blackfan Anemia | Alpha-Thalassemia | Complex and Transfusion-dependent Hemoglobinopathies

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Retrovirus Epidemiology Donor Study-II (REDS-II)

HIV Infections | Acquired Immunodeficiency Syndrome | Retroviridae Infections | Hepatitis B | Hepatitis, Viral, Human | Blood Transfusion | HIV-1 | Blood Donors | Hepacivirus | HIV-2 | HTLV-I | HTLV-II | West Nile Virus
Columbia University

Completed

High-Tc Susceptometer to Monitor Transfusional Iron Overload

Myelodysplastic Syndromes | Sickle Cell Disease | Aplastic Anemia | Transfusional Iron Overload | Thalassemia Major

United States
Novartis Pharmaceuticals

Completed

An Epidemiological Study to Assess Iron Overload Using MRI in Patients With Transfusional Siderosis (TIMES Study)

Thalassemia, Non-transfusional-dependent Thalassemia (NTDT), Myeloplastic Dysplasia (MDS), Other Anemia

Australia
Bloodworks
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Prospective Study of HIV Infection in Hemophiliacs

HIV Infections | Acquired Immunodeficiency Syndrome | Hemophilia A | Hepatitis, Viral, Human | Blood Disease | Cytomegalovirus Infections | Blood Transfusion
Novartis

Completed

Magnetic Resonance Imaging (MRI) Assessments of the Heart and Liver Iron Load in Patients With Transfusion Induced Iron Overload

Myelodysplastic Syndromes | Hemoglobinopathies | Diamond-Blackfan Anemia | Transfusional Iron Overload | Other Inherited or Acquired Anaemia | MPD Syndrome | Other Rare Anaemias

Australia

Clinical Trials on Transfusion; Maternofetal

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