Clinical Trials on Treatment Failure

Total 13370 results

R3 Stem Cell

Not yet recruiting

Safety and Clinical Outcomes With Amniotic and Umbilical Cord Tissue Therapy for Numerous Medical Conditions

Stroke | Autoimmune Diseases | Kidney Diseases | Urologic Diseases | Renal Insufficiency | Arthritis | Renal Failure | Alzheimer Disease | Erectile Dysfunction | Cardiomyopathies | Pulmonary Disease | Neurologic Disorder | Orthopedic Disorder | COPD | Cardiac Event | CHF | Neuropathy;Peripheral
Lawson Health Research Institute
Western University, Canada

Completed

Dyspnea Assessment in Hemodialysis Patients

End Stage Renal Disease | Chronic Lung Disease | Dyspnea; Uremic | Chronic Heart Disease | Hemodialysis-Induced Symptom | Sodium Excess

Canada
Oxford University Clinical Research Unit, Vietnam
Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

Completed

Awake Prone Positioning in Moderate to Severe COVID-19

COVID-19 | SARS-CoV2 Infection | Respiratory Distress Syndrome, Adult | Acute Hypoxemic Respiratory Failure | COVID-19 Acute Respiratory Distress Syndrome

Vietnam
The University of Texas Health Science Center at...
The Claude D. Pepper Older Americans Independence Centers

Withdrawn

Effects of mTOR Inhibition With Sirolimus (RAPA) in Patients With COVID-19 to Moderate the Progression of ARDS (RAPA-CARDS)

Respiratory Failure | Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS) | Sars-CoV2

United States
Brigham and Women's Hospital

Completed

Remote Physician Care for Home Hospital Patients

Heart Failure | Chronic Kidney Diseases | Chronic Obstructive Pulmonary Disease | Asthma | Infection | Gout Flare | Hypertensive Urgency | Anticoagulants; Increased | Atrial Fibrillation Rapid

United States
Simon Fraser University
Canadian Institutes of Health Research (CIHR); Michael Smith Foundation for...

Completed

Trial of an Internet-based Platform for Managing Chronic Diseases at a Distance (iCDM)

Heart Failure | Diabetes | Chronic Obstructive Pulmonary Disease | Chronic Kidney Disease | Ischemic Heart Disease

Canada
University of Erlangen-Nürnberg Medical School
German Research Foundation; University Hospital, Essen; Wuerzburg University... and other collaborators

Unknown

Open-label Clinical Trial to Investigate the Safety and Tolerability of Allogeneic B-cell Concentrates for Immune Reconstitution After Allogeneic Stem Cell Transplantation Measured as Response to a Antedated Single Vaccination (B-cell therapy)

Acute Myeloid Leukemia | Multiple Myeloma | Acute Lymphoblastic Leukemia | Chronic Myeloid Leukemia | Myelodysplastic Syndrome | Aplastic Anemia | Non Hodgkin's Lymphoma | Hodgkin's Disease

Germany
University of California, San Francisco

Completed

Phase II Study Evaluating Busulfan and Fludarabine as Preparative Therapy in Adults With Hematopoietic Disorders Undergoing MUD SCT

Multiple Myeloma | Non-Hodgkin's Lymphoma | Chronic Myeloid Leukemia | Acute Lymphocytic Leukemia | Acute Myelogenous Leukemia | Myelodysplasia | Severe Aplastic Anemia | Lymphoproliferative Disease | Advanced Myeloproliferative Disease

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Study of the Emotional Needs of Caregivers of Stem Cell Transplantation Patients

Lymphoma | Myelodysplastic Syndromes | Leukemia | Testicular Germ Cell Tumor | Breast Cancer | Chronic Myeloproliferative Disorders | Ovarian Cancer | Gestational Trophoblastic Tumor | Neuroblastoma | Multiple Myeloma and Plasma Cell Neoplasm | Myelodysplastic/Myeloproliferative Diseases | Psychosocial Effects...

United States
University of Liverpool

Recruiting

Multi-morbidity Screening in People With Type 2 Diabetes and Pre Diabetes

Heart Failure | Obstructive Sleep Apnea | Type 2 Diabetes | Pre Diabetes | Non-Alcoholic Fatty Liver Disease

United Kingdom
Allegheny Singer Research Institute (also known...
ElectroCore INC

Terminated

Study Assessing Vagus Nerve Stimulation in CoViD-19 Respiratory Symptoms (SAVIORII)

Respiratory Failure | COVID | Corona Virus Infection | Respiratory Distress Syndrome, Adult | SARS (Severe Acute Respiratory Syndrome) | ARDS, Human

United States
Hôpital Louis Mourier

Completed

Extended Prone Position Duration COVID-19-related ARDS: a Retrospective Study

Pressure Ulcer | Hypoxemic Respiratory Failure | COVID-19 Acute Respiratory Distress Syndrome | Respiratory Distress Syndrome, Acute

France
University of Sao Paulo General Hospital

Withdrawn

Cholecalciferol Supplementation in Restless Leg Syndrome in Patients With Chronic Kidney Disease (RLS)

Vitamin D Deficiency | Hyperparathyroidism, Secondary | Renal Disease, End Stage | Adynamic Bone Disease | Restless Leg Disorder | Renal Disease Bone

Brazil
NYU Langone Health
Michael J. Fox Foundation for Parkinson's Research

Completed

Retinal Abnormalities as Biomarker of Disease Progression and Early Diagnosis of Parkinson Disease

Parkinson Disease | Multiple System Atrophy | REM Sleep Behavior Disorder | Pure Autonomic Failure | Dementia With Lewy Bodies

United States
VA Office of Research and Development
US Department of Veterans Affairs

Completed

Evaluation of Implementation of a National Point-of-Care Ultrasound Training Program

Heart Failure | Pneumonia | Cellulitis | Urinary Retention | Deep Venous Thrombosis | Hydronephrosis | Pleural Effusion | Abdominal Aortic Aneurysm | Acute Cholecystitis | Other Acute Illnesses Presenting to the Hospital | Peritoneal Free Fluid

United States
University Hospital, Essen
Nico Reinsch M. D.; Till Neumann Prof. M. D.

Completed

A Prospective Observational Trial to Determine Cardiovascular Diseases in HIV-infected Patients (HIV-HEART10)

Myocardial Infarction | Heart Failure | Aging | Coronary Heart Disease | HIV-infection | HIV-encephalopathy

Germany
National Eye Institute (NEI)

Completed

Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure

Menopause | Turner Syndrome | Ovarian Failure, Premature | Sex Chromosome Aberrations | Perimenopause

United States
University of Chicago

Completed

T-Cell Depleted Allogeneic Stem Cell Transplantation for Patients With Hematologic Malignancies

Myelodysplastic Syndromes | Chronic Lymphocytic Leukemia | Anemia, Aplastic | Acute Myelogenous Leukemia | Chronic Myelogenous Leukemia | Myeloproliferative Disorder | Hodgkin's Disease | Lymphoid Leukemia | Malignant Lymphoma

United States
Indiana University School of Medicine

Completed

Investigation of the Cylex® ImmuKnow® Assay

Myelodysplastic Syndromes | Leukemia | Myeloproliferative Disorders | Multiple Myeloma | Non-Hodgkin's Lymphoma | Chronic Lymphocytic Leukemia | Chronic Myelogenous Leukemia | Aplastic Anemia | Hodgkin's Disease

United States
Massachusetts General Hospital

Recruiting

Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood Disorders (BMT)

Autoimmune Diseases | Multiple Myeloma | Hodgkin Disease | AL Amyloidosis | Myelofibrosis | Chronic Kidney Disease | Sickle Cell Anemia | Thalassemia | Aplastic Anemia | Chronic Lymphocytic Leukemia (CLL) | Acute Myeloid Leukemia (AML) | Acute Lymphoblastic Leukemia (ALL) | Myelodysplastic Syndrome (MDS) | Non-Hodgkin... and other conditions

United States
Emory University

Completed

Bone Marrow Transplant With Abatacept for Non-Malignant Diseases

Sickle Cell Disease | Fanconi Anemia | Hurler Syndrome | Chronic Granulomatous Disease | Severe Congenital Neutropenia | Hemophagocytic Lymphohistiocytosis | Wiskott-Aldrich Syndrome | Diamond-Blackfan Anemia | Severe Aplastic Anemia | Glanzmann Thrombasthenia | Shwachman-Diamond Syndrome | Thalassemia Major | Leukocyte... and other conditions

United States
University of Aarhus

Recruiting

The Danish TURNER Cryopreservation Study (DANTE)

Fertility Disorders | Turner Syndrome | Premature Ovarian Failure

Denmark
Australian and New Zealand Intensive Care Research...
The Alfred

Not yet recruiting

Trial of ECMO to De-Sedate, Extubate Early and Mobilise in Hypoxic Respiratory Failure (REDEEM)

Pneumonia | Extracorporeal Membrane Oxygenation | Mechanical Ventilation Complication | Hypoxemia | COVID-19 Respiratory Infection | Acute Respiratory Distress Syndrome Due to COVID-19

Australia, Germany
University of Alberta
Canadian Institutes of Health Research (CIHR)

Active, not recruiting

Evidence Based Mental Wellness Programming Online for Adults Across Chronic Physical Conditions (EMPOwer)

Heart Failure | Cancer | Chronic Kidney Diseases | Cirrhosis, Liver | Primary Biliary Cholangitis | Digestive Diseases | Women Who Have Experienced a Cardiac Event | Post-Transplant | Other Chronic Physical Condition

Canada
OSF Healthcare System

Enrolling by invitation

Analysis of the Virtual Acute Care at Home Experience (HaH)

Heart Failure | Infections | Hypertension | Diabetes | Fever | Bronchitis | Asthma, Chronic Obstructive Pulmonary Disease (COPD) | Conditions | Renal and Urinary Disorders

United States
Brigham and Women's Hospital

Completed

The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome

Fibromyalgia | Chronic Fatigue Syndrome | Orthostatic Hypotension | Postural Orthostatic Tachycardia Syndrome | Dysautonomia | Myalgic Encephalomyelitis | Exercise Intolerance | Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | Low Ventricular Filling Pressures (Preload Failure)

United States
Case Comprehensive Cancer Center

Completed

Combination Chemotherapy Followed By Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer or Severe Aplastic Anemia

Lymphoma | Myelodysplastic Syndromes | Leukemia | Chronic Myeloproliferative Disorders | Multiple Myeloma and Plasma Cell Neoplasm | Myelodysplastic/Myeloproliferative Diseases

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection (P2C2)

Heart Diseases | Cardiovascular Diseases | HIV Infections | Acquired Immunodeficiency Syndrome | Heart Failure | Lung Diseases | Cytomegalovirus Infections | Pneumocystis Carinii Infections | Ebstein-Barr Virus Infections
University of Edinburgh

Recruiting

Cardiomyopathies and Heart Muscle Diseases: Cardiac Imaging in the Evaluation of Myocardial Fibrosis Transition (CHIEFTain)

Myocarditis | Hypertrophic Cardiomyopathy | Cardiac Sarcoidosis | Heart Failure With Preserved Ejection Fraction | Hypertensive Heart Disease | Arrhythmogenic Right Ventricular Cardiomyopathy 1 | Tako Tsubo Cardiomyopathy

United Kingdom
West Virginia School of Osteopathic Medicine

Not yet recruiting

Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients

Heart Failure | Hypertension | Obesity | Polycystic Ovary Syndrome | Metabolic Syndrome | Hyperlipidemias | Coronary Heart Disease | Depression, Anxiety | Type II Diabetes

United States
KU Leuven

Not yet recruiting

The Use of a Monitoring Device by General Practitioners During Out-of-hours Care

Heart Failure | Pneumonia | Pneumothorax | Emergencies | Atrial Fibrillation | Asthma | Hyperventilation | Acute Coronary Syndrome | Cardiac Arrest | Atrial Flutter | Pulmonary Embolism | Acute Myocardial Infarction | Pulmonary Edema | Rhythm; Abnormal | Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Belgium
Jennifer Woyach
Janssen Scientific Affairs, LLC

Completed

Ibrutinib for the Treatment of COVID-19 in Patients Requiring Hospitalization

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm | Monoclonal Gammopathy of Undetermined Significance | Myelodysplastic Syndrome | Aplastic Anemia | Symptomatic COVID-19 Infection Laboratory-Confirmed | Monoclonal B-Cell Lymphocytosis

United States
University of Aarhus

Completed

Sleep Apnea, Coronary Atherosclerosis and Heart Failure in Diabetes Patients With Nephropathy (SLEEP)

Vascular Diseases | Kidney Diseases | Sleep Apnea | Diabetic Nephropathy Type 2 | Arterial Stiffness | Coronary Atheroscleroses | Heart Insufficiency

Denmark
Vanderbilt University
National Cancer Institute (NCI)

Completed

Methemoglobinemia in Young Patients With Hematologic Cancer or Aplastic Anemia Treated With Dapsone

Lymphoma | Myelodysplastic Syndromes | Leukemia | Chronic Myeloproliferative Disorders | Multiple Myeloma and Plasma Cell Neoplasm | Nonmalignant Neoplasm | Lymphoproliferative Disorder | Myelodysplastic/Myeloproliferative Neoplasms | Methemoglobinemia

United States
University College, London
Wellcome Trust; National Institute for Health Research, United Kingdom

Unknown

Understanding the Role of Autoimmune Disorders on the Initial Presentation of Cardiovascular Disease

Myocardial Infarction | Heart Failure | Stroke | Ischemic Stroke | Peripheral Arterial Disease | Venous Thrombosis | Transient Ischemic Attack | Stable Angina Pectoris | Unstable Angina | Abdominal Aortic Aneurysm | Subarachnoid Haemorrhage

United Kingdom
University of Colorado, Denver
National Institute on Aging (NIA)

Completed

Advancing Understanding of Transportation Options (AUTO)

Stroke | Multiple Sclerosis | Glaucoma | Brain Injuries | Macular Degeneration | Arthritis | Chronic Obstructive Pulmonary Disease | Parkinson Disease | Restless Legs Syndrome | Diabetic Retinopathy | Insomnia | Retinitis Pigmentosa | Obstructive Sleep Apnea | Dementia | End Stage Renal Disease | Sleep Apnea | Syncope | Seizures and other conditions

United States
Eurasian Association of Therapists

Recruiting

Real Clinical Practice Register of AlbUminuRia Detection in Patients With Previously undiAgnosed Chronic Kidney Disease (AURA)

COVID-19 | Hypertension | Cancer | Chronic Kidney Diseases | Chronic Obstructive Pulmonary Disease | Atrial Fibrillation | PreDiabetes | Ischemic Heart Disease | Chronic Heart Failure | Urolithiasis

Russian Federation
Zachariah Michael DeFilipp
Regimmune Corporation

Active, not recruiting

Haplo Peripheral Blood Sct In GVHD Prevention

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Hodgkin Lymphoma | Chronic Myelomonocytic Leukemia | Acute Lymphoblastic Leukemia | AML | Non Hodgkin Lymphoma | MDS | Myeloproliferative Disorder | GVHD | Graft Vs Host Disease | ALL | CMML | Blood Stem Cell Transplant Failure | MPN | Chemosensitive Hodgkin Lymphoma

United States
Massachusetts General Hospital
Genzyme, a Sanofi Company; Scott and White Hospital & Clinic

Terminated

Kidney Information Network for Disease Research and Education (KINDRED)

Kidney Diseases | Genetic Diseases, X-Linked | End Stage Renal Disease | ESRD | Fabry Disease | Rare Diseases

United States
Beth Israel Deaconess Medical Center
Amgen

Completed

Nonmyeloablative Allo SCT for the Treatment of Hematologic Disorders (MINI HEME)

AML | MDS | CLL | ALL | CML Chronic Phase, Accelerated Phase, or Blast Crisis | RELAPSED NON-HODGKIN'S OR HODGKIN'S LYMPHOMA | APLASTIC ANEMIA | MULTIPLE MYELOMA | MYELOPROLIFERATIVE DISORDER (P Vera, CMML, ET)
NYU Langone Health

Recruiting

Natural History Study of Synucleinopathies

Parkinson Disease | Multiple System Atrophy | Neurogenic Orthostatic Hypotension | REM Sleep Behavior Disorder | Pure Autonomic Failure | Dementia With Lewy Bodies | Patients With Synucleinopathies | Shy-Drager Disease

Korea, Republic of, United States, Argentina, Spain
Bellicum Pharmaceuticals

Active, not recruiting

Study of Gene Modified Donor T-cells Following TCR Alpha Beta Positive Depleted Stem Cell Transplant

Lymphoma, Non-Hodgkin | Myelodysplastic Syndromes | Acute Lymphoblastic Leukemia | Anemia, Aplastic | Primary Immune Deficiency Disorder | Cytopenia | Osteopetrosis | Leukemia, Acute Myeloid (AML), Child | Hemoglobinopathy in Children

United States
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

In Vitro Effect Study of Interleukin-2 Muteins on Regulatory T Cells of Patients With Different Autoimmune, Allo-immune or Inflammatory Diseases (MuTreg)

Multiple Sclerosis | Autoimmune Diseases | Rheumatoid Arthritis | Systemic Lupus Erythematosus | Atopic Dermatitis | Vitiligo | Alopecia | Autoimmune Thyroiditis | Inflammatory Disease | Acquired Bone Marrow Aplasia | Gvhd
Academisch Medisch Centrum - Universiteit van Amsterdam...
Alrijne Hospital

Completed

Effectiveness of Drainage by PCN vs. JJ in Patients With Symptoms of Obstructive Kidney Disease Caused by Urolithiasis (STONE)

Kidney Diseases | Urologic Diseases | Kidney Calculi | Urinary Calculi | Urolithiasis | Stone Ureter | Stone, Kidney | Urinary Stone | Pyelonephritis | Hydronephrosis | Obstruction | Kidney Failure, Acute | Ureter Obstruction | Urinary Obstruction | Kidney Dysfunction | Kidney Insufficiency | Pyelonephritis Acute | Stone, Urinary and other conditions

Netherlands
Centre Hospitalier Universitaire de Saint Etienne
Ministry of Health, France

Completed

Influence of a Multi-parametric Optimization Strategy for General Anesthesia on Postoperative Morbidity and Mortality (OPTI-AGED)

Heart Failure | Stroke | Alcoholism | Diabetes | Cancer | Renal Insufficiency | Pulmonary Disease, Chronic Obstructive | Peripheral Vascular Diseases | Respiratory Insufficiency | Arrhythmias, Cardiac | Dementia | Coronary; Ischemic

France
University of Illinois at Chicago

Completed

Fludarabine Based Conditioning for Allogeneic Transplantation for Advanced Hematologic Malignancies

Acute Myeloid Leukemia | Polycythemia Vera | Multiple Myeloma | Myelofibrosis | Acute Leukemia | Chronic Myelogenous Leukemia | Aplastic Anemia | Myeloproliferative Disorder | Hodgkin's Disease | Malignant Lymphoma | Lymphocytic Leukemia

United States
Uppsala University

Recruiting

Mechanisms for Organ Dysfunction in Covid-19 (UMODCOVID19)

COVID-19 | Septic Shock | Acute Kidney Injury | Acute Respiratory Distress Syndrome | Organ Dysfunction Syndrome, Multiple | Organ Dysfunction Syndrome Sepsis

Sweden
University of Vermont
University of Massachusetts, Worcester; Arizona State University; Case Western... and other collaborators

Active, not recruiting

Integrating Behavioral Health and Primary Care for Comorbid Behavioral and Medical Problems (IBHPC)

Depression | Heart Failure | Hypertension | Diabetes | Arthritis | Chronic Pain | Irritable Bowel Syndrome | Insomnia | Asthma | Fibromyalgia | Anxiety | Substance Use Disorder | Chronic Obstructive Lung Disease | Problem Drinking

United States
Phoenix Children's Hospital

Completed

A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT

Myelodysplastic Syndromes | Vitamin D Deficiency | Pediatric Cancer | Aplastic Anemia | Stem Cell Transplant Complications | Sickle Cell Anemia in Children | Thalassemia in Children | Blood Disorder | Pediatric Acute Myeloid Leukemia | Pediatric Acute Lymphoid Leukemia

United States
Sidney Kimmel Cancer Center at Thomas Jefferson...

Completed

Bone Marrow Transplantation of Patients in Remission Using Partially Matched Relative Donor

Lymphoma | Acute Myeloid Leukemia | Myelodysplastic Syndromes | Chronic Lymphocytic Leukemia | Chronic Myeloid Leukemia | Acute Lymphocytic Leukemia | Aplastic Anemia | Hodgkin's Disease | Biphenotypic Leukemia | Plasma Cell Neoplasms

United States

Clinical Trials on Treatment Failure

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