Clinical Trials on Unresectable Soft Tissue Sarcoma

Total 3999 results

University of Washington
Aadi Bioscience, Inc.

Active, not recruiting

Nab-Sirolimus and Pazopanib Hydrochloride in Treating Patients With Advanced Nonadipocytic Soft Tissue Sarcomas

Advanced Soft Tissue Sarcoma | Metastatic Soft Tissue Sarcoma | Locally Advanced Soft Tissue Sarcoma

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Active, not recruiting

Cabozantinib and Temozolomide for the Treatment of Unresectable or Metastatic Leiomyosarcoma or Other Soft Tissue Sarcoma

Metastatic Leiomyosarcoma | Stage III Uterine Corpus Leiomyosarcoma AJCC v8 | Stage IV Uterine Corpus Leiomyosarcoma AJCC v8 | Unresectable Leiomyosarcoma | Stage IIIA Uterine Corpus Leiomyosarcoma AJCC v8 | Stage IIIB Uterine Corpus Leiomyosarcoma AJCC v8 | Stage IIIC Uterine Corpus Leiomyosarcoma... and other conditions

United States
National Cancer Institute (NCI)

Suspended

Testing Ipilimumab and Nivolumab Combination With or Without Cabozantinib in People >= 18 Years Old With Advanced Soft Tissue Sarcoma

Locally Advanced Leiomyosarcoma | Metastatic Undifferentiated Pleomorphic Sarcoma | Locally Advanced Liposarcoma | Locally Advanced Undifferentiated Pleomorphic Sarcoma | Locally Advanced Extraskeletal Myxoid Chondrosarcoma | Locally Advanced Unresectable Soft Tissue Sarcoma

United States, Canada
National Cancer Institute (NCI)

Terminated

18F-Fluoromisonidazole and Fludeoxyglucose F 18 PET/CT Patients With Soft Tissue Sarcoma

Recurrent Adult Soft Tissue Sarcoma | Stage III Adult Soft Tissue Sarcoma | Stage IV Adult Soft Tissue Sarcoma | Stage I Adult Soft Tissue Sarcoma | Stage II Adult Soft Tissue Sarcoma

United States
OHSU Knight Cancer Institute
National Cancer Institute (NCI)

Withdrawn

Fluorothymidine F-18 PET in Diagnosing Patients With Intermediate or High Grade Soft Tissue Sarcoma

Stage III Adult Soft Tissue Sarcoma | Stage IV Adult Soft Tissue Sarcoma | Stage II Adult Soft Tissue Sarcoma | Stage IIA Adult Soft Tissue Sarcoma | Stage IIB Adult Soft Tissue Sarcoma | Stage IIC Adult Soft Tissue Sarcoma
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Shorter Course, Hypofractionated Pre-Surgery Radiation Therapy in Treating Patients With Localized, Resectable Soft Tissue Sarcoma of the Extremity of Superficial Trunk

Stage II Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8 | Stage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8 | Stage IIIA Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8 | Stage IIIB Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8 | Resectable... and other conditions

United States
National Institutes of Health Clinical Center (CC)

Completed

Isolated Limb Perfusion of Melphalan With or Without Tumor Necrosis Factor in Treating Patients With Soft Tissue Sarcoma of the Arm or Leg

Recurrent Adult Soft Tissue Sarcoma | Stage III Adult Soft Tissue Sarcoma | Stage IVA Adult Soft Tissue Sarcoma | Stage IIB Adult Soft Tissue Sarcoma | Stage IIC Adult Soft Tissue Sarcoma | Stage IVB Adult Soft Tissue Sarcoma
Radiation Therapy Oncology Group
National Cancer Institute (NCI)

Withdrawn

Combination Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Primary or Recurrent Sarcoma

Recurrent Adult Soft Tissue Sarcoma | Stage III Adult Soft Tissue Sarcoma | Stage IVA Adult Soft Tissue Sarcoma | Stage IIB Adult Soft Tissue Sarcoma | Stage IIC Adult Soft Tissue Sarcoma

United States, Canada
Institut Bergonié
Incyte Biosciences International Sàrl

Recruiting

Neoadjuvant Chemotherapy and Retifanlimab in Patients With Selected Sarcomas (TORNADO) (TORNADO)

Resectable Sarcoma

France
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Not yet recruiting

Implantable Microdevice for the Delivery of Drugs and Their Effect on Tumors in Patients With Metastatic or Recurrent Sarcoma

Metastatic Sarcoma | Resectable Sarcoma | Recurrent Sarcoma

United States
Stella Pharma Corporation
Cancer Intelligence Care Systems, Inc.

Recruiting

A Phase II Study by Using CICS-1 and SPM-011 Commissioned by CICS and STELLA PHARMA

Unresectable Angiosarcoma

Japan
Di Wu

Not yet recruiting

Study of Anlotinib Hydrochloride and Toripalimab in Subjects With Unresectable or Metastatic Undifferentiated Pleomorphic Sarcoma

Undifferentiated Pleomorphic Sarcoma | Soft Tissue Sarcomas

China
Centre Leon Berard
Novartis; National Cancer Institute, France

Recruiting

HDM201 and Pazopanib in Patients With P53 Wild-type Advanced/Metastatic Soft Tissue Sarcomas (AMPHISARC)

Advanced Soft-tissue Sarcoma | Metastatic Soft-tissue Sarcoma

France
UNICANCER

Recruiting

Comparison of Oral Cyclophosphamide vs Doxorubicin in ≥65 Years Old Advanced or Metastatic Soft Tissue Sarcoma Patients (GERICO14)

Advanced Soft-tissue Sarcoma | Metastatic Soft-tissue Sarcoma

France
University of Colorado, Denver
Agenus Inc.

Recruiting

Doxorubicin Plus Dual Checkpoint Blockade for Soft Tissue Sarcomas

Advanced Soft Tissue Sarcoma | Metastatic Soft Tissue Sarcoma

United States
Wake Forest University Health Sciences
Merck Sharp & Dohme LLC

Completed

Safety, Tolerability, and Efficacy of Doxorubicin and Pembrolizumab for Sarcoma

Soft Tissue Sarcoma, Adult | Soft Tissue Sarcoma, Child

United States
National Cancer Institute (NCI)
National Comprehensive Cancer Network

Completed

Selumetinib With or Without Temsirolimus in Treating Patients With Metastatic, Recurrent, or Locally Advanced Soft Tissue Sarcoma That Cannot Be Removed By Surgery

Recurrent Adult Soft Tissue Sarcoma | Stage III Adult Soft Tissue Sarcoma | Stage IV Adult Soft Tissue Sarcoma

United States
National Cancer Institute (NCI)

Completed

Perifosine in Treating Patients With Advanced Soft Tissue Sarcoma

Recurrent Adult Soft Tissue Sarcoma | Stage III Adult Soft Tissue Sarcoma | Stage IV Adult Soft Tissue Sarcoma

United States
Centre Leon Berard

Recruiting

Gene Signatures Searching of Sensitivity/Resistance to Neoadjuvant Radiotherapy in Patients With Resectable STS (RADIOSARC)

Soft Tissue Sarcomas

France
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

TLR4 Agonist GLA-SE and Radiation Therapy in Treating Patients With Soft Tissue Sarcoma That Is Metastatic or Cannot Be Removed by Surgery

Stage III Adult Soft Tissue Sarcoma | Stage IV Adult Soft Tissue Sarcoma

United States
University of Washington
National Cancer Institute (NCI)

Completed

Pazopanib Hydrochloride Followed by Chemotherapy and Surgery in Treating Patients With Soft Tissue Sarcoma

Stage III Adult Soft Tissue Sarcoma | Stage IV Adult Soft Tissue Sarcoma | Stage IIA Adult Soft Tissue Sarcoma

United States
National Cancer Institute (NCI)

Active, not recruiting

Testing Atezolizumab in People 2-17 Years Old With Clear Cell Sarcoma or Advanced Chondrosarcoma

Dedifferentiated Chondrosarcoma | Central Chondrosarcoma, Grade 2 | Central Chondrosarcoma, Grade 3 | Metastatic Clear Cell Sarcoma of Soft Tissue | Metastatic Primary Central Chondrosarcoma | Unresectable Primary Central Chondrosarcoma

United States, Canada
Memorial Sloan Kettering Cancer Center
Incyte Corporation

Active, not recruiting

Retifanlimab (Anti-PD-1 Antibody) With Gemcitabine and Docetaxel in Patients With Advanced Soft Tissue Sarcoma

Sarcoma | Soft Tissue Sarcoma | Soft Tissue Sarcoma Adult | Sarcoma,Soft Tissue

United States
University of Southern California
National Cancer Institute (NCI)

Completed

Real-Time Contrast-Enhanced Ultrasonography and Shear Wave Elastography in Predicting Treatment Response in Patients With Soft Tissue Sarcoma

Bone Sarcoma | Retroperitoneal Sarcoma | Adult Soft Tissue Sarcoma

United States
Asociación Europea y Latinoamericana SELNET para...

Recruiting

Selinexor Plus Gemcitabine in Selected Advanced Soft-tissue Sarcoma (SeliSarc) (SeliSarc)

Sarcoma,Soft Tissue

Spain
University Hospital Heidelberg

Recruiting

Neoadjuvant Irradiation of Retroperitoneal Soft Tissue Sarcoma With Ions Retro-Ion (Retro-Ion)

Sarcoma,Soft Tissue

Germany
Sun Yat-sen University

Recruiting

Anlotinib Combined With Toripalimab in Refractory and Advanced Soft-tissue Sarcoma

Sarcoma,Soft Tissue

China
Grupo Espanol de Investigacion en Sarcomas

Active, not recruiting

Olaratumab Plus Trabectedin in Advanced Soft-tissue Sarcoma Patients Soft-tissue Sarcoma Patients (OLATRASTS)

Sarcoma, Soft Tissue

Spain
Institut Bergonié
National Cancer Institute, France

Completed

A Study of Olaparib With Concomitant Radiotherapy in Locally Advanced/Unresectable Soft-tissue Sarcoma (RADIOSARP)

Soft-tissue Sarcoma

France
University Health Network, Toronto

Completed

High Precision RT For Soft-Tissue Sarcoma

Soft-Tissue Sarcoma

Canada
European Organisation for Research and Treatment...
Boehringer Ingelheim

Terminated

Ph II Nintedanib vs. Ifosfamide in Soft Tissue Sarcoma (ANITA)

Sarcoma, Soft Tissue

France, Belgium, Poland, Spain, Lithuania, Netherlands, United Kingdom
Heidelberg University
GlaxoSmithKline; German Cancer Research Center; University Hospital Heidelberg; Universitätsmedizin Mannheim and other collaborators

Terminated

Study of Preoperative Therapy With Pazopanib (Votrient®) to Treat High-risk Soft Tissue Sarcoma (NOPASS)

Sarcoma, Soft-tissue

Germany
Washington University School of Medicine
Novartis Pharmaceuticals

Completed

Pazopanib as Front-Line Therapy in Patients With Non-Resectable or Metastatic Soft Tissue Sarcomas Who Are Not Candidates for Chemotherapy

Soft Tissue Sarcoma | Sarcoma, Soft Tissue

United States
Technical University of Munich
University of Washington

Completed

Radiomics for Tumor Grading of Soft Tissue Sarcomas.

Sarcoma, Soft Tissue

Germany
GlaxoSmithKline

Completed

Pazopanib In Patients With Relapsed Or Refractory Soft Tissue Sarcoma

Sarcoma, Soft Tissue

Belgium, Netherlands, United Kingdom, France, Hungary
Cooperative Weichteilsarkom Study Group
Deutsche Krebshilfe e.V., Bonn (Germany)

Completed

a Multicenter Clinical Trial for the Treatment of Children and Adolescents With Soft Tissue Sarcoma Stage 4

Sarcoma, Soft Tissue

Germany
Dana-Farber Cancer Institute
Massachusetts General Hospital; Brigham and Women's Hospital

Completed

Study of Gemcitabine and Vinorelbine in Soft Tissue Sarcomas

Sarcoma, Soft Tissue

United States
Abbott

Completed

Study Evaluating the Safety and Efficacy of ABT-510 in Subjects With Locally Advanced or Metastatic Soft Tissue Sarcoma

Sarcoma, Soft Tissue

United States
National Cancer Institute (NCI)

Terminated

BMS-247550 in Treating Patients With Advanced Soft Tissue Sarcoma

Recurrent Adult Soft Tissue Sarcoma | Stage III Adult Soft Tissue Sarcoma | Stage IV Adult Soft Tissue Sarcoma

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Recruiting

Testing the Addition of Cemiplimab to Palbociclib for the Treatment of Advanced Dedifferentiated Liposarcoma

Stage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8 | Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8 | Advanced Dedifferentiated Liposarcoma | Metastatic Dedifferentiated Liposarcoma | Locally Advanced Dedifferentiated Liposarcoma | Unresectable Dedifferentiated...

United States
City of Hope Medical Center

Terminated

Nelfinavir Mesylate in Treating Patients With Recurrent, Metastatic, or Unresectable Liposarcoma

Recurrent Adult Soft Tissue Sarcoma | Stage III Adult Soft Tissue Sarcoma | Stage IV Adult Soft Tissue Sarcoma | Adult Liposarcoma

United States
National Cancer Institute (NCI)
Radiation Therapy Oncology Group

Terminated

Preoperative Thalidomide With Radiation Therapy For Patients With Low-Grade Primary Soft Tissue Sarcoma or Thalidomide With Radiation Therapy and Chemotherapy For Patients With High-Grade or Intermediate-Grade Primary Soft Tissue Sarcoma of the Arm, Leg, or Body Wall

Recurrent Adult Soft Tissue Sarcoma | Stage I Adult Soft Tissue Sarcoma AJCC v7 | Stage II Adult Soft Tissue Sarcoma AJCC v7 | Stage III Adult Soft Tissue Sarcoma AJCC v7

United States
Wuhan Union Hospital, China

Recruiting

Camrelizumab Plus Doxorubicin for the First Line Treatment of Adcanced Soft Tissue Sarcoma

Soft Tissue Sarcoma | Neoplasms, Connective and Soft Tissue | Sarcoma Metastatic | Sarcoma,Soft Tissue

China
Massachusetts General Hospital
Jazz Pharmaceuticals

Recruiting

Lurbinectedin + Doxorubicin In Leiomyosarcoma

Advanced Soft-tissue Sarcoma | Metastatic Soft-tissue Sarcoma | Advanced Leiomyosarcoma | Leiomyosarcoma Metastatic

United States
Steven W Thorpe
National Cancer Institute (NCI)

Not yet recruiting

Fluorescent Aided Resection and Evaluation of Soft Tissue Sarcomas (FLARES)

Soft Tissue Sarcoma | Soft Tissue Sarcoma Adult

United States
Sun Yat-sen University
Nanjing Geneseeq Technology Inc.

Recruiting

Study on Dynamic CtDNA Analysis in Pediatric Soft Tissue Sarcoma

Pediatric Soft Tissue Sarcoma

China
McGill University Health Centre/Research Institute...

Recruiting

Pre-operative RadiothErapy for Soft Tissue SarcOmas (PRESTO)

Soft Tissue Sarcoma Adult

Canada
N.N. Petrov National Medical Research Center of...

Recruiting

Combined Treatment of Patients With Soft Tissue Sarcoma Including Preoperative Stereotactic Radiation Therapy and Postoperative Conformal Radiation Therapy

Soft Tissue Sarcoma Adult

Russian Federation
Institut Bergonié
Ministry of Health, France

Recruiting

Impact of Locoregional Treatment of Soft Tissue Sarcoma on Status of Patients Aged 70 Years and Over (SARCOLD)

Soft Tissue Sarcoma Adult

France
Monopar Therapeutics

Terminated

Camsirubicin + Pegfilgrastim to Determine MTD in ASTS

Advanced Soft-tissue Sarcoma

United States

Clinical Trials on Unresectable Soft Tissue Sarcoma

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