Clinical Trials on p53 Mutations
Total 1116 results
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Istituto Scientifico Romagnolo per lo Studio e...UnknownAML | FLT3-ITD Mutation | FLT3-TKD MutationItaly
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University Hospital, GhentFox Chase Cancer Center; Ziekenhuis Oost-LimburgCompletedBRCA1 Mutation | BRCA2 Mutation | hCGBelgium
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Cancer Institute and Hospital, Chinese Academy...UnknownDiffuse Large B-Cell Lymphoma | Sintilimab | TP53 Mutation
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D3 Bio (Wuxi) Co., LtdRecruitingAdvanced Solid Tumors With MAPK Pathway MutationsAustralia, China, United States
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Nested Therapeutics, IncRecruitingGlioma | Melanoma | NSCLC | Oncology | Solid Tumor, Adult | MEK Mutation | RAF Gene Mutation | Ras (KRAS or NRAS) Gene Mutation | MAPK Pathway Gene MutationUnited States, Australia
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Pasithea Therapeutics Corp.RecruitingAdvanced Solid Tumors | RAS Mutation | NF1 Mutation | RAF MutationUnited States
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AZ-VUBAstraZeneca; Kom Op Tegen KankerRecruitingAdvanced Cancers Harbouring Mutations in HRGBelgium
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Abramson Cancer Center at Penn MedicineRecruiting
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Arog Pharmaceuticals, Inc.AvailableFLT3-ITD Mutation | FLT3/TKD Mutation | PDGFR-Alpha D842V | PDGFRA Gene AmplificationItaly
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Deciphera Pharmaceuticals LLCRecruitingMelanoma | Non-Small Cell Lung Cancer | Advanced Solid Tumor | Pancreatic Ductal Adenocarcinoma | BRAF Gene Mutation | RAS Mutation | NF1 Mutation | RAF Mutation | CRAF Gene MutationUnited States
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Hillel Yaffe Medical CenterUnknown
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Chinese PLA General HospitalZhejiang UniversityRecruitingLymphoma | Solid Tumor, Adult | EphA2 Overexpression | TP53 R273H | TP53 R175H | TP53 R248Q | TP53 R249SChina
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Columbia UniversityRecruitingCancer | Insulin Resistance | MTOR Gene Mutation | PI3K Gene Mutation | AKT Gene MutationUnited States
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Anita TurkEli Lilly and CompanyTerminatedCancer | Cancer Metastatic | BRAF V600E | MEK1 Gene Mutation | MEK2 Gene Mutation | ERK Mutation | RAF1 Gene MutationUnited States
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Johns Hopkins UniversityMuscular Dystrophy Association; Actio Biosciences, IncRecruiting
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IRCCS Azienda Ospedaliero-Universitaria di BolognaRecruitingCancer Gene MutationItaly
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Fujian Cancer HospitalUnknown
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Case Comprehensive Cancer CenterNational Institutes of Health (NIH); National Institute of Environmental Health...Not yet recruiting
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Pathway GenomicsCompletedNeoplasms | MutationUnited States
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Ascentage Pharma Group Inc.Merck Sharp & Dohme LLCRecruitingMelanoma | P53 Mutation | Uveal Melanoma | Cutaneous Melanoma | Mucosal Melanoma | Malignant Peripheral Nerve Sheath Tumors | MPNST | Unresectable or Metastatic Melanoma or Advanced Solid Tumors | MDM2 Gene MutationUnited States, Australia
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Fujian Cancer HospitalUnknown
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Alliance for Clinical Trials in OncologyNational Cancer Institute (NCI); Eli Lilly and Company; Genentech, Inc.; Kazia... and other collaboratorsRecruitingMetastatic Malignant Solid Neoplasm | Metastatic Malignant Neoplasm in the Brain | NTRK Family Gene Mutation | CDK Gene Mutation | PI3K Gene Mutation | ROS1 Gene Mutation | KRAS G12C MutationUnited States
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European Institute of OncologyIstituto Oncologico Veneto IRCCS; Ente Ospedaliero Ospedali Galliera; Istituto...Not yet recruitingDuctal Carcinoma in Situ | RAD51C Gene Mutation | RAD51D Gene Mutation | PALB2 Gene Mutation | Lobular Carcinoma in Situ | ATM Gene Mutation | CDH1 Gene Mutation | CHEK2 Gene Mutation | BRCA MutationItaly
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Astellas Pharma Global Development, Inc.WithdrawnSolid Tumors | Epidermal Growth Factor Receptor (EGFR) Mutations
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Thai Red Cross AIDS Research CentreChulalongkorn University; Queen Savang Vadhana Memorial Hospital, ThailandCompletedNVP Plasma Level | NVP Related Mutation | 3TC Related MutationThailand
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Dana-Farber Cancer InstituteNational Cancer Institute (NCI); Baylor College of Medicine; City of Hope Medical...RecruitingTP53 Gene Mutation | Li-Fraumeni Syndrome | Hereditary Cancer Syndrome | Mosaicism | Clonal HematopoiesisUnited States
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Incyte CorporationTerminatedAdvanced or Metastatic Solid Tumors | FGFR Mutations | FGFR TranslocationsUnited States
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Boehringer IngelheimActive, not recruitingSolid Tumors, KRAS MutationSpain, United Kingdom, United States, Belgium
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iOMEDICO AGRoche Pharma AGActive, not recruitingNTRK Family Gene MutationSwitzerland, Germany
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Shanghai Jiatan Pharmatech Co., LtdCompletedPIK3CA Mutation-Related TumorsChina
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University of PennsylvaniaInovio PharmaceuticalsRecruiting
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University of California, San FranciscoThe Bluefield Project to Cure Frontotemporal DementiaCompletedProgranulin Mutation CarriersUnited States
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)Active, not recruitingHereditary Breast and Ovarian Cancer Syndrome | Premenopausal | Deleterious BARD1 Gene Mutation | Deleterious BRCA1 Gene Mutation | Deleterious BRCA2 Gene Mutation | Deleterious BRIP1 Gene Mutation | Deleterious EPCAM Gene Mutation | Deleterious MLH1 Gene Mutation | Deleterious MSH2 Gene Mutation | Deleterious... and other conditionsUnited States
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AZ-VUBUnknownCancers Harbouring an EGFR Mutation, (Excluding Non-squamous Non- Small Cell Lung Cancer, a Registered Indication), a HER2 Mutation or a HER3 MutationBelgium
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Cumhuriyet UniversityCompletedLung Neoplasms | Gene, p53Turkey
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Weill Medical College of Cornell UniversityCompletedBreast Cancer | Gynecologic Cancer | BRCA1 Mutation | BRCA2 MutationUnited States
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Fondazione IRCCS Istituto Nazionale dei Tumori,...Istituto Oncologico di BariCompletedBreast Cancer | BRCA1 Mutation | BRCA2 Mutation | Dietary ModificationItaly
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Boehringer IngelheimCompletedSolid Tumors, KRAS MutationJapan
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Illumina, Inc.CompletedDetection and Genotyping of Factor V and Factor II Point Mutations
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Rabin Medical CenterCompletedBRCA1 Gene Mutation | BRCA2 Gene MutationIsrael
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Blueprint Medicines CorporationActive, not recruitingNeoplasms | Neoplasms by Histologic Type | Lung Diseases | Neoplasms by Site | Adenocarcinoma | Carcinoma | Carcinoma, Non-Small-Cell Lung | Respiratory Tract Neoplasms | Carcinoma, Bronchogenic | Bronchial Neoplasms | Metastatic Lung Cancer | Antineoplastic Agents | Brain Metastases | Lung Neoplasm Malignant | EGFR... and other conditionsUnited States, Canada, Korea, Republic of, Japan, Taiwan
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University of California, Los AngelesBoston Children's Hospital; Duke University; Children's Hospital Medical Center...RecruitingBohring-Opitz Syndrome | ASXL1 Gene Mutation | Shashi-Pena Syndrome | ASXL2 Gene Mutation | Bainbridge-Ropers Syndrome | ASXL3 Gene MutationUnited States
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Cancer Institute and Hospital, Chinese Academy...RecruitingEndometrial Carcinoma | Recurrent or Metastatic | TP53 MutationChina
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Jonsson Comprehensive Cancer CenterAstraZenecaActive, not recruitingGlioblastoma | Recurrent Glioblastoma | EGFR Gene Mutation | Supratentorial Glioblastoma | EGFR Gene Amplification | TP53 wt AlleleUnited States
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Scripps HealthJ. Craig Venter InstituteCompletedLi-Fraumeni Syndrome | Hereditary Cancer Syndromes | TP53 Gene Germline Mutation CarrierUnited States
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Sidney Kimmel Comprehensive Cancer Center at Johns...Merck Sharp & Dohme LLCActive, not recruitingHigh Tumor Mutation Burden | High TMB (Tumor Mutation Burden) | MSS (Microsatellite Stable)United States
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University of ChicagoRecruitingMyeloproliferative Neoplasm | Blood Cancer | IDH2 Gene Mutation | IDH1 Mutation | IDH MutationUnited States
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Iambic Therapeutics, IncRecruiting
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Affiliated Hospital to Academy of Military Medical...RecruitingEndoscopy | Mitochondrial DNA MutationChina
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The University of Hong KongUnknownAML | FLT3-ITD MutationHong Kong