Search clinical trials for: AD-214

Total 3635 results

Zeria Pharmaceutical

Completed

To Evaluate Efficacy and Safety of Z-215 in Erosive Esophagitis

Esophagitis, Reflux

Japan
Ripple Therapeutics Pty Ltd
Novotech (Australia) Pty Limited

Completed

Safety and Efficacy of IBE-814 Intravitreal (IVT) Implant - A Sustained, Low Dose Dexamethasone Therapy

Diabetic Macular Oedema | Retinal Vein Occlusion With Macular Oedema

Australia, New Zealand, Hong Kong, Canada
Bristol-Myers Squibb
Nektar Therapeutics

Terminated

A Study of Bempegaldesleukin (BEMPEG: NKTR-214) in Combination With Nivolumab in Children, Adolescents and Young Adults With Recurrent or Treatment-resistant Cancer (PIVOT IO 020)

Ewing Sarcoma | Ependymoma | Medulloblastoma | Neuroblastoma | Rhabdomyosarcoma | High-grade Glioma | Leukemia and Lymphoma | Miscellaneous Brain Tumors | Miscellaneous Solid Tumors | Relapsed, Refractory Malignant Neoplasms

United States, Australia, France, Germany, Italy, Spain
Boehringer Ingelheim

Completed

Relative Bioavailability, Pharmacokinetics, Safety and Tolerability of BIIL 284 BS in Healthy Volunteers

Healthy
Duke University

Not yet recruiting

A Phase 1 Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of JCXH-211 (SElf-Replicating RNA IL-12) Intratumoral Injection in Patients With Recurrent or Progressive High-Grade Glioma (SERIL)

Recurrent or Progressive High-grade Glioma
Afferent Pharmaceuticals, Inc.

Completed

A Dose Escalation Study of Gefapixant (AF-219/MK-7264) in Refractory Chronic Cough (MK-7264-010)

Refractory Chronic Cough
Afferent Pharmaceuticals, Inc.

Completed

An 8-Week Refractory Chronic Cough Study (MK-7264-021)

Refractory Chronic Cough

United States
Huons Co., Ltd.

Unknown

A Phase 1/3 Clinical Trial to Evaluate the Safety and Efficacy of HUTOX Compared to Botox® in Subjects With Moderate to Severe Crow's Feet Lines

Crow's Feet Lines

Korea, Republic of
Afferent Pharmaceuticals, Inc.

Completed

Effect of Gefapixant (MK-7264/AF-219) on Cough Reflex Sensitivity in Healthy and Chronic Cough Participants (MK-7264-014)

Refractory Chronic Cough
Elusys Therapeutics

Completed

Intramuscular Dose-Escalation Study With ETI-204 in Adult Volunteers

Inhalational Anthrax

United States
Orsenix LLC

Completed

A Phase I, Two-part Study to Determine the Recommended Dose and Evaluate the Safety and Tolerability of a Novel Oral Arsenic Trioxide Formulation (ORH-2014) in Subjects With Advanced Hematological Disorders

Advanced Hematological Disorders

United States
Amgen

Completed

Phase 2 AMG 714 in Rheumatoid Arthritis

Rheumatoid Arthritis
Bristol-Myers Squibb
Nektar Therapeutics

Completed

A Study of NKTR-214 Combined With Nivolumab vs Nivolumab Alone in Participants With Previously Untreated Inoperable or Metastatic Melanoma

Melanoma

Canada, Australia, France, Italy, Brazil, United States, Argentina, Austria, Belgium, Chile, Czechia, Finland, Germany, Greece, Ireland, Israel, Mexico, Netherlands, New Zealand, Poland, Portugal, Romania, Russian Federation, Spain, Sweden and more
Bristol-Myers Squibb
Ono Pharmaceutical Co. Ltd; Nektar Therapeutics

Completed

An Investigational Study of NKTR-214 Combined With Nivolumab in Japanese Participants With Advanced Solid Tumors

Advanced Cancer

Japan
Onze Lieve Vrouw Hospital
Universiteit Antwerpen; MSD Belgium BVBA

Completed

Functional Respiratory Imaging After Neostigmine or Sugammadex (FRINeoS)

Respiratory-Gated Imaging Techniques

Belgium
Coherus Biosciences, Inc.

Recruiting

Study of CHS-114 in Participants With Advanced Solid Tumors

Advanced Solid Tumor | Head and Neck Squamous Cell Carcinoma

United States
Yusuf Menda
National Cancer Institute (NCI); National Institutes of Health (NIH); Holden...

Not yet recruiting

A Safety Study of 212Pb-Pentixather Radioligand Therapy

Carcinoid Tumor Lung | Neuroendocrine Tumor of the Lung | Carcinoma, Small-Cell Lung

United States
Biomea Fusion Inc.

Suspended

Study of BMF-219 in Healthy Adult Subjects and in Adult Subjects With Type 2 Diabetes Mellitus (T2D)

Type 2 Diabetes Mellitus

United States, Canada
University Hospital, Montpellier
Centre Hospitalier Universitaire de Nīmes

Completed

Microglial Activation in Narcolepsy Type 1 and Kleine-Levin Syndrome: Positron Emission Tomography (PET) Study in [18F] DPA-714 (NARCOGLIE)

Kleine-Levin Syndrome | Narcolepsy 1

France
Amsterdam UMC, location VUmc
ZonMw: The Netherlands Organisation for Health Research and Development

Enrolling by invitation

Neuro-inflammation and Post-infectious Fatigue in Individuals With and Without COVID-19 (COVFATI)

COVID-19

Netherlands
Celgene

Completed

ACY 241 in Combination With Paclitaxel in Patients With Advanced Solid Tumors

Advanced Solid Tumors

United States
BIND Therapeutics

Completed

A Phase 2 Study to Determine the Safety and Efficacy of BIND-014 (Docetaxel Nanoparticles for Injectable Suspension), Administered to Patients With Metastatic Castration-Resistant Prostate Cancer

Prostate Cancer | CRPC

United States
BIND Therapeutics

Completed

A Study of BIND-014 Given to Patients With Advanced or Metastatic Cancer

Cancer | Metastatic Cancer | Solid Tumors

United States
AstraZeneca

Completed

Study in Healthy Subjects to Measure the Effects of Food on the Pharmacokinetics of TC-5214 (TC-5214)

Healthy Subjects

United States
BIND Therapeutics

Completed

A Phase 2 Study to Determine the Safety and Efficacy of BIND-014 (Docetaxel Nanoparticles for Injectable Suspension) as Second-line Therapy to Patients With Non-Small Cell Lung Cancer

Non-small Cell Lung Cancer

United States, Russian Federation
Vertex Pharmaceuticals Incorporated

Completed

A Safety Study for Cethrin (BA-210) in the Treatment of Acute Thoracic and Cervical Spinal Cord Injuries

Spinal Cord Injury

United States, Canada
AstraZeneca

Completed

To Compare the Pharmacokinetics of a Single Oral Dose of TC-5214 in Subjects With Renal Impairment and With Subjects With Normal Renal Function

Renal Impairment | Healthy Volunteers | Pharmacokinetics | Patients

United States
AstraZeneca

Completed

Single Oral Dose of 60 mg [14C]AZD9668 in Healthy Male Volunteers (ADME)

Healthy

United Kingdom
Biogen

Completed

A Study to Evaluate SAGE-217 in Participants With Severe Postpartum Depression

Postpartum Depression

United States
Praxis Precision Medicines

Terminated

A Clinical Trial of PRAX-114 in Participants With Post-Traumatic Stress Disorder

Stress Disorders, Post-Traumatic | Trauma and Stressor Related Disorders | Post Traumatic Stress Disorder | Stress Disorder | Post-traumatic Stress Disorder | Mental Disorder

United States
AbbVie
AbbVie

Recruiting

RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Neovascular Age-Related Macular Degeneration (nAMD) (AAVIATE) (AAVIATE)

Neovascular Age-Related Macular Degeneration (nAMD)

United States
Nektar Therapeutics
Bristol-Myers Squibb

Terminated

Study to Compare Adjuvant Immunotherapy of Bempegaldesleukin Combined With Nivolumab Versus Nivolumab After Complete Resection of Melanoma in Patients at High Risk for Recurrence (PIVOT-12)

Melanoma | Melanoma (Skin) | Melanoma Stage IV | Melanoma Stage III

United States, Spain, Germany, France, Australia, Italy, Greece, Israel, Russian Federation, New Zealand, Austria, United Kingdom, Netherlands, Portugal, Poland, Czechia, Romania
OX2 Therapeutics

Recruiting

CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults

Diffuse Midline Glioma, H3 K27M-Mutant | Recurrent High Grade Glioma

United States
Takeda

Terminated

Safety and Tolerability of Pioglitazone-Azilsartan in Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2
Alcon Research

Completed

Assessing the Efficacy and Tolerability of AZARGA® (Brinzolamide 1%/Timolol 0.5% Fixed Combination) as Replacement Therapy in Patients on Brimonidine 0.2%/Timolol 0.5% Fixed Combination Therapy (COMBIGAN®) in Latin America

Glaucoma
Alcon Research

Terminated

Assessing the Efficacy and Tolerability of AZARGA® (Brinzolamide 1%/Timolol 0.5% Fixed Combination) as Replacement Therapy in Patients on COMBIGAN® (Brimonidine 0.2%/Timolol 0.5% Fixed Combination) Therapy in Brazil

Glaucoma

Brazil
Nobelpharma

Completed

A Study for Kidney Transplant Recipients at High-Risk of Cytomegalovirus Infection

Cytomegalovirus Disease

United States, Japan
Serina Therapeutics

Active, not recruiting

A Study of Weekly Subcutaneous Injections of SER-214 in Subjects With Parkinson's Disease (PD), to Determine the Safety, Tolerability and Pharmacokinetic (PK) Profile of SER-214

Parkinson's Disease

United States
Nektar Therapeutics
Bristol-Myers Squibb

Completed

A Single-Arm Study of Bempegaldesleukin (NKTR-214) Plus Nivolumab in Cisplatin Ineligible Patients Who Have Locally Advanced or Metastatic Urothelial Cancer (PIVOT-10)

Neoplasm Metastasis | Urinary Bladder Neoplasm

United States, Spain, United Kingdom, Belgium, Canada, Australia, France, Italy, Greece, Germany, Portugal, Argentina, Israel, Russian Federation, Turkey, Mexico, Finland, Netherlands
Biocad

Recruiting

A Clinical Study of BCD-217 (Nurulimab + Prolgolimab) Followed by Anti-PD-1 Compared to Anti-PD-1 Monotherapy as First-Line Treatment in Subjects With Unresectable/Metastatic Melanoma (OCTAVA)

Melanoma | Melanoma (Skin) | Melanoma Stage IV | Melanoma Stage III | Melanoma Metastatic | Melanoma Unresectable | Melanoma Advanced

India, Russian Federation, Belarus
University of Alabama at Birmingham

Withdrawn

Neuroinflammation and Age-associated Brain Pathology: Two Potential Mechanisms of Cognitive Impairment in Ovarian Cancer

Ovarian Cancer

United States
Biocad

Active, not recruiting

Study of Efficacy and Safety of BCD-217 (Anti-CTLA-4 and Anti-PD-1) Followed By BCD-100 (Anti-PD-1) Versus BCD-100 Monotherapy as First-Line Treatment in Patients With Unresectable or Metastatic Melanoma (OBERTON)

Melanoma | Melanoma Metastatic

Russian Federation, Belarus
Royal Brompton & Harefield NHS Foundation Trust
Olympus Corporation

Completed

EBUS-TBNA vs Flex 19G EBUS-TBNA

Lymphoma | Lung Cancer | Lymphadenopathy | Sarcoidosis

United Kingdom
AstraZeneca

Completed

An Open Label, Single Centre Mass Balance C14 Study in Patients With Acute Myeloid Leukaemia (AML)

Acute Myeloid Leukaemia

United Kingdom
Sage Therapeutics
Biogen

Completed

A Study to Evaluate SAGE-217 in Adult Participants With Major Depressive Disorder (MDD)

Major Depressive Disorder

United States
Selecta Biosciences, Inc.

Completed

A Study to Compare the Efficacy of SEL-212 to KRYSTEXXA® in Gout Participants Refractory to Conventional Therapy (COMPARE)

Chronic Gout

United States
Seikagaku Corporation

Completed

A Clinical Study Evaluating the Safety and Efficacy of SI-614 Ophthalmic Solution in Patients With Dry Eye.

Dry Eye Syndromes

United States
Huons Co., Ltd.

Completed

The Safety and Efficacy Study of HU-014 Versus Botox® in Subject With Moderate to Severe Glabellar Lines

Glabellar Lines

Korea, Republic of
Zeria Pharmaceutical

Completed

Mass Balance and Metabolism Study of 14C-Z-215

Healthy Male Subjects

United Kingdom
Boehringer Ingelheim

Completed

Effect of Different Food Compositions on Bioavailability of BIIL 284 BS in Healthy Male Volunteers

Healthy

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