Search clinical trials for: AGG-523 (Aggrecanase Inhibitor)

Total 890 results

Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating AGG-523 in Subjects With Severe Osteoarthritis Requiring Total Knee Replacement

Osteoarthritis

United States
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses in Healthy

Osteoarthritis | Healthy Subjects

United States
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

A Study of the Safety, Tolerability, and Pharmacokinetics of AGG-523 in Healthy Japanese Males

Healthy

Japan
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating AGG-523 in Subjects With Osteoarthritis

Osteoarthritis

United States
Cytokinetics

Completed

Pharmacokinetics Study of AMG 423 in Healthy Subjects and Subjects With Various Degrees of Renal Insufficiency

Heart Failure

United States
Amgen

Withdrawn

Study Evaluating the Safety, Tolerability, and Efficacy of FLT3 CAR-T AMG 553 in FLT3-positive Relapsed/Refractory AML

Relapsed/Refractory Acute Myeloid Leukemia

United States
Amgen

Completed

A Study to Examine the Safety, Pharmacokinetics and Pharmacodynamics of AMG 623 in Subjects With Systemic Lupus Erythematosus

Systemic Lupus Erythematosus
Amgen

Completed

A Study to Examine the Safety, Pharmacokinetics and Pharmacodynamics of Single Dose of AMG 623 in Subjects With Systemic Lupus Erythematosus

Systemic Lupus Erythematosus
Amgen

Completed

AMG 529 First in Human Study

Cardiovascular

United States
Amgen

Completed

Study to Assess Fixed Dosing of AMG 223 in Subjects With Chronic Kidney Disease on Hemodialysis With Hyperphosphatemia

End Stage Renal Disease | Chronic Kidney Disease | Kidney Disease | Hyperphosphatemic
Cytokinetics

Withdrawn

Omecamtiv Mecarbil Post-trial Access Study

Chronic Heart Failure With Reduced Ejection Fraction
Cytokinetics

Withdrawn

Pharmacokinetic Study of Omecamtiv Mecarbil in Heart Failure Patients

Heart Failure
Cytokinetics

Completed

Pharmacokinetics and Safety Study of Omecamtiv Mecarbil in Healthy Japanese Adults

Healthy Volunteer

Japan
Cytokinetics

Completed

Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects With Heart Failure (METEORIC-HF)

Heart Failure With Reduced Ejection Fraction

United States, Hungary, France, Canada, Netherlands, Germany, Poland, Italy, Sweden
Cytokinetics

Completed

Study to Evaluate the Safety and Efficacy of IV Infusion Treatment With Omecamtiv Mecarbil in Subjects With Left Ventricular Systolic Dysfunction Hospitalized for Acute Heart Failure (ATOMIC-AHF)

Heart Failure

United States, Canada, Germany, Italy, Netherlands, Belgium, France, Czechia, Australia, Russian Federation, Hungary, Poland, Bulgaria, Slovakia, United Kingdom, Finland, Greece, Lithuania, Norway
Cytokinetics

Completed

Registrational Study With Omecamtiv Mecarbil (AMG 423) to Treat Chronic Heart Failure With Reduced Ejection Fraction (GALACTIC-HF)

Heart Failure

United States, Belgium, Canada, Denmark, France, Italy, Netherlands, United Kingdom, Hungary, Colombia, Mexico, Poland, Russian Federation, Switzerland, Czechia, Turkey, China, Spain, Australia, New Zealand, Chile, Austria, Slovakia, ... and more
Cytokinetics

Completed

A Pharmacokinetic and Pharmacodynamic Study of Omecamtiv Mecarbil in Healthy Volunteers

Heart Failure

United Kingdom
M.D. Anderson Cancer Center
Bayer

Completed

Trial of Ra-223 Dichloride in Combination With Hormonal Therapy and Denosumab in the Treatment of Patients With Hormone-Positive Bone-Dominant Metastatic Breast Cancer

Breast Cancer

United States
UNC Lineberger Comprehensive Cancer Center
Pfizer; BioMed Valley Discoveries, Inc

Recruiting

Ulixertinib/Palbociclib in Patients With Advanced Pancreatic and Other Solid Tumors

Melanoma | Pancreatic Cancer | Tumor, Solid

United States
Hutchmed

Completed

HMPL-523 Food Effect and Proton Pump Inhibitor Study

Relapsed or Refractory Lymphoma

United States
M.D. Anderson Cancer Center
Bayer; Prostate Cancer Foundation

Completed

Radium 223 in Castrate Resistant Prostate Cancer Bone Metastases

Prostate Cancer

United States
Cytokinetics

Completed

COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure (COSMIC-HF)

Chronic Heart Failure | Pharmacokinetics | Left Ventricular Systolic Dysfunction | Left Ventricular Ejection Fraction | Modified Release Oral Formulation | History of Chronic Heart Failure | Echocardiogram

United States, Canada, Italy, Netherlands, United Kingdom, Belgium, Czechia, Australia, Hungary, Poland, Bulgaria, Lithuania, Germany
Cytokinetics

Completed

Study to Assess the Effect of Omecamtiv Mecarbil (OM) on QT/QTc Intervals in Healthy Adults

QT Intervals Changes | QTc Intervals Changes

United Kingdom
Amgen Research (Munich) GmbH

Completed

A Phase 1 Multiple Dose Study to Compare the Effects of AMG 223 and Sevelamer HCL (Renagel®)

Healthy Volunteers
Hutchison Medipharma Limited

Terminated

Phase I Study of HMPL-523+Azacitidine in Elderly Patients With Acute Myeloid Leukemia

Acute Myeloid Leukemia

China
Sidney Kimmel Cancer Center at Thomas Jefferson...
Bayer; Janssen, LP; Prostate Cancer Clinical Trials Consortium

Completed

Phase IB Trial of Radium-223 and Niraparib in Patients With Castrate Resistant Prostate Cancer (NiraRad)

Stage IV Prostate Adenocarcinoma | Hormone-refractory Prostate Cancer | Prostate Carcinoma Metastatic to the Bone

United States
Dana-Farber Cancer Institute
Bayer

Completed

Exploratory Study of Radium-223 and VEGF-Targeted Therapy in Patients With Metastatic Renal Cell Carcinoma and Bone Mets

Metastatic Renal Cell Carcinoma

United States
Merck Sharp & Dohme LLC

Completed

A De-Escalating Strategy for Antibiotic Treatment of Pneumonia in The Medical Intensive Care Unit (0787B-092)

Pneumonia | Infection
Amgen

Completed

A Multiple Dose Study to Evaluate Subcutaneous AMG 108 in Subjects With Rheumatoid Arthritis

Rheumatoid Arthritis
Jonsson Comprehensive Cancer Center
Merck Sharp & Dohme LLC; Seagen Inc.

Not yet recruiting

Pembrolizumab and Enfortumab Vedotin With Pembrolizumab Prior to and After Radical Nephroureterectomy for High-Risk Upper Tract Urothelial Cancer

Renal Pelvis and Ureter Urothelial Carcinoma

United States
Emory University
National Cancer Institute (NCI); Merck Sharp & Dohme LLC; Astellas Pharma Inc; Seagen...

Recruiting

Enfortumab Vedotin Plus Pembrolizumab for the Treatment of Locally Advanced or Metastatic Bladder Cancer of Variant Histology

Stage III Bladder Cancer AJCC v8 | Stage IV Bladder Cancer AJCC v8 | Bladder Adenocarcinoma | Bladder Squamous Cell Carcinoma | Metastatic Bladder Carcinoma | Urachal Adenocarcinoma | Locally Advanced Bladder Carcinoma | Malignant Renal Pelvis Neoplasm | Malignant Ureter Neoplasm | Malignant Urethral Neoplasm and other conditions

United States
Atea Pharmaceuticals, Inc.
Hoffmann-La Roche

Completed

Drug-drug Interaction Study of Rosuvastatin and AT-527 (R07496998)

Healthy Volunteer Study

Canada
University of Utah
BioMed Valley Discoveries, Inc

Completed

Ulixertinib (BVD-523) and Hydroxychloroquine in Patients w Advanced MAPK-Mutated Gastrointestinal Adenocarcinomas (UTAH)

Gastrointestinal Neoplasms

United States
BioMed Valley Discoveries, Inc

Recruiting

Trial of Ulixertinib in Combination With Hydroxychloroquine in Patients With Advanced Gastrointestinal (GI) Malignancies

Gastrointestinal Cancer | Tumor, Solid

United States
University Hospital Freiburg

Unknown

Treatment of Advanced Castration Resistant Prostate Carcinoma With Limited Bone Metastases (α-RT) (α-RT)

Prostate Carcinoma

Germany
Amgen

Completed

AMG386 Comb w. Either Pegylated Liposomal Doxorubicin or Topotecan Subjects w. Advanced Recurrent Epithelial Ovarian CR

Carcinoma | Cancer | Ovarian Cancer | Fallopian Tube Cancer | Solid Tumors | Oncology | Tumors | Metastases | Gynecological Malignancies

Belgium, United States, Australia
GE Healthcare
Quintiles, Inc.; H2O Clinical LLC

Completed

Open-label, Test-retest Study Assessing Reproducibility of Quantitative Measurements of Myocardial Uptake of AdreView.

Ventricular Dysfunction, Left | Heart Failure (HF)

United States
Celgene

Completed

Study Assessing Safety, Pharmacokinetics and Efficacy of CC-223 With Either Erlotinib or Oral Azacitidine in Advanced Non-Small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung | Non-Small Cell Lung Cancer

United States, Spain
MedImmune LLC

Completed

Study of MEDI-573 Plus Standard Endocrine Therapy for Women With Hormone-sensitive Metastatic Breast Cancer

Hormone-sensitive, HER-2 Negative Metastatic Breast Cancer

Spain, United States, Belgium, France, United Kingdom, Canada, Israel, Germany, Hungary, Poland, Bahamas
Ascentage Pharma Group Inc.
Suzhou Yasheng Pharmaceutical Co., Ltd.

Recruiting

A Study of APG-1252 Plus Osimertinib(AZD9291) in EGFR TKI Resistant NSCLC Patients

EGFR Positive Non-small Cell Lung Cancer

China
Blessing Corporate Services, Inc
Takeda Pharmaceuticals North America, Inc.

Withdrawn

Aralast NP With Antiviral Treatment and Standard of Care Versus Antiviral Treatment With Standard of Care in Hospitalized Patients With Pneumonia and COVID-19 Infection

Pneumonia, Viral | Covid19

United States
SWOG Cancer Research Network
National Cancer Institute (NCI)

Recruiting

Testing the Use of Targeted Treatment (AMG 510) for KRAS G12C Mutated Advanced Non-squamous Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)

Lung Adenocarcinoma | Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Lung Non-Small Cell Carcinoma | Stage IV Lung Cancer AJCC v8 | Recurrent Lung Non-Squamous Non-Small Cell Carcinoma

United States, Guam
Amgen

Completed

AMG 386, 20060159 Phase 2, RCC 1st Line in Combination With Sorafenib

Advanced Renal Cell Carcinoma
Amgen

Completed

Phase 2 Study of AMG 386 (20060439) in Combination With Cisplatin & Capecitabine in Subjects With Metastatic Gastric, Gastroesophageal Junction, or Distal Esophageal Adenocarcinoma

Gastrointestinal Cancer
Amgen

Completed

A Phase 2, Randomized, Double Blind, Placebo Controlled Study of AMG 386 in Combination With FOLFIRI in Subjects With Previously Treated Metastatic Colorectal Carcinoma

Carcinoma | Cancer | Metastatic Colorectal Cancer | Colorectal Cancer | Rectal Cancer | Metastatic Cancer | Colon Cancer | Gastrointestinal Cancer | Oncology | Metastases
NantCell, Inc.

Completed

QUILT-2.013: A Trial of AMG 479 or AMG 102 in Combination With Platinum-based Chemotherapy as First-Line Treatment for Extensive Stage Small Cell Lung Cancer

Small Cell Lung Cancer | Lung Cancer | Extensive-stage Small Cell Lung Cancer | Solid Tumors
Almirall, S.A.

Active, not recruiting

Observational Real-world Evidence (RWE) Study to Assess Patient-reported Wellbeing Using Tildrakizumab in Live Setting - POSITIVE Study (POSITIVE)

Plaque Psoriasis

Germany
Zonguldak Bulent Ecevit University

Completed

AGC Mode vs Minimal Flow in Breast Surgery

Breast Diseases | Anesthesia; Functional | Volatil Agent Consumption | Automatic End-tidal Controlled Anesthesia

Turkey
Ohio State University

Recruiting

Achieving Nutritional Adequacy Of Vitamins E and K With An Egg/Plant-Based Food Pairing - Study 1

Nutritional Requirements

United States
Mitsubishi Tanabe Pharma Corporation

Completed

Long-term Safety Study of MP-513 in Patients With Type 2 Diabetes

Type 2 Diabetes Mellitus

Japan

Search clinical trials for: AGG-523 (Aggrecanase Inhibitor)

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