Search clinical trials for: AGN-231868

Total 2525 results

The University of Hong Kong

Completed

Promoting Smoking Cessation for Female Smokers in Hong Kong Through Training Female Youth SCRA

Smoking Cessation

China
AGIRx Ltd.

Terminated

Safety and Pharmacodynamic Study of a New Formulation, AGI - 101H Vaccine in the Treatment of Advanced Melanoma

Melanoma

Poland
Alnylam Pharmaceuticals

Completed

Dose Escalation Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Intravenous ALN-VSP02 In Patients With Advanced Solid Tumors With Liver Involvement

Solid Tumors

United States, Spain
Alnylam Pharmaceuticals

Terminated

A Study to Evaluate ALN-XDH in Healthy Subjects and Patients With Gout

Gout

United Kingdom
University of South-Eastern Norway
Norwegian University of Science and Technology

Completed

Performance Determinants Factors in Elite Endurance Athletes.

Exercise Physiology

Norway
Institut Paoli-Calmettes
Janssen-Cilag Ltd.

Unknown

Active Surveillance With or Without Apalutamide Treatment in Low Risk Prostate Cancer (PC-ARN)

Low Risk Prostate Cancer

France
Assistance Publique Hopitaux De Marseille

Unknown

Predisposition to Infectious Endocarditis

Infective Endocarditis

France
Alnylam Pharmaceuticals

Completed

A Safety and Tolerability Study of an Investigational Drug, ALN-TTRSC02, in Healthy Subjects

Transthyretin-mediated Amyloidosis (ATTR Amyloidosis)

United Kingdom
Alnylam Pharmaceuticals
The Medicines Company

Completed

A Phase 1 Study of an Investigational Drug, ALN-PCSSC, in Subjects With Elevated Low Density Lipoprotein Cholesterol (LDL-C)

Hypercholesterolemia

United Kingdom
Alnylam Pharmaceuticals

Completed

Trial to Evaluate Safety, Tolerability, and Parmacokinetics of ALN-TTR02 in Healthy Volunteer Subjects

TTR-mediated Amyloidosis

United Kingdom
Alnylam Pharmaceuticals

Completed

Multi-center, Open Label, Extension Study of ALN-VSP02 in Cancer Patients Who Have Responded to ALN-VSP02 Treatment

Solid Tumors

United States, Spain
Alnylam Pharmaceuticals

Completed

Trial to Evaluate Safety and Tolerability of ALN-PCS02 in Subjects With Elevated LDL-Cholesterol (LDL-C)

Elevated LDL-Cholesterol (LDL-C)

United Kingdom
Alnylam Pharmaceuticals

Completed

Trial to Evaluate Safety and Tolerability of ALN-TTR01 in Transthyretin (TTR) Amyloidosis

Transthyretin Mediated Amyloidosis (ATTR)

United Kingdom, France, Portugal, Sweden
Zafgen, Inc.

Terminated

An Efficacy and Safety Study of Beloranib in Obese Subjects With Type 2 Diabetes Mellitus

Obesity | Type 2 Diabetes

Australia
Beijing Hospital of Traditional Chinese Medicine
Beijing HuiLongGuan Hospital; Peking University Sixth Hospital; Guizhou Yi Bai...

Unknown

Clinical Trial Scheme of Shu Gan yi Yang Capsule

Depression With Erectile Dysfunction
University of Medicine and Pharmacy at Ho Chi Minh...

Completed

Comparison of Quality of Life After Discharge of the Mild and Moderate COVID-19 Patients With or Without Herbal Medicine

Quality of Life | COVID-19 Pandemic

Vietnam
Medical Research Council Unit, The Gambia

Completed

The Interaction Between Measles and DTP Vaccination

Non-target Heterologous Effects of Vaccines | Vaccine Interactions
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Apalutamide in Treating Patients With Prostate Cancer Before Radical Prostatectomy

Prostate Adenocarcinoma | Stage IIB Prostate Cancer AJCC v8

United States
Roswell Park Cancer Institute
National Cancer Institute (NCI)

Terminated

Vaccine Therapy Before Surgery in Treating Patients With Localized Kidney Cancer

Recurrent Renal Cell Carcinoma | Stage I Renal Cell Cancer | Stage II Renal Cell Cancer

United States
Zafgen, Inc.

Completed

An Efficacy, Safety, and Pharmacokinetics Study of Beloranib in Obese Subjects With Hypothalamic Injury

Obesity | Craniopharyngioma | Over-weight | Hypothalamic Injury

United States, Australia
Regeneron Pharmaceuticals

Not yet recruiting

A Trial to Learn if Receiving ALN-PNP siRNA is Safe and Well Tolerated, and How it Works in Adult Participants With Nonalcoholic Fatty Liver Disease (NAFLD) and a Genetic Risk Factor

Nonalcoholic Steatohepatitis (NASH) | Nonalcoholic Fatty Liver Disease (NAFLD) | Genetic Risk Factor
Dongzhimen Hospital, Beijing

Recruiting

Efficacy and Safety of Tian Ma Bian Chun Zhi Gan Tablets in Mild to Moderate Vascular Dementia

Cognitive Impairment | Vascular Dementia

China
Princess Nourah Bint Abdulrahman University
King Faisal Specialist Hospital & Research Center; King Fahad Hospital

Recruiting

Estimating Length of Endotracheal Tube Insertion Using Gestational Age or Nasal-Tragus Length in Newborn Infants (ELEGANT)

Pneumothorax | Death | Bronchopulmonary Dysplasia | Endotracheal Tube Tip Position | Duration, Ventilator

Saudi Arabia
Alnylam Pharmaceuticals

Active, not recruiting

APOLLO-B: A Study to Evaluate Patisiran in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR Amyloidosis With Cardiomyopathy)

Transthyretin Amyloidosis (ATTR) With Cardiomyopathy

United States, Australia, Brazil, Bulgaria, France, Italy, Japan, Mexico, Netherlands, Taiwan, United Kingdom, Belgium, Czechia, Denmark, New Zealand, Sweden, Korea, Republic of, Argentina, Chile, Hong Kong, Portugal
Alnylam Pharmaceuticals

Terminated

A Study of ALN-HSD in Healthy Adult Subjects and Adult Patients With Nonalcoholic Steatohepatitis (NASH)

Nonalcoholic Steatohepatitis | NASH

United States, Bulgaria, United Kingdom, Belgium, Turkey
Alnylam Pharmaceuticals

Completed

The Study of ALN-TTR02 (Patisiran) for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis in Patients Who Have Already Been Treated With ALN-TTR02 (Patisiran)

TTR-mediated Amyloidosis

Portugal, Sweden, Brazil, United States, France, Spain, Germany
Alnylam Pharmaceuticals

Active, not recruiting

HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

Transthyretin Amyloidosis (ATTR) With Cardiomyopathy

United States, Poland, Argentina, Australia, Belgium, France, Germany, Japan, Netherlands, Portugal, Spain, Sweden, United Kingdom, Canada, Czechia, Denmark, Hungary, Ireland, Norway, Korea, Republic of, Austria, Croatia, Israel, Latvia, Lithuan... and more
Alnylam Pharmaceuticals

Terminated

A Study of Cemdisiran in Adults With Immunoglobulin A Nephropathy (IgAN)

IgA Nephropathy (IgAN) | Berger Disease | Glomerulonephritis, IgA

Canada, Malaysia, France, Sweden, United Kingdom, Philippines, Singapore, Spain, Taiwan
Lenus Therapeutics, LLC

Terminated

Evaluation of the Safety and Efficacy Study of RGN-137 Topical Gel for Junctional and Dystrophic Epidermolysis Bullosa (CELEB)

Dystrophic Epidermolysis Bullosa | Junctional Epidermolysis Bullosa

United States
Shenzhen Kangzhe Pharmaceutical Co., Ltd.

Unknown

Expanding Phase III Study of Tyroserleutide for Injection

Hepatocellular Carcinoma
Aragon Pharmaceuticals, Inc.

Completed

A Study to Assess the Relative Bioavailability of 7 Test Tablet Formulations of JNJ-56021927 With Respect to the Capsule Formulation of JNJ-56021927 in Healthy Male Participants

Healthy

United States
Alnylam Pharmaceuticals

Completed

A Study of the Safety, Tolerability and Pharmacokinetics of ALN-TTR02 in Japanese Healthy Volunteers

Transthyretin (TTR)-Mediated Amyloidosis

United Kingdom
Seagen Inc.

Completed

Study of SGN-30 (Anti-CD30 mAb) in Patients With Primary Cutaneous Anaplastic Large Cell Lymphoma

Large Cell Lymphoma

United States
Ablynx

Completed

Study Of Single Dose Of ATN-103 Administered To Healthy Japanese Male Subjects (ATN-103)

Healthy

Japan
Antalya Training and Research Hospital

Completed

Esophageal Calibration During Laparoscopic Fundoplication Reduces Dysphagia

Dysphagia

Turkey
Attenuon

Terminated

ATN-161 in Advanced Renal Cell Cancer

Carcinoma, Renal Cell

United States
Regeneron Pharmaceuticals

Recruiting

A Precision Medicine Approach Using Gene Silencing to Treat a Chronic Liver Disease Called Non-Alcoholic Steatohepatitis (NASH) in Adult Participants at Increased Genetic Risk for This Condition (NASHGEN-2)

Non-alcoholic Steatohepatitis (NASH) | Metabolic Dysfunction Associated Steatohepatitis (MASH)

United States, Korea, Republic of, Puerto Rico, Japan
Imperial College Healthcare NHS Trust
Imperial College London

Recruiting

Psycho-educational Tool to Prevent Psychological Sequelae Following Paediatric Intensive Care Unit Admission (4PICU)

PTSD

United Kingdom
Center for International Blood and Marrow Transplant...
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute... and other collaborators

Completed

Composite Health Assessment Risk Model (CHARM) for Older Adults (BMT CTN 1704) (BMT CTN 1704)

Hematologic Malignancy

United States
University Hospitals of Derby and Burton NHS Foundation...
British Renal Society; Kidney Care UK

Completed

Kidney Transplant Low-AGE Diet Study (Transplant LAD)

Renal Transplant

United Kingdom
ArmaGen, Inc

Completed

Safety and Dose Ranging Study of Human Insulin Receptor MAb-IDUA Fusion Protein in Adults and Children With MPS I

Mucopolysaccharidosis I

Brazil
Alnylam Pharmaceuticals

Terminated

A Study of ALN-AAT02 in Healthy Participants and Participants With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

United Kingdom
VA Connecticut Healthcare System

Completed

Cognitive Training to Enhance VA Work Program Outcomes

Depression | PTSD | Schizophrenia | Bipolar Disorder | Mental Illness

United States
Alnylam Pharmaceuticals

Completed

ENDEAVOUR: Phase 3 Multicenter Study of Revusiran (ALN-TTRSC) in Patients With Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC)

Amyloid Neuropathies | Amyloid Neuropathies, Familial | Amyloidosis, Hereditary | Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC) | Amyloidosis, Hereditary, Transthyretin-Related | Familial Transthyretin Cardiac Amyloidosis

United States, France, Italy, Spain, Canada, Germany, Belgium, Sweden, United Kingdom
Alnylam Pharmaceuticals

Completed

A Phase 1 Study of Givosiran (ALN-AS1) in Patients With Acute Intermittent Porphyria (AIP)

Acute Intermittent Porphyria

United States, United Kingdom, Sweden
University of Washington
National Cancer Institute (NCI); Janssen Scientific Affairs, LLC

Terminated

Apalutamide in Treating Patients With Prostate Cancer Who Are in Active Surveillance

Prostate Adenocarcinoma

United States
Zafgen, Inc.

Terminated

Double-Blind, Placebo Controlled, Phase 3 Trial of ZGN-440 (Beloranib) in Obese Subjects With Prader-Willi Syndrome (bestPWS)

Obesity | Prader-Willi Syndrome

United States
Centers for Disease Control and Prevention
International Centre for Diarrhoeal Disease Research, Bangladesh

Completed

Duration of IPV Priming and Antibody Decay

Poliomyelitis

Bangladesh
InnoCon Medical

Recruiting

UCon Treatment of Overactive Bladder (OAB) in Males

Urinary Incontinence | Urge Incontinence | Urinary Incontinence, Urge | Nocturia | Urinary Frequency More Than Once at Night | Incontinence, Nighttime Urinary

Netherlands
Iran University of Medical Sciences

Not yet recruiting

Any Unique Identifier Assigned to the Protocol by the Sponsor

Neovascular Glaucoma

Iran, Islamic Republic of

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