Search clinical trials for: Actemra(EU-licensed)

Total 581 results

Mylan Inc.
Mylan GmbH

Completed

Adalimumab PK Bioequivalence Study to EU and US Sourced Humira

Healthy Volunteers

Belgium
Samsung Bioepis Co., Ltd.

Completed

Pharmacokinetic, Safety, Tolerability and Immunogenicity Study of SB5 in Healthy Subjects

Healthy

Germany
Tongji Hospital
Wuhan Central Hospital; Wuhan No.1 Hospital; Hubei Xinhua Hospital

Unknown

Tocilizumab vs CRRT in Management of Cytokine Release Syndrome (CRS) in COVID-19 (TACOS)

Covid-19 | Cytokine Storm | Cytokine Release Syndrome | SARS | Tocilizumab

China
Hoffmann-La Roche

Completed

A Study of the Effect of Tocilizumab on Markers of Atherogenic Risk in Patients With Moderate to Severe Rheumatoid Arthritis

Rheumatoid Arthritis

United States, Canada, Puerto Rico, United Kingdom
Hoffmann-La Roche

Completed

A Study to Assess the Effect of Tocilizumab + Methotrexate on Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid Arthritis Currently on Methotrexate Therapy

Rheumatoid Arthritis

France, Germany, Italy, Australia, United States, Canada, Mexico, United Kingdom, Sweden, Belgium, Switzerland, Netherlands, Puerto Rico, Iceland
Hoffmann-La Roche

Completed

A Study of RoActemra/Actemra (Tocilizumab) With or Without Methotrexate in Patients With Mild to Moderate Rheumatoid Arthritis With an Inadequate Response to Methotrexate

Rheumatoid Arthritis

Austria
Hoffmann-La Roche

Completed

A Study to Assess the Effect of Tocilizumab Plus Methotrexate on Safety and Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid Arthritis

Rheumatoid Arthritis

Colombia, Costa Rica, Mexico, Ecuador, Brazil, Argentina, Chile, Venezuela, Peru, Uruguay
Hoffmann-La Roche

Completed

A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Non-biologic DMARDs

Rheumatoid Arthritis

Indonesia
U.S. Army Medical Research and Development Command
GlaxoSmithKline

Completed

A Phase I/II Trial of a Tetravalent Live Attenuated Dengue Vaccine in Flavivirus Antibody Naïve Children

Dengue Fever

Thailand
Mahidol University
The Government Pharmaceutical Organization

Recruiting

Immunogenicity and Safety of Tri Fluvac, a Seasonal Trivalent Inactivated Split Virion Influenza Vaccine, in Healthy Thai Elderly

Influenza

Thailand
Enzene Biosciences Ltd.
Alkem Laboratories Ltd

Recruiting

Study to Compare the Pharmacokinetics, Pharmacodynamics, Safety, Tolerability, and Immunogenicity of Biosimilar Denosumab With Prolia® in Healthy Adult Male Volunteers

Healthy Male Subjects

Bulgaria, Poland
Shanghai Henlius Biotech

Completed

Compare Pharmacokinetics, Safety, and Immunogenicity of HLX11 vs. Perjeta in Healthy Chinese Male Subjects

Healthy Male Volunteers

China
Pronova BioPharma

Completed

Bioavailability of Omega-3 Food Supplement in Healthy Subjects

Biological Availability

United Kingdom
Boehringer Ingelheim

Completed

Pharmacokinetics and Safety in Healthy Volunteers

Healthy

Belgium, New Zealand
Mylan Pharmaceuticals Inc
Mylan GmbH

Completed

Phase 1 Study of Trastuzumab Administered as a Single Intravenous Infusion

Healthy
Pfizer

Completed

A Study Of PF-06410293 (Adalimumab-Pfizer) And Adalimumab (Humira) In Healthy Subjects (REFLECTIONS B538-07)) (B538-07)

Healthy Subjects

United States
Hoffmann-La Roche

Completed

A Study of Subcutaneous RoActemra/Actemra (Tocilizumab) as Monotherapy or in Combination With Methotrexate or Other Non-Biologic DMARDs in Patients With Active Rheumatoid Arthritis

Rheumatoid Arthritis

Spain, Portugal, Ireland
Hoffmann-La Roche

Completed

A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate Versus RoActemra/Actemra Monotherapy in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate

Rheumatoid Arthritis

Spain
Hoffmann-La Roche

Completed

A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Disease-Modifying Antirheumatic Drugs (DMARDs) (ALABASTER)

Rheumatoid Arthritis

Bosnia and Herzegovina
Hoffmann-La Roche

Completed

A Study to Assess the Effect of Tocilizumab + Methotrexate on Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid Arthritis

Rheumatoid Arthritis

France, Israel, Italy, Switzerland, Germany, Mexico, Canada, Austria, Thailand, Singapore, Bulgaria, Australia, Argentina, Brazil, Slovakia, Hungary, China
ViiV Healthcare
GlaxoSmithKline

Completed

PENTA Fosamprenavir Study

Infection, Human Immunodeficiency Virus
University of Athens

Unknown

Effects of Interleukin-6 Inhibition on Vascular, Endothelial and Left Ventricular Function in Rheumatoid Arthritis

Inflammation | Rheumatoid Arthritis

Greece
Ente Ospedaliero Ospedali Galliera

Active, not recruiting

Ferrochelating Treatment in Patients Affected by Neurodegeneration With Brain Iron Accumulation (NBIA)

Iron Overload | Neurodegenerative Disease

Italy
Stanford University
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Responses to Influenza Vaccine in Patients With Mitochondrial Disorders (MELAS)

MELAS Syndrome

United States
Novavax

Completed

A Study Looking at the Effectiveness, Immune Response, and Safety of a COVID-19 Vaccine in Adults in the United Kingdom

COVID-19 | SARS-CoV-2 Infection

United Kingdom
Hoffmann-La Roche

Completed

A Study of Subcutaneous (SC) Tocilizumab (RoActemra/Actemra) in Participants With Active Rheumatoid Arthritis (RA) and Inadequate Response to Disease-Modifying Anti-Rheumatic Drugs (DMARDs)

Rheumatoid Arthritis

Denmark, Finland, Norway, Sweden
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Withdrawn

Tocilizumab for Chronic Graft-versus-Host Disease Treatment

Graft Versus Host Disease

United States
Nanjing First Hospital, Nanjing Medical University

Recruiting

Effects of Coffee Consumption on Metabolic Markers in Adults With Prediabetes and Obesity

Prediabetes

China
Xentria, Inc.

Recruiting

Single Dose, Three-arm Study to Compare the Pharmacokinetic Similarity of MAB-22 Versus Prolia®

Healthy Participants

Netherlands, Hungary
Luye Pharma Group Ltd.
Parexel

Completed

A Pharmacokinetic Similarity Study in Healthy Male Subjects to Evaluate Pharmacokinetics, Pharmacodynamics, Safety and Immunogenicity of LY06006 Versus US-Prolia and EU-Prolia by Single-dose Subcutaneous Injection

Healthy

Germany
mAbxience Research S.L.

Completed

Pharmacokinetic Study Comparing MB05 (Proposed Palivizumab Biosimilar), EU-sourced Synagis® and US-sourced Synagis® in Healthy Volunteers.

Healthy Volunteers

Australia, New Zealand
University Hospital Southampton NHS Foundation...
Imperial College London; Public Health England

Completed

Safety of Nasal Influenza Immunisation in Egg Allergic Children (SNIFFLE)

Egg Hypersensitivity

United Kingdom
Hoffmann-La Roche

Completed

A Study of Glucocorticoid Use to Evaluate Systematic Methylprednisolone Reduction in Patients With Rheumatoid Arthritis on Background RoActemra/Actemra (Tocilizumab) (ACT-ALONE)

Rheumatoid Arthritis

Belgium
GlaxoSmithKline
University of California, Los Angeles; Kaiser Permanente

Completed

Post-marketing Safety Study of GSK Biological's Pediarix™ Vaccine

Hepatitis B | Tetanus | Diphtheria | Acellular Pertussis | Poliomyelitis
Globus Medical Inc

Withdrawn

Patient Outcomes Using an Expandable Spacer

Degenerative Disc Disease

United States
ModernaTX, Inc.

Active, not recruiting

Study of mRNA-1010 Seasonal Influenza Vaccine in Adults (IGNITE P303)

Seasonal Influenza

United States
ModernaTX, Inc.

Completed

A Study of mRNA-1010 Seasonal Influenza Vaccine in Adults 50 Years Old and Older

Seasonal Influenza

Spain, United States, Denmark, Poland, United Kingdom, Germany, Canada, Taiwan, Bulgaria, Netherlands, Estonia
ModernaTX, Inc.

Completed

A Study of mRNA-1010 Seasonal Influenza Vaccine in Adults

Seasonal Influenza

Philippines, Australia, Colombia, Argentina, Panama
Pfizer

Completed

A Study to Describe the Immunogenicity, Safety, and Tolerability of Neisseria Meningitidis Serogroup B Bivalent Recombinant Lipoprotein 2086 Vaccine (Bivalent rLP2086) in Healthy Subjects Aged ≥24 Months to <10 Years

MENINGOCOCCAL INFECTION

Finland, Poland
Ludwig-Maximilians - University of Munich

Completed

Acute Application of Pegvisomant and Octreotide in Acromegaly

Acromegaly

Germany
Genzyme, a Sanofi Company
Bioenvision

Completed

A Phase II, Open-Label Study of Clofarabine in Paediatric Patients With Refractory/Relapsed Acute Lymphoblastic Leukaemia

Acute Lymphoblastic Leukemia

France, Germany, United Kingdom, Netherlands, Italy, Austria
Genentech, Inc.
Hoffmann-La Roche

Recruiting

A Study Evaluating the Safety, Pharmacokinetics, and Activity of Cevostamab in Participants With Relapsed or Refractory Multiple Myeloma (CAMMA 1)

Multiple Myeloma

Korea, Republic of, United States, Denmark, Italy, Spain, France, Japan, Israel, United Kingdom, Poland, Australia, Czechia, Canada
Hoffmann-La Roche

Completed

A Study of Tocilizumab (RoActemra/Actemra) in Monotherapy or in Combination With Methotrexate or Other Non-Biologic DMARDs in Participants With Active Rheumatoid Arthritis and an Inadequate Response to Current Non-Biologic DMARD Therapy or the First Anti-TNF Biologic Agent (ACT-MOVE)

Rheumatoid Arthritis

United Kingdom
Brian Miller

Completed

An Open-Label Trial of Tocilizumab in Schizophrenia

Schizophrenia

United States
Celltrion

Completed

A Phase I Study to Evaluate the Safety and Pharmacokinetics of CT-P41 and EU-approved Prolia in Healthy Male Subjects

Healthy Male Subjects

Australia
Emory University
National Cancer Institute (NCI)

Withdrawn

Tocilizumab for the Treatment of Cytokine Release Syndrome in Patients With COVID-19 (SARS-CoV-2 Infection)

Coronary Artery Disease | Diabetes Mellitus | Chronic Obstructive Pulmonary Disease | Cerebrovascular Accident | Chronic Renal Failure | Malignant Neoplasm | SARS Coronavirus 2 Infection

United States
Hoffmann-La Roche

Completed

A Study With Tocilizumab [RoActemra/Actemra] Monotherapy or in Combination With Methotrexate in Patients With Rheumatoid Arthritis (PICTURE)

Rheumatoid Arthritis

Egypt
Rigshospitalet, Denmark

Completed

IL-6 Regulation of Substrate Metabolism and Influence of Obesity

Healthy | Obesity

Denmark
CureVac

Completed

A Phase 2b/3, Randomized, Observer-Blinded, Placebo-Controlled, Multicenter Clinical Study Evaluating the Efficacy and Safety of Investigational SARS-CoV-2 mRNA Vaccine CVnCoV in Adults 18 Years of Age and Older

Covid19 | SARS-CoV-2

Belgium, Spain, Germany, Argentina, Colombia, Dominican Republic, Mexico, Netherlands, Panama, Peru
Emory University
National Cancer Institute (NCI)

Recruiting

Venetoclax and Tocilizumab for the Treatment of Patients With Relapsed or Refractory t(11;14) Multiple Myeloma

Refractory Plasma Cell Myeloma | Recurrent Plasma Cell Myeloma

United States

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