Search clinical trials for: Autologous Tumor Infiltrating Lymphocytes

Total 363 results

NeogenTC

Not yet recruiting

TIL Therapy for Patients With Advanced Solid Tumors

Advanced Breast Cancer | Advanced Lung Cancer
Children's National Research Institute

Active, not recruiting

Research Study Utilizing Expanded Multi-antigen Specific Lymphocytes for the Treatment of Solid Tumors (REST)

Solid Tumors

United States
Dana-Farber Cancer Institute

Completed

Adoptive Transfer of MART1/Melan-A CTL for Malignant Melanoma

Melanoma (Skin)

United States
Sheba Medical Center

Recruiting

A Phase 2, Single-Center, Open Label Study of Autologous, Adoptive Cell Therapy Following a Reduced Intensity, Non-myeloablative, Lymphodepleting Induction Regimen in Metastatic Urothelial Carcinoma Patients

Metastatic Urothelial Carcinoma

Israel
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Ex Vivo-activated Autologous Lymph Node Lymphocytes in Treating Patients With Chronic Lymphocytic Leukemia

Anemia | Weight Loss | Thrombocytopenia | Fever | Chronic Lymphocytic Leukemia | Lymphadenopathy | Prolymphocytic Leukemia | Richter Syndrome | Cancer Fatigue | Recurrent Chronic Lymphocytic Leukemia | Lymphocytosis | Infectious Disorder | Night Sweats | Secondary Malignant Neoplasm

United States
National Cancer Institute (NCI)

Completed

Vaccine Therapy and Biological Therapy in Treating Patients With Advanced Cancer

Cervical Cancer | Breast Cancer | Colorectal Cancer | Pancreatic Cancer | Ovarian Cancer | Lung Cancer

United States
Gangnam Severance Hospital

Recruiting

Investigator-initiated Pilot Study to Investigate the Efficacy and Safety of Immuncell-LC in Combination With Nivolumab (Opdivo) in Subjects With Advanced or Recurrent Gastric Cancer

Gastro-esophageal Junction Cancer | Relapsed or Advanced Gastric Adenocarcinoma

Korea, Republic of
Case Comprehensive Cancer Center
National Cancer Institute (NCI)

Terminated

Ex Vivo-Activated Lymph Node Lymphocytes in Treating Patients With Stage IIIC-IV Melanoma

Stage IIIC Skin Melanoma | Stage IV Melanoma

United States
H. Lee Moffitt Cancer Center and Research Institute

Recruiting

Clinical Trial of CD40L-Augmented TIL for Patients With EGFR, ALK, ROS1 or HER2-Driven NSCLC

Non Small Cell Lung Cancer | Stage IV Non-small Cell Lung Cancer | Recurrent Non Small Cell Lung Cancer

United States
Jonsson Comprehensive Cancer Center
National Cancer Institute (NCI)

Completed

Biological Therapy in Treating Patients With Prostate Cancer

Prostate Cancer

United States
Vastra Gotaland Region
Miltenyi Biomedicine GmbH

Recruiting

Hepatic Arterial Infusion of Autologous Tumor Infiltrating Lymphocytes in Patients With Melanoma and Liver Metastases (HAITILS)

Metastatic Cutaneous Melanoma | Metastatic Uveal Melanoma

Sweden
Vastra Gotaland Region

Not yet recruiting

Locoregional Administration of TIL and Lymphodepletion in Patients With Melanoma and Liver Metastases (HAITILS-PHP)

Metastatic Cutaneous Melanoma | Uveal Melanoma
Milton S. Hershey Medical Center

Unknown

Vaccine Therapy and Interleukin-2 in Treating Young Patients With Relapsed or Refractory Ewing's Sarcoma or Neuroblastoma

Sarcoma | Neuroblastoma

United States
Eutilex

Recruiting

A Multi-center, Single-arm, Open, Phase I/IIa Clinical Trial to Evaluate the Efficacy and Safety of EBViNT Cell (EBV Specific Autologous CD8+ T Cell) in Patients With Treatment Failed Epstein Barr Virus (EBV)-Positive Malignancies

EBV Associated Extranodal NK/T-cell Lymphoma | EBV-Associated GastricCarcinoma or Esophageal AdenoCarcinoma

Korea, Republic of
H. Lee Moffitt Cancer Center and Research Institute
Bristol-Myers Squibb; Stand Up To Cancer; Iovance Biotherapeutics, Inc.; Prometheus...

Completed

Nivolumab and Tumor Infiltrating Lymphocytes (TIL) in Advanced Non-Small Cell Lung Cancer

Non-Small Cell Lung Cancer | Adenocarcinomas | Squamous Cell Carcinoma | Advanced NSCLC | Metastatic Non-small Cell Lung Cancer | Adenosquamous Carcinoma

United States
Tianjin Medical University Cancer Institute and...

Unknown

Study of Autologous Cytotoxic T Lymphocyte Immunotherapy Combination With PD-1 Inhibitor in the Advanced NSCLC

Non-small Cell Lung Cancer | Second-line Treatment

China
Baylor College of Medicine
The Methodist Hospital Research Institute; Center for Cell and Gene Therapy...

Terminated

Administration of CMV-Specific Cytotoxic T Cells in Patients With Glioblastoma Multiforme (COGLI)

Brain Cancer | Glioblastoma Multiforme | GBM

United States
Northwestern University
National Cancer Institute (NCI)

Completed

Peripheral Blood Lymphocyte Therapy to Prevent Lymphoproliferative Disorders Caused by Epstein-Barr Virus in Patients Who Have Undergone Transplantation

Lymphoma | Leukemia | Multiple Myeloma and Plasma Cell Neoplasm

United States
Catherine Bollard
Johns Hopkins University; Children's National Research Institute

Recruiting

Multi-institutional Prospective Research of Expanded Multi-antigen Specifically Oriented Lymphocytes for the Treatment of VEry High Risk Hematopoietic Malignancies (RESOLVE)

Relapsed/Refractory Hematopoietic Malignancies, Acute Myeloid Leukemia and MDS

United States
Quanli Gao

Recruiting

L-TIL Plus Tislelizumab for PD1 Antibody Resistant aNSCLC

Non-small Cell Lung Cancer

China
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Cellular Adoptive Immunotherapy Using Genetically Modified T-Lymphocytes in Treating Patients With Recurrent or Refractory High-Grade Malignant Glioma

Brain and Central Nervous System Tumors
Immetacyte Ltd

Withdrawn

OVSTAR TIL Trial (OVarian Cancer Co-STimulatory Antigen Receptor TIL Trial) (OVSTAR)

Ovarian Cancer Metastatic

United Kingdom
Gary Archer Ph.D.
National Cancer Institute (NCI)

Completed

Vaccine Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme (ATTAC)

Malignant Neoplasms of Brain

United States
University of Maryland, Baltimore
University of Maryland Greenebaum Cancer Center

Completed

Chemotherapy and Peripheral Stem Cell Transplantation Followed By Immunotherapy in Treating Patients With Multiple Myeloma

Infection | Multiple Myeloma and Plasma Cell Neoplasm

United States
Agenus Inc.

Completed

Survival Study Of Oncophage® vs. Observation In Patients With Kidney Cancer

Renal Cell Carcinoma

United States, France, Poland, United Kingdom, Spain, Israel, Canada, Belgium, Norway, Sweden, Austria
Roswell Park Cancer Institute
National Cancer Institute (NCI)

Withdrawn

Specialized Immune Cells (nCTLs) and a Vaccine (Alpha-type-1 Polarized Dendritic Cells) in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Stage III Fallopian Tube Cancer AJCC v8 | Stage III Ovarian Cancer AJCC v8 | Stage III Primary Peritoneal Cancer AJCC v8 | Stage IIIA Fallopian Tube Cancer AJCC v8 | Stage IIIA Ovarian Cancer AJCC v8 | Stage IIIA Primary Peritoneal Cancer AJCC v8 | Stage IIIA1 Fallopian Tube Cancer AJCC v8 | Stage... and other conditions

United States
Newish Technology (Beijing) Co., Ltd.
Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Recruiting

NewishT Cell Therapy for HCC With High Risk of Recurrence After Radical Resection

Hepatocellular Carcinoma

China
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Laboratory Treated T Cells in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Non-Hodgkin Lymphoma, or Acute Lymphoblastic Leukemia

Recurrent Mantle Cell Lymphoma | Recurrent Adult Acute Lymphoblastic Leukemia | Recurrent Small Lymphocytic Lymphoma | Recurrent Diffuse Large B-Cell Lymphoma | Refractory Diffuse Large B-Cell Lymphoma | Refractory Chronic Lymphocytic Leukemia | Recurrent Non-Hodgkin Lymphoma | Refractory Non-Hodgkin... and other conditions

United States
Sidney Kimmel Comprehensive Cancer Center at Johns...
National Cancer Institute (NCI)

Completed

Activated White Blood Cells With ASCT for Newly Diagnosed Multiple Myeloma

Multiple Myeloma and Plasma Cell Neoplasm

United States
National Cancer Institute (NCI)

Completed

Therapy to Treat Ewing's Sarcoma, Rhabdomyosarcoma or Neuroblastoma

Sarcoma | Neuroectodermal Tumors, Primitive, Peripheral | Neuroblastoma | Rhabdomyosarcoma-Embryonal | Rhabdomyosarcoma- Alveolar

United States
Erasmus Medical Center

Completed

Dendritic Cell-based Immunotherapy in Mesothelioma

Malignant Pleural Mesothelioma

Netherlands
Anosys

Suspended

Immunotherapy With Autologous Dexosomes for Patients With Stage IV Melanoma

Melanoma
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Terminated

Genetically Modified T-Cell Therapy in Treating Patients With Advanced ROR1+ Malignancies

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm | Recurrent Mantle Cell Lymphoma | Metastatic Lung Non-Small Cell Carcinoma | Refractory Chronic Lymphocytic Leukemia | Stage IIIA Lung Non-Small Cell Cancer AJCC v7 | Recurrent Acute Lymphoblastic Leukemia | Metastatic Triple-Negative... and other conditions

United States
Clinica Universidad de Navarra, Universidad de...
Spanish National Health System

Unknown

Rituximab and Autologous Effector Lymphocytes in Non-Hodgkin Follicular Lymphoma in Response to First Line Chemotherapy

Follicular Lymphoma | Follicular Non-Hodgkin´s Lymphoma | Autologous Effector Lymphocytes

Spain
University Hospital Erlangen
University Hospital, Essen; University Hospital Tuebingen; Universitätsklinikum... and other collaborators

Active, not recruiting

Dendritic Cells Plus Autologous Tumor RNA in Uveal Melanoma

Uveal Melanoma

Germany
Dartmouth-Hitchcock Medical Center
National Cancer Institute (NCI)

Completed

Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma

Melanoma (Skin)

United States
Dermatologische Klinik MIT Poliklinik-Universitaetsklinikum...

Unknown

Vaccine Therapy in Treating Patients With Stage IV Melanoma

Melanoma (Skin)

Germany
National Institutes of Health Clinical Center (CC)
National Cancer Institute (NCI)

Completed

Gene-Modified White Blood Cells Followed By Interleukin-2 and Vaccine Therapy in Treating Patients With Metastatic Melanoma

Melanoma (Skin)

United States
M.D. Anderson Cancer Center
Bristol-Myers Squibb; National Cancer Institute (NCI); Iovance Biotherapeutics

Active, not recruiting

Autologous Tumor Infiltrating Lymphocytes MDA-TIL in Treating Patients With Recurrent or Refractory Ovarian Cancer, Colorectal Cancer, or Pancreatic Ductal Adenocarcinoma

Malignant Solid Neoplasm | Metastatic Colorectal Adenocarcinoma | Stage IV Colorectal Cancer AJCC v8 | Stage IVA Colorectal Cancer AJCC v8 | Stage IVB Colorectal Cancer AJCC v8 | Stage IVC Colorectal Cancer AJCC v8 | Platinum-Resistant Ovarian Carcinoma | Metastatic Pancreatic Ductal Adenocarcinoma | Metastatic Ovarian Carcinoma and other conditions

United States
University of Medicine and Dentistry of New Jersey

Unknown

Papilloma Virus Vaccine Therapy in Treating Young Patients With Recurrent Papilloma of the Larynx

Precancerous Condition

United States
National Cancer Institute (NCI)

Terminated

Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Melanoma

Skin Cancer | Metastatic Melanoma

United States
National Center for Research Resources (NCRR)
Duke University

Unknown

A Safety and Feasibility Study of Active Immunotherapy in Patients With Metastatic Prostate Carcinoma Using Autologous Dendritic Cells Pulsed With Antigen Encoded in Amplified Autologous Tumor RNA

Prostate Cancer

United States
University Health Network, Toronto

Completed

TILs & Low-Dose IL-2 Therapy Following Cyclophosphamide and Fludarabine in Pleural Mesothelioma Patients

Pleural Mesothelioma

Canada
National Cancer Institute (NCI)

Completed

Phase II Study of Metastatic Melanoma With Lymphodepleting Conditioning and Infusion of Anti-MART-1 F5 TCR-Gene-Engineered Lymphocytes

Melanoma | Skin Cancer

United States
Roswell Park Cancer Institute

Completed

Vaccine Therapy in Treating Patients With Non-Small Cell Lung Cancer

Lung Cancer

United States
H. Lee Moffitt Cancer Center and Research Institute

Active, not recruiting

Lymphodepletion Plus Adoptive Cell Transfer With High Dose IL-2 in Patients With Metastatic Melanoma

Metastatic Melanoma

United States
Hadassah Medical Organization

Unknown

Autologous and Allogeneic Whole Cell Cancer Vaccine for Metastatic Tumors

Melanoma | Kidney Cancer | Breast Cancer | Gastric Cancer | Colorectal Cancer | Ovarian Cancer | Lung Cancer

Israel
Roger Williams Medical Center
Beth Israel Deaconess Medical Center

Completed

Gene Therapy in Treating Patients With Cancer

Cancer

United States
Boston Medical Center

Terminated

Vaccine Therapy in Treating Patients With Acute Myeloid Leukemia

Leukemia

United States
Beijing Tiantan Hospital
Tasly Pharmaceutical Group Co., Ltd; Beijing Neurosurgical Institute

Recruiting

Tris-CAR-T Cell Therapy for Recurrent Glioblastoma

Recurrent Glioblastoma

China

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