Search clinical trials for: Autologous regulatory T cell product

Total 2908 results

Xuzhou Medical University

Not yet recruiting

Safety and Efficacy of Treg Cell in the Treatment of GVHD

GVHD
The Nordic Network For Clinical Islet Transplantation

Active, not recruiting

Infusion of Autologous T Regulatory Cells (T Reg) at the Time of Transplantation of Allogenic Islets of Langerhans

Type1diabetes

Sweden
Ain Shams University

Not yet recruiting

Autologous Adoptive T Regulatory Cell Transfer in Autoimmune Diseases.

Type 1 Diabetes Mellitus | Lupus Nephritis

Egypt
Guy's and St Thomas' NHS Foundation Trust
King's College London

Completed

Safety and Efficacy Study of Regulatory T Cell Therapy in Liver Transplant Patients (ThRIL)

End-stage Liver Disease

United Kingdom
King's College Hospital NHS Trust

Recruiting

Autologous Tregs for Aplastic Anaemia (TIARA)

Aplastic Anemia

United Kingdom
National Institute of Allergy and Infectious Diseases...
Autoimmunity Centers of Excellence

Terminated

Autologous Polyclonal Tregs for Lupus

Lupus Erythematosus, Systemic | Lupus Erythematosus, Cutaneous | Lupus Erythematosus, Discoid

United States
Laura Johnston
National Institutes of Health (NIH)

Completed

Phase 1 Infused Donor T Regulatory Cells in Steroid Dependent/Refractory Chronic GVHD

Graft Versus Host Disease | Allogeneic Hematopoietic Cell Transplant Recipient

United States
Guy's and St Thomas' NHS Foundation Trust
King's College London

Completed

The ONE Study UK Treg Trial (ONETreg1)

End-stage Renal Failure

United Kingdom
Everett Meyer
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health...

Completed

Phase 1-2 MAHCT w/ TCell Depleted Graft w/ Simultaneous Infusion Conventional and Regulatory T Cell

Lymphoma, Non-Hodgkin | Acute Myeloid Leukemia | Acute Leukemia | Acute Myelogenous Leukemia | Chronic Myelogenous Leukemia | Myelodysplastic Syndromes (MDS) | Acute Lymphoblastic Leukemia (ALL) | Myeloid Leukemia, Chronic | Myeloproliferative Syndrome

United States
Assistance Publique - Hôpitaux de Paris

Suspended

Treatment of the Bilateral Severe Uveitis by IVT of Regulator T-cells: Study of Tolerance of Dose (UVEREG)

Uveitis

France
John Lister
Miltenyi Biotec, Inc.; Lentigen Technology, Inc.; AHN (Allegheny Health Network)...

Recruiting

Local Manufacture of CAR T-Cell Products for the Treatment of B-Cell Lymphoma and B-Acute Lymphoblastic Leukemia

Follicular Lymphoma | Mantle Cell Lymphoma | Marginal Zone Lymphoma | Chronic Lymphocytic Leukemia | Lymphoplasmacytic Lymphoma | Diffuse Large B Cell Lymphoma | B Acute Lymphoblastic Leukemia | B-Cell Lymphoma | Transformed Lymphoma

United States
King's College London
Imperial College London; Medical Research Council; Guy's and St Thomas' NHS Foundation... and other collaborators

Unknown

Treg Immunotherapy in Crohn's Disease (TRIBUTE)

Crohn Disease
Massachusetts General Hospital
Dana-Farber Cancer Institute; University of Regensburg

Completed

Infusion of T-Regulatory Cells in Kidney Transplant Recipients (The ONE Study)

Kidney Failure, Kidney Transplant

United States
Assiut University

Not yet recruiting

T Regulatory Cells IN LUPUS NEPHRITIS

Lupus Nephritis
Mario Arpinati
European Commission

Recruiting

Multiple Donor Treg DLI for Severe Refractory Chronic GVHD (TREG2015001)

Chronic Graft Versus Host Disease

Italy
University of Erlangen-Nürnberg Medical School

Completed

Autologous Ex Vivo Expanded Regulatory T Cells in Ulcerative Colitis

Autoimmune Diseases | Ulcerative Colitis

Germany
Stanford University

Withdrawn

Safety of T Regulatory Cell Therapy in Subjects With COVID-19 Induced Acute Respiratory Distress Syndrome

Covid19 | Acute Respiratory Distress Syndrome

United States
Fundación Pública Andaluza para la gestión de la...

Recruiting

Donor Regulatory T-cells for cGVHD in Patients Who do Not Obtain Complete Remission With Ruxolitinib (Treg4GVHD)

Chronic Graft vs Host Disease

Spain
Fundación Pública Andaluza para la gestión de la...

Completed

Donor Regulatory T-cells for Steroid-Refractory Chronic Graft-versus-host-Disease (GVHD-TReG)

Chronic Graft vs Host Disease

Spain
Eureka Therapeutics Inc.

Terminated

Study of ET140203 T Cells in Adults With Advanced Hepatocellular Carcinoma (ARYA-1)

Hepatocellular Carcinoma | Liver Neoplasm | Liver Cancer | Metastatic Liver Cancer

United States
Eureka Therapeutics Inc.

Terminated

Study of ET140202 T Cells in Adults With Advanced Hepatocellular Carcinoma (ET-109)

Hepatocellular Carcinoma | Liver Neoplasm | Liver Cancer | Metastatic Liver Cancer

United States
Loma Linda University

Recruiting

Dd-cfDNA and Treg in Prediction of Kidney Transplant Acute Rejection

Graft Failure | Acute Rejection of Renal Transplant

United States
University of California, San Francisco
National Institute of Allergy and Infectious Diseases (NIAID); Juvenile Diabetes...

Completed

T1DM Immunotherapy Using CD4+CD127lo/-CD25+ Polyclonal Tregs (Treg)

Type 1 Diabetes Mellitus

United States
Masonic Cancer Center, University of Minnesota

Terminated

Donor T Cells in Treating Patients With High-Risk Hematologic Cancer Undergoing Donor Peripheral Blood Stem Cell Transplant

Lymphoma | Myelodysplastic Syndromes | Leukemia | Multiple Myeloma and Plasma Cell Neoplasm | Graft Versus Host Disease

United States
University of Alberta
Juvenile Diabetes Research Foundation; Diabetes Research Institute Foundation; Alberta Diabetes Institute and other collaborators

Active, not recruiting

PolyTreg Immunotherapy in Islet Transplantation

Diabetes | Diabetes Mellitus, Type 1

Canada
Assistance Publique - Hôpitaux de Paris
Pierre and Marie Curie University; Université Paris XII

Completed

Amplifying Graft-Versus-Tumor Effect by Donor Regulatory T-Cell Depletion Before Donor Lymphocytes Infusion (ILD-Treg)

Hematologic Neoplasms | Relapse

France
Nanjing Medical University

Unknown

Safety and Efficacy Study of Regulatory T Cells in Treating Autoimmune Hepatitis (Treg)

Autoimmune Diseases
Zhejiang University
Yake Biotechnology Ltd.

Recruiting

Autologous Hematopoietic Stem Cell Transplantation Combined With CAR-T Cells in the Treatment of Refractory and Relapsed Malignant Lymphoma

Lymphoma

China
Nanjing Medical University
University of Minnesota

Unknown

Safety Study of Using Regulatory T Cells Induce Liver Transplantation Tolerance (Treg)

Chronic Rejection of Liver Transplant

China
Mustang Bio

Enrolling by invitation

Long-term Follow-up Study in Patients Previously Treated With a Mustang Bio CAR-T Cell Investigational Product.

Diffuse Large B Cell Lymphoma | Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) | Hairy Cell Leukemia | Mantle Cell Lymphoma Recurrent | Mantle Cell Lymphoma Refractory | Chronic Lymphocytic Leukemia in Relapse | Small Lymphocytic Lymphoma, Relapsed | Waldenstrom's Macroglobulinemia Recurrent | Follicular B-cell Non-Hodgkin's Lymphoma and other conditions

United States
PersonGen BioTherapeutics (Suzhou) Co., Ltd.
Anhui Provincial Hospital

Recruiting

CAR-T CD19/CD20 for Patients With Advanced CD19/CD20+ B Cell Line Recurrent or Refractory Hematological Malignancies

CAR

China
National Institute of Allergy and Infectious Diseases...
Rho Federal Systems Division, Inc.; Autoimmunity Centers of Excellence

Terminated

Polyclonal Regulatory T Cells (PolyTregs) for Pemphigus

Pemphigus Vulgaris | Pemphigus Foliaceus

United States
Everett Meyer
National Cancer Institute (NCI)

Withdrawn

Donor Regulatory T Cells in Treating Patients With Visceral Acute Graft-versus-Host Disease After Stem Cell Transplant

Graft Versus Host Disease

United States
Beijing GoBroad Hospital

Not yet recruiting

CD5 Chimeric Antigen Receptor (CAR) T Cells in Subjects With Relapsed or Refractory T-Cell Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia, in Relapse | Refractory Acute Lymphoblastic Leukemia | T-Cell Acute Lymphocytic Leukemia
Instituto de Medicina Molecular João Lobo Antunes
Hospital de Santa Maria, Portugal; IPOFG Lisboa, Portugal; IPOFG Porto, Portugal

Unknown

A Phase 1/2 Trial of Donor Regulatory T-cells for Steroid-Refractory Chronic Graft-versus-Host-Disease (TREGeneration)

Graft vs Host Disease

Portugal
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

REGulatory T Cells in Autism Induced by Maternal Immune Activation (REGAIN)

Autism Spectrum Disorder

France
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Terminated

Genetically Modified T-Cell Therapy in Treating Patients With Advanced ROR1+ Malignancies

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm | Recurrent Mantle Cell Lymphoma | Metastatic Lung Non-Small Cell Carcinoma | Refractory Chronic Lymphocytic Leukemia | Stage IIIA Lung Non-Small Cell Cancer AJCC v7 | Recurrent Acute Lymphoblastic Leukemia | Metastatic Triple-Negative... and other conditions

United States
The First Affiliated Hospital of Soochow University
Shanghai Unicar-Therapy Bio-medicine Technology Co.,Ltd; Suzhou Hongci Hematology...

Recruiting

Clinical Study of CAR-T Cell Therapy Following ASCT for R/R B-cell Non-Hodgkin's Lymphoma

Lymphoma, B-Cell | Autologous Stem Cell Transplantation

China
University of Pennsylvania

Completed

Autologous Redirected RNA Meso-CIR T Cells

Malignant Pleural Mesothelioma

United States
Michael Sekela

Completed

Stem Cell Heart Injections During Laser Revascularization Surgery for Treatment of Chronic Ischemic Heart Disease

Chronic Ischemic Heart Disease

United States
Peking University
CARsgen Therapeutics Co., Ltd.

Recruiting

Claudin18.2-redirected Chimeric Antigen Receptor T Cells With Co-expression of Cytokines in Solid Tumors

Pancreatic Cancer | Gastric Adenocarcinoma | Gastroesophageal Junction Adenocarcinoma

China
Hebei Senlang Biotechnology Inc., Ltd.
Hebei Yanda Ludaopei Hospital; Beijing Lu Daopei Hospital

Recruiting

CAR-T Cells for Relapsed or Refractory Haematopoietic and Lymphoid Malignancies

Lymphoma | Leukemia | Multiple Myeloma of Bone (Diagnosis)

China
Jeffrey Bluestone
National Institute of Allergy and Infectious Diseases (NIAID); Immune Tolerance...

Terminated

Tregs for the Treatment of Acute Respiratory Distress Syndrome (ARDS) Associated With COVID-19 (regARDS) (regARDS)

Acute Respiratory Distress Syndrome Due to Disease Caused by 2019-nCoV

United States
VTBIO Co. LTD
BHT Lifescience Austrailia Pty Ltd.

Unknown

A Safety and Tolerability Study of GB301

Alzheimer Disease

Australia
Adaptimmune

Completed

MAGE A10ᶜ⁷⁹⁶T for Advanced NSCLC

Carcinoma | Non-Small Cell Lung Cancer

United States, Spain, United Kingdom, Canada
University of Pennsylvania

Completed

Autologous CD4 T-Cells in HIV (C34-CXCR4)

Hiv

United States
Beijing GoBroad Hospital

Recruiting

Autologous and Donor-derived CD7 CAR-T Therapy in Refractory or Relapsed T-cell Acute Lymphoblastic Leukemia/Lymphoma

Acute Lymphoblastic Leukemia, in Relapse | Refractory Acute Lymphoblastic Leukemia | T-cell Acute Lymphoblastic Leukemia

China
The Affiliated Hospital of Qingdao University

Not yet recruiting

Safety, Efficacy and Pharmacokinetics of XKDCT023 in DLBCL

Diffuse Large B Cell Lymphoma
Cogent Biosciences, Inc.

Terminated

Long-Term Follow-Up Study of Subjects Treated With ACTR T Cell Product

Multiple Myeloma | Solid Tumor | HER-2 Protein Overexpression | B Cell Lymphomas

United States
The First Affiliated Hospital of Nanchang University

Unknown

Humanized CAR-T Cells of Anti-BCAM and Anti-CD19 Against Relapsed and Refractory Multiple Myeloma

Relapsed or Refractory Multiple Myeloma

China

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