Search clinical trials for: BMN190 recombinant human tripeptidyl peptidase-1 (rhTPP1)

Total 296 results

BioMarin Pharmaceutical

Approved for marketing

A Multicenter, Multi-national Open-label Program to Provide BMN 190 to Patients Diagnosed With CLN2 Disease

CLN2 Disease

United Kingdom, United States, Germany, Italy
BioMarin Pharmaceutical

Completed

A Safety, Tolerability, and Efficacy Study of Intracerebroventricular BMN 190 in Pediatric Patients < 18 Years of Age With CLN2 Disease

Batten Disease | CLN2 Disease | Late-Infantile Neuronal Ceroid Lipofuscinosis Type 2 | Jansky-Bielschowsky Disease | CLN2 Disorder

United States, Germany, Italy, United Kingdom
BioMarin Pharmaceutical

Completed

A Phase 1/2 Open-Label Dose-Escalation Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Efficacy of Intracerebroventricular BMN 190 in Patients With Late-Infantile Neuronal Ceroid Lipofuscinosis (CLN2) Disease

Batten Disease | CLN2 Disease | Late-Infantile Neuronal Ceroid Lipofuscinosis Type 2 | Jansky-Bielschowsky Disease

United States, Italy, Germany, United Kingdom
BioMarin Pharmaceutical

Completed

An Extension Study to Evaluate the Long-Term Efficacy and Safety of BMN 190 in Patients With CLN2 Disease

Batten Disease | CLN2 Disease | Late-Infantile Neuronal Ceroid Lipofuscinosis Type 2 | Jansky-Bielschowsky Disease | CLN2 Disorder

United States, Germany, Italy, United Kingdom
Peking Union Medical College
Shenyang Sunshine Pharmaceutical Co., LTD.

Unknown

Efficacy and Safety Study of Maintenance Treatment With rhTPO in Thrombocytopenic Subjects With ITP

Thrombocytopenia | Immune Thrombocytopenia | Idiopathic Thrombocytopenic Purpura

China
Shandong University
Shandong Provincial Hospital; The First Affiliated Hospital of Dalian Medical...

Completed

An Investigation of rhTPO With Different Frequencies in the Management of ITP

Immune Thrombocytopenia

China
Tianjin Medical University General Hospital

Unknown

Efficacy and Safety of Thrombopoietin In Patients With Severe and Very Severe Aplastic Anemia

Anemia, Aplastic

China
Nanfang Hospital of Southern Medical University
First Affiliated Hospital, Sun Yat-Sen University; Guangdong Provincial People... and other collaborators

Unknown

Efficacy and Safety of rHuTPO on Platelet Engraftment After Allo-HSCT (TPO)

Allogeneic Hematopoietic Stem Cell Transplantation | Myeloablative | Delayed Platelet Engraftment

China
Institute of Hematology & Blood Diseases Hospital

Completed

Efficacy and Safety of rhTPO for the Treatment of Thrombocytopenia After Chemotherapy in AML Patients

Thrombocytopenia

China
Chinese Society of Lung Cancer

Terminated

Clinical Trial on the Prevention of Thrombocytopenia After First-line Chemotherapy

Carcinoma, Non-Small-Cell Lung

China
First Affiliated Hospital Xi'an Jiaotong University
Shenyang Pharmaceutical University

Unknown

High-dose Use of rhTPO in CIT Patients (HUrhTPOCITP)

Thrombocytopenia

China
Shandong University
Peking University People's Hospital; The Affiliated Hospital of Qingdao University and other collaborators

Unknown

Recombinant Human Thrombopoietin(rhTPO) in Pregnancy With Immune Thrombocytopenia

Immune Thrombocytopenia

China
Shenyang Sunshine Pharmaceutical Co., LTD.

Unknown

The Tolerability，Safety，PK/PD Study of rhTPO in the Patients With Liver Function Impairment

Liver Cirrhosis

China
The First Affiliated Hospital of Dalian Medical...
Cancer Institute and Hospital, Chinese Academy of Medical Sciences; Chinese... and other collaborators

Recruiting

Efficacy and Safety of rhTPO's Prophylactic Treatment of CTIT in Patients With High Risk of Cardiac Injury (Circular)

Cancer Treatment Induced Thrombocytopenia

China
Institute of Hematology & Blood Diseases Hospital...
Xijing Hospital; Xi'an Central Hospital; The Second Hospital of Hebei Medical... and other collaborators

Active, not recruiting

A Randomized Trial Comparing Optimized rhTPO Treatment With Eltrombopag Treatment in Pre-treated ITP Pts (TE-ITP)

Previously Treated Primary Immune Thrombocytopenia

China
Shandong University
The First Affiliated Hospital of Anhui Medical University; The Affiliated Hospital... and other collaborators

Completed

rhTPO Combining Rituximab Versus Low-dose Rituximab in Management of ITP

Purpura | Idiopathic Thrombocytopenic Purpura

China
Ruilan Wang
Changhai Hospital; Shanghai Jiao Tong University School of Medicine; Shanghai... and other collaborators

Recruiting

The Effect of REcombinant Human Thrombopoietin (rhTPO) on Sepsis Patients With aCUte Severe thrombocytopEnia (RESCUE)

Sepsis | Thrombocytopenia

China
Shenyang Sunshine Pharmaceutical Co., LTD.

Not yet recruiting

A Phase Ib Clinical Study for rhTPO in the Treatment of Thrombocytopenia in Patients With Chronic Liver Disease

Thrombocytopenia | Liver Disease Chronic

China
Ming Hou
Peking Union Medical College Hospital; Cancer Institute and Hospital, Chinese... and other collaborators

Completed

Recombinant Human Thrombopoietin in Combination With Rituximab in Immune Thrombocytopenia (ITP)

Purpura | Idiopathic Thrombocytopenic Purpura

China
Daiichi Sankyo, Inc.

Completed

Evaluation of the Effects of Carperitide in Patients With Congestive Heart Failure

Heart Failure, Congestive | Heart Decompensation | Left Ventricular Failure | Myocardiopathies | Systolic or Diastolic Left Ventricular Dysfunction

United States, Canada
Digna Biotech S.L.

Unknown

Clinical Trial to Assess the Safety, Tolerability and Pharmacokinetics of Cardiotrophin-1 in Healthy Volunteers

Healthy

Spain
The First Affiliated Hospital of Zhengzhou University
Jiangsu HengRui Medicine Co., Ltd.

Not yet recruiting

A Clinical Study of Herombopag in Tumors-associated Thrombocytopenia

Tumor Therapy-related Thrombocytopenia
Zensun Sci. & Tech. Co., Ltd.

Recruiting

Evaluation of the Effect of Injectable Neucardin on Cardiac Function and Reversal Ventricular Remodeling in Patients With Chronic Systolic Heart Failure

Chronic Systolic Heart Failure

China
Shandong University
China Medical University, China; The Affiliated Hospital of the Chinese Academy... and other collaborators

Withdrawn

Recombinant Human Thrombopoietin (rhTPO) Combining Rituximab Versus High-dose Dexamethasone for Initial Treatment of Primary Immune Thrombocytopenia (ITP)

Purpura | Idiopathic Thrombocytopenic Purpura

China
Shandong University
China Medical University, China; The Affiliated Hospital of the Chinese Academy... and other collaborators

Completed

rhTPO Combining Dexamethasone Versus High-dose Dexamethasone for Initial Treatment of ITP

Purpura | Idiopathic Thrombocytopenic Purpura

China
EMD Serono

Terminated

Onercept in the Treatment and Re-Treatment of Subjects With Moderate to Severe Plaque Psoriasis

Arthritis, Psoriatic

United States, Canada
Sichuan Clover Biopharmaceuticals, Inc.

Recruiting

A Clinical Trial Evaluating SCB-219M in in Chemotherapy-induced Thrombocytopenia (CIT)

Chemotherapy-induced Thrombocytopenia (CIT)

China
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

2018-0674 - IL-7 for T-Cell Recovery Post Haplo and CB Transplant - Phase I/II

Acute Myeloid Leukemia | Myelodysplastic Syndrome | Myeloproliferative Neoplasm | Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Cord Blood Transplant Recipient

United States
Columbia University
Tercica

Terminated

Differential Effects of rhGH vs. rhIGF-1 on Cardiovascular Risk Factors

Growth Hormone Deficiency

United States
VA Office of Research and Development

Terminated

Metabolic Effects of Natriuretic Peptide Hormones (MENP)

Obesity | Metabolism | Cardiovascular Physiological Phenomena

United States
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.

Recruiting

Study of the SG001 Injection for Patients With Relapsed or Metastatic Uterine Cervical Cancer

Uterine Cervical Cancer

China
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.

Recruiting

Study of Recombinant Human Anti-PD-1 Monoclonal Antibody in Patients With Advanced Tumours

Lymphoma | Cervical Cancer | Malignant Mesothelioma | Advanced Solid Tumours | Non-Small-Cell Lung Cancer

China
Mayo Clinic
Patient-Centered Outcomes Research Institute

Active, not recruiting

Second-line Therapies for Patients With Type 2 Diabetes and Moderate Cardiovascular Disease Risk

Type 2 Diabetes | Cardiac Disease

United States
Shanghai Zhongshan Hospital

Not yet recruiting

Preliminary Study on the Clinical Effect of Recombinant Human Brain Natriuretic Peptide on Sepsis Complicated With Heart Failure

Sepsis

China
Tianjin Medical University Second Hospital

Recruiting

Oncolytic Adenovirus(H101) Combined With PD-1 Inhibitors in Patients With Advanced Malignant Pleural Mesothelioma

Malignant Pleural Mesothelioma, Advanced

China
Guangzhou Gloria Biosciences Co., Ltd.

Completed

Study of Recombinant Human Anti-PD-1 Monoclonal Antibody for Patients With Advanced Solid Tumors

Advanced Solid Tumors

China
CardioVascular BioTherapeutics, Inc.

Not yet recruiting

Fibroblast Growth Factor-1 (FGF-1) for the Treatment of Coronary Heart Disease

Myocardial Ischemia | Coronary Disease | Coronary Heart Disease | Coronary Arteriosclerosis
National Institute of Diabetes and Digestive and...

Unknown

ADD-ON Study to Existing Hypoparathyroidism Studies

Hypoparathyroidism

United States
Shengjing Hospital

Enrolling by invitation

rhBNP in Type 3 Pulmonary Hypertension

Group 3 Pulmonary Hypertension

China
Henan Institute of Cardiovascular Epidemiology

Not yet recruiting

Effect of rhBNP on CMD in Patients With STEMI After PPCI

STEMI
Janssen Research & Development, LLC

Completed

Cardiovascular Outcomes in Participants With Type 2 Diabetes Mellitus (T2DM)

Diabetes Mellitus, Type 2

United States
Herlev Hospital
University of Copenhagen; The Danish Medical Research Council; The Danish Diabetes...

Completed

GIP, GLP-1 and GLP-2 in Type 2 Diabetic Hyperglucagonemia

Type 2 Diabetes Mellitus

Denmark
Shahid Beheshti University of Medical Sciences
praxisgemeinschaft für zelltherapie

Unknown

Ezrin Peptide (HEP-1) for Treatment of Coronavirus Disease (COVID-19) Infection

Covid19 | Corona Virus Infection | Treatment

Iran, Islamic Republic of
Chiesi Farmaceutici S.p.A.
ICON plc

Not yet recruiting

A Study to Learn About the Safety and Effects of the Study Drug PRX-102 in Children and Adolescents With Fabry Disease (FLY)

Fabry Disease
Attikon Hospital

Recruiting

The Effect of Semaglutide on Cardiovascular Markers and Liver Function

Diabetes Type 2

Greece
Shanghai Jiao Tong University School of Medicine

Completed

Effects of rhBNP in Pediatrics After Corrective Repair of Tetralogy Of Fallot

Congenital Heart Defects | Tetralogy Of Fallot

China
LI ZHAO

Completed

Acute Effects of rhBNP in Patients With PH Associated With Acute Exacerbation of Chronic Pulmonary Disease

Pulmonary Hypertension

China
National Vaccine and Serum Institute, China
Lanzhou Institute of Biological Products Co., Ltd

Not yet recruiting

Phase III Clinical Trial to Evaluate the Human Norovirus Bivalent (GⅠ.1/GⅡ.4)Vaccine，Recombinant (Hansenula Polymorpha)

Norwalk Gastroenteritis | Norovirus Infections
University Hospital, Gentofte, Copenhagen
Danish Heart Foundation

Completed

Vasodilatory and Metabolic Effects of Glucagon-like Peptide-1 in Periphery Circulation in Patients With and Without Type 2 Diabetes Mellitus

Type 2 Diabetes | Blood Flow | Human Physiology | Glucagon-like Peptide-1 | Blod Pressure

Denmark
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.

Not yet recruiting

A Study of Duvelisib Combined With SG001 Injection in Patient With Advanced Solid Tumors

Advanced Solid Tumors

Search clinical trials for: BMN190 recombinant human tripeptidyl peptidase-1 (rhTPP1)

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Israel

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations