Search clinical trials for: Bardoxolone methyl

Total 2981 results

Reata, a wholly owned subsidiary of Biogen

Completed

A Single-Dose, Open-Label, Randomized, Food Effect and Blinded, Randomized, Dose Proportionality Study in Healthy Volunteers With Bardoxolone Methyl

Healthy Volunteers

United States
Reata, a wholly owned subsidiary of Biogen

Completed

A Phase I Study to Investigate the Absorption, Metabolism and Excretion in Healthy Male Subjects

Healthy

United States
Reata, a wholly owned subsidiary of Biogen

Withdrawn

Pilot Assessment of the Effects of Bardoxolone Methyl on Renal Perfusion, Systemic Haemodynamics and Cardiac Function in Patients With Chronic Kidney Disease and Type 2 Diabetes

Diabetes Mellitus, Type 2 | Renal Insufficiency, Chronic
Reata, a wholly owned subsidiary of Biogen

Completed

Single-Dose, Open-Label Pharmacokinetic Study of Bardoxolone Methyl in Subjects With Mild, Moderate, and Severe Hepatic Impairment and Normal Hepatic Function

Healthy | Hepatic Impairment

United States
Reata, a wholly owned subsidiary of Biogen

Withdrawn

A Double-Blind, Randomized, Placebo-Controlled Study Evaluating the Effects of Bardoxolone Methyl on Body Composition in Patients With Stage 4 Chronic Kidney Disease and Type 2 Diabetes Mellitus

Diabetes Mellitus, Type 2 | Renal Insufficiency, Chronic
Reata, a wholly owned subsidiary of Biogen

Terminated

Pharmacokinetic and Pharmacodynamic Study of Bardoxolone Methyl in Patients With Chronic Kidney Disease and Type 2 Diabetes

Diabetes Mellitus, Type 2 | Renal Insufficiency, Chronic
Reata, a wholly owned subsidiary of Biogen

Terminated

An Extended Access Program for Bardoxolone Methyl in Patients With CKD (EAGLE) (EAGLE)

Chronic Kidney Diseases | Autosomal Dominant Polycystic Kidney | Alport Syndrome

United States, France, Australia, Japan, Spain, Puerto Rico
Reata, a wholly owned subsidiary of Biogen

Completed

Phase IIa Trial to Determine the Effects of Bardoxolone Methyl on Renal Function in Patients With Diabetic Nephropathy

Diabetic Nephropathy

United States
Reata, a wholly owned subsidiary of Biogen

Completed

Phase II Pharmacodynamic Trial to Determine the Effects of Bardoxolone Methyl on eGFR in Patients With Type 2 Diabetes and Chronic Kidney Disease

Diabetes Mellitus, Type 2 | Renal Insufficiency, Chronic

United States
NYU Langone Health
Reata Pharmaceuticals, Inc.

Completed

BARCONA: A Study of Effects of Bardoxolone Methyl in Participants With SARS-Corona Virus-2 (COVID-19)

Covid19

United States
Reata, a wholly owned subsidiary of Biogen

Withdrawn

A Double-Blind, Randomized, Placebo-Controlled Safety Study Evaluating the Effects of Residual Renal Function (RFF) in Patients With End-Stage Renal Disease and Type 2 Diabetes Mellitus on Peritoneal Dialysis

Type 2 Diabetes Mellitus | End-Stage Renal Disease
Kyowa Kirin Co., Ltd.

Terminated

A Phase 3 Study of Bardoxolone Methyl in Patients With Diabetic Kidney Disease; AYAME Study

Diabetic Kidney Disease

Japan
Kyowa Kirin Co., Ltd.

Completed

A Study of RTA 402 in Obese Adults

Obese Adult Male

Japan
Reata, a wholly owned subsidiary of Biogen

Terminated

Extended Access Program to Assess Long-term Safety of Bardoxolone Methyl in Patients With Pulmonary Hypertension RANGER (RANGER)

Pulmonary Hypertension

United States, Spain, Australia, United Kingdom, Canada, Belgium, Argentina, Israel, Japan, Philippines, Germany, Mexico, Brazil, Czechia, Netherlands
Reata, a wholly owned subsidiary of Biogen

Completed

RTA 402 in Patients With Advanced Solid Tumors or Lymphoid Malignancies

Advanced Solid Tumors | Lymphoid Malignancies

United States
Kyowa Kirin Co., Ltd.

Completed

A Clinical Pharmacology Study of Bardoxolone Methyl in Healthy Adults

Healthy Subject

Japan
Reata, a wholly owned subsidiary of Biogen

Completed

Trial to Determine the Effects of Bardoxolone Methyl on eGFR in Patients With Type 2 Diabetes and Chronic Kidney Disease

Diabetic Nephropathy | Type 2 Diabetes | Chronic Kidney Disease

United States
Biogen

Terminated

A Pharmacodynamic Study of Measured Glomerular Filtration Rate in Patients With Chronic Kidney Disease and Type 2 Diabetes

Type 2 Diabetes | Chronic Kidney Disease
Reata, a wholly owned subsidiary of Biogen

Terminated

Bardoxolone Methyl Evaluation in Patients With Chronic Kidney Disease and Type 2 Diabetes (BEACON)

Diabetes Mellitus, Type 2 | Renal Insufficiency, Chronic
Reata, a wholly owned subsidiary of Biogen

Completed

Bardoxolone Methyl Evaluation in Patients With Pulmonary Hypertension (PH) - LARIAT

Idiopathic Pulmonary Fibrosis | Pulmonary Arterial Hypertension | Pulmonary Hypertension | Interstitial Lung Disease | Sarcoidosis | Idiopathic Interstitial Pneumonia | Cryptogenic Organizing Pneumonia | Desquamative Interstitial Pneumonia | Respiratory Bronchiolitis Associated Interstitial Lung Disease and other conditions

United States, Germany
Reata, a wholly owned subsidiary of Biogen

Completed

A Phase 2/3 Trial of the Efficacy and Safety of Bardoxolone Methyl in Patients With Alport Syndrome - CARDINAL (CARDINAL)

Alport Syndrome

United States, United Kingdom, Japan, Australia, France, Germany, Puerto Rico, Spain
Reata, a wholly owned subsidiary of Biogen

Terminated

Bardoxolone Methyl in Patients With Connective Tissue Disease-associated Pulmonary Arterial Hypertension - CATALYST

Connective Tissue Disease-Associated Pulmonary Arterial Hypertension

United States, Spain, Japan, Australia, United Kingdom, Canada, Germany, Belgium, Argentina, Israel, Mexico, Brazil, Czechia, Netherlands, Philippines
Reata, a wholly owned subsidiary of Biogen

Terminated

A Trial of Bardoxolone Methyl in Patients With ADPKD - FALCON (FALCON)

Autosomal Dominant Polycystic Kidney | ADPKD

United States, Spain, United Kingdom, Australia, France, Japan, Germany, Belgium, Czechia, Italy
Reata, a wholly owned subsidiary of Biogen

Completed

A Phase 2 Trial of the Safety and Efficacy of Bardoxolone Methyl in Patients With Rare Chronic Kidney Diseases - PHOENIX (PHOENIX)

Focal Segmental Glomerulosclerosis | IgA Nephropathy | Autosomal Dominant Polycystic Kidney | CKD Associated With Type 1 Diabetes

United States
Pfizer

Terminated

Long-Term Safety Study Of Inhaled Insulin (CP-464,005, Inhaler) In Japanese Patients With Type1 or Type2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes Mellitus, Type 1

Japan
Reata, a wholly owned subsidiary of Biogen

Completed

Multiple-Dose Study of Effect of Bardoxolone Methyl on QT/QTC Interval Volunteers

Healthy Volunteers

United States
Reata, a wholly owned subsidiary of Biogen

Completed

A Trial of Bardoxolone Methyl in Patients With CKD at Risk of Rapid Progression (MERLIN) (MERLIN)

Chronic Kidney Diseases

United States
Reata, a wholly owned subsidiary of Biogen

Terminated

Study With Gemcitabine and RTA 402 for Patients With Unresectable Pancreatic Cancer

Pancreatic Neoplasms | Pancreatic Cancer

United States
Stanford University

Active, not recruiting

Abemaciclib in Metastatic or Locally Advanced Anaplastic/Undifferentiated Thyroid Cancer

Thyroid Cancer | Anaplastic Thyroid Cancer | Undifferentiated Thyroid Cancer

United States
Photolitec LLC
National Cancer Institute (NCI); Roswell Park Cancer Institute

Recruiting

Intracavitary Photodynamic Therapy as an Adjuvant to Resection of Glioblastoma or Gliosarcoma Using IV Photobac®

Glioblastoma Multiforme of Brain | Glioma, Sarcomatous

United States
Constellation Pharmaceuticals

Completed

A Study Evaluating CPI-1205 in Patients With B-Cell Lymphomas

B-Cell Lymphoma

United States
The University of Texas Health Science Center at...
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

Ketones, SGLT2, HFrEF

Heart Failure With Reduced Ejection Fraction | Type2diabetes

United States
Constellation Pharmaceuticals

Completed

ORIOn-E: A Study Evaluating CPI-1205 in Patients With Advanced Solid Tumors

Advanced Solid Tumors

United States
Promomed, LLC

Completed

Safety and Efficacy of the Therapy With BRAINMAX® for the Treatment of Patients With Asthenia After COVID-19

COVID-19 | Asthenia

Russian Federation
Reata, a wholly owned subsidiary of Biogen

Completed

Effect of Itraconazole on the Pharmacokinetics of Bardoxolone Methyl in Healthy Adults

Healthy Volunteers

United States
Crimson Biopharm Inc.

Not yet recruiting

CM93 Treatment in Subjects With Epidermal Growth Factor Receptor (EGFR)-Modified Recurrent Glioblastoma (rGBM)

Glioblastoma
EA Pharma Co., Ltd.
Kissei Pharmaceutical Co., Ltd.

Completed

A Study to Evaluate the Safety and Efficacy of AJM300 in Participants With Active Ulcerative Colitis

Colitis, Ulcerative

Japan
Peter MacCallum Cancer Centre, Australia
Melbourne Health

Completed

NMP in Relapsed / Refractory Myeloma

Multiple Myeloma

Australia
Assuta Hospital Systems

Unknown

Checking Wether the m-ALA Cream Could Mark Correctly the Borders of BCC's Tumors

Basal Cell Carcinoma

Israel
Galderma R&D

Completed

PRO With Luxerm® in the Field Treatment of Thin and Non-hyperkeratotic Non-pigmented AK (SESAME 2)

Actinic Keratoses

Germany
Biogen

Completed

Extension Study of BG00012 in Pediatric Subjects With Relapsing Remitting Multiple Sclerosis (RRMS)

Multiple Sclerosis, Relapsing-Remitting

Poland, Belgium, Turkey, Bulgaria, United States, Czechia, Germany, Kuwait, Latvia, Lebanon
University Hospital Muenster
Biogen

Completed

Investigation of the Effect of Dimethyl Fumarate on T Cells in Patients With Relapsing Remitting Multiple Sclerosis (DIMAT-MS)

Multiple Sclerosis, Relapsing-Remitting

Germany
ImmunoGen, Inc.
GOG Foundation

Recruiting

Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Ovarian, Fallopian Tube, or Peritoneal Cancer (GLORIOSA)

Ovarian Cancer | Fallopian Tube Cancer | Peritoneal Cancer

United States, Korea, Republic of, Spain, Australia, Canada, United Kingdom, Italy, Czechia, Philippines, Israel, Belgium
Vedic Lifesciences Pvt. Ltd.

Completed

Effect of LANCONONE in Weight-bearing Joint Pain

Osteo Arthritis Knee

India
Constellation Pharmaceuticals

Active, not recruiting

ProSTAR: A Study Evaluating CPI-1205 in Patients With Metastatic Castration Resistant Prostate Cancer

Metastatic Castration Resistant Prostate Cancer (mCRPC)

United States
Promomed, LLC

Completed

Efficacy of the Therapy With BRAINMAX® Using fMRI for the Treatment of Patients With Asthenia After COVID-19

COVID-19 | Asthenia | Cognitive Impairment | Functional MRI

Russian Federation
Banner Life Sciences LLC

Completed

Study to Compare GI Tolerability Following Oral Administration of Bafiertam™ or Tecfidera to Healthy Volunteers

Multiple Sclerosis

United States
Cairo University

Unknown

Measuring Quality of Life of Poly-amide Complete Dentures

Denture, Complete
Galderma R&D

No longer available

Compassionate Use of Metvix® (Methyl Aminolevulinate) Photodynamic Therapy (PDT) in Subjects With Field Actinic Keratoses, Large/Multiple Superficial Basal Cell Carcinomas (BCCs), or Bowen's Disease

Basal Cell Carcinoma | Bowen's Disease | Field Actinic Keratoses
Anthera Pharmaceuticals

Terminated

A Study of the Pharmacokinetics and Safety of Varespladib in Subjects With Normal or Impaired Renal Function

Renal Impairment

United States

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