Search clinical trials for: CD4 Immunoadhesins

Total 1396 results

HealthPartners Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Enrolling by invitation

Weight Loss Clinical Decision Support (BMI-CDS)

Obesity | Diabetes Mellitus, Type 2

United States
Paul Szabolcs

Enrolling by invitation

Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases (BOLT+BMT)

Chronic Granulomatous Disease (CGD) | Wiskott-Aldrich Syndrome | Severe Chronic Neutropenia | Severe Combined Immunodeficiency (SCID) | Immunodeficiency With Predominant T-cell Defect, Unspecified | Hyper IgE Syndromes | Hyper IgM Deficiencies | Mendelian Susceptibility to Mycobacterial Disease | Common...

United States
Wenzhou Medical University

Completed

Color Doppler Ultrasound in Lacrimal Sac Space-occupying Lesions

Computed Tomography | Dacryocystitis; Chronic | Lacrimal Sac Space-occupying Lesions | Color Doppler Ultrasound

China
G1 Therapeutics, Inc.

Completed

First-in-Human Safety, PK, and Food Effect Study of Single Ascending Doses of G1T38 in Healthy Volunteers

Healthy Volunteers

Netherlands
AZ-VUB
KU Leuven; Universiteit Antwerpen; Erasme University Hospital

Completed

Extension of Phase II Therapeutic Trial With a Humanized Non-Mitogenic CD3 (ChAgly CD3) Monoclonal Antibody in Recently Diagnosed Type 1 Diabetic Patients

Diabetes Mellitus, Type 1

Belgium, Germany
Celgene
The Leukemia and Lymphoma Society

Completed

Study of ACY-1215 Alone and in Combination With Bortezomib and Dexamethasone in Multiple Myeloma (ACY-1215)

Multiple Myeloma

United States
Hunan Cancer Hospital

Not yet recruiting

Real-World Study on CDK4/6 Inhibitors Combined With Endocrine Therapy and Subsequent Treatment in HR+/HER2- MBC.

Breast Cancer | Endocrine Therapy | CDK4/6 Inhibitors | Subsequent Treatment
VA Office of Research and Development

Recruiting

Improving Rehabilitation for Veterans After Total Knee Arthroplasty Using Individualized Recovery Trajectories

Total Knee Arthroplasty

United States
Mitchell Cairo

Recruiting

AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion

Hodgkin Lymphoma | Sickle Cell Disease | Acute Leukemia | Beta-Thalassemia | Non-hodgkin Lymphoma | Severe Aplastic Anemia | Diamond Blackfan Anemia | Amegakaryocytic Thrombocytopenia | Kostmann

United States
M.D. Anderson Cancer Center

Recruiting

Compassionate Access of the Miltenyi Device for CD34+ Cell Selection

Blood And Marrow Transplantation

United States
National Cancer Institute (NCI)

Active, not recruiting

Dinaciclib in Treating Patients With Stage IV Melanoma

Stage IV Cutaneous Melanoma AJCC v6 and v7 | Recurrent Melanoma | Lentigo Maligna Melanoma | Mucosal Melanoma | Acral Lentiginous Melanoma | Cutaneous Nodular Melanoma | Low-CSD Melanoma

United States
Washington University School of Medicine
Society of Family Planning

Completed

Computerized Contraceptive Decision Aid (CDM RCT)

Contraception | Satisfaction | Decision Making | Evaluation
Institut Paoli-Calmettes
Innate Pharma

Unknown

Study of a Humanized Antibody Initiated 2 Months After an HLA Matched Allogenic Stem Cell Transplantation (PIRAT)

Hematologic Malignancies

France
National Institute of Allergy and Infectious Diseases...
Immune Tolerance Network (ITN)

Terminated

PsA Treatment With hOKT3γ1 (Ala-Ala) (PART)

Arthritis, Psoriatic

United States
Bambino Gesù Hospital and Research Institute

Not yet recruiting

CD7-CAR-T Cells in Pediatric Relapsed/Refractory CD7+ T-ALL/LL (CD7-CAR01)

T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Hoffmann-La Roche
Foundation Medicine

Recruiting

A Study to Evaluate the Impact of Liquid Biopsy in Participants With a Clinical Diagnosis of Advanced Cancer (L1st)

Metastatic Lung Cancer | Metastatic Gastrointestinal Cancer

Spain, France, Italy, Germany, Netherlands
Beijing Boren Hospital

Recruiting

Donor-Derived CD5 CAR T Cells in Subjects With Relapsed or Refractory T-Cell Acute Lymphoblastic Leukemia

T-Cell Acute Lymphoblastic Leukemia

China
Victor Aquino

Temporarily not available

Treatment Use of the CliniMACS® CD34 TCR Alpha/Beta for Allogenic Transplant (Expanded Access Use)

Transplant-Related Disorder | GVH - Graft Versus Host Reaction

United States
T-knife GmbH

Terminated

A Phase 1/ 2, First-in-Human, Open-Label, Accelerated-Titration, Two-Part Clinical Trial of TK-8001 in Patients With HLA-A*02:01 Genotype and Advanced-Stage/ Metastatic MAGE-A1+ Solid Tumors (IMAG1NE)

Advanced Solid Tumors

Germany, Belgium, Spain, Netherlands, United Kingdom
Hospital Universitario Reina Sofia de Cordoba

Completed

New Therapeutic Approach in Upper Limb Lymphedema Secondary to Breast Cancer: Activity-oriented Proprioceptive Antiedema Therapy (TAPA)

Breast Cancer Lymphedema | Post-Mastectomy Secondary Lymphedema

Spain
Imperial College London

Completed

Autologous Bone Marrow Stem Cells in Ischemic Stroke.

Infarction, Middle Cerebral Artery | Stroke, Acute

United Kingdom
University Hospital Inselspital, Berne

Completed

Transpharyngeal Doppler Sonography for Cerebral Perfusion Monitoring (TaPaS)

Cerebral Perfusion

Switzerland
Neuromed IRCCS

Unknown

Emotion Recognition in Benign Epilepsy of Childhood With Centro-Temporal Spikes (BECTS) (BECTS)

Epilepsy, Rolandic | BECTS

Italy
University of Cologne

Unknown

Incidence and Economic Burden of Clostridium Difficile Infections (CDI) in the German Health Care System (IBIS) (IBIS)

Clostridium Difficile Infection | Clostridium Difficile Diarrhea

Germany
Active Biotech AB

Completed

ABR-217620 in Patients With Advanced Non-Small Cell Lung Cancer, Renal Clear Cell Carcinoma or Pancreatic Cancer

Renal Cell Carcinoma | Pancreatic Cancer | Non-Small-Cell Lung Carcinoma

United States, Norway, United Kingdom
Michael Rapoff, Ph.D.
National Institute of Neurological Disorders and Stroke (NINDS)

Completed

Headstrong Intervention for Pediatric Headache

Chronic Headaches

United States
AGO Study Group

Completed

Randomized, Multicenter, 2-Dose Level. Open-Label, Phase IIa Study With the Intraperitoneally Infused Trifunctional Bispecific Antibody Removab(TM) (Anti-EpCAM x Anti-CD3) to Select the Better Dose Level in Platinum Refractory Epithelial Ovarian Cancer Patients

Fallopian Tube Neoplasms | Peritoneal Neoplasms | Ovarian Cancer

Germany
National Jewish Health

Completed

Lung Cancer Screening Study With Low-dose CT Scan and Blood Biomarker

High Risk of Developing Lung Cancer

United States
Chinese PLA General Hospital

Completed

GSL Synthetase Inhibitor in Combination With Immune Checkpoint Inhibitor in Previously Treated Blood and Solid Tumor

Solid Tumor | Hematologic Malignancy

China
Tiziana Life Sciences LTD

Withdrawn

A Study of Oral Foralumab in Participants With Moderate to Severely Active Crohn's Disease

Crohn's Disease
Vanderbilt University
National Institutes of Health (NIH)

Completed

Optimizing Integrated PMTCT Services in Rural North-Central Nigeria

HIV | Suspected Damage to Fetus From Viral Disease in the Mother

Nigeria, Niger
Cocrystal Pharma, Inc.

Completed

Study of CDI-31244 in Combination With Sofosbuvir (SOF) and Velpatasvir (VEL)

Chronic Hepatitis C

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); AstraZeneca; Juno Therapeutics, Inc.; MedImmune...

Terminated

JCAR014 and Durvalumab in Treating Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma

Recurrent Diffuse Large B-Cell Lymphoma | Recurrent Primary Mediastinal (Thymic) Large B-Cell Lymphoma | Refractory Diffuse Large B-Cell Lymphoma | Refractory Primary Mediastinal (Thymic) Large B-Cell Lymphoma | Refractory High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements | Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

United States
Prometheus Biosciences, Inc., a subsidiary of Merck...

Recruiting

Phase 2 Safety and Efficacy Study of Tulisokibart (MK-7240/PRA023) in Subjects With Systemic Sclerosis Associated With Interstitial Lung Disease (SSc-ILD) (MK-7240-007) (ATHENA-SSc-ILD)

Diffuse Cutaneous Systemic Sclerosis | Interstitial Lung Disease

United States, Australia, Belgium, Canada, France, Germany, Hungary, Israel, Italy, Netherlands, Norway, Poland, Spain, Switzerland, United Kingdom
Henan Cancer Hospital

Recruiting

A Trail of CDK4 / 6 Inhibitor and MEK Inhibitor in the Treatment of Metastatic Digestive System Tumors

Digestive System Tumors

China
Baylor College of Medicine
The Methodist Hospital Research Institute; Center for Cell and Gene Therapy...

Recruiting

Ex Vivo T-Cell Depletion of Mobilized Peripheral Blood Stem Cells Via CD34-Selection (EXCESS)

Stem Cell Transplant | Allogeneic

United States
National Institute of Allergy and Infectious Diseases...

Enrolling by invitation

pCCLCHIM-p47 (Lentiviral Vector Transduced CD34 Plus Cells) in Patients With p47 Autosomal Recessive Chronic Granulomatous Disease (AR-CGD)

Chronic Granulomatous Disease | p47 | Autosomal Recessive

United States
Centre Georges Francois Leclerc

Active, not recruiting

Relevance of T Lymphocytes Tumor Infiltrates CD8 and Foxp3 as Immune Prognostic Biomarker in Breast Cancer Treated by Neo Adjuvant Chemotherapy (PRIMUNEO)

Breast Cancer

France
Rajni Agarwal

Completed

CD34+ Cell Enriched and T Cell Depleted Allogeneic Stem Cell Transplantation for Patients With Mismatched Related Donors or Borderline Organ Function

Malignant Diseases | Non-malignant Diseases

United States
Shanghai Public Health Clinical Center

Active, not recruiting

Clinical Safty and Efficacy Study of Infusion of iNKT Cells and CD8+T Cells in Patients With Advanced Solid Tumor

Renal Cell Carcinoma | Small Cell Lung Cancer | Hepatocellular Carcinoma | Gastric Cancer | Non-small Cell Lung Cancer | Pancreas Cancer

China
Genethon

Active, not recruiting

Long Term Safety Follow up of Haematopoietic Stem Cell Gene Therapy for the Wiskott Aldrich Syndrome (WASFUP)

Wiskott-Aldrich Syndrome

United Kingdom, France
PersonGen BioTherapeutics (Suzhou) Co., Ltd.
The First Affiliated Hospital of Zhengzhou University

Unknown

CD7-CART in the Treatment of r / r CD7 Positive Hemolymph System Malignancies on Increasing Dose and Open Label Study

Angioimmunoblastic T-cell Lymphoma | Enteropathy-Associated T-Cell Lymphoma | Anaplastic Large Cell Lymphoma, ALK-negative | T Lymphoblastic Leukemia/Lymphoma | Extramedullary NK-T-cell Lymphoma, Nasal Type | Peripheral T-cell Lymphoma, Nonspecific | T-cell Lymphoblastic Leukemia

China
Chinese Academy of Sciences

Completed

Temperature and Mortality

Cardiovascular Diseases
Izun Pharma Ltd

Completed

Efficacy Study of IZN-6D4 Gel for the Treatment of Diabetic Foot Ulcers

Diabetic Foot Ulcer

Israel
Losordo, Douglas, M.D.
Baxter Healthcare Corporation

Completed

Injection of Autologous CD34-Positive Cells for Critical Limb Ischemia (ACT34-CLI)

Peripheral Vascular Disease | Peripheral Artery Disease | Critical Limb Ischemia

United States
University Hospital, Rouen

Recruiting

Glycocalyx Monitoring in Major Abdominal Surgery (GLYCOCHIP)

Major Abdominal Surgery

France
Cocrystal Pharma, Inc.
Cocrystal Pharma Australia Pty Ltd.; Nucleus Network Pty Ltd.; Beyond Drug Development... and other collaborators

Recruiting

CDI-988 Safety Study in Healthy Participants

Healthy Volunteers

Australia
Zhejiang University
Yake Biotechnology Ltd.

Recruiting

CD7 CAR-T Bridging to alloHSCT for R/R CD7+Malignant Hematologic Diseases

Neoplasms | Hematologic Diseases

China
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells

MDS (Myelodysplastic Syndrome) | Severe Aplastic Anemia

United States
Prometheus Biosciences, Inc., a subsidiary of Merck...

Active, not recruiting

A Phase 2a Safety and Efficacy Open-Label Study of PRA023 in Subjects With Moderately to Severely Active Crohn's Disease (APOLLO-CD)

Crohn Disease

United States, Australia, Belgium, Canada, Czechia, France, Georgia, Poland

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