Search clinical trials for: Cysteine Proteinase Inhibitors

Total 64807 results

Boehringer Ingelheim

Completed

Safety and Tolerability of Dabigatran Etexilate in Adolescents

Venous Thromboembolism

Canada
Boehringer Ingelheim

Completed

Bioequivalence of Two Different Capsule Types of Dabigatran

Healthy

Germany
Boehringer Ingelheim

Terminated

Long-term, Open-label Follow-up Treatment of Patients With A-fib Who Have Been Previously Treated With BIBR 1048

Stroke | Atrial Fibrillation

United States, Denmark, Netherlands, Sweden
Huashan Hospital

Not yet recruiting

Clinical Efficacy of Ulinastatin for Treatment of Sepsis With Systemic Inflammatory Response Syndrome (CURE-SepSIRS)

Sepsis

China
China-Japan Friendship Hospital

Not yet recruiting

Effectiveness and Safety of Rivaroxaban Used in Extended Anticoagulation for Pulmonary Embolism Patients

Pulmonary Embolism
Erasmus Medical Center
Daiichi Sankyo, Inc.

Recruiting

Rotterdam EDOXaban Leaflet Evaluation in Patients After Transcatheter Aortic Valve Implantation (REDOX-TAVI)

Aortic Valve Stenosis

Netherlands
Pfizer

Completed

Effectiveness And Safety Of Oral Anticoagulants Among Obese Patients With Non-Valvular A-Fib In VA Patients With Medicare

Obesity | Atrial Fibrillation | Anticoagulants

United States
Portola Pharmaceuticals

Completed

The Effect o f Hepatic Impairment on the Pharmacokinetics and Pharmacodynamics of Betrixiban, an Oral FXa Antagonist

Hepatic Impairment

United States
New York Medical College

Completed

Oral Anticoagulant Apixaban for Treatment of Venous Thromboembolism (VTE)

Venous Thromboembolism

United States
Assistance Publique - Hôpitaux de Paris

Completed

Xarelto Versus no Treatment for the Prevention of Recurrent Thrombosis in Patients With Chronic Portal Vein Thrombosis. (RIPORT)

Deep Vein Thrombosis | Chronic Portal Vein Thrombosis

France
Fadoi Foundation, Italy
University Of Perugia

Completed

Rivaroxaban or Placebo for Extended Antithrombotic Prophylaxis After Laparoscopic Surgery for Colorectal Cancer. (PRO-LAPSII)

Prevention of Venous Thromboembolism

Italy
Thomas Jefferson University

Completed

Pharmacokinetics of Apixaban in Patients Undergoing Pancreaticoduodenectomy (PAP-UP)

Pancreas Cancer | Pulmonary Embolism | DVT

United States
Johns Hopkins University

Completed

Apixaban Pharmacokinetics in Bariatric Patients (APB) (APB)

Obesity | Bariatric Surgery

United States
Samsung Medical Center
Bayer

Unknown

Rivaroxaban in Elderly NVAF Patients With or Without Renal Impairment (XAIENT)

Renal Insufficiency | Atrial Fibrillation | Elderly | Rivaroxaban

Korea, Republic of
University of Alberta

Completed

Eliquis Acute Stroke Safety Evaluation (EASSE)

Ischemic Stroke | Atrial Fibrillation | Transient Ischemic Attack

Canada
Daiichi Sankyo, Inc.

Completed

Edoxaban Management in Diagnostic and Therapeutic Procedures (EMIT-AF/VTE)

Atrial Fibrillation | Venous Thromboembolism
Daiichi Sankyo, Inc.

Completed

Edoxaban Treatment in Routine Clinical Practice in Patients With Venous Thromboembolism in Korea and Taiwan (ETNA-VTE-KOR-TWN)

Venous Thromboembolism

Taiwan, Korea, Republic of
Astellas Pharma Inc

Completed

A Study to Compare the Pharmacokinetics of YM150 Formulation-A and Formulation-B

Healthy Volunteer | Pharmacokinetics of YM150

Japan
University of Michigan Rogel Cancer Center
CSL Behring; The Leukemia and Lymphoma Society

Completed

A Pilot Study of Alpha-1-Antitrypsin (AAT) in Steroid Refractory Acute Graft vs Host Disease

Graft vs Host Disease

United States
Rabin Medical Center

Unknown

Safety and Efficacy of Inhaled Alpha-1 Antitrypsin in Preventing Bronchiolitis Obliterable Syndrome in Lung Transplant Recipients

Lung Transplantation | Bronchiolitis Obliterable Syndrome
Heidelberg Pharma AG

Completed

Gemcitabine With or Without WX-671 in Treating Patients With Locally Advanced Pancreatic Cancer That Cannot Be Removed By Surgery

Pancreatic Cancer

Spain, Germany, Hungary, Italy, Russian Federation, Ukraine
University of Alberta
Shire

Completed

Aralast NP in Islet Transplant

Type 1 Diabetes Mellitus

Canada
Baxalta now part of Shire
Arriva Pharmaceuticals, Inc.

Completed

Study of the Effect of Aerosolized, Recombinant Alpha 1-Antitrypsin on Epithelial Lining Fluid Analytes in Subjects With Alpha 1-Antitrypsin Deficiency

Alpha1-antitrypsin Deficiency

United States
Lin Zhao

Recruiting

Effect of Evolocumab on Chronic Total Occlusions (EVOLO-CTO)

In-stent Restenosis | Major Adverse Cardiovascular Events

China
Irina Ermolaeva

Recruiting

RE-ELECT. Dabigatran vs Warfarin in AF Patients With T2DM and CKD (RE-ELECT)

Chronic Kidney Diseases | Atrial Fibrillation | T2DM (Type 2 Diabetes Mellitus)

Russian Federation
George Washington University

Completed

Intravenous AII for the Treatment of Severe Hypotension in High Output Shock: A Pilot Study (ATHOS)

Septic Shock

United States
University of Illinois at Chicago
La Jolla Pharmaceutical Company

Completed

Angiotensin II in the Perioperative Management of Hypotension in Kidney Transplant Recipients

Shock | Kidney Transplant; Complications | Hypotension and Shock | Intraoperative Hypotension | Shock, Surgical | Postoperative Hypotension

United States
Boehringer Ingelheim

Completed

Comparative Effectiveness and Safety Between Warfarin and Dabigatran

Atrial Fibrillation

Japan
Boehringer Ingelheim

Completed

BIBR 1048 in the Prevention of Venous Thromboembolism in Patients Undergoing Primary Elective Total Hip Replacement Surgery

Venous Thromboembolism
Boehringer Ingelheim

Completed

Pradaxa Study in Non-valvular Atrial Fibrillation Patients With Severely Impaired Renal Function

Atrial Fibrillation

United States
Boehringer Ingelheim

Completed

Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of BI 655075 Administered Alone or With Dabigatran Etexilate

Healthy

Belgium
Pfizer

Completed

Drug Interaction Study Between Bosutinib And Dabigatran

Healthy

United States
AstraZeneca

Terminated

Long Term Open Follow-up With H376/95 vs. Warfarin

Stroke Prevention in Patients With Atrial Fibrillation

Sweden, Norway, Poland, United Kingdom, Finland, Denmark, United States, Czech Republic, Belgium
Grifols Therapeutics LLC

Completed

Deposition of Inhaled Prolastin in Cystic Fibrosis Patients (CF2)

Cystic Fibrosis
International Bio service

Not yet recruiting

Bioequivalence Study of Apixaban 5 mg Film-coated Tablets in Healthy Thai Volunteers

Healthy Volunteer
Ono Pharmaceutical Co. Ltd

Completed

Multiple-dose Study of FOY-305 in Japanese Healthy Adult Male Subjects

Healthy Volunteers

Japan
Daiichi Sankyo, Inc.

Completed

Edoxaban Treatment in Routine Clinical Practice for Patients With Non Valvular Atrial Fibrillation (ETNA-AF-EU)

Atrial Fibrillation

Spain, Italy, Germany, Switzerland, Portugal, Belgium, Austria, Ireland, Netherlands, United Kingdom
Novartis Pharmaceuticals

Withdrawn

Efficacy and Safety of MAA868 in Patients With Atrial Fibrillation

Atrial Fibrillation
Walter Ageno

Unknown

Rivaroxaban for the Treatment of Symptomatic Isolated Distal Deep Vein Thrombosis (RIDTS)

Deep Vein Thrombosis

Italy
Mayo Clinic
Bristol-Myers Squibb

Withdrawn

Patients With Patent Foramen Ovale and Endocardial Device Leads on Apixaban for Prevention of Paradoxical Emboli (PARADOX)

Patent Foramen Ovale | Cardiac Implantable Electronic Device

United States
Octapharma

Withdrawn

Study Comparing Weekly Intravenous Administration of OctaAlpha1 With a Marketed Preparation Glassia® in Subjects With Alpha-1-antitrypsin Deficiency

Alpha 1-Antitrypsin Deficiency
Medical University Innsbruck

Completed

Argatroban in Critically Ill Patients With Heparin Resistance

Achievement of a Sufficient Thrombosis Prohpylaxis in Clitically Ill Patients With Heparin Resistance

Austria
Sherief Abd-Elsalam

Unknown

Efficacy and Safety of Rivaroxaban in the Management of Acute Non-neoplastic PVT Compensated Cirrhosis

Portal Vein Thrombosis

Egypt
Astellas Pharma Inc

Completed

A Pharmacokinetic Study to Investigate the Effect of Food on the Pharmacokinetics of YM150

Healthy | Pharmacokinetics of YM150

Japan
The Affiliated Hospital Of Guizhou Medical University

Not yet recruiting

Population Pharmacokinetic Study of the Effect of Polymorphisms in the ABCB1 and CES1 Genes on the Pharmacokinetics of Dabigatran

Combined Analysis of Polymorphisms and Dabigatran Pharmacokinetic Parameters
Loxo Oncology, Inc.
Eli Lilly and Company

Completed

A Drug Drug Interaction (DDI) Study of Selpercatinib and Dabigatran in Healthy Participants

Healthy

United States
Boehringer Ingelheim

Completed

Treatment of Patients Undergoing Primary Unilateral Elective Total Knee or Hip Replacement With Dabigatran Etexilate

Arthroplasty, Replacement | Prevention of Venous Thromboembolism | Moderate Renal Impairment (CrCl 30-50 mL/Min)

Austria, Canada, Czechia, Finland, Netherlands, Sweden
Boehringer Ingelheim

Completed

Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Dabigatran Etexilate in Patients With Moderate Hepatic Impairment Compared to Subjects With Normal Hepatic Function

Hepatic Insufficiency
National Institute of Cardiovascular Diseases,...

Recruiting

Rivaroxaban in Left Ventricular Thrombus

Acute Coronary Syndrome | Left Ventricular Thrombus

Pakistan
Pfizer

Completed

Safety and Effectiveness of Apixaban in Very Elderly Patients With Non-valvular Atrial Fibrillation (NVAF) Compared to Warfarin Using Administrative Claims Data

Non-valvular Atrial Fibrillation

Japan

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