Search clinical trials for: Farnesyl Protein Transferase Inhibitor

Total 10988 results

Baxalta now part of Shire
Arriva Pharmaceuticals, Inc.

Completed

Study of the Effect of Aerosolized, Recombinant Alpha 1-Antitrypsin on Epithelial Lining Fluid Analytes in Subjects With Alpha 1-Antitrypsin Deficiency

Alpha1-antitrypsin Deficiency

United States
Zhejiang Provincial People's Hospital

Recruiting

Efficacy and Safety of Abatacept Combined With JAK Inhibitor for Refractory Rheumatoid Arthritis

Rheumatoid Arthritis | Treatment Compliance | Abatacept

China
Samsung Medical Center

Not yet recruiting

Lazertinib 160mg in EGFR T790M NSCLC

Lung Cancer Stage IV | EGFR T790M

Korea, Republic of
University of Michigan Rogel Cancer Center
CSL Behring; The Leukemia and Lymphoma Society

Completed

A Pilot Study of Alpha-1-Antitrypsin (AAT) in Steroid Refractory Acute Graft vs Host Disease

Graft vs Host Disease

United States
Rabin Medical Center

Unknown

Safety and Efficacy of Inhaled Alpha-1 Antitrypsin in Preventing Bronchiolitis Obliterable Syndrome in Lung Transplant Recipients

Lung Transplantation | Bronchiolitis Obliterable Syndrome
Icahn School of Medicine at Mount Sinai

Recruiting

JAK Inhibition in Food Allergy

Food Allergy

United States
National Cancer Institute (NCI)

Recruiting

Evaluating Efficacy of Tivozanib (AV-951) in Biliary Tract Cancers

Cholangiocarcinoma | Bile Duct Neoplasm | Biliary Tract Malignancy

United States
Novartis Pharmaceuticals

Available

Global Managed Access Program Cohort for Remibrutinib in Adult Patients With Chronic Spontaneous Urticaria

Chronic Spontaneous Urticaria
Pfizer

Completed

Efficacy and Safety of Tofacitinib in Subjects With Active Ankylosing Spondylitis (AS)

Ankylosing Spondylitis

United States, Poland, Bulgaria, Korea, Republic of, Czechia, China, Israel, Australia, Turkey, Canada, Hungary, Russian Federation, France, Ukraine
GlaxoSmithKline

Completed

Safety, Pharmacokinetic (PK) and Pharmacodynamic (PD) Study of Repeat Doses of Inhaled Nemiralisib in Patients With APDS/PASLI

Activated PI3K-delta Syndrome

United Kingdom
Globe Pharmaceuticals Limited
Globe pharmaceuticals Ltd, Dhaka, Bangladesh

Unknown

Safety and Efficacy of Tofacitinib in the Treatment of NSAID Refractory Axial Spondyloarthritis:A Clinical Trial

Axial Spondyloarthritis

Bangladesh
Pfizer

Recruiting

Tofacitinib in Adult Patients With Moderate to Severe Ulcerative Colitis (TOFAST)

Ulcerative Colitis

France
Bangabandhu Sheikh Mujib Medical University, Dhaka...
Incepta Pharmaceuticals Ltd

Completed

Tofacitinib in the Treatment of Refractory Axial Spondyloarthritis Patients: A Dose Escalation Study

Axial Spondyloarthritis

Bangladesh
City of Hope Medical Center
National Cancer Institute (NCI)

Active, not recruiting

Acalabrutinib for the Treatment of Relapsed or Refractory Autoimmune Hemolytic Anemia in Patients With Chronic Lymphocytic Leukemia

Chronic Lymphocytic Leukemia | Autoimmune Hemolytic Anemia | Warm Antibody Autoimmune Hemolytic Anemia | Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

United States
Dong Wang

Unknown

Endostar/PD-1 Inhibitors Combined With PP for Advanced NSCLC

Non-squamous Non-small Cell Lung Cancer

China
National Cancer Institute (NCI)

Terminated

Lapatinib Ditosylate and Akt Inhibitor MK2206 in Treating Women With Metastatic Breast Cancer

Stage IV Breast Cancer | Recurrent Breast Carcinoma | Estrogen Receptor Negative | Estrogen Receptor Positive | HER2/Neu Positive | Progesterone Receptor Negative | Progesterone Receptor Positive

United States
University Hospital, Lille
Pfizer

Terminated

Effects of Tofacitinib on Body Composition, Bone Mineral Density and Bone Marrow Adiposity in Patients With Rheumatoid Arthritis: the TOFAT Project (TOFAT)

Rheumatoid Arthritis

France
Italian Group for the study of Inflammatory Bowel...

Recruiting

Real-world Effectiveness of Tofacitinib on Ulcerative Colitis Associated Spondyloarthropathy (RETUCAS)

Ulcerative Colitis | Spondyloarthropathy

Italy
Jennifer Eva Selfridge

Not yet recruiting

Oral TGF-beta Receptor I Inhibitor Vactosertib in SOC Chemoradiotherapy for Esophageal Adenocarcinoma

Siewert Type II Adenocarcinoma of Esophagogastric Junction | Adenocarcinoma Esophagus | Siewert Type I Adenocarcinoma of Esophagogastric Junction | Locally Advanced Adenocarcinoma
Sun Yat-sen University

Not yet recruiting

Zimberelimab Plus Lenvatinib After Progression on Prior Immune Checkpoint Inhibitors for Advanced Cervical Cancer

Cervical Cancer | Cervical Carcinoma

China
Jinnah Hospital

Completed

Efficacy of Oral Tofacitinib in Moderate to Severe Alopecia Areata, Totalis and Universalis at Tertiary Care Hospital, Karachi.

Alopecia Areata | Alopecia Totalis | Alopecia Universalis

Pakistan
Pfizer

Completed

Observational Study to Determine How Physicians Make Treatment Decisions in Patients Treated With Tofacitinib for Moderate to Severe Active Rheumatoid Arthritis (ESCALATE-RA)

Arthritis, Rheumatoid

Germany
National Health Research Institutes, Taiwan
National Taiwan University Hospital; China Medical University Hospital; Chang... and other collaborators

Completed

Prospective Study of First-line Antibiotic Therapy for Early-stage Gastric MALT Lymphoma for Treatment Outcome

Gastric MALT Lymphoma

Taiwan
Cancer Institute and Hospital, Chinese Academy...

Active, not recruiting

Efficacy and Safety of Concurrent PD-1 Inhibitor and Radiotherapy With Immunonutrition for Esophageal Squamous Cell Carcinoma

Radiotherapy | Sintilimab | Concurrent Chemoradiotherapy | Immunonutrition | Locally Advanced Esophageal Squamous Cell Carcinoma

China
Northwestern University
National Cancer Institute (NCI); Boehringer Ingelheim; Robert H. Lurie Cancer...

Active, not recruiting

Nintedanib and Azacitidine in Treating Participants With HOX Gene Overexpression Relapsed or Refractory Acute Myeloid Leukemia

Recurrent Adult Acute Myeloid Leukemia | Refractory Acute Myeloid Leukemia | Acute Myeloid Leukemia With t(9;11)(p22.3;q23.3); MLLT3-KMT2A | Fibroblast Growth Factor Basic Form Measurement | FLT3 Internal Tandem Duplication

United States
Takeda

Completed

Efficacy of TAK-438, Amoxicillin and Clarithromycin in the First Line Eradication of H. Pylori

H. Pylori Infection

Japan
Emory University
National Cancer Institute (NCI)

Recruiting

MRX-2843 and Osimertinib for the Treatment of Advanced EGFR Mutant Non-small Cell Lung Cancer

Metastatic Lung Non-Small Cell Carcinoma | Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Advanced Lung Non-Small Cell Carcinoma

United States
Mackay Memorial Hospital

Completed

Intraluminal Therapy for Helicobacter Pylori Infection

Helicobacter Pylori Infection

Taiwan
National Health Research Institutes, Taiwan

Completed

Eradication of Helicobacter Pylori in the Management of Stage IE & IIE-1 Primary Low-grade B Cell Lymphoma of MALToma

MALT Lymphoma

Taiwan
Istanbul University

Completed

The Effects of Helicobacter Pylori Eradication on Proteinuria in Patients With Membranous Nephropathy

Glomerulonephritis | Nephrotic Syndrome | Membranous Nephropathy

Turkey
AstraZeneca

Completed

Drug-Drug Interaction Study With AZD9291 and Omeprazole in Healthy Volunteers

Healthy Volunteer

United States
Fudan University

Recruiting

Apatinib Combined With cdk4/6i in First-line Treatment for HR+/HER2- SNF4 Subtype Breast Cancer

Advanced Breast Cancer | HR+/HER2- Breast Cancer

China
National Cancer Institute (NCI)

Active, not recruiting

Ibrutinib in Treating Patients With Refractory Metastatic Cutaneous Melanoma

Metastatic Melanoma | Stage IV Cutaneous Melanoma AJCC v6 and v7 | Recurrent Cutaneous Melanoma

United States
National Cancer Institute (NCI)

Active, not recruiting

Testing Crizotinib as a Potential Targeted Treatment in Cancers With ROS1 Genetic Changes (MATCH-Subprotocol G)

Hematopoietic and Lymphoid Cell Neoplasm | Advanced Lymphoma | Advanced Malignant Solid Neoplasm | Refractory Lymphoma | Refractory Malignant Solid Neoplasm | Refractory Multiple Myeloma

United States
Pfizer

Recruiting

Observational Study To Assess The Effectiveness and Treatment Adherence Of Tofacitinib of Ulcerative Colitis In Clinical Practice In Sweden (ODEN)

Ulcerative Colitis

Sweden
Novartis Pharmaceuticals

Recruiting

A Study to Investigate Efficacy, Safety, and Tolerability of Remibrutinib Compared With Placebo in Adults With CINDU Inadequately Controlled by H1-antihistamines

Chronic Inducible Urticaria

China, United States, Australia, Korea, Republic of, Israel, Turkey, Hong Kong, Japan, Argentina, Malaysia, Singapore, Thailand, Canada
Pfizer
PPD

Recruiting

A Study of How Safe Abrocitinib (CIBINQO) is in Pregnant Women and Their Offspring

Atopic Dermatitis

United States
Pfizer

Recruiting

A Study to Learn About Abrocitinib in Adult Patients With Moderate to Severe Atopic Dermatitis. (ADAIR)

Eczema | Atopic Dermatitis

France
Peking University People's Hospital

Recruiting

Efficacy, Safety and Immunological Evaluation of Tofacitinib in the Treatment of Primary Sjogren's Syndrome

Primary Sjögren's Syndrome

China
Cambridge University Hospitals NHS Foundation Trust

Completed

Vatalanib in Treating Patients With Metastatic Cutaneous Melanoma That Cannot be Removed by Surgery

Melanoma (Skin)

United Kingdom
Shandong University
Zibo Central Hospital; Peking University Care Luzhong Hospital; Taierzhuang District... and other collaborators

Recruiting

Bismuth Quadruple Therapy in Helicobacter Pylori Rescue Therapy of Different Tetracycline Doses and Frequencies.

Helicobacter Pylori Infection

China
Taipei Veterans General Hospital, Taiwan

Terminated

Proton Pump Inhibitor Plus Propranolol Versus Proton Pump Inhibitor Alone on Peptic Ulcer Healing in Patients With Liver Cirrhosis (PU)

Liver Cirrhosis | Peptic Ulcer

Taiwan
Emory University
National Cancer Institute (NCI); Merck Sharp & Dohme LLC; National Institutes... and other collaborators

Completed

Pembrolizumab and XL888 in Patients With Advanced Gastrointestinal Cancer

Unresectable Pancreatic Carcinoma | Metastatic Pancreatic Adenocarcinoma | Recurrent Pancreatic Carcinoma | Stage III Pancreatic Cancer | Stage IV Pancreatic Cancer | Recurrent Colorectal Carcinoma | Colorectal Adenocarcinoma | Stage IV Colorectal Cancer | Stage IVA Colorectal Cancer | Stage IVA Pancreatic... and other conditions

United States
Children's Hospital Medical Center, Cincinnati
Pfizer

Completed

Open-label Study of Tofacitinib for Moderate to Severe Skin Involvement in Young Adults With Lupus

Systemic Lupus Erythematosus | Cutaneous Lupus

United States
National Cancer Institute (NCI)
Children's Oncology Group

Active, not recruiting

Trametinib in Treating Patients With Relapsed or Refractory Juvenile Myelomonocytic Leukemia

Juvenile Myelomonocytic Leukemia | Neurofibromatosis Type 1

United States
H. Lee Moffitt Cancer Center and Research Institute
National Comprehensive Cancer Network

Withdrawn

Sorafenib and Bavituximab Plus SBRT in Unresectable Hepatocellular Carcinoma

Liver Cancer | HepatoCellular Carcinoma | Unresectable HepatoCellular Carcinoma

United States
Sung Yong Lee
Yuhan Corporation

Recruiting

A Study of Lazertinib as Consolidation Therapy in Patients With Locally Advanced, Unresectable, EGFR-Mutant Non-Small Cell Lung Cancer (Stage III) Following Chemoradiation Therapy (PLATINUM)

Non-small Cell Lung Cancer Stage III | Non-squamous Non-small-cell Lung Cancer | EGFR Positive Non-small Cell Lung Cancer

Korea, Republic of
Johns Hopkins University
Pfizer; Duke University

Completed

Efficacy of Abrocitinib for Reducing Pruritus in Adults With Prurigo Nodularis and Chronic Pruritus of Unknown Origin

Skin Diseases | Pruritus | Prurigo Nodularis | Chronic Pruritus | Chronic Prurigo

United States
Università Politecnica delle Marche

Unknown

TOFAcitinib in SARS-CoV2 Pneumonia

SARS-COv2 Related Interstitial Pneumonia

Italy
Pfizer

Completed

Multiple Dose Escalation Study In Medically Stable Subjects With Psoriasis

Psoriasis | Immunomodulation

United States

Search clinical trials for: Farnesyl Protein Transferase Inhibitor

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