Search clinical trials for: High dose

Total 10962 results

Vistakon Pharmaceuticals

Completed

Safety and Efficacy of a Drug Delivery System in Glaucoma

Ocular Hypertension | Open-angle Glaucoma

United States
Fovea Pharmaceuticals SA

Completed

Safety and Efficacy Study of Topical Administration of FOV2304 (High Dose or Low Dose) for the Treatment of Center-involving Clinically Significant Macular Edema Associated With Diabetic Retinopathy

Diabetic Macular Edema

United States, Australia, Belgium, Czech Republic, France, Germany, Israel, Italy, Poland, Spain
National Institute of Allergy and Infectious Diseases...
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Safety and Efficacy of an H1N1 Influenza Vaccine in People With Asthma

H1N1 Influenza Virus

United States
Memorial Sloan Kettering Cancer Center
Genentech, Inc.

Terminated

Study of the PD-L1 Inhibitor Atezolizumab With or Without Low-dose, Local Radiation in Patients With Relapsed or Refractory Advanced Stage Follicular Lymphoma

Lymphoma

United States
The Cleveland Clinic
Laboratoires Biocodex (Montrouge, France)

Completed

Effectiveness of Nefopam for Thermoregulation During Surgery

Hypothermia

Switzerland
Sanofi Pasteur, a Sanofi Company

Completed

Safety and Immunogenicity of Quadrivalent Influenza mRNA Vaccine MRT5407 in Adult Participants18 Years of Age and Older

Influenza Immunization

Puerto Rico, United States
Istituto Scientifico Romagnolo per lo Studio e...

Withdrawn

Vaccination With Dendritic Cells Pulsed With Autologous Tumor Homogenate in Combination With HD-IL2 and Immunomodulating Radiotherapy in Metastatic RCC (RENALVax-2)

Carcinoma, Renal Cell | Secondary | Vaccination

Italy
Shandong University

Completed

Efficacy of Tailored Bowel Preparation Strategy Guided by a Predictive Model

Colonoscopy | Bowel Cleansing Quality

China
University of North Carolina
National Cancer Institute (NCI)

Completed

Phase I Clinical Study of Soy Isoflavones in Healthy, Post-Menopausal Women

Drug Toxicity
Monyan Pharmaceutical (Shanghai) Co., Ltd.

Recruiting

A Multicenter Clinical Trial on DH001 Tablets in the Prevention of Doxorubicin-induced Cardiotoxicity in Cancer Patients

Heart Failure | Cancer | Arrhythmia | Doxorubicin Induced Cardiomyopathy | Doxorubicin Adverse Reaction

China
CyanVac LLC

Completed

Phase 1 Study of Intranasal PIV5 COVID-19 Vaccine Expressing SARS-CoV-2 Spike Protein in Healthy Adults and Adolescents (CVXGA1-001)

Covid19

United States
Tasly Pharmaceutical Group Co., Ltd

Completed

Study of Jitongning Tablet to Treat Spondyloarthritis

Spondyloarthritis

China
Yale University

Completed

Improving Post-Prandial Blood Glucose Control With Afrezza During Closed-Loop Therapy

Post-Prandial Hyperglycemia | Post-Prandial Hypoglycemia

United States
Boehringer Ingelheim

Completed

Safety, Tolerability and Pharmacokinetics of BI 653048 H3PO4 Oral Drinking Solution in Healthy Male Volunteers

Healthy
Helixmith Co., Ltd.

Unknown

Safety and Efficacy Study of Gene Therapy for Acute Myocardial Infarction in Korea

Ischemic Heart Disease | Acute Myocardial Infarction

Korea, Republic of
Centers for Disease Control and Prevention
Kenya Medical Research Institute

Completed

Brief Bactericidal Activity of Anti-Tuberculosis Drugs (BBA)

Tuberculosis | Drug-resistant Tuberculosis | Isoniazid Resistant Tuberculosis (Disorder)

India
Shenzhen Beike Bio-Technology Co., Ltd.
No.85 Hospital, Changning, Shanghai, China

Completed

Human Umbilical Cord Mesenchymal Stem Cells Transplantation for Patients With Decompensated Liver Cirrhosis

Liver Cirrhosis

China
University of Zurich

Completed

Impact of Antioxidant Agents on the Number of DNA Double-strand Breaks After Radiation-based Cardiac Examinations

Focus of the Study: DNA Damage Due to Medical Diagnostic X-ray

Switzerland
Boehringer Ingelheim

Completed

Effects of Tipranavir/Ritonavir on the Pharmacokinetic Characteristics of Triple Drug Nucleoside and Non-nucleoside Reverse Transcriptase Inhibitor Therapy in HIV-1-infected Subjects

HIV Infections
Medicago
Health Sciences Centre, Winnipeg, Manitoba; Syneos Health; Public Health Agency...

Completed

Safety, Tolerability and Immunogenicity of a Plant-made H7 Virus-like Particle (VLP) Influenza Vaccine in Adults.

RNA Virus Infections | Virus Diseases | Respiratory Tract Infections | Respiratory Tract Diseases

Canada
Radiation Therapy Oncology Group
National Cancer Institute (NCI); NRG Oncology

Completed

Radiation Therapy in Treating Patients With Stage II or Stage III Prostate Cancer

Prostate Cancer

United States
RespireRx
Duke University

Unknown

Antagonism of Opioid-Induced Respiratory Depression by CX1739 With Preservation of Opioid Analgesia

Opiate Induced Respiratory Depression

United States
Jiangsu Province Centers for Disease Control and...
Beijing Minhai Biotechnology Co., Ltd

Completed

Safety and Immunogenicity of a Sabin Inactivated Poliovirus Vaccine.

Polio and Post-Polio Syndrome

China
Amway (China) R&D Center

Recruiting

The Efficacy of Amway Uric Acid Lowering Product on Hyperuricemia

Hyperuricemia

China
Huashan Hospital
Shanghai 10th People's Hospital; Shanghai East Hospital; The Second Affiliated... and other collaborators

Completed

CHinese Acute Tissue-Based Imaging Selection for Lysis In Stroke -Tenecteplase (CHABLIS-T)

Stroke

China
Sidney Kimmel Comprehensive Cancer Center at Johns...
Howard University; Prostate Cancer Clinical Trials Consortium

Completed

Effects of Two Doses of MPX Capsules on Rising Prostate-specific Antigen Levels in Men Following Initial Therapy for Prostate Cancer

Prostate Cancer

United States
Inje University

Completed

Effect of Remifentanil on Postoperative Vomiting in Pediatric Strabismus Surgery

Strabismus

Korea, Republic of
Xi'an Xintong Pharmaceutical Research Co.,Ltd.

Unknown

A Study to Investigate the Safety, Tolerability, Pharmacokinetics of Single and Multiple Doses of Hepenofovir Fumarate Tablets in Healthy Volunteers.

Chronic Hepatitis b
Mayo Clinic

Recruiting

Adipose-derived MSC to Treat Rejection in Kidney Transplant Recipients

Kidney Transplant

United States
Janssen Vaccines & Prevention B.V.
National Institute of Allergy and Infectious Diseases (NIAID); Beth Israel... and other collaborators

Completed

Safety, Tolerability, and Immunogenicity Study of Homologous Ad26 Mosaic Vector Vaccine Regimens or Heterologous Ad26 Mosaic and MVA Mosaic Vector Vaccine Regimens With Glycoprotein 140 (gp140) for Human Immunodeficiency Virus (HIV) Prevention

Healthy

United States, South Africa, Thailand, Uganda, Rwanda
Vanderbilt University

Completed

Standard Versus High-Dose Trivalent Inactivated Flu Vaccine in Pediatric Acute Lymphoblastic Leukemia Patients

Pediatric Patients With Acute Lymphoblastic Leukemia

United States
Dong-A ST Co., Ltd.

Completed

Phase II Study of DA-6034 Eye Drops in Dry Eye Syndrome (DES)

Dry Eye Syndrome

Korea, Republic of
Boehringer Ingelheim
Eli Lilly and Company

Completed

Pharmacokinetic Single Dose Trial of Empagliflozin in Children and Adolescents With Type 2 Diabetes Mellitus

Diabetes Mellitus, Type 2

United States, France, Israel, Mexico, South Africa
Universitätsklinikum Hamburg-Eppendorf

Completed

Preoxygenation in the Intensive Care Unit Using a Nose-mouth Mask Versus High-flow Nasal Cannula Oxygen.

Respiratory Failure

Germany
N.N. Petrov National Medical Research Center of...

Recruiting

HDR Brachytherapy vs SABR in Early-intermediate Prostate Cancer

Biochemical Relapse Free Survival | Complications Rates (Erectile Dysfunction, GI, GU Complications)

Russian Federation
Istituto Scientifico Romagnolo per lo Studio e...

Unknown

Radiotherapy as an Immunological Booster in Patients With Metastatic Melanoma or Renal Cell Carcinoma Treated With High-dose Interleukin-2 (IL2HD)

Metastatic Renal Cell Cancer | Malignant Melanoma, Metastatic

Italy
Yonsei University

Completed

Sequential High-dose Dexamethasone and Response Adopted PAD or VAD Induction Chemotherapy Followed by High-dose Chemotherapy With Autologous Stem Cell Transplantation for Newly Diagnosed Multiple Myeloma

Multiple Myeloma

Korea, Republic of
National Taiwan University Hospital
National Science Council, Taiwan

Unknown

Efficacy of 10-day Concomitant Regimen Versus High Dose Dual Therapy in Anti-Helicobacter Pylori Rescue Therapy

Helicobacter Pylori Infection

Taiwan
AstraZeneca

Terminated

An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Crohn's Disease (INTREPID)

Crohn's Disease | IBD

United States, Italy, Taiwan, Korea, Republic of, Spain, Germany, Poland, Russian Federation, Israel, Ukraine, Canada, Czechia, South Africa, United Kingdom, Hungary, India, Slovakia
Vanderbilt University
University of Pittsburgh; MCM Vaccines B.V.

Completed

Standard Dose Versus High-Dose Inactivated Flu Vaccine in Pediatric Solid Organ Transplant Patients

Pediatric Solid Organ Transplant Patients

United States
American Heart Association

Completed

Improving Outcomes In Diabetic Patients During CABG Surgery By Optimizing Glycemic Control

Glycemic Control

United States
Toray Industries, Inc
Astellas Pharma Inc

Completed

TRK-100STP Clinical Study - Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis)

Chronic Renal Failure | Glomerular Disease | Nephrosclerosis

China, Hong Kong, Taiwan, Malaysia, Japan, Korea, Republic of, Thailand
Forest Laboratories

Completed

A Randomized, Double-Blind, Dose Response-Control, Crossover Study to Evaluate the Safety and Efficacy of Two Doses of EUR-1008 (APT-1008) in Chronic Pancreatitis (CP) Participants With Exocrine Pancreatic Insufficiency (EPI)

Chronic Pancreatitis | Exocrine Pancreatic Insufficiency

United States, Italy, Ukraine
University of Bern
Roche Pharma AG; University of Lausanne; University of Basel; Cantonal Hospital... and other collaborators

Completed

High Dose Ribavirin in the Treatment of Chronic Hepatitis C

Chronic Hepatitis C

Switzerland
GlaxoSmithKline

Completed

A Study to Evaluate Safety, Reactogenicity and Immunogenicity of GSK Biologicals' RSV Investigational Vaccine Based on Viral Proteins Encoded by Chimpanzee-derived Adenovector (ChAd155-RSV) (GSK3389245A) in RSV-seropositive Infants

Respiratory Syncytial Virus Infections

Taiwan, Spain, United States, Italy, Canada, Panama, Mexico, Poland
Santen Pharmaceutical Co., Ltd.

Completed

A Study Assessing the Efficacy and Safety of DE-127 Ophthalmic Solution in Subjects With Mild or Moderate Myopia (APPLE)

Myopia

Singapore
Medicago

Completed

Safety, Tolerability and Immunogenicity of a Plant-made Seasonal Quadrivalent VLP Influenza Vaccine in Adults

RNA Virus Infections | Virus Diseases | Respiratory Tract Infections | Respiratory Tract Diseases

United States
Medicago

Completed

Immunogenicity, Safety and Tolerability of a Plant-Derived Seasonal Virus-Like-Particle Quadrivalent Influenza Vaccine in Adults

RNA Virus Infections | Virus Diseases | Respiratory Tract Infections | Respiratory Tract Diseases

United States
N.N. Petrov National Medical Research Center of...

Recruiting

High-dose Chemotherapy as Second-line Drug Therapy for Relapsed Germ Cell Tumors (GERMAN)

Germ Cell Tumor

Russian Federation
Sir Mortimer B. Davis - Jewish General Hospital
Sanofi

Completed

A Study on the Timing of FOLFOX for Patients With Operable, Node Positive Rectal Cancer

Operable T2-3N+M0 Rectal Cancer (Stage III)

Canada

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