Search clinical trials for: High dose of methotrexate

Total 7320 results

Universidad Católica San Antonio de Murcia

Completed

Study to Analyze the Aerobic Performance Efficacy of Chronic Intake With a β-alanine Supplement in Recreational Cyclists (B-AC3)

Beta Alanine Supplementation

Spain
Universidad Católica San Antonio de Murcia

Completed

Study to Analyze the Efficacy of Chronic Intake With a β-alanine Supplement in Recreational Cyclists (B-AC2)

Beta Alanine Supplementation

Spain
Mahidol University

Completed

Clinical Outcome Study of High-dose Meropenem in Sepsis and Septic Shock Patients

Sepsis | Critical Illness | Septic Shock | Morality | Pharmacokinetic | Carbapenem | Pharmacodynamic | Clinical Outcome | Organ Failure, Multiple

Thailand
Teva Branded Pharmaceutical Products R&D, Inc.

Completed

Assessment of LBR-101 In Chronic Migraine

Chronic Migraine

United States
Asarina Pharma
Ergomed

Completed

A Study of Efficacy and Safety of Sepranolone (UC1010) in Patients With Premenstrual Dysphoric Disorder (PMDD)

Premenstrual Dysphoric Disorder

Sweden, Germany, Poland, United Kingdom
University of Wisconsin, Madison

Completed

Trial of High Dose vs. Standard Dose Influenza Vaccine in Inflammatory Bowel Disease Patients

Inflammatory Bowel Disease (IBD)

United States
St. Jude Children's Research Hospital

Completed

Immunogenicity of Fluzone HD,A High Dose Influenza Vaccine, In Children With Cancer or HIV

Cancer | HIV

United States
GlaxoSmithKline

Completed

A Study to Evaluate Safety, Reactogenicity and Immunogenicity of GSK Biologicals' RSV Investigational Vaccine Based on Viral Proteins Encoded by Chimpanzee-derived Adenovector (ChAd155-RSV) (GSK3389245A) in RSV-seropositive Infants

Respiratory Syncytial Virus Infections

Taiwan, Spain, United States, Italy, Canada, Panama, Mexico, Poland
MicuRx
Worldwide Clinical Trials

Completed

Single Dose Escalation and Multiple Dose Escalation Trial of an Intravenous Formulation of MRX-4

Safety
Visterra, Inc.

Completed

Study of Efficacy and Safety of IV VIS410 Plus Oseltamivir Versus Oseltamivir in Hospitalized Adults With Influenza A

Influenza A

United States, Australia, Belarus, Belgium, Bulgaria, Canada, Estonia, France, Georgia, Latvia, Malaysia, New Zealand, Russian Federation, Serbia, Singapore, South Africa, Spain, Thailand, Turkey, Ukraine
The Second Hospital of Nanjing Medical University

Recruiting

Washed Microbiota Transplantation for Chronic Constipation in Adults

Constipation

China
Dr. D. Robert Siemens

Completed

GTN Therapy on Biomarkers of Immune Escape in Men With Biochemical Recurrence of Prostate Cancer After Primary Therapy (GTN)

Prostate Cancer

Canada
Medigen Vaccine Biologics Corp.

Completed

A Study to Evaluate MVC-COV1901 Vaccine Against COVID-19 in Elderly Adults

Covid19 Vaccine

Taiwan
University of Aarhus

Completed

Bioavailability of Anthocyanins From Aronia Extract in Healthy Men - a Pilot Study

Bioavailability

Denmark
Bristol-Myers Squibb

Withdrawn

Evaluate the Bioavailability Between 2 BMS-986141 Formulations in Healthy Participants

Healthy
Shanghai Greenvalley Pharmaceutical Co., Ltd.
Shanghai Mental Health Center

Completed

Safety, Efficacy and Dose Titration of Sodium Oligo-mannurarate Capsule on Mild to Moderate Alzheimer's Disease

Cognitive Impairment | Alzheimer Disease

China
University of Bergen
Olympic Seafood AS

Completed

Krill Oil as Supplementation to Healthy Young Adults.

Healthy

Norway
Inviragen Inc.

Completed

Safety and Immunogenicity Study to Assess TDV, a Live Attenuated Tetravalent Vaccine for Prevention of Dengue Fever

Dengue Fever

Colombia
Centre Hospitalier Universitaire de Nice

Recruiting

Study of the Impact of Time of Vaccination on Response to Influenza Vaccine in Kidney Transplant Recipients -ChronoVAX (CHRONOVAX)

Vaccination; Infection

France
Centers for Disease Control and Prevention
Kaiser Permanente; Baylor Scott and White Health; Abt Associates

Completed

Immunogenicity Trial of Egg- Versus Non-Egg-Based Influenza Vaccines Among HCP

Influenza

United States
First Affiliated Hospital Xi'an Jiaotong University
Xi'an Gaoxin Hospital

Unknown

Effects of Fat-soluble Vitamins Supplementation on Common Complications and Neural Development in Very Low Birth Weight Infants

Sepsis | Anemia | Vitamin D Deficiency | Vitamin A Deficiency | Bronchopulmonary Dysplasia | Very Low Birth Weight Infants | Vitamin E Deficiency

China
Amber Ophthalmics, Inc.

Recruiting

NEXAGON for the Treatment of Corneal Persistent Epithelial Defects Following Severe Ocular Chemical and/or Thermal Injuries (EXPEDE)

Corneal Persistent Epithelial Defect

United States
Mayo Clinic

Completed

Effect of Gum Arabic on Gastrointestinal Transit and Permeability

Diverticulitis

United States
Virginia Commonwealth University
American Heart Association

Completed

Interleukin (IL)-1 Blockade in Acute Heart Failure (Anakinra ADHF)

Heart Failure

United States
King Saud Medical City

Unknown

Safety and Efficacy Study of High Dose Colistin

Infectious Diseases

Saudi Arabia
Access Business Group

Completed

A 12 Week, 3-Period Study to Evaluate the Effects of a Dietary Supplement on Lipid Metabolism

Hyperlipidemia

United States
Chiang Mai University

Unknown

The Effect of Dosage of Caffeine on Intraocular Pressure

Intraocular Pressure | Caffeine Dosage

Thailand
Boehringer Ingelheim

Completed

Klimadynon® in Comparison to Conjugated Oestrogens in Women Suffering From Menopausal Complaints

Menopause
Boehringer Ingelheim

Completed

Pharmacodynamic Effects, Safety and Tolerability of Cilobradine, Compared to Metoprolol Succinate and Placebo in Healthy Volunteers

Healthy
Oryn Therapeutics, LLC

Withdrawn

A Study of ORTD-1 in Patients Hospitalized With COVID-19 Related Pneumonia

COVID-19

United States
Sanofi Pasteur, a Sanofi Company

Completed

Safety and Immunogenicity of ChimeriVax-WN02 West Nile Vaccine in Healthy Adults

West Nile Fever

United States
Boehringer Ingelheim

Completed

4 Week Combination of BI 207127 NA With Peg-IFN and Ribavirin in Chronic HCV Patients

Hepatitis C, Chronic

France, Germany, Switzerland
Cellular Biomedicine Group Ltd.
RenJi Hospital

Completed

Autologous Adipose Tissue Derived Mesenchymal Stem Cells Therapy for Patients With Knee Osteoarthritis

Knee Osteoarthritis

China
Boehringer Ingelheim

Completed

4 Weeks Treatment With Empagliflozin (BI 10773) in Japanese Type 2 Diabetic Patients (T2DM)

Diabetes Mellitus, Type 2

Japan
Shenzhen Ausa Pharmed Co.,Ltd
Ruijin Hospital; Xuzhou Medical University; Second Affiliated Hospital of Nanchang...

Unknown

Efficacy of Amlodipine-Folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine

Essential Hypertension

China
Pfizer

Completed

Evaluation of a Single Vaccination With One of Three Ascending Dose Levels of a 4-Antigen Staphylococcus Aureus Vaccine (SA4Ag) in Healthy Adults Aged 18 to <65 Years

Staphylococcal Infections

United States
Helixmith Co., Ltd.

Unknown

Safety and Efficacy Study of Gene Therapy for Acute Myocardial Infarction in Korea

Ischemic Heart Disease | Acute Myocardial Infarction

Korea, Republic of
AstraZeneca
MedImmune LLC

Completed

A Study to Evaluate the Efficacy and Safety of MEDI0382 in the Treatment of Overweight and Obese Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2

Germany, United States, Canada, Russian Federation, Slovakia, Czechia, Bulgaria, Mexico
Santen Inc.

Completed

Multi-center Phase II Study Assessing the Safety and Efficacy of DE-117 Ophthalmic Solution in Subjects With Primary Open-angle Glaucoma or Ocular Hypertension (SEE-1)

Ocular Hypertension | Open-angle Glaucoma

United States
Boehringer Ingelheim

Completed

Effects of Tipranavir/Ritonavir on the Pharmacokinetic Characteristics of Triple Drug Nucleoside and Non-nucleoside Reverse Transcriptase Inhibitor Therapy in HIV-1-infected Subjects

HIV Infections
Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd

Active, not recruiting

Phase I Clinical Trial of Inactivated Rotavirus Vaccine in a Population Aged 6 Weeks-49 Years Old

Healthy Volunteers

China
Centre Antoine Lacassagne
Roche Pharma AG; Centre Hospitalier Universitaire de Caen

Recruiting

Stereotaxic Body Irradiation of Oligometastase in Sarcoma (Stereosarc) (Stereosarc)

Sarcoma | Radiosurgery

France
University of Oklahoma
Stephenson Cancer Center

Completed

High Dose Chemo With Autologous BMT for Treatment of Metastatic Breast Cancer

Breast Neoplasms

United States
Flinders University
Flinders Medical Centre; Lyell McEwin Hospital

Recruiting

Assessment of Myocardial Injury in Patients Treated With Immune Checkpoint Inhibitors (MIICI)

Myocardial Injury | Myocarditis | Cardiotoxicity | Immune Checkpoint Inhibitors

Australia
Peking University

Recruiting

R-MTX-zanbrutinib in Secondary CNS Lymphoma

Secondary Central Nervous System Lymphoma

China
Memorial Sloan Kettering Cancer Center

Withdrawn

Feasibility and Safety Study Using Preoperative High-Dose Single-Fraction Image-Guided Radiotherapy for Men Undergoing Radical Prostatectomy at High-Risk for Extraprostatic Cancer

Prostate Cancer

United States
Peking Union Medical College Hospital

Completed

Optimizing the Anticoagulation Regimen of Enoxaparin During Percutaneous Coronary Intervention (OPTIENOX-PCI) (OPTIENOX-PCI)

Coronary Artery Disease | Percutaneous Coronary Intervention

China
Vanderbilt-Ingram Cancer Center

Completed

Standard vs High-Dose Trivalent Inactivated Flu Vaccine in Adult Hematopoetic Stem Cell Transplant (HSCT) Recipients

Adult Stem Cell Hematopoetic Transplant

United States
Inotrem

Active, not recruiting

Efficacy, Safety and Tolerability of Nangibotide in Patients With Septic Shock (ASTONISH)

Shock, Septic

Belgium, France, Spain, Denmark, Finland, Ireland
InQpharm Group

Completed

Benefit and Tolerability of IQP-LU-104 in Weight Loss

Obesity | Overweight

Germany

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