Search clinical trials for: Hyperpolarized [13C] Pyruvate

Total 2063 results

Chang Gung Memorial Hospital

Completed

Long-Term Vesicular Monoamine Transporter II Imaging and Clinical Assessment of Parkinson's Disease Progression

Parkinson Disease
Chang Gung Memorial Hospital

Completed

Positron-Emission Tomography With Vesicular Monoamine Transporter Ligand ([18F]-DTBZ) In Healthy Elderly And Young Subjects

Healthy
Motus Therapeutics, Inc.
Mayo Clinic

Completed

Effect of Relamorelin on Satiation, Gastric Volume, Gastric Accommodation and Distal Gastric Function in Healthy Volunteers

Gastric Motility

United States
Biogen

Completed

Single Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of BIIB061 in Healthy Adult Volunteers Including Absolute Bioavailability and Food Effect

Healthy

United States
AstraZeneca

Completed

Study to Assess the Distribution, Metabolism and Excretion of [14C]AZD6765 After a Single-Dose Intravenous Administration (AZD6765)

Major Depressive Disorder

United Kingdom
Lexicon Pharmaceuticals

Completed

An Open-label Study to Evaluate the Absorption, Metabolism, and Excretion of [14C]-Telotristat Etiprate in Males (LX1606-104)

Carcinoid Syndrome

United Kingdom
Molecular Insight Pharmaceuticals, Inc.

Terminated

Phase I Safety and Dosimetry Study in Patients With Confirmed Metastatic Melanoma

Metastatic Melanoma

United States
AstraZeneca

Completed

Positron Emission Tomography (PET) Study With [11C]AZ12713580 to Determine Central mGluR5 Receptor Occupancy of AZD2066 (PET)

Healthy

Sweden
Stealth BioTherapeutics Inc.

Completed

Study to Evaluate Safety, Tolerability, and Pharmacokinetics (PK) of Intravenous (IV) Infusion of MTP-131 (Bendavia™) in Healthy Adults

Healthy

United States
Bastiaan Driehuys
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Non-Invasive Diagnosis of Pulmonary Vascular Disease Using Inhaled 129Xe Magnetic Resonance Imaging (XenonMRI)

Pulmonary Vascular Disease

United States
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Study of [11C]JNJ-42491293, a Possible PET Ligand for the mGlu2 Receptor, in Healthy Adult Volunteers

Healthy
Takeda

Completed

Study to Evaluate Absorption, Metabolism, and Excretion, of TAK-994 in 6 Healthy Male Adults

Healthy Volunteers

United States
Theravance Biopharma

Completed

TD-1473 Absorption, Distribution, Metabolism and Excretion (ADME) Study in Healthy Male Subjects

Bowel Diseases, Inflammatory | Intestinal Disorders

United States
Vanderbilt University

Completed

Deep Brain Stimulation (DBS) Frequency Effects on Gait in Parkinson's Disease(PD)

Parkinson Disease

United States
Jubilant DraxImage Inc.

Available

Expanded Access Protocol Using 131I-MIBG

Neuroblastoma | Pheochromocytoma | Paraganglioma

United States
University of Alabama at Birmingham

Recruiting

Renal Metabolism of Glycolate to Oxalate

Healthy

United States
Centre Hospitalier Universitaire, Amiens

Recruiting

Monitoring of the Bone Free Flaps With Microdialysis (MTM2018)

Flap Necrosis

France
Patrick Lao
National Institute on Aging (NIA)

Recruiting

Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease (ADVISe)

Alzheimer Disease

United States
Washington University School of Medicine
The Foundation for Barnes-Jewish Hospital

Completed

Sex and Obesity: Effects on Heart Failure Study

Heart Failure | Obesity

United States
Basilea Pharmaceutica

Completed

Mass Balance and Pharmacokinetics Study of Derazantinib in Healthy Male Subjects

Healthy Volunteers

United Kingdom
The University of Texas Health Science Center,...

Recruiting

Identifying Correlates of Brain Microglial Activation in Neuropsychiatric Syndromes: A Dimensional Approach

Neuropsychiatric Syndromes

United States
Institut Claudius Regaud

Recruiting

Evaluation of the Interest of a Video-assisted Remote Speech Therapy Consultation in Patients With ORL Cancer (TELE ORTHOPHONIE)

ORL Cancer

France
Ausper Biopharma Co., Ltd.

Recruiting

A Study to Evaluate the Safety and Efficacy of AHB-137 in Healthy Participants and Chronic Hepatitis B Patients

Hepatitis B, Chronic

China
Yale University
National Institute on Drug Abuse (NIDA)

Recruiting

SV2A in Older Adults

Cannabis Use

United States
Memorial Sloan Kettering Cancer Center
GT Medical Technologies, Inc.

Recruiting

Intracavitary Carrier-embedded Cs131 Brachytherapy for Recurrent Brain Metastases: a Randomized Phase II Study

Recurrent Brain Metastases

United States
TenNor Therapeutics (Suzhou) Limited

Completed

Human Mass Balance and Biotransformation Study of [14C]TNP-2198

Helicobacter Pylori Infection

China
BeiGene

Completed

A Study to Investigate the Absorption, Metabolism and Excretion of [14C]-BGB-11417

Healthy Volunteers

United States
Gilead Sciences

Approved for marketing

Expanded Access for IMMU-132

Metastatic Triple-Negative Breast Carcinoma
Stealth BioTherapeutics Inc.

Completed

An Open-Label, Phase 1 Clinical Study to Evaluate the Safety and Tolerability of Subcutaneous Elamipretide in Subjects With Intermediate Age-Related Macular Degeneration

Age-Related Macular Degeneration

United States
BioMed Valley Discoveries, Inc

Completed

Absorption, Metabolism and Excretion (AME) of Single Dose Radiolabeled BVD-523 in Volunteers

Healthy
Boehringer Ingelheim

Completed

Excretion Balance of 14c-radiolabeled BIRB 796 BS in Normal Male Subjects

Healthy
Astellas Pharma Inc

Completed

A Study to Assess the Systemic Disposition of ASP1585 After Administration of 14C-labeled Drug

Healthy | Pharmacokinetics of ASP1585

United States
University of Pennsylvania
Fox Chase Cancer Center; Columbia University; Thomas Jefferson University

Enrolling by invitation

Penn Medicine Biobank Return of Results Program (ROR)

Cardiovascular Diseases | Cancer | Genetic Disease

United States
NeuShen Therapeutics

Recruiting

First-into-human Study of NS-136 in Healthy Subjects

Healthy Subjects

Australia
Massachusetts General Hospital

Recruiting

Imaging Histone Deacetylase in the Heart

Diabetes | Aortic Valve Stenosis | Heart Failure With Normal Ejection Fraction | Left Ventricular Hypertrophy

United States
AusperBio Therapeutics Inc.

Active, not recruiting

A Study Evaluating AHB-137 in Healthy Participants and Participants With Chronic Hepatitis B

Chronic Hepatitis B

United States, Hong Kong, Taiwan, New Zealand
Oscotec Inc.

Completed

A Study of the Absorption, Metabolism, and Excretion of [14C]-SKI-O-703 Following a Single Oral Dose in Healthy Male Subjects

Healthy Volunteers

United States
Betta Pharmaceuticals Co., Ltd.

Active, not recruiting

The Absorption, Metabolism and Excretion of [14C]D-0316 in Human

Advanced or Metastatic Non-small Cell Lung

China
Allergan

Completed

Safety and Efficacy of Relamorelin Administered to Participants With Vomiting Symptoms and Moderate to Severe Diabetic Gastroparesis

Diabetes Mellitus | Gastroparesis | Diabetes Mellitus Complications

United States, United Kingdom, Belgium, Israel, Germany, Poland, Sweden
Niiki Pharma Inc.

Completed

Dose Escalation Study of NKP-1339 to Treat Advanced Solid Tumors

Solid Tumors

United States
Afferent Pharmaceuticals, Inc.

Completed

A Pharmacokinetics Study of AF-130 in Healthy Subjects

Healthy Volunteers

United Kingdom
Boehringer Ingelheim

Completed

Metabolism and Pharmacokinetics of [14C]-BIIL 284 BS in Healthy Volunteers

Healthy
Charite University, Berlin, Germany

Unknown

WT1 Peptide Vaccination in Acute Myeloid Leukemia (AML)

Acute Myeloid Leukemia | Myelodysplastic Syndrome

Germany
Charite University, Berlin, Germany

Unknown

WT1 Peptid Vaccination in Carcinomas

WT1 Expressing Carcinoma

Germany
Neurocrine Biosciences
Takeda

Completed

A Study to Assess Absolute Bioavailability (ABA) of TAK-831 and to Characterize Mass Balance, Pharmacokinetics (PK), Metabolism, and Excretion of [14C]TAK-831 in Male Healthy Participants

Healthy Volunteers

United States
Pfizer

Completed

Study to Characterize Absorption, Distribution, Metabolism and Excretion of 14C PF-06651600 and to Evaluate the Absolute Oral Bioavailability and Fraction Absorbed of PF-06651600. (B7981011)

Healthy Volunteers

Netherlands
Drugs for Neglected Diseases

Completed

ADME Study of Acoziborole in Healthy Subjects

Trypanosomiases, African

United Kingdom
Pfizer

Completed

Study To Characterize Mass Balance, Absolute Bioavailability, Fraction Absorbed And Pharmacokinetics Of 14C PF-06882961

Healthy Volunteer

Netherlands
Bristol-Myers Squibb

Recruiting

A Study to Evaluate the Drug Levels, Physical and Chemical Changes, and Removal of BMS-986196 in Healthy Male Participants

Healthy Male Volunteers

United States
Imperial College London

Recruiting

Quantifying 18kDa TSPO Expression in the Lung in Pulmonary Artery Hypertension (PAH)

Healthy | Pulmonary Arterial Hypertension

United Kingdom

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