Search clinical trials for: IL-17A Antagonist

Total 34283 results

University of Manchester
Northern Care Alliance NHS Foundation Trust; National Institute for Health... and other collaborators

Active, not recruiting

SC IL-1Ra in SAH - Phase III Trial (SCIL) (SCIL)

Subarachnoid Hemorrhage

United Kingdom
Adrian Parry-Jones
Northern Care Alliance NHS Foundation Trust; Manchester University NHS Foundation... and other collaborators

Completed

BLOC-ICH: Interleukin-1 Receptor Antagonist in Intracerebral Haemorrhage (BLOC-ICH)

Intracerebral Haemorrhage

United Kingdom
Merck KGaA, Darmstadt, Germany

Completed

Multiple Ascending Dose Trial of MSB0010841 (Anti-IL17A/F Nanobody) in Psoriasis Subjects

Psoriasis

Germany
Jiangsu HengRui Medicine Co., Ltd.

Suspended

A Clinical Study of SHR-1314 Injection in the Treatment of Moderate to Severe Plaque Psoriasis in Adults

Plaque Psoriasis

China
Sinocelltech Ltd.

Not yet recruiting

Efficacy and Safety of SCT650C in Participants With Axial Spondyloarthritis

Axial Spondyloarthritis

Turkey
Sinocelltech Ltd.

Not yet recruiting

Evaluate the Safety and Tolerability of SCT650C in Healthy Volunteers

Autoimmune Disease

Australia
Mayo Clinic

Completed

Safety of Intra-Articular Sc-rAAV2.5IL-1Ra in Subjects With Moderate Knee OA (AAVIL-1Ra)

Osteoarthritis, Knee

United States
Janssen Pharmaceutica N.V., Belgium

Active, not recruiting

A Study of Guselkumab and Interleukin-17 (IL-17) Inhibitor Therapies in Participants With Psoriatic Arthritis in Routine Clinical Practice (PsABIOnd)

Arthritis, Psoriatic

United Kingdom, Korea, Republic of, France, Belgium, Japan, Taiwan, Austria, Canada, Netherlands, Spain, Italy, Germany, Australia, Switzerland, Mexico, Sweden, Greece, Argentina, Colombia, Russian Federation
Oregon Health and Science University
Eli Lilly and Company

Completed

Ixekizumab in the Treatment of Pityriasis Rubra Pilaris (PRP)

Pityriasis Rubra Pilaris

United States
Kanuni Sultan Suleyman Training and Research Hospital

Completed

GDM Patients and Serum Amyloid A and Interleukin-1 (IL-1) Receptor Antagonist

Gestational Diabetes

Turkey
Beijing Tongren Hospital
Chengdu Rhodiola Bio-Pharmaceutical Co Ltd

Unknown

Phase 1 Study for Safety and Tolerability of IL-1-Ra Topically Administered to Eyes of Healthy Adult Subjects

Blepharokeratoconjunctivitis

China
Shanghai Junshi Bioscience Co., Ltd.
Sponsor GmbH

Recruiting

Evaluate the Preliminary Efficacy, Safety, and PK of Subcutaneous JS005 in Chinese Adult Patients With Active Nr-axSpA

Non-radiographic Axial Spondyloarthritis

China
Shanghai Junshi Bioscience Co., Ltd.
Sponsor GmbH

Recruiting

Evaluate the Preliminary Efficacy, Safety, and PK of Subcutaneous JS005 in Chinese Adult Patients With Active AS

Active Ankylosing Spondylitis

China
Vanderbilt University Medical Center
American Heart Association

Not yet recruiting

Long COVID Immune Profiling

Long COVID | Autonomic Dysfunction | POTS - Postural Orthostatic Tachycardia Syndrome
Marc Y.Donath

Completed

Role of Interleukin-1 in the Regulation of Muscle Derived Interleukin-6 During Exercise (MUSIL)

Type 2 Diabetes

Switzerland
Genrix (Shanghai) Biopharmaceutical Co., Ltd.

Completed

to Evaluate the Preliminary Efficacy and Safety of GR1501 Injection in Patients With Active Axial Spondyloarthritis

Axial Spondyloarthritis

China
University of Zurich
Steno Diabetes Center Copenhagen

Completed

Treatment of Patients With Type 2 Diabetes With an Interleukin-1 Antagonist

Type 2 Diabetes

Switzerland, Denmark
Sohag University

Not yet recruiting

IL17 in Systemic Lupus Erythematosus Patients: Association With Disease Activity and Organ Damage

Systemic Lupus Erythematosus

Egypt
Reza Dana, MD

Completed

Topical IL-1-Ra for Treatment of Posterior Blepharitis

Posterior Blepharitis
Bio-Thera Solutions

Active, not recruiting

Assessment on Efficacy and Safety of BAT2306 and Cosentyx® in Plaque Psoriasis Patients

Plaque Psoriasis

China
Reza Dana, MD

Terminated

Topical IL-1-Ra for Treatment of Corneal Neovascularization

Corneal Neovascularization

United States
University of Alabama at Birmingham

Completed

Early Treatment of Cytokine Storm Syndrome in Covid-19

COVID-19 | Cytokine Storm

United States
CHU de Reims

Completed

Interest of Dosage of Anti-PB230, Anti-PB180 and Cytokines for Monitoring of Patients Suffering From Bullous Pemphigoid (Cyto-PB)

Bullous Pemphigoid

France
Shanghai Junshi Bioscience Co., Ltd.

Recruiting

A Clinical Study to Evaluate the Efficacy and Safety of Subcutaneous JS005 Injection in the Treatment of Adults With Moderate to Severe Chronic Plaque Psoriasis

Moderate to Severe Chronic Plaque Psoriasis

China
Shanghai Junshi Bioscience Co., Ltd.
Sponsor GmbH

Recruiting

A Clinical Study of JS005 in Patients With Ankylosing Spondylitis

Ankylosing Spondylitis

China
Shanghai Junshi Bioscience Co., Ltd.

Unknown

Phase I Study of Comparing Single Dose JS005 (Recombinant Humanized Monoclonal Antibody Against IL-17A) With Placebo in Tolerability, Safety, Immunogenicity and Pharmacokinetic in Healthy Volunteers

Tolerability, Safety, Immunogenicity and Pharmacokinetic of JS005

China
Shanghai Junshi Bioscience Co., Ltd.

Completed

Safety, Tolerance, Efficacy and Pharmacokinetics of JS005 Multiple Dosing

Moderate to Severe Psoriasis

China
Riphah International University
KRL Hospital, Islamabad

Recruiting

Diagnostic and Prognostic Blood Markers in Non Specific Low Back Pain

Low Back Pain

Pakistan
Centre Hospitalier Universitaire de Nīmes

Recruiting

Optimizing Anti-IL17 Antibody Therapy by Associating Fiber Supplementation to Correct Treatment-aggravated Gut Dysbiosis in Axial Spondyloarthritis - RESPOND-IL17 (RESPOND-IL17)

Axial Spondyloarthritis

France
Centre Hospitalier Universitaire de Nīmes

Completed

Contribution of Inflammation and Neuronal Integrity Markers in Patients With First-episode Conversive Motor Disorder (HYCOIN)

Conversion Disorder

France
National Institute of Allergy and Infectious Diseases...
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Safety and Effectiveness of CD4-IgG2 in HIV-Positive Children

HIV Infections

United States
jiangjingting

Unknown

Anti-CD19:TCRζ Chimeric Antigen Receptor-T Cells in the Treatment for CD19+ B Cell Lymphoma

Lymphoma, B Cell

China
Bausch Health Americas, Inc.

Enrolling by invitation

LTS of Siliq vs. Other Therapies Treating of Adults With Moderate-to-Severe Psoriasis

Psoriasis

United States
Sohag University

Recruiting

IL6&8 in Malnourished Children With Acute Diarrhea

Acute Gastroenteritis | Severe Acute Malnutrition | Acute Diarrhea

Egypt
Sohag University

Recruiting

Evaluation of Serum Interleukin 6 and 8 in Children With Acute Gastroenteritis

Acute Gastroenteritis | Acute Diarrhea

Egypt
Peking University Third Hospital

Recruiting

Low Dose IL-2 in the Treatment of Immune-associated ALS Syndrome

Amyotrophic Lateral Sclerosis

China
Brigham and Women's Hospital

Terminated

Novel Strategies to Improve Immunomodulation and Non-invasive Clinical Monitoring in VCA

Abdominal Wall Defect | Amputation, Traumatic | Amputation;Traumatic;Old | Face Injury | Face; Deformity

United States
Peking University People's Hospital

Unknown

The Incidence of Infection in Treatment of Low-dose IL-2 of SLE Patients

Infection

China
Merck Sharp & Dohme LLC

Terminated

Safety and Efficacy Study of IL-10 (Tenovil TM) in the Prevention of Post-ERCP Acute Pancreatitis (Study P02580)(TERMINATED)

Gallbladder Diseases | Biliary Tract Diseases | Pancreatic Diseases | Pancreatitis | Bile Duct Diseases
Genexine, Inc.

Completed

Clinical Trial of GX-I7 in Healthy Volunteers

Healthy

Korea, Republic of
National Institute of Allergy and Infectious Diseases...
HIV Vaccine Trials Network

Completed

Safety and Effectiveness of PENNVAX-B Vaccine Alone, With Il-12, or IL-15 in Healthy Adults

HIV Infections

United States
National Cancer Institute (NCI)

Completed

A Phase I Study of Intravenous Recombinant Human IL-15 in Adults With Refractory Metastatic Malignant Melanoma and Metastatic Renal Cell Cancer

Melanoma | Carcinoma, Renal Cell

United States
Fourth Affiliated Hospital of Guangxi Medical University
Liuzhou Maternity and Child Healthcare Hospital

Unknown

Interleukin-10 Promoter-1082A/G Polymorphism and Idiopathic Recurrent Miscarriage Risk

Abortion, Spontaneous

China
Sophiris Bio Corp

Withdrawn

Convection Enhanced Localized Administration of PRX321 With Real-time Imaging for Therapy of Recurrent Glioblastoma (CLARITY-1) (CLARITY-1)

Glioblastoma Multiforme
National Cancer Institute (NCI)

Terminated

Combination Therapy of Interleukin-12 and Interleukin-2 to Treat Advanced Cancer

Sarcoma | Breast Neoplasm | Lung Neoplasm | Kidney Neoplasm

United States
Hamamatsu University
Yokoyama Foundation for Clinical Pharmacology

Unknown

Cytokine Gene Polymorphisms in Gastric Diseases

Gastric Cancer | Gastric Ulcer | Duodenal Ulcer

Japan
University Hospital, Basel, Switzerland

Completed

Effects of Interleukin-1 Receptor Antagonism on Hyperandrogenemia in Women With Polycystic Ovary Syndrome (FertIL)

Polycystic Ovary Syndrome

Switzerland
The George Washington University Biostatistics...
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS)

Pregnancy | Preterm Birth | Multifetal

United States
Federal Research Institute of Pediatric Hematology...

Completed

IL-1 Receptor Inhibitor for Granulomatous Complications in Patients With Chronic Granulomatous Disease

Chronic Granulomatous Disease

Russian Federation
National Cancer Institute (NCI)

Completed

Continuous Infusion of rhIL-15 for Adults With Advanced Cancer

Lymphoma | Carcinoma

United States

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