Search clinical trials for: Immunosuppressive Drugs

Total 257340 results

Assistance Publique - Hôpitaux de Paris
Novartis

Completed

Use of RAD001 as Monotherapy in the Treatment of Neurofibromatosis 1 Related Internal Plexiform Neurofibromas (NFitor)

Neurofibromatoses | Neurofibromatosis Type 1 | Plexiform Neurofibroma

France
Queen Mary University of London
AstraZeneca; Cancer Research UK

Terminated

A Study Comparing AZD2014 vs Everolimus in Patients With Metastatic Renal Cancer (ZEBRA)

Metastatic Clear Cell Renal Carcinoma

United Kingdom
NYU Langone Health
Novartis Pharmaceuticals

Completed

RAD001 Plus Carboplatin in Breast Cancer Patients

Breast Cancer

United States
University of California, Los Angeles
Genzyme, a Sanofi Company

Withdrawn

Role of Intraoperative Thymoglobulin in Decreasing Ischemia-Reperfusion Injury in Pediatric Heart Transplant Recipients

Heart Transplantation | Ischemia Reperfusion Injury

United States
Vanderbilt-Ingram Cancer Center
National Cancer Institute (NCI)

Terminated

Everolimus and Whole-Brain Radiation Therapy in Treating Patients With Brain Metastasis From Non-Small Cell Lung Cancer

Lung Cancer | Metastatic Cancer

United States
National Eye Institute (NEI)

Completed

Leflunomide to Treat Uveitis

Uveitis

United States
The University of Queensland

Recruiting

A Trial to Treat Polyomavirus Infections (BKPyV) in Kidney and Simultaneous Kidney Pancreas Transplant Recipients (BEAT-BK)

Kidney Transplant Infection | Kidney Transplant Failure and Rejection | BK Viremia

Australia
Institute of Hematology & Blood Diseases Hospital

Recruiting

Cyclophosphamide Added to Standard Immunosuppressive Therapy With Eltrombopag as Front-line Therapy in Patients With Severe Aplastic Anemia

Severe Aplastic Anemia

China
University of Sao Paulo
Northwestern University; Genzyme, a Sanofi Company

Completed

Safety and Efficacy Study of Autologous Stem Cell Transplantation for Early Onset Type I Diabetes Mellitus

Type 1 Diabetes Mellitus

Brazil
Alexion Pharmaceuticals, Inc.

Completed

ALXN1210 (Ravulizumab) Versus Eculizumab in Complement Inhibitor Treatment-Naïve Adult Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Paroxysmal Nocturnal Hemoglobinuria (PNH)

Italy, United States, Taiwan, Thailand, Brazil, Russian Federation, United Kingdom, Belgium, Canada, Korea, Republic of, Poland, Malaysia, Japan, Czechia, Spain, Germany, Austria, France, Serbia, Mexico, Sweden, Estonia, Singapore, Ar... and more
University Hospital, Tours
Hospices Civils de Lyon; University Hospital, Strasbourg, France; University... and other collaborators

Active, not recruiting

Personalized Spacing of Eculizumab Infusions Based on Therapeutic Pharmacological Monitoring (EspacECU) (EspacECU)

Hemolytic-Uremic Syndrome, Atypical

France
University Ghent
Merck Sharp & Dohme LLC; the Flanders Institute for Biotechnology

Completed

Efficacy of Golimumab in Early Axial Spondyloarthritis in Relation to Gut Inflammation (GO-GUT)

Axial Spondyloarthritis

Belgium
Janssen Research & Development, LLC

No longer available

Pre-Approval Access to Golimumab Subcutaneous for the Treatment of Stage 3 Type-1 Diabetes Mellitus in Children and Young Adults

Diabetes Mellitus, Type 1

United States
Guy's and St Thomas' NHS Foundation Trust
Merck Sharp & Dohme LLC

Completed

Study of the Golimumab Exposure-Response Relationship Using Serum Trough Levels (GO-LEVEL)

Ulcerative Colitis

United Kingdom
Gary Archer Ph.D.
National Cancer Institute (NCI)

Completed

Basiliximab in Treating Patients With Newly Diagnosed Glioblastoma Multiforme Undergoing Targeted Immunotherapy and Temozolomide-Caused Lymphopenia (REGULATe)

Malignant Neoplasms Brain

United States
Merck Sharp & Dohme LLC

Completed

Correlation of Soluble Suppression of Tumorigenicity 2 (ST2) With Golimumab (MK-8259) Response in Participants With Ulcerative Colitis (UC) (MK-8529-022). (EVOLUTION)

Colitis, Ulcerative
GlaxoSmithKline

Completed

Single Dose Study to Investigate the Pharmacokinetics (PK) and Safety of Belimumab 200 Milligrams (mg) Intravenous and 200 mg Subcutaneous Via Auto-injector in Chinese Healthy Subjects

Systemic Lupus Erythematosus

China
Novartis Pharmaceuticals

Completed

Safety and Efficacy of AEB071 and EVEROLIMUS in Patients With CD79-mutant or ABC Subtype Diffuse Large B-Cell Lymphoma (COEB071X2103)

CD79 Mutant or ABC-subtype Diffuse Large B-Cell Lymphoma

Taiwan, Italy, Netherlands, Hong Kong, Germany, United States, Korea, Republic of, France
Swiss Group for Clinical Cancer Research

Completed

Everolimus as First-Line Therapy in Treating Patients With Prostate Cancer

Prostate Cancer

Switzerland
Biogen

Completed

Effect of BG00012 on Lymphocyte Subsets and Immunoglobulins in Subjects With Relapsing Remitting Multiple Sclerosis (RRMS).

Multiple Sclerosis | Multiple Sclerosis, Relapsing-Remitting

United States, Bulgaria, Belgium, Poland, Lithuania, Kuwait, Turkey
Novartis Pharmaceuticals

Completed

Efficacy and Safety of Everolimus in Patients With Metastatic Colorectal Cancer Who Have Failed Prior Targeted Therapy and Chemotherapy

Colorectal Cancer

United States
Astellas Pharma Inc

Completed

Pharmacokinetics Study in Patients With Impaired Renal Function and Subjects With Normal Renal Function

Patients With Impaired Renal Function

Japan
UCB BIOSCIENCES, Inc.
PPD; Parexel

Completed

A Multicenter, Postmarketing Study Evaluating the Concentration of Cimzia® in Mature Breast Milk of Lactating Mothers (CRADLE)

Rheumatoid Arthritis | Crohn's Disease | Psoriatic Arthritis | Ankylosing Spondylitis | Axial Spondyloarthritis (AxSpA) | Non-radiographic Evidence-AxSpA

United States, Netherlands, Switzerland
Biogen

Completed

Study of Utilization Patterns of Dimethyl Fumarate in Germany

Multiple Sclerosis

Germany
Janssen Pharmaceutical K.K.

Completed

A Safety and Effectiveness Study of Golimumab in Japanese Patients With Moderately to Severely Active Ulcerative Colitis.

Colitis, Ulcerative

Japan
Janssen-Cilag, S.A.

Terminated

Registry for Analysis of Compliance in Colombian Participants With Rheumatoid Arthritis Exposed to Golimumab (Go-Compl-Ar)

Rheumatoid Arthritis

Colombia
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Accuracy of a Subset of the Length-109 Probe Set Panel (a Genetic Test) in Predicting Response to Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis

Colitis, Ulcerative

France, Ukraine, United States, Poland, Bulgaria, Canada, Netherlands, Belgium, Russian Federation, Germany, Hungary, Czech Republic
Biogen

Withdrawn

Study to Evaluate Fatigue in Participants With Relapsing Remitting Multiple Sclerosis When Treated With Dimethyl Fumarate (TECNERGY)

Multiple Sclerosis | Relapsing-Remitting Multiple Sclerosis
UCB Pharma SA
Parexel

Completed

A Study of Certolizumab Pegol to Evaluate Pharmacokinetics and Safety in Adult Healthy Chinese Subjects

Healthy Subjects

China
European Institute of Oncology
Istituto Clinico Humanitas

Terminated

Allogenic Haematopoietic Cell Transplantation for Patients With Refractory "Triple Negative" Breast Cancer

Breast Cancer

Italy
LG Life Sciences

Unknown

Phase III Trial to Evaluate the Efficacy and Safety of Gemigliptin 50mg qd Added to Ongoing Glimepiride as Fix-dose Combination in Patients With Type 2 Diabetes

Type 2 Diabetes Mellitus

Korea, Republic of
House Research Institute
Janssen Services, LLC

Terminated

Intratympanic Injection for Autoimmune Inner Ear Disease (AIED)

Autoimmune Inner Ear Disease
Astellas Pharma Global Development, Inc.
Janssen Biotech, Inc.

Completed

A Study to Assess the Relative Bioavailability Between Two ASP015K Tablets and the Food Effect of a New Tablet in Healthy Adult Subjects

Healthy Subjects | Bioavailability of ASP015K | Pharmacokinetics of ASP015K | Food Effect of ASP015K

United States
Human Genome Sciences Inc.
GlaxoSmithKline

Terminated

Phase 2 Study of Belimumab Administered Subcutaneously to Subjects With Systemic Lupus Erythematosus (SLE)

Systemic Lupus Erythematosus

United States, Mexico
Takeda

Completed

Double Blind Comparative Study of TAK-875

Diabetic Patients

Japan
French Innovative Leukemia Organisation
Novartis Pharmaceuticals

Completed

Phase I Study in RAD 001 Patients With Relapse AML

AML

France
Pfizer
National Cancer Institute (NCI)

Completed

Leflunomide in Treating Patients With Anaplastic Astrocytoma in First Relapse

Brain and Central Nervous System Tumors

United States, Canada
German Breast Group
Novartis

Unknown

Efficacy of RAD001 in Breast Cancer Patients With Bone Metastases (RADAR)

Breast Cancer

Germany
UCB Pharma

Completed

Rheumatoid Arthritis (RA) Moderate to Low Disease Activity Study (CERTAIN)

Rheumatoid Arthritis

France, Poland, Germany, Austria, Italy
National Health Research Institutes, Taiwan
Novartis

Unknown

Randomized Phase I/II of RAD001 in Advanced Hepatocellular Carcinoma (HCC)

Hepatocellular Carcinoma

Taiwan
University of California, San Francisco
Johns Hopkins All Children's Hospital

Completed

A Study of Withdrawal of Immunosuppression and Donor Lymphocyte Infusions Following Allogeneic Transplant for Pediatric Hematologic Malignancies

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Juvenile Myelomonocytic Leukemia | Acute Lymphoblastic Leukemia | Acute Leukemia | Chronic Myelogenous Leukemia | Biphenotypic Leukemia | Pre-leukemic Syndromes | Monosomy 7 | Bone Marrow Clonal Malformations

United States
Ultragenyx Pharmaceutical Inc
Abeona Therapeutics, Inc

Enrolling by invitation

A Long-term Follow-up Study of Patients With MPS IIIA Treated With ABO-102

Mucopolysaccharidosis III-A

United States, Australia, Spain
Memorial Sloan Kettering Cancer Center
Boston Children's Hospital; Fred Hutchinson Cancer Center; Children's Hospital... and other collaborators

Completed

Hematopoietic Stem Cell Transplantation for the Treatment of Patients With Fanconi Anemia Lacking a Genotypically Identical Donor, Using a Chemotherapy Only Cytoreduction With Busulfan, Cyclophosphamide and Fludarabine

Leukemia | Myelodysplastic Syndrome | Aplastic Anemia

United States
Anhui Provincial Hospital

Recruiting

Conditioning Regimen Containing Low Dose ATG for The Treatment of Acquired SAA Receiving sUCBT

Severe Aplastic Anemia

China
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Recruiting

Cladribine Tablets Level of Response Predictors in Clinical Practice (CLODINA)

Multiple Sclerosis

Greece, Czechia, Portugal, Belgium, Netherlands, Poland
Pharming Technologies B.V.

Completed

Prevention of Severe SARS-CoV-2 Infection in Hospitalized Patients With COVID-19

Confirmed Coronavirus Disease

United States
Xuanwu Hospital, Beijing

Withdrawn

Dimethyl Fumarate for the Treatment of Intracerebral Hemorrhage

Intracerebral Hemorrhage

China
Biogen

Completed

Dimethyl Fumarate (DMF) Observational Study (ESTEEM)

Multiple Sclerosis

United States, Denmark, Italy, Netherlands, Switzerland, Canada, Australia, New Zealand, United Kingdom, Slovakia, Austria, Hungary, Czechia, Portugal, Germany, Spain, Poland, Puerto Rico, France, Argentina, Ireland, Norway
Alexion Pharmaceuticals

Completed

Ravulizumab in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria Currently Treated With High-Dose Eculizumab

Paroxysmal Nocturnal Hemoglobinuria

United Kingdom
Tiziana Life Sciences LTD

Withdrawn

A Study of Oral Foralumab in Participants With Moderate to Severely Active Crohn's Disease

Crohn's Disease

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