Search clinical trials for: Insulin intensive therapy: Human Insulin (Novolin-R, Novo Nordisk)

Total 133 results

Charles University, Czech Republic

Completed

Comparison of Three Protocols for Tight Glycemic Control in Cardiac Surgery Patients

Hyperglycemia

Czech Republic
Julphar Gulf Pharmaceutical Industries
Parexel; Profil Institut für Stoffwechselforschung GmbH

Completed

Pharmacokinetic (PK) Bioequivalence and Pharmacodynamics of Julphar Insulin R and Huminsulin® Normal

Diabetes Mellitus

Germany
HealthPartners Institute

Recruiting

Measurement of Insulin Levels in Cerebral Spinal Fluid (CSF) of Healthy Adults After a Single Intranasal Dose (INI-CSF)

Healthy

United States
Northumbria University
Newcastle University

Completed

Combined Basal-bolus Insulin and Post-exercise Carbohydrate Feeding Strategy in T1DM

Type 1 Diabetes Mellitus

United Kingdom
Johns Hopkins University

Terminated

Intranasal Insulin for the Treatment of HAND

HIV Dementia | HIV-Associated Cognitive Motor Complex

United States
HealthPartners Institute
United States Department of Defense; Uniformed Services University of the Health...

Not yet recruiting

Measurement of Insulin Levels in the Cerebrospinal Fluid of Healthy Adults After a Single Intranasal Dose - Middle Age (INI-CSF-MA)

Healthy

United States
Wake Forest University Health Sciences
Alzheimer's Association

Completed

Study of Nasal Insulin to Fight Forgetfulness - Long-acting Insulin Detemir - 120 Days (SL120) (SL120)

Mild Cognitive Impairment | Alzheimer's Disease

United States
Guillermo Umpierrez, MD
Medical University of South Carolina; Sanofi; Texas A&M University

Completed

Basal Bolus Versus Basal Insulin in Type 2 Diabetes Mellitus (T2DM) (Basal-Plus)

Hyperglycemia | Type 2 Diabetes

United States
Geropharm

Completed

Comparative Study of Rinsulin R (GEROPHARM) and Humulin Regular (Eli Lilly) Euglycemic Hyperinsulinemic Clamp Method

Bioequivalence | Therapeutic Equivalency

Russian Federation
Beijing Hospital

Completed

A Study Evaluating the Bioavailability of Oral Insulin (N11005)

PK, PD, and Safety

China
Sun Yat-sen University

Not yet recruiting

Effects of Structured Simplified Short-term Intensive Insulin Therapy on Long-term Glycemic Remission

Newly Diagnosed Type 2 Diabetes | Simplified Short-term Intensive Insulin Therapy | Glycemic Remission

China
Arkansas Children's Hospital Research Institute

Completed

Preservation of Pancreatic Beta Cell Function Through Insulin Pump Therapy (ktpump)

Diabetes Mellitus

United States
Sansum Diabetes Research Institute
Sanofi

Completed

Comparator Trial Using Insulin Glulisine vs. Insulin Lispro for Treatment of Gestational Diabetes

Diabetes During Pregnancy

United States
Université NAZI BONI
Juvenile Diabetes Research Foundation; International Society for Pediatric... and other collaborators

Recruiting

Comparative Efficacy of a Two Daily Mixed Insulin Injection Versus a Basal-bolus Scheme With Human Insulin

Type 1 Diabetes

Burkina Faso
Novo Nordisk A/S

Terminated

Safety of Inhaled Preprandial Human Insulin in Subjects With Diabetes and Asthma (iINHALE 9)

Diabetes Mellitus, Type 2 | Diabetes | Diabetes Mellitus, Type 1 | Asthma

United States, Slovakia, India, Malaysia, Australia, Former Serbia and Montenegro
HealthPartners Institute

Recruiting

Intranasal Insulin in Parkinson's Disease (INI-PD)

Parkinson Disease

United States
Xijing Hospital

Unknown

Effect of Intensive Insulin Therapy on Clinical Prognosis of Infants Undergoing Cardiac Surgery

Cardiac Surgery

China
Halozyme Therapeutics

Completed

Safety Study of Subcutaneously-Injected Prandial INSULIN-PH20 NP Compared to Insulin Lispro Injection in Participants With Type 1 Diabetes Mellitus

Diabetes Mellitus, Type 1

United States
Halozyme Therapeutics

Completed

Pharmacokinetic (PK), Pharmacodynamic (PD), and Safety Study of Subcutaneously Administered Humalog® With and Without Recombinant Human Hyaluronidase (rHuPH20)and Humulin-R® With and Without rHuPH20

Diabetes Mellitus

United States
University of Guadalajara

Completed

Effect of Insulin Degludec Versus Insulin Glargine on Glycemic Variability in Patients With Type 2 Diabetes Mellitus (Diabetes)

Type 2 Diabetes Mellitus

Mexico
Hygieia, Inc
TKL Research, Inc.

Completed

Efficacy and Safety of Frequently Modified Intensive Insulin

Diabetes

United States
Halozyme Therapeutics

Completed

Pharmacokinetic and Glucodynamic Crossover Study of Subcutaneously (SC) Administered Insulin Lispro + Recombinant Human Hyaluronidase (rHuPH20) and Regular Human Insulin + rHuPH20 Compared to Insulin Lispro Alone

Diabetes Mellitus

United States
Shanghai Zhongshan Hospital

Recruiting

Regimen Switch After Intensive Insulin Therapy

Insulin

China
Halozyme Therapeutics

Completed

Liquid Meal Study With Insulin Lispro With/Without Recombinant Human Hyaluronidase PH20 (rHuPH20) and Regular Human Insulin With rHuPH20 to Compare Pharmacokinetics, Postprandial Glycemic Response, and Optimal Insulin Dose in Participants With Type 2 Diabetes Mellitus (T2DM)

Diabetes Mellitus, Type 2

United States
Eli Lilly and Company

Terminated

Hospital Management of Hyperglycemia Study of Insulin Glargine Plus Insulin Lispro Versus Human Regular Insulin (HMH)

Hyperglycemia

United States
Profil Institut für Stoffwechselforschung GmbH
Emisphere Technologies, Inc.

Completed

Oral Insulin: A Comparison With Subcutaneous Regular Human Insulin in Patients With Type 2 Diabetes

Type 2 Diabetes

Germany
Amphastar Pharmaceuticals, Inc.

Completed

Comparison of the Pharmacokinetics (PK) and Pharmacodynamics (PD) Biosimilarity of Proposed Biosimilar Rapid-Acting Insulin Aspart (I004) and NovoLog After Single-Dose Subcutaneous Administration to Healthy Volunteers

Pharmacokinetics | Pharmacodynamics

United States
McGill University Health Centre/Research Institute...

Unknown

The Effect of Insulin on Protein Metabolism After Cardiac Surgery

Cardiac Surgery

Canada
Servier (Tianjin) Pharmaceutical Co. LTD.

Completed

Study of Combination Therapy of Gliclazide MR and Basal Insulin Versus Insulin Monotherapy to Treat Type 2 Diabetes (CODMS)

Type 2 Diabetes

China
Halozyme Therapeutics

Completed

Dose-Ranging, Pharmacokinetic (PK), Glucodynamic (GD), Safety and Tolerability Study of Subcutaneously (SC) Administered Humulin R and Humalog With or Without rHuPH20

Healthy Volunteers

United States
Novo Nordisk A/S

Completed

Observational Study of Type 2 Diabetes Patients Failing on Oral Anti-diabetic Agents Initiated on Levemir® or Insulatard® (EVIDENCE)

Diabetes Mellitus, Type 2 | Diabetes

Romania
Halozyme Therapeutics

Completed

Phase II Pharmacokinetics Study of Humalog and Humulin-R With and Without rHuPH20 in Type 1 Diabetes Mellitus

Type 1 Diabetes Mellitus

United States
Novo Nordisk A/S

Completed

Efficacy and the Safety of Insulin Detemir in Subjects With Insulin Requiring Diabetes

Diabetes | Diabetes Mellitus, Type 1

Japan
Novo Nordisk A/S

Completed

Comparison of Insulin Detemir With NPH Insulin in Type 1 Diabetes

Diabetes | Diabetes Mellitus, Type 1

India, Macedonia, The Former Yugoslav Republic of, Malaysia, Turkey, Croatia, Bulgaria, Romania, Australia, South Africa, Argentina
Novo Nordisk A/S

Completed

Pharmacodynamics and Pharmacokinetics of Insulin Detemir in Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

Germany
Novo Nordisk A/S

Completed

Frequency of Hypoglycaemic Episodes During Treatment With Insulin Detemir in Well Controlled Subjects With Type 1 Diabetes

Diabetes | Diabetes Mellitus, Type 1

Denmark, Croatia, Australia, South Africa, Italy, Sweden
Florida Atlantic University
Advanced Diabetes Treatment Centers

Withdrawn

Effects of Pulsatile Intravenous Insulin Therapy on Cardiac Disease in Patients With Diabetes

Diabetes Mellitus, With Complications

United States
Halozyme Therapeutics

Completed

CONSISTENT 1: Metabolic and Safety Outcomes of Hylenex Recombinant (Hyaluronidase Human Injection) Preadministered at CSII Infusion Site in Participants With Type 1 Diabetes Mellitus (T1DM)

Type 1 Diabetes Mellitus

United States
Biocon Limited
Profil Institut für Stoffwechselforschung GmbH

Completed

Comparison of the Pharmacokinetic and Pharmacodynamic Properties of Biocon's Insulin R U-500 With Humulin® R U-500 (US Reference Product) in Healthy Subjects (RHINE-4)

Healthy Volunteers

Germany
ikfe-CRO GmbH
IKFE Institute for Clinical Research and Development

Completed

Beta-Cell Function of Insulin Glargine Compared to Neutral Protamine Hagedorn (NPH) Insuline and to Insulin Detemir in Combination With Metformin

Type 2 Diabetic Patients | Insufficient Metabolic Control | OAD Treatment

Germany
Halozyme Therapeutics

Completed

Safety/Efficacy Study of Subcutaneously Injected Prandial Insulins Compared to Insulin Lispro Alone in Patients With Type 2 Diabetes Mellitus

Diabetes Mellitus, Type II

United States
Halozyme Therapeutics

Completed

Randomized, Double Blind, 2 Way Crossover Study of CSII With, Versus Without, Pretreatment With Human Hyaluronidase

Type 1 Diabetes Mellitus

United States
Massachusetts General Hospital
Boston University

Terminated

Individualizing Automated Closed Loop Glucose Control Through Pharmacokinetic Profiling in an Insulin-Only Bionic Pancreas

Type 1 Diabetes Mellitus

United States
Policlinico Hospital
Eli Lilly and Company

Completed

Effect of Hyperglycemia in PAI-1 Activity and the Relationship With Outcome in Severe Sepsis and Septic Shock

Septic Shock | Severe Sepsis

Italy
University Hospital, Grenoble

Completed

I3LTE4: Intensive Insulin Therapy and Production of LTE4 in Patients With Diabetes

Diabetes Mellitus | Leucotrienes

France
The George Institute
National Health and Medical Research Council, Australia; University of British... and other collaborators

Completed

Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation (NICE - SUGAR STUDY)

Hyperglycemia | Critical Illness

Australia
Halozyme Therapeutics

Completed

A Pharmacokinetic and Glucodynamic Study of Subcutaneously Administered Insulin Analogs With rHuPH20 Compared to Insulin Analogs Alone

Healthy

United States
Halozyme Therapeutics

Completed

Randomized, Double-blind, Crossover, Pharmacokinetic (PK) and Glucodynamic (GD) Study of Continuous Subcutaneous Insulin Infusion (CSII) in Participants With Type 1 Diabetes Mellitus (T1DM)

Type 1 Diabetes Mellitus

United States
Eli Lilly and Company

Completed

Study of Human Regular U-500 Insulin in Adult Participants With Type 2 Diabetes

Diabetes Mellitus, Type 2

United States, Puerto Rico
Charles University, Czech Republic

Completed

Continuous Glucose Monitoring Combined With Computer Algorithm for Intensive Insulin Therapy in Cardiosurgical Patients

Hyperglycemia | Cardiac Surgery

Czech Republic

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