Search clinical trials for: Investigator's choice of treatment

Total 4347 results

Tan Tock Seng Hospital
Melbourne Health; National University Hospital, Singapore; Samsung Medical Center and other collaborators

Recruiting

Early Oral Step-down Antibiotic Therapy for Uncomplicated Gram-negative Bacteraemia

Gram-negative Bacteraemia

Singapore
Novartis Pharmaceuticals

Completed

Pharmacokinetic Drug-drug Interaction Study of Dovitinib (TKI258) in Patients With Advanced Solid Tumors

Advanced Solid Tumors, Excluding Breast Cancer

United States
Daiichi Sankyo, Inc.
Medpace, Inc.

Completed

Drug-drug Interaction Study of Tivantinib (ARQ 197) With Omeprazole, S-warfarin, Caffeine, Midazolam, and Digoxin in Cancer Subjects

Solid Tumors

United States
The Canadian College of Naturopathic Medicine
Canada Post Corporation; Canadian Union of Postal Workers

Completed

Naturopathic Treatment for the Prevention of Cardiovascular Disease (Cardio pilot)

Cardiovascular Disease

Canada
PETHEMA Foundation

Completed

PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia

Spain
Fudan University

Recruiting

Enhanced Systemic Combined With Local Treatment for Primary and Metastatic Lesions in Oligo-metastatic Prostate Cancer

Prostate Cancer

China
EMS

Completed

Efficacy and Safety of the Combination of Ketoprofen and Cyclobenzaprine and Caffeine in Osteomuscular Treatment

Musculoskeletal Pain

Brazil
Merck Sharp & Dohme LLC
AESCA Pharma GmbH

Terminated

Induction of Remission in RA Patients at Low Disease Activity by Additional Infliximab Therapy (Study P04644AM1) (TERMINATED)

Rheumatoid Arthritis
Assistance Publique - Hôpitaux de Paris

Withdrawn

Effectiveness of the Eradication of Helicobacter Pylori and an Inhibitor of Pump With Proton Versus Control (Aspylori)

Coronary Thrombosis | Positive Helicobacter Pylori Serology | Supra-aortic Artery Thrombosis

France
European Organisation for Research and Treatment...
Gruppo Italiano Malattie EMatologiche dell'Adulto

Unknown

Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Promyelocytic Leukemia

Leukemia

France, Netherlands, Belgium, Czech Republic, Italy, Austria, Germany, Croatia, Turkey
Vion Pharmaceuticals

Completed

VNP20009 in Treating Patients With Advanced or Metastatic Solid Tumors That Have Not Responded to Previous Therapy

Unspecified Adult Solid Tumor, Protocol Specific

United States
Swiss Dermatology Network for Targeted Therapies

Recruiting

Swiss Dermatology Network of Targeted Therapies (SDNTT) (SDNTT)

Psoriasis

Switzerland
National Cancer Institute (NCI)

Recruiting

Comparing Retreatment of 177Lu-DOTATATE PRRT Versus Everolimus in Patients With Metastatic Unresectable Midgut Neuroendocrine Tumors, NET RETREAT Trial

Metastatic Midgut Neuroendocrine Tumor | Unresectable Midgut Neuroendocrine Tumor | Metastatic Midgut Neuroendocrine Tumor G1 | Metastatic Midgut Neuroendocrine Tumor G2

United States, Canada
Sheba Medical Center

Completed

Corticosteroids+5-aminosalicylic Acid Compared to Corticosteroids in the Treatment of Moderate-severe Ulcerative Colitis

Ulcerative Colitis

Israel, China, France, Greece, Italy, Korea, Republic of, Serbia
Centre Hospitalier Universitaire de Nīmes

Completed

Low Energy Shockwave Therapy for Improving Erectile Dysfunction (Shock-ED)

Erectile Dysfunction

France
Holbaek Sygehus
Aase and Ejnar Danielsens Foundation; Region Sjælland

Unknown

Procalcitonin as a Marker of Antibiotic Therapy in Patients With Lower Respiratory Tract Infections

Pneumonia | Acute Exacerbation of Chronic Obstructive Airways Disease

Denmark
Heinrich-Heine University, Duesseldorf
University Hospital, Essen

Unknown

Effects of Remote Ischemic PreConditioning in Off-pump Versus On-pump Coronary Artery Bypass Grafting(RIPCON) (RIPCON)

Myocardial Injury

Germany
Mayo Clinic

Recruiting

Evaluation of a Pain Management Intervention Preparatory to a Future Pragmatic Trial, ASCENT Study

Malignant Solid Neoplasm | Lymphoma | Multiple Myeloma | Hematopoietic and Lymphoid System Neoplasm | Chronic Leukemia

United States
The Alfred

Unknown

A Study Comparing Continuous Infusion Antibiotics to Standard Treatment for Lung Infections in Cystic Fibrosis (CISTIC)

Cystic Fibrosis

Australia
Natividad Medical Center

Completed

A Prospective Trial of Nasal Mupirocin, Hexachlorophene Body Wash, and Systemic Antibiotics for Prevention of Recurrent Methicillin Resistant Staphylococcus Aureus Infections

Methicillin Resistant Staphylococcus Aureus Skin Infections
National Cancer Institute (NCI)

Recruiting

Comparing the New Anti-cancer Drug Eribulin With Chemotherapy Against the Usual Chemotherapy Alone in Metastatic Urothelial Cancer

Metastatic Bladder Urothelial Carcinoma | Metastatic Renal Pelvis Urothelial Carcinoma | Metastatic Ureter Urothelial Carcinoma | Metastatic Urethral Urothelial Carcinoma | Metastatic Urothelial Carcinoma | Stage IV Bladder Cancer AJCC v8 | Stage IV Renal Pelvis Cancer AJCC v8 | Stage IV Ureter Cancer... and other conditions

United States
OHSU Knight Cancer Institute
Janssen Scientific Affairs, LLC; Oregon Health and Science University

Active, not recruiting

Advanced ChemoHormonal Therapy for Treatment Naive Metastatic Prostate Cancer

Metastatic Prostate Carcinoma | Stage IVB Prostate Cancer AJCC v8 | Castration-Sensitive Prostate Carcinoma

United States
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI)

Completed

Monoclonal Antibody 3F8 and Sargramostim in Treating Patients With Neuroblastoma

Neuroblastoma

United States
M.D. Anderson Cancer Center

Recruiting

Androgen Ablation Therapy With or Without Niraparib After Radiation Therapy for the Treatment of High-Risk Localized or Locally Advanced Prostate Cancer

Prostate Carcinoma | Stage IIIA Prostate Cancer AJCC v8 | Stage IIIB Prostate Cancer AJCC v8 | Stage IIC Prostate Cancer AJCC v8 | Stage III Prostate Cancer AJCC v8 | Stage IIIC Prostate Cancer AJCC v8 | Stage IVA Prostate Cancer AJCC v8

United States
University of Melbourne
Australian and New Zealand Intensive Care Research Centre; The Peter Doherty... and other collaborators

Active, not recruiting

Australasian COVID-19 Trial (ASCOT) ADAptive Platform Trial (ASCOT)

SARS-CoV-2 Infection (COVID-19)

Australia
Iowa City Veterans Affairs Medical Center
US Department of Veterans Affairs

Completed

Tailored Tobacco Quitline for Rural Veterans

Cigarette Smoking

United States
Guangzhou Women and Children's Medical Center

Completed

Mometasone Furoate and Oxymetazoline in the Treatment of Adenoid Hypertrophy

Adenoidal Hypertrophy
Lundquist Institute for Biomedical Innovation at...
Abbott Nutrition; DaVita Dialysis

Completed

Anit-Inflammatory and Anti-Oxidative Nutrition in Dialysis Patients (AIONID)

Inflammation | Oxidative Stress | Hypoalbuminemia | Protein-energy Malnutrition | Chronic Kidney Disease (CKD) Hemodialysis

United States
St. Jude Children's Research Hospital

Recruiting

A Phase II Pediatric Study of a Graft-VS.-Host Disease (GVHD) Prophylaxis Regimen With no Calcineurin Inhibitors After Day +60 Post First Allogeneic Hematopoietic Cell Transplant for Hematological Malignancies

Hematologic Malignancy | Myeloid Malignancy

United States
University of Southern California

Completed

Herbal Therapy for Treatment of Recurrent Prostate Cancer

Prostate Cancer

United States
Heather Wakelee
Eli Lilly and Company; Genentech, Inc.

Completed

Phase 2 Trial of Bevacizumab in Combination With Pemetrexed

Neoplasm Metastasis | Lung Cancer | Non-small Cell Lung Cancer (NSCLC)

United States
Henry Ford Health System

Recruiting

Nonopioid Analgesia After Labral Surgery

Narcotic Use

United States
Peking University

Recruiting

Sedation Compaired With Anesthesia With THRIVE in Endotracheal Intubation With Difficult Airways

Airway Control | Sedative, Hypnotic, or Anxiolytic Withdrawal

China
St. Jude Children's Research Hospital

Suspended

Reduced Intensity Transplantation for Severe Sickle Cell Disease

Sickle Cell Disease

United States
Merck Sharp & Dohme LLC

Completed

A Single-Dose Study to Investigate the Pharmacokinetics of MK-7655 in Participants With Impaired Renal Function (MK-7655-005)

Infectious Disease
Northwestern University
National Cancer Institute (NCI); Varian Medical Systems

Recruiting

Stereotactic Body Radiation Therapy Planning With Artificial Intelligence-Directed Dose Recommendation for Treatment of Primary or Metastatic Lung Tumors, RAD-AI Study

Lung Non-Small Cell Carcinoma | Lung Carcinoma | Stage II Lung Cancer AJCC v8 | Stage IIIA Lung Cancer AJCC v8 | Stage I Lung Cancer AJCC v8 | Metastatic Malignant Neoplasm in the Lung

United States
Hoffmann-La Roche
Gilead Sciences; Seagen Inc.

Recruiting

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer (Morpheus-panBC)

Breast Cancer

Korea, Republic of, Spain, United States, Israel, United Kingdom, France, Australia, Germany
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Efficacy and Safety of Daratumumab in Pediatric and Young Adult Participants Greater Than or Equal to (>=)1 and Less Than or Equal to (<=) 30 Years of Age With Relapsed/Refractory Precursor B-cell or T-cell Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

Precursor Cell Lymphoblastic Leukemia-Lymphoma

United States, United Kingdom, France, Sweden, Germany, Spain, Italy, Belgium, Israel, Netherlands
Kadmon Corporation, LLC
Quotient Sciences

Completed

Drug-drug Interaction Between Belumosudil, Itraconazole, Rifampicin, Rabeprazole, and Omeprazole in Healthy Volunteers

Autoimmune Diseases | Drug-drug Interaction | Fibrotic Disease

United Kingdom
Chiesi Farmaceutici S.p.A.

Completed

Single-Dose Clinical Pharmacology Study in Asthmatic Adolescent and Adult Patients (ADO pMDI)

Asthma

Poland
Uppsala University

Completed

Neo-adjuvant Chemo + Peritonectomy + Hyperthermic Intraperitoneal Chemo in Peritoneal Carcinomatosis From Gastric Cancer

Gastric Cancer | Peritoneal Carcinomatosis

Sweden
Humanity and Health Research Centre
Beijing 302 Hospital; Nanfang Hospital of Southern Medical University

Completed

DAAs Treatment for Chronic HCV/HBV Co-infection Patients(DASCO) (DASCO)

Chronic Hepatitis C Infection | Hepatitis B Reactivation | HBV Coinfection

China
Instituto Nacional de Enfermedades Respiratorias
Consorcio de Investigación sobre VIH/SIDA/TB (CISIDAT).

Terminated

Simultaneous Versus Sequential Antiretroviral Therapy (ARV) Therapy and Mycobacterium Tuberculosis (MTB) Treatment

HIV | Tuberculosis | AIDS

Mexico
Fundacion SEIMC-GESIDA

Active, not recruiting

Study to Evaluate the Efficacy and Safety of a Rilpivarine-based Antiretroviral Tratment Regimen in HIV- Infected Patients With Liver Metabolic Disease Who Maintain Udetectable HIV Viral Load (MAFALDA-R)

HIV Infections | Fatty Liver Disease

Spain
French National Agency for Research on AIDS and...
Bristol-Myers Squibb

Completed

Randomised Trial of Structured Treatment Interruption of HAART in HIV-Infected Adults in Abidjan (ANRS 1269 TRIVACAN)

HIV Infections

Côte D'Ivoire
Liverpool Heart and Chest Hospital NHS Foundation...

Completed

Investigating the Incretin Effect in Cystic Fibrosis (IECF)

Cystic Fibrosis

United Kingdom
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Terminated

Milademetan Tosylate and Low-Dose Cytarabine With or Without Venetoclax in Treating Participants With Recurrent or Refractory Acute Myeloid Leukemia

Acute Myeloid Leukemia | Recurrent Acute Myeloid Leukemia | Refractory Acute Myeloid Leukemia

United States
NRG Oncology
National Cancer Institute (NCI)

Withdrawn

Testing the Addition of an Anti-cancer Viral Gene Therapy, Toca 511/Toca FC, to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed Glioblastoma

Glioblastoma | Anaplastic Astrocytoma | Oligodendroglioma | Supratentorial Glioblastoma
University of Florida

Withdrawn

Comparison of Topical Therapies in Post op Endoscopic Sinus Surgery Patients

Chronic Rhinosinusitis (Diagnosis)

United States
Robert Redner, MD
Cephalon

Completed

Bendamustine in Combination With Lenalidomide and Dexamethasone in Refractory or Relapsed Multiple Myeloma

Myeloma

United States

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