Search clinical trials for: Low-volume C1-esterase inhibitor

Total 1594 results

CSL Behring

Completed

A Study to Evaluate the Clinical Efficacy and Safety of Subcutaneously Administered C1-esterase Inhibitor in the Prevention of Hereditary Angioedema

Hereditary Angioedema Types I and II

United States, Spain, Australia, Canada, Czechia, Hungary, Israel, Italy, Romania, United Kingdom
CSL Behring
Parexel

Completed

A Study to Evaluate the Clinical Pharmacology and Safety of C1-esterase Inhibitor Administered by the Subcutaneous Route

Hereditary Angioedema Types I and II

United States, Germany
AO GENERIUM

Withdrawn

Efficacy and Safety of GNR-038 vs Berinert® in Patients With Hereditary Angioedema

Hereditary Angioedema

Russian Federation
Shire

Completed

A Study to Evaluate the Safety and Effect of Escalating Doses of CINRYZE

Hereditary Angioedema

United States
CSL Behring

Terminated

Efficacy and Safety of Human Plasma-derived C1-esterase Inhibitor as add-on to Standard of Care for the Treatment of Refractory Antibody Mediated Rejection (AMR) in Adult Renal Transplant Recipients

Antibody-mediated Rejection

United States, Spain, France, Netherlands, United Kingdom, Belgium, Germany
CSL Behring

Completed

A Study to Evaluate the Long-term Clinical Safety and Efficacy of Subcutaneously Administered C1-esterase Inhibitor in the Prevention of Hereditary Angioedema

Hereditary Angioedema Types I and II

United States, Spain, Germany, Australia, Canada, Czechia, Hungary, Israel, Italy, Romania, United Kingdom
Shire

Completed

Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Prevention of Acute Hereditary Angioedema (HAE) Attacks (CHANGE 3)

Hereditary Angioedema

United States
Shire

Completed

A Pilot Study to Evaluate the Use of C1 Esterase Inhibitor (Human) in Patients With Acute Antibody-Mediated Rejection

Graft Rejection

United States, Germany
IMMUNOe Research Centers

Completed

A Study to Evaluate the Benefit of RUCONEST® in Subjects Who Experience ADRs Related to IVIG Infusions

CVI - Common Variable Immunodeficiency

United States
CSL Behring
Chiltern International Inc.

Completed

Patient Registry Study of Berinert® in Normal Clinical Practice

Includes: Hereditary Angioedema

United States, Denmark, Germany, Switzerland
Shire

Completed

C1 Esterase Inhibitor (C1INH-nf) for the Treatment of Acute Hereditary Angioedema (HAE) Attacks

Hereditary Angioedema

United States
Shire

Completed

Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetics of Recombinant Human C1 Esterase Inhibitor in Healthy Adult Subjects

Hereditary Angioedema (HAE)

United States
Stanley Jordan, MD
CSL Behring

Completed

Safety & Tolerability of Berinert® (C1 Inhibitor) Therapy to Prevent Rejection

Kidney Transplantation

United States
CSL Behring

Completed

C1 Esterase Inhibitor in Hereditary Angioedema (HAE)(Extension Study)

Hereditary Angioedema

United States, Canada
Radboud University Medical Center

Completed

In Vivo Effects of C1-esterase Inhibitor on the Innate Immune Response During Human Endotoxemia (VECTOR)

Inflammation | Endotoxemia | Multi Organ Dysfunction Syndrome

Netherlands
Haaglanden Medical Centre
Takeda; Leiden University Medical Center

Not yet recruiting

Complement Inhibition: Attacking the Overshooting Inflammation @Fter Subarachnoid Hemorrhage (CIAO@SAH) (CIAO@SAH)

Subarachnoid Hemorrhage, Aneurysmal
Cedars-Sinai Medical Center
OneLegacy Foundation

Active, not recruiting

Berinert (C1INH) vs Placebo for DGF/IRI

Chronic Kidney Diseases | End Stage Renal Disease

United States
Shire

Completed

C1 Esterase Inhibitor (C1INH-nf) for the Prevention of Acute Hereditary Angioedema (HAE) Attacks

Hereditary Angioedema

United States
Shire

Completed

Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Treatment of Acute Hereditary Angioedema (HAE) Attacks (CHANGE 2)

Hereditary Angioedema

United States
Shire

Completed

Pharmacokinetics of C1 Esterase Inhibitor in Hereditary Angioedema Subjects

Hereditary Angioedema

United States
Michael Levy
ViroPharma

Completed

C1-esterase Inhibitor (Cinryze) for Acute Treatment of Neuromyelitis Optica Exacerbation

Neuromyelitis Optica

United States
University Hospital Schleswig-Holstein

Unknown

Regional Lung Opening and Closing Pressures in Patients With Acute Lung Injury

Acute Lung Injury

Germany
Johann Wolfgang Goethe University Hospital
CSL Behring; University of Milan; PharmaPart; Clinical trial center Rhine-Main; ZKI... and other collaborators

Completed

Berinert P Study of Subcutaneous Versus Intravenous Administration (PASSION)

Hereditary Angioedema

Germany
Shire

Completed

Study to Evaluate the Clinical Efficacy and Safety of Subcutaneously Administered C1 Esterase Inhibitor for the Prevention of Angioedema Attacks in Adolescents and Adults With Hereditary Angioedema

Hereditary Angioedema (HAE)

Spain, Israel, United States, Hungary, Germany, Canada, Romania
Cedars-Sinai Medical Center

Completed

C1INH Inhibitor Preoperative and Post Kidney Transplant to Prevent DGF & IRI (C1INHDGF)

End Stage Renal Disease | Ischemic Reperfusion Injury | Kidney Failure | Delayed Graft Function

United States
UMC Utrecht
Prothya Biosolutions

Terminated

Effect of C1-esterase Inhibitor on Systemic Inflammation in Trauma Patients With a Femur or Pelvic Fracture (CAESAR)

Sepsis | Inflammation | Trauma | Multiple Organ Dysfunction Syndrome

Netherlands
Shire
Halozyme Therapeutics

Completed

A Study to Evaluate the Safety and Pharmacology of Subcutaneous Administration of CINRYZE With Recombinant Human Hyaluronidase

Hereditary Angioedema

United States
Shire

Completed

Subcutaneous CINRYZE With Recombinant Human Hyaluronidase for Prevention of Angioedema Attacks

Hereditary Angioedema (HAE)

United States, Germany, Spain, Sweden
University Hospital, Basel, Switzerland
Pharming Technologies B.V.; Clinical Trial Unit, University Hospital Basel,...

Completed

Recombinant Human C1 Esterase Inhibitor in the Prevention of Contrast-induced Nephropathy in High-risk Subjects (PROTECT)

Acute Kidney Injury

Switzerland
CSL Behring

Completed

Human C1 Esterase Inhibitor (C1-INH) in Subjects With Acute Abdominal or Facial Hereditary Angioedema (HAE) Attacks

Hereditary Angioedema

Bulgaria, United States, Poland, Spain, Hungary, United Kingdom, Russian Federation, Macedonia, The Former Yugoslav Republic of, Argentina, Australia, Canada, Czech Republic, Israel, Romania, Sweden
Federal University of Rio Grande do Sul
Programa de Pós-Graduação em Clínica Médica; Faculdade de Medicina

Completed

High Tidal Volume Induces Inflammation In Normal Lungs (Normallung)

Mechanically Ventilated Patients | Normal Lungs

Brazil
Radboud University Medical Center
UMC Utrecht; Prothya Biosolutions

Completed

In Vivo Effects of C1-esterase Inhibitor on the Innate Immune Response During Human Endotoxemia - VECTOR II (VECTORII)

Sepsis | Inflammation | Endotoxemia | Innate Immune Response

Netherlands
The Cleveland Clinic

Completed

Effects of High and Low Tidal Volumes on Arterial Oxygenation and Pulmonary Shunt During One-Lung Ventilation

Postoperative Lung Injury

Hungary
Peking University Third Hospital

Recruiting

A Comparative Study of High and Low Tidal Volume in Preventing Hypoxemia in Patients With Mechanical Ventilation After Cervical Spinal Cord Injury

Cervical Spinal Cord Injury

China
The University of Texas Health Science Center,...
National Center for Advancing Translational Sciences (NCATS); TIRR Memorial... and other collaborators

Active, not recruiting

Comparison of Low and High Tidal Volumes in Acute Spinal Cord Injury

Spinal Cord Injuries

United States
Academisch Medisch Centrum - Universiteit van Amsterdam...
Amsterdam UMC, location VUmc; Leiden University Medical Center; Gelre Hospitals; Tergooi Hospital and other collaborators

Completed

PRotective VENTilation in Patients Without ARDS (PReVENT-NL)

Ventilator-free Days

Netherlands
Inje University

Completed

Low Volume PEG With Low Residue Test Meals Versus High Volume Split-dose PEG Bowel Preparation (LOWPEG)

Colonoscopy | Bowel Preparation

Korea, Republic of
Universitätsklinikum Hamburg-Eppendorf

Unknown

Influence of Different PEEP Levels and Tidal Volumes on Regional Lung Function

Pulmonary Ventilation; Newborn, Abnormal

Germany
Aarhus University Hospital

Not yet recruiting

Treatment of Fecal Incontinence and Chronic Constipation With Low-volume Irrigation

Constipation | Fecal Incontinence
University of Calgary

Unknown

Diabetes Exercise and Lifestyle Trial (DEAL)

Diabetes Mellitus

Canada
Southeast University, China

Not yet recruiting

Epidemiology and Treatment Strategy of Open Respiratory Phenotype in Critically Ill Patients

Critical Illness | Mechanical Ventilation Pressure High

China
University of the Basque Country (UPV/EHU)
HOSPITAL SANTIAGO APOSTOL. MIRANDA DE EBRO. BURGOS. SPAIN

Unknown

High Intensity Aerobic Interval Training With Mediterranean Diet Recommendations in Post-Myocardial Infarct Patients (INTERFARCT)

Myocardial Infarction

Spain
National Taiwan Normal University

Recruiting

The Effect of Acute Resistance Exercise on Inhibitory Control

Exercise | Cognitive Function

Taiwan
Federal University of Rio Grande do Sul

Completed

The Influence of Pilates Exercises Training Volume on Metabolic Outcomes in Dyslipidemic Women.

Dyslipidemias

Brazil
Cairo University

Completed

COMPARISON BETWEEN TWO SUB-TYPES OF HIGH INTENSITY INTERVAL TRAINING

Diabetes Mellitus

Egypt
State University of New York at Buffalo
National Center for Advancing Translational Sciences (NCATS)

Completed

Salivary Biomarkers for Concussion Recovery

Concussion, Brain

United States
Larissa University Hospital
University of Thessaly

Completed

Study of the Influence of Various Tidal Volumes on Exhaled Breath Condensate (EBC) in Mechanically Ventilated Patients (TDEBC)

Inflammation

Greece
Riphah International University

Completed

Dose Response of Nordic Hamstring Exercise on Performance in Athletes

Hamstring Injury

Pakistan
Boston Medical Center

Terminated

Biomarkers of Lung Injury With Low Tidal Volume Ventilation Compared With Airway Pressure Release Ventilation

Acute Lung Injury | Adult Respiratory Distress Syndrome

United States
Mayo Clinic

Terminated

The Affect of Low-Volume Bowel Preparation for Hospitalized Patients Colonoscopies

Colonoscopy

United States

Search clinical trials for: Low-volume C1-esterase inhibitor

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