Search clinical trials for: No Proton Pump Inhibitors

Total 11439 results

Livzon Pharmaceutical Group Inc.

Completed

Ilaprazole for the Treatment of Gastroesophageal Reflux Disease (GERD) in Chinese Patients

Gastroesophageal Reflux Disease
Eisai Inc.

Completed

Rabeprazole Extended-Release, 50 mg, Versus Esomeprazole, 40 mg, for Healing and Symptomatic Relief of Moderate to Severe Erosive Gastroesophageal Reflux Disease (GERD)

Gastroesophageal Reflux Disease (GERD)

Chile, Canada, United States, Estonia, India, Hungary, Bulgaria, Croatia, Australia, Lithuania, Latvia, Argentina, France, Germany
Astellas Pharma Europe B.V.

Completed

A Study to Assess the Effects of Single Ascending Doses (SAD) of ASP8477, the Effect That Food Has on the Drug, and the Interaction Between ASP8477 and Omeprazole in Healthy Postmenopausal Females and Healthy Young Vasectomized Males

Pharmacokinetics of ASP8477 | Pharmacodynamics of ASP8477

France, Belgium
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Unknown

Efficacy and Safety of L-Pantoprazole Sodium Injection to Treat Upper Gastrointestinal Ulcer Bleeding

Bleeding Gastric Ulcer | Bleeding Duodenal Ulcer

China
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Comparing a Pantoprazole Formulation to the Currently Marketed Tablet for GERD and Erosive Esophagitis

Gastroesophageal Reflux | Esophagitis

United States
AstraZeneca

Completed

Nexium (Esomeprazole) in Symptom Adapted Therapy in GERD Patients (MAESTRO)

GERD

France
AstraZeneca

Completed

Study of Intragastric pH Profile After 5 Days Pantoprazole 40 mg iv Followed by Oral Esomeprazole 40 mg po or Oral Pantoprazole 40 mg po

Healthy

United States
AstraZeneca

Completed

Esomeprazole in PPI Failures - IMPROVE

Gastroesophageal Reflux Disease

Sweden
First Affiliated Hospital of Harbin Medical University

Terminated

Clinical Study of Apatinib in the Treatment of Platinum Resistant Recurrent Ovarian Cancer

Ovarian Cancer

China
Fudan University
Jiangsu HengRui Medicine Co., Ltd.

Completed

Study of Apatinib in Metastatic Triple-Negative Breast Cancer Patients

Metastatic Breast Cancer

China
Carlos Roberto Simons-Linares

Recruiting

OPEN Versus InTact Capsule Proton Pump Inhibitors for the Treatment of Marginal Ulcers (OPEN-IT)

Marginal Ulcer

United States
Onconic Therapeutics Inc.

Recruiting

JP-1366 20mg Versus Esomeprazole 40mg in Patients With Erosive Esophagitis

Erosive Esophagitis

Korea, Republic of
AstraZeneca
Laboratory Corporation of America; Medidata Solutions; IQVIA RDS Inc.; Calyx; Thermo... and other collaborators

Recruiting

Endoscopic Evidence of Maintenance of Healing With Oral NEXIUM in Patients 1 to 11 Years Old With Erosive Esophagitis. (EE)

Erosive Esophagitis

United States, Italy, Belgium, Vietnam, Spain, Portugal, Russian Federation, Argentina, Greece, Australia, Lithuania
Universitaire Ziekenhuizen KU Leuven

Completed

PPI and Microbiome in Healthy Volunteers and Functional Dyspepsia

Dysbiosis

Belgium
Celgene

Completed

Relative Bioavailability Study of CC-292

Healthy Volunteers

United States
Sihuan Pharmaceutical Holdings Group Ltd.

Completed

A Phase 2 Randomised Controlled Trial to Evaluate Efficacy and Safety of Anaprazole in Patients With Duodenal Ulcers.

Duodenal Ulcer，DU

China
Kaohsiung Veterans General Hospital.

Completed

On-demand PPI Therapy is Effective on Controlling Symptoms in Patients With Barrett's Esophagus.

Barrett Esophagus | Reflux | Proton Pump Inhibitor | Symptom
First Affiliated Hospital, Sun Yat-Sen University

Completed

The Primary Symptoms of GERD(Gastroesophageal Reflux Disease) in Chinese Outpatients in Gastroenterology Department

Gastroesophageal Reflux

China
Indiana University

Terminated

The Effects of Dexlansoprazole for the Treatment of Throat-Related Reflux

Laryngopharyngeal Reflux

United States
Takeda

Completed

A Study to Evaluate the Bioequivalence of Single Oral Dose of Esomeprazole Capsule and Tablet Formulation in Healthy Participants

Healthy Participants

United States
Pfizer

Completed

Pilot Study To Investigate The Association Between Acid Control And Heartburn Symptoms After Proton Pump Inhibitor Treatment

Heartburn

United States
Ahn-Gook Pharmaceuticals Co.,Ltd

Unknown

S-pantoprazole 10mg Phase III Clinical Study

Non Erosive Reflux Disease

Korea, Republic of
Norgine

Completed

A Three-Period Study to Investigate the Relative Bioavailability and Pharmacodynamic Profiles of a Zegerid 20mg Capsule, Zegerid 20mg Powder for Oral Suspension and Losec 20mg Capsule in Healthy Adult Volunteers Under Fasting Conditions

Acid Reflux | Gastro Oesophageal Reflux Disease

United Kingdom
American Institute for Voice and Ear Research

Terminated

Safety and Efficacy of Lansoprazole 30mg Twice Daily in Treatment of Laryngitis Associated With Gastroesophageal Reflux

Laryngopharyngeal Reflux

United States
Chang Gung Memorial Hospital

Completed

Efficacy and Safety of Sodium Alginate Oral Suspension to Treat Non-erosive Gastro-esophageal Reflux Disease

Gastroesophageal Reflux Disease | Heartburn

Taiwan
University of North Carolina, Chapel Hill
AstraZeneca

Completed

The Utility of Nexium in Chronic Cough and Reflux Disease

Cough | GERD

United States
Takeda

Completed

The Use of Lansoprazole to Treat Infants With Symptoms of Gastroesophageal Reflux

Gastroesophageal Reflux Disease

Poland, United States
Eisai Inc.

Completed

E3810-A001-313: Efficacy and Safety of 10 mg Rabeprazole for Treating Heartburn in Frequent Sufferers

Heartburn

United States
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Completed

A Trial of SHR-1210 (an Anti-PD-1 Antibody) in Combination With Apatinib in Patients With Advanced TNBC

Breast Cancer

China
University of Florida
Bristol-Myers Squibb; Sanofi

Completed

PPI and Clopidogrel Response

Drug Interaction

United States
Finni Kollins

Completed

Recurrence Rate Comparison Between Esomeprazole and Lansoprazole in Eradicating Helicobacter Pylori Infection Among Children

Helicobacter Pylori Infection

Indonesia
Sheba Medical Center

Withdrawn

Clopidogrel Proton-Pump Inhibitors Study

Coronary Artery Disease

Israel
Yonsei University

Not yet recruiting

Efficacy of Fexuprazan for Prevention or Control of Gastritis Symptoms in Patients on Treatment With Systemic Steroids

Patients on Treatment With Systemic Steroids

Korea, Republic of
Afferent Pharmaceuticals, Inc.
Celerion

Completed

A Multiple-Dose Pharmacokinetics Study of Two Gefapixant (AF-219/MK-7264) Formulations

Healthy

United States
Agios Pharmaceuticals, Inc.

Completed

A Study to Compare the Relative Bioavailability of Two AG-881 Formulations and Evaluate the Effect of Food and Omeprazole on the Pharmacokinetics of AG-881

Healthy Volunteers

United States
Children's Hospital Srebrnjak
Belupo; University Hospital Center Sisters of Charity, Zagreb, Croatia

Completed

Omeprazole 20 mg in Patients With Laryngopharyngeal reﬂux and Comorbid Chronic Rhinosinusitis

Chronic Rhinosinusitis (Diagnosis) | Laryngopharyngeal Reflux
Aswan University Hospital

Unknown

Esomeprazole for the Prevention of Preeclampsia

Pre-Eclampsia

Egypt
Pfizer

Completed

A Study Of Glasdegib In Healthy Volunteers To Establish The Bioequivalence Of The Phase 2 Formulation To The ICH Formulation (B1371026)

Healthy Volunteers

United States
Mayo Clinic

Completed

Does Intensive Acid Suppression Reduce Esophageal Inflammation and Recurrent Barrett's Esophagus Following Ablation?

Inflammation | Barrett's Esophagus

United States
Chang Gung Memorial Hospital
TTY Biopharm

Unknown

Esomeprazole Plus Alginate vs. Esomeprazole Alone for Treatment of Nighttime Reflux Symptom and Sleep Disturbances

Sleep Disturbance | Gastroesophageal Reflux Disease | Heartburn

Taiwan
Il-Yang Pharm. Co., Ltd.

Completed

Efficacy/Safety Study as H. Pylori Eradication of Triple Therapy for 7 Days Treatment

Peptic Ulcer

Korea, Republic of
HK inno.N Corporation

Completed

Safety, Tolerability, PK, PD of Escalating Single and Multiple Oral Doses of CJ-12420 in Healthy Male Subjects

Healthy

Korea, Republic of
Takeda

Completed

Efficacy of TAK-438 Compared to AG-1749 (Lansoprazole) in the Treatment of Erosive Esophagitis

Erosive Esophagitis

Japan
AstraZeneca

Completed

Barrett's Esophagus - 315 - 3 Way Cross-Over

Barrett's Esophagus
AstraZeneca

Completed

A Multicenter, Randomized, Double Blind, Double Dummy, Parallel-Group Efficacy Study Comparing 8 Weeks of Treatment With Esomeprazole Magnesium (40mg qd) to Lansoprazole (30mg qd) for the Healing of Erosive Esophagitis in Patients With Moderate or Severe Erosive Esophagitis

Erosive Esophagitis
AstraZeneca

Completed

Multicenter, Randomized, Double-Blind, Double-Dummy, Parallel-Group Comparison of the Remission Rates of Once Daily Treatment With Esomeprazole 20mg and Lansoprazole 15mg for 6 Months in Patients Whose EE Has Been Healed

Erosive Esophagitis
EMS

Withdrawn

Food Effect on the Eradication Rate of H. Pylori With Triple Therapy With Esomeprazole

Helicobacter Pylori Infection

Brazil
AstraZeneca

Completed

Drug-Drug Interaction Study With AZD9291 and Omeprazole in Healthy Volunteers

Healthy Volunteer

United States
Shandong University
Zibo Central Hospital; Peking University Care Luzhong Hospital; Taierzhuang District... and other collaborators

Recruiting

Bismuth Quadruple Therapy in Helicobacter Pylori Rescue Therapy of Different Tetracycline Doses and Frequencies.

Helicobacter Pylori Infection

China
Onconic Therapeutics Inc.

Not yet recruiting

Clinical Trial to Evaluate the Efficacy and Safety of JP-1366 in Patients With Gastric Ulcer

Gastric Ulcer

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