Search clinical trials for: opioid anesthesia

Total 9060 results

Janssen Research & Development, LLC

Completed

A Study to Evaluate the Effect of Ibrutinib on the Pharmacokinetics of Oral Contraceptives, CYP2B6, and CYP3A4 Substrates in Female Participants With B Cell Malignancy

Leukemia, Lymphocytic, Chronic, B-Cell

Spain, Poland
HTL-Strefa S.A.

Completed

Characteristics of Different Types of Safety Lancets on Blood Volume and Perceived Pain in Male and Female Volunteers

Healthy

Poland
Bristol-Myers Squibb

Completed

A Study to Assess the Effect of BMS-986142 on Pharmacokinetics (PK) of Probe Substrates

Rheumatoid Arthritis

United States
Boehringer Ingelheim

Completed

The Effect of BI 187004 on the Pharmacokinetics of Cytochrome P450 Substrates (Caffeine, Warfarin, Omeprazole, Metoprolol and Midazolam) and a P Glycoprotein Substrate (Digoxin)

Healthy

Germany
AstraZeneca

Completed

A Phase I Study in Healthy Volunteers to Assess the Effect of Cytochrome3A4 (CYP3A4) Inhibitors (Diltiazem and Itraconazole) on the Pharmacokinetics (PK) of AZD3293 and the Effects of AZD3293 on the Pharmacokinetics of Midazolam, a Cytochrome 3A4 and Cytochrome 3A5 (CYP3A4/CYP3A5) Substrate (AZD3293DDI)

Healthy Volunteers | Pharmacologic Action

United States
University of Santiago de Compostela

Completed

Bacteraemia Secondary to Tooth Extraction: Chlorhexidine Prophylaxis Protocols

Bacteremia | Tooth Extraction Status Nos

Portugal, Spain
University of Miami

Terminated

Chemotherapy for Relapsed Epstein Barr Virus Associated Lymphoma

Epstein Barr Virus Associated Non Hodgkin's Lymphoma | Epstein Barr Virus Associated Hodgkin's Lymphoma | Post-Transplant Lymphoproliferative Disease

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Laboratory-Treated T Cells and Ipilimumab in Treating Patients With Metastatic Melanoma

Recurrent Melanoma | Stage IV Melanoma

United States
GlaxoSmithKline

Completed

Drug Interaction Study of Darunavir/Ritonavir and Lopinavir/Ritonavir on GSK2248761 PK and CYP450 Probe Drugs

Healthy Subjects | Infection, Human Immunodeficiency Virus

United States
Bristol-Myers Squibb

Completed

Drug Interaction Study With a Potential Alzheimer's Disease Compound

Alzheimer Disease

United States
Thammasat University
Boontanapibul, Krit, M.D.

Completed

Multimodal Drug Infiltration in Total Knee Arthroplasty: Is Posterior Capsular Infiltration Worth the Risk?

Osteoarthritis, Knee

Thailand
Chiesi Farmaceutici S.p.A.

Completed

A Thorough QT (TQT) Study of CHF5993 pMDI in Healthy Volunteers (HV)

Asthma | Chronic Obstructive Pulmonary Disease (COPD)

United States
Janssen Research & Development, LLC

Suspended

A Study to Evaluate the Effect of Ustekinumab on Cytochrome P450 Enzyme Activities Following Induction and Maintenance Dosing in Participants With Active Crohn's Disease or Ulcerative Colitis

Crohn Disease | Ulcerative Colitis

Germany, United States, United Kingdom, Belgium
University Health Network, Toronto

Completed

IPACK Study in Total Knee Arthroplasty Patients

Knee Replacement Arthroplasty

Canada
Loyola University

Terminated

Efficacy of Oral Antibiotic Therapy Compared to Intravenous Antibiotic Therapy for Osteomyelitis (CRO-OSTEO)

Osteomyelitis

United States
Boehringer Ingelheim

Completed

Study to Evaluate the Effect of Multiple Doses of BIRT 2584 XX Tablets on the Pharmacokinetic Parameters of Warfarin, Omeprazole, Caffeine, and Dextromethorphan in Healthy Male Volunteers

Healthy
Seoul National University Bundang Hospital

Recruiting

The Efficacy of the 7 Days Tailored Therapy as the 1st Eradication of H. Pylori Infection

Helicobacter Infection

Korea, Republic of
Beni-Suef University
University of Arizona; Maternity and Children Hospital, Makkah; Benisuef university...

Completed

Different Treatment Modalities in the Management of the Painful Crisis in Pediatric Sickle- Cell Anemia

Sickle Cell Disease | Vaso-occlusive Crisis | Sickle Cell Anemia in Children

Egypt, Saudi Arabia
Seoul National University Hospital

Completed

Identification and Evaluation of Endogenous Markers for the Assessment of CYP3A Activity

Healthy

Korea, Republic of
AstraZeneca
Parexel

Completed

A Study to Evaluate the Food Effect on Drug Availability, Pharmacokinetic (PK) Properties, Safety and Tolerability of Two Different Dose Combination Therapy of Saxagliptin/Dapagliflozin/Metformin Extended-release (XR) Against Individual Component Co-administration.

Type 2 Diabetes Mellitus

United States
Guangdong Raynovent Biotech Co., Ltd

Completed

Drug-durg Interaction of Leritrelvir(RAY1216) With Midazolam, Omeprazole, Rosuvastatin, Verapamil, and Rifampin

Drug Drug Interaction

China
Jiangsu HengRui Medicine Co., Ltd.

Completed

A Drug-drug Interaction Study Of Fluzoparib (SHR3162) on Patients With Recurrent Ovarian Cancer

Recurrent Ovarian Cancer

China
Natalia Valadares de Moraes
University of Sao Paulo; Fundação de Amparo à Pesquisa do Estado de São Paulo

Enrolling by invitation

Impact of Bariatric Surgery on Pharmacokinetic Study of Simvastatin and Carvedilol

Obesity | Bariatric Surgery | Roux-en Y Gastric Bypass

United States
Seagen Inc.
Millennium Pharmaceuticals, Inc.

Completed

Clinical Pharmacology Study of Brentuximab Vedotin (SGN-35)

Neoplasms | Lymphoma, Non-Hodgkin | Lymphoma, Large-Cell, Anaplastic | Disease, Hodgkin | Carcinomas

United States
Bristol-Myers Squibb

Completed

A Study to Assess the Effect of BMS-986419 on the Single Dose Drug Levels of Probe Substrates in Healthy Participants

Healthy Volunteers

United States
Bristol-Myers Squibb

Completed

A Study to Evaluate the Drug-drug Interaction Potential of BMS-986196 in Healthy Participants

Healthy Volunteers

United States
Amgen

Completed

A Study in Healthy Volunteers to Evaluate the Drug-Drug Interaction Potential of CCX168 With Concomitant Medications

Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis

United States
Inje University

Completed

Development of Minidose Inje Cocktail Method for Simultaneous Evaluating Five Cytochrome P450 Isoforms in Human

Healthy
Merck Sharp & Dohme LLC

Completed

Pharmacokinetics of Midazolam, Dabigatran, Pitavastatin, Atorvastatin, and Rosuvastatin in Participants With Renal Insufficiency in the Presence and Absence of Rifampin (MK-0000-386)

Renal Insufficiency

United States
University of Washington
National Institute of General Medical Sciences (NIGMS)

Completed

The Effects of Multiple Dose Fluoxetine and Metabolites on CYP1A2, CYP2C19, CYP2D6 and CYP3A4 Activity (FLUOXETINE)

Healthy Volunteers | Drug-Drug Interaction
St. Jude Children's Research Hospital

Terminated

Bortezomib and Vorinostat in Younger Patients With Refractory or Relapsed MLL Rearranged Hematologic Malignancies

Acute Myeloid Leukemia | Acute Lymphoid Leukemia | Mixed Lineage Acute Leukemia

United States
Boehringer Ingelheim

Completed

Effects of BI 201335 NA on Cytochrome P450 and P-glycoprotein Activity Using a Probe Drug Cocktail in Healthy Volunteers

Healthy
Kaohsiung Veterans General Hospital.

Completed

Comparing the Efficacy of Hybrid, High-dose Dual and Bismuth Quadruple Therapies

Helicobacter Pylori Infection

Taiwan
Children's Oncology Group

Recruiting

A Study to Give Treatment Inside the Eye to Treat Retinoblastoma

Bilateral Retinoblastoma | Childhood Intraocular Retinoblastoma | Unilateral Retinoblastoma | Group D Retinoblastoma | Stage I Retinoblastoma

United States
Pfizer

Completed

Voxelotor CYP and Transporter Cocktail Interaction Study

Sickle Cell Disease

United States
Reata, a wholly owned subsidiary of Biogen
Covance

Completed

A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone

Healthy Adult Subjects

United States
University of Cologne
Umm Al-Qura University

Completed

Effect of Acute Ethanol Consumption on The Activity of Major Cytochrome P450 Enzymes, NAT2 and P-glycoprotein

AOD Effects and Consequences

Germany
Janssen-Cilag International NV

Completed

A Study in Healthy Participants to Evaluate the Effects of Multiple Doses of JNJ-55308942 on Cytochrome P450 Substrate Activity and on the Pharmacokinetics of Levonorgestrel/Ethinyl Estradiol

Healthy

Belgium
Turku University Hospital

Completed

Dabigatran in an Interaction Probe Drug Cocktail (D-cocktail)

Healthy Volunteers

Finland
Eisai Inc.

Completed

A 2-Part Study to Assess Potential Metabolism-Based Drug-Drug Interactions of E2006 When Coadministered With Itraconazole, Rifampin, Midazolam, or Bupropion

Healthy Subjects

United States
Benazir Bhutto Hospital, Rawalpindi

Completed

Role of Emotional Freedom Techniques in Reducing Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy (EFT)

Postoperative Nausea and Vomiting

Pakistan
Masonic Cancer Center, University of Minnesota

Completed

Allo HSCT Using RIC for Hematological Diseases

Follicular Lymphoma | Myelodysplastic Syndromes | Multiple Myeloma | Non-Hodgkin's Lymphoma | Lymphoblastic Lymphoma | Chronic Lymphocytic Leukemia | Lymphoplasmacytic Lymphoma | Acute Lymphocytic Leukemia | Acute Myelogenous Leukemia | Mantle-Cell Lymphoma | Chronic Myelogenous Leukemia | Prolymphocytic Leukemia and other conditions

United States
Pfizer

Completed

A Study to Learn About the Drug-drug Interactions of Sisunatovir in Healthy Adult Participants

Respiratory Syncytial Virus Infections

United Kingdom
University of Southern Denmark

Terminated

Metformin's Effect on Drug Metabolism in Patients With Type 2 Diabetes

Diabetes Mellitus, Type 2

Denmark
Centre hospitalier de l'Université de Montréal...
Canadian Institutes of Health Research (CIHR)

Completed

Evaluation of CYP450 Activities in Diabetic Patients vs. Non-diabetic Subjects

Type 2 Diabetes

Canada
Janssen Scientific Affairs, LLC

Completed

Family Intervention in Recent Onset Schizophrenia Treatment (FIRST) (FIRST)

Schizophrenia

United States
Chonbuk National University Hospital

Completed

Clinical Trials on Evaluate the Red Ginseng and Fermented-Red Ginseng Affect to Drug Metabolizing Enzyme and Transporter in Healthy Volunteers

Healthy

Korea, Republic of
Daniel Benjamin
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care (PTN_POPS)

Heart Failure | Epilepsy | Pain | Pneumonia | Sepsis | Inflammation | Hypertension | Chronic Kidney Diseases | Hemophilia | Schizophrenia | Central Nervous System Infections | Nosocomial Pneumonia | Insomnia | Anxiety | Bipolar Disorder | Neutropenia | Staphylococcal Infections | Bradycardia | Seizures | Urinary Tract Infections | Pulmonary... and other conditions

United States, Canada, United Kingdom, Israel, Singapore
University of Southern Denmark
SignaTope GmbH, Germany

Completed

Flucloxacillin as an Inducer of CYP-enzymes

Healthy Volunteers | Drug Drug Interaction

Denmark
Abliva AB

Completed

Drug-drug Interaction Study of KL1333 in Healthy Subjects

Mitochondrial Disease

United Kingdom

Search clinical trials for: opioid anesthesia

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