Search clinical trials for: PPI (proton pump inhibitor)

Total 11473 results

AstraZeneca

Completed

Drug-Drug Interaction Study With AZD9291 and Omeprazole in Healthy Volunteers

Healthy Volunteer

United States
Sheba Medical Center

Withdrawn

Clopidogrel Proton-Pump Inhibitors Study

Coronary Artery Disease

Israel
Shandong University
Zibo Central Hospital; Peking University Care Luzhong Hospital; Taierzhuang District... and other collaborators

Recruiting

Bismuth Quadruple Therapy in Helicobacter Pylori Rescue Therapy of Different Tetracycline Doses and Frequencies.

Helicobacter Pylori Infection

China
Deborah Siegal

Not yet recruiting

Reducing Gastrointestinal Bleeding With Proton Pump Inhibitor Therapy in Acute Venous Thromboembolism

Venous Thromboembolism | Blood Clot | Gastro Intestinal Bleeding
Jiangsu HengRui Medicine Co., Ltd.

Completed

Effect of Omeprazole on Pharmacokinetics of SHR2554 in Healthy Subjects

Malignant Tumor

China
Cinclus Pharma AG
Parexel

Completed

A Study in Patients With Erosive Esophagitis to Investigate Safety, Tolerability, and Healing Rates After 4 Weeks Treatment of X842 or Lansoprazole and Symptom Pattern During Subsequent 4 Weeks Treatment With Lansoprazole

Erosive Esophagitis

Poland, Bulgaria, Serbia, Georgia, United States, Czechia, Hungary, Ukraine
MetroHealth Medical Center

Completed

Symptom Control Satisfaction With Proton Pump Inhibitor Regimen

Heartburn

United States
Afferent Pharmaceuticals, Inc.
Celerion

Completed

A Study to Assess the Effect of Intragastric pH and Fasting on the Pharmacokinetics of Gefapixant (AF-219/MK-7264)

Healthy Volunteers
Millennium Pharmaceuticals, Inc.

Completed

A Trial to Evaluate the Effect of the Proton Pump Inhibitor Esomeprazole on the Single-dose Pharmacokinetics (PK) of Oral TAK-906 in Healthy Adult Participants

Healthy Volunteers

United States
Shire

Completed

SSP-002358 Drug Interaction Study With Omeprazole

Healthy

Netherlands
Peking University First Hospital
Cancer Institute and Hospital, Chinese Academy of Medical Sciences; Shandong...

Unknown

Phase I Single-dose Escalation Clinical Trial of Salvianolic Acid A Tablets

Neuropathy of Diabetes

China
Millennium Pharmaceuticals, Inc.

Completed

A Study to Evaluate the Relative Bioavailability, Effect of Food, and Gastric Potential Hydrogen (pH) Modification on the Pharmacokinetics of TAK-117 (MLN1117) in Healthy Participants

Neoplasm, Advanced or Metastatic
University of Louisville
Bausch Health Americas, Inc.

Completed

Pharmacokinetics of Immediate-Release vs. Delayed-Release Omeprazole in Gastroparesis

Gastroesophageal Reflux Disease | Gastroparesis

United States
Afferent Pharmaceuticals, Inc.

Completed

A Multiple-Dose Pharmacokinetics Study of Three Gefapixant (AF-219/MK-7264) Formulations

Healthy

United States
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Pharmacokinetic and Relative Bioavailability Study With Rabeprazole Sodium in Healthy Adult Volunteers

Gastroesophageal Reflux

United States
Takeda
Richmond Pharmacology Limited

Completed

Safety, Tolerability, and Pharmacokinetics of TAK-438 in Healthy Western Male Subjects, Preliminary Food Effect Analysis, and an Ethnic Comparison With Japanese Subjects

Dose Finding Study
USDA Beltsville Human Nutrition Research Center

Completed

Gastric pH and Anthocyanin Absorption

Anthocyanin Metabolism

United States
Takeda

Completed

Efficacy of TAK-438 Compared to AG-1749 (Lansoprazole) in the Treatment of Gastric Ulcer

Gastric Ulcer

Japan
Ahn-Gook Pharmaceuticals Co.,Ltd

Unknown

Investigate a Pharmacodynamics Between S-pantoprazole 10, 20, 40mg and Pantoprazole 20, 40mg in Healthy Male Subjects (AGSPT_PD)

Healthy Male Subjects
Lise Tarnow
Novo Nordisk A/S; Steno Diabetes Center Copenhagen; Chr Hansen; Statens Serum Institut

Completed

The Effect of Nexium and Probiotics on Insulin Secretion and Cardiovascular Risk Factors in Patients With Type 2 Diabetes (Nexium)

Type 2 Diabetes
Takeda

Completed

Pantoprazole Magnesium 40 mg Versus Esomeprazole 40 mg in Patients With Erosive Gastroesophageal Reflux Disease (PAMES 0109)

GERD

Brazil
Torrent Pharmaceuticals Limited

Completed

Bioequivalence Study of Torrent Pharmaceutical Limited's Pantoprazole Sodium 40 mg Delayed Release Tablets Under Fed Conditions

Healthy

India
Chinese University of Hong Kong

Completed

A Study Comparing High Dose Omeprazole Infusion Against Scheduled Second Endoscopy for Bleeding Peptic Ulcer

Peptic Ulcer Hemorrhage

China
Teva Pharmaceuticals USA

Completed

Lansoprazole 30 mg DR Capsule Replicate Food Study

Healthy

United States
Teva Pharmaceuticals USA

Completed

Lansoprazole 30 mg DR Capsule Fasting Replicate Sprinkle Study

Healthy

United States
Wyeth is now a wholly owned subsidiary of Pfizer
Nycomed

Completed

Study Evaluating Pantoprazole Sodium Enteric-Coated Spheroid Suspension In Infants With Presumed GERD

Gastroesophageal Reflux

Poland, Italy, United States, France, Australia, Switzerland, Belgium, Germany
Dr. Reddy's Laboratories Limited

Completed

Bioequivalence Study of Omeprazole Magnesium 20 mg DR Capsules Under Fasting Conditions

Healthy

India
VA Greater Los Angeles Healthcare System
Eisai Inc.; PriCara, Unit of Ortho-McNeil, Inc.

Completed

Comparison of the Nighttime Effects of Two Different Drugs on Subjects With GERD

Gastroesophageal Reflux Disease

United States
AstraZeneca
UMC Utrecht

Completed

PPI Test in GP Patients

GERD

Netherlands
National Taiwan University Hospital

Unknown

The Role of CYP2C19 on the Eradication of H. Pylori Infection:Implication of PK/PD Relationships

Peptic Ulcer With H. Pylori Infection | Gastritis With H. Pylori Infection

Taiwan
EMS

Withdrawn

Food Effect on the Eradication Rate of H. Pylori With Triple Therapy With Esomeprazole

Helicobacter Pylori Infection

Brazil
Onconic Therapeutics Inc.

Not yet recruiting

Clinical Trial to Evaluate the Efficacy and Safety of JP-1366 in Patients With Gastric Ulcer

Gastric Ulcer
Daewoong Pharmaceutical Co. LTD.

Completed

Study to Evaluate the Efficacy and Safety of DWP14012 in Patients With Erosive Gastroesophageal Reflux Disease (Phase 2, Therapeutic Exploratory Study)

Erosive Gastroesophageal Reflux Disease

Korea, Republic of
Torax Medical Incorporated

Completed

The CALIBER Study Randomized Controlled Trial of LINX Versus Double-Dose Proton Pump Inhibitor Therapy for Reflux Disease (CALIBER)

GERD Gastroesophageal Reflux Disease

United States
Jordan Collaborating Cardiology Group
University of Jordan

Completed

The Effect of Proton Pump Inhibition on Palpitations

Arrhythmia

Jordan
Damascus Hospital

Withdrawn

Comparison of Low Against High Regimen of Proton Pump Inhibitors for Treatment of Acute Peptic Ulcer Bleeding

Peptic Ulcer Hemorrhage | Marginal Ulcer | Gastroduodenal Ulcer

Syrian Arab Republic
Eisai Co., Ltd.

Completed

Prognostic Study of Gastric MALT Lymphoma After Eradication of Helicobacter Pylori

Gastric Low-grade MALT Lymphoma With Helicobacter Pylori Positive

Japan
University of Utah

Terminated

Elucidation of Acid-Induced Pulmonary Inflammation

Asthma | Gastroesophageal Reflux

United States
Pfizer

Completed

PPI And Food Effect Study For PF-06463922 In Healthy Volunteers

Healthy

Belgium
Yuhan Corporation

Completed

Phase 2 Clinical Trial to Investigate the Safety, Tolerability and Efficacy of YH1885L in Patients With Non-erosive Reflux Disease(NERD)

Non-erosive Reflux Disease

Korea, Republic of
Yuhan Corporation

Completed

Food Effect on Pharmacokinetics of YH4808 in Healthy Male Subjects

Healthy

Korea, Republic of
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating Pantoprazole in Children With GERD

Gastroesophageal Reflux

United States
AstraZeneca

Completed

Use Of Esomeprazole In Postoperative Bariatric Surgery Patients Users And Non-Users Of Nonsteroidal Anti-Inflammatory Drugs (NSAIDS)

Postoperative Bariatric Surgery
PriCara, Unit of Ortho-McNeil, Inc.
Eisai Inc.

Completed

A Study of Rabeprazole and Pantoprazole on Stomach Acid and Esophageal Acid Exposure in Patients With Gastroesophageal Reflux Disease (GERD) and a History of Nighttime Heartburn

Gastroesophageal Reflux
Tampere University Hospital

Completed

The Effect of Esomeprazole and Fundoplication on Airways

Airway Responsiveness

Finland
Mayo Clinic

Not yet recruiting

Ibrutinib for the Prevention of Chronic Graft-Versus-Host Disease in Patients Undergoing Donor Stem Cell Transplant

Chronic Graft Versus Host Disease | Hematopoietic and Lymphatic System Neoplasm

United States
University of Florida
Bristol-Myers Squibb; Sanofi

Completed

PPI and Clopidogrel Response

Drug Interaction

United States
Shanghai Jiao Tong University School of Medicine

Completed

Empirical Rescue Therapies of Helicobacter Pylori Infection

Functional Dyspepsia | Scarred Peptic Ulcer

China
Qingdao Municipal Hospital
Jiangsu HengRui Medicine Co., Ltd.

Unknown

Apatinib in Combination With S-1 as First-Line Treatment in Patients With Advanced Gastric Cancer

Gastric Cancer
The First Affiliated Hospital of Zhengzhou University

Unknown

A Study of Apatinib for Advanced Hepatocellular Carcinoma Patients After First-line Treatment Failure

Hepatocellular Carcinoma

3

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