Search clinical trials for: Pegylated asparaginase

Total 984 results

National Cancer Institute (NCI)

Completed

Phase II Study of Clinical Activity of Pegaspargase in Women With Relapsed or Refractory Epithelial Ovarian Cancer, Fallopian Tube Cancer, and/or Primary Peritoneal Cancer

Ovarian Neoplasms | Fallopian Tube Neoplasms | Primary Peritoneal Neoplasms

United States
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Erwinia Asparaginase After Allergy to PEG-Asparaginase in Treating Young Patients With Acute Lymphoblastic Leukemia

Childhood Acute Lymphoblastic Leukemia | Adult Acute Lymphoblastic Leukemia

United States
medac GmbH

Completed

Comparative Efficacy and Safety of Two Asparaginase Preparations in Children With Previously Untreated Acute Lymphoblastic Leukaemia

Acute Lymphoblastic Leukemia

Netherlands
Children's Cancer Group, China
Xiangya Hospital of Central South University; Tongji Hospital; Qilu Hospital... and other collaborators

Active, not recruiting

LBL-2016 for Children or Adolescents in China

Lymphoblastic Lymphoma

China
medac GmbH

Completed

Efficacy and Safety of Recombinant Asparaginase in Infants With Previously Untreated Acute Lymphoid Leukemia (ALL)

Acute Lymphoid Leukemia

Germany, Netherlands
Memorial Sloan Kettering Cancer Center
Jazz Pharmaceuticals

Withdrawn

Intravenous Erwinia Chrysanthemi Asparaginase in Patients With Newly Diagnosed Philadelphia Chromosome Negative Acute Lymphoblastic Leukemia Aged 60 Years or Older

Acute Lymphoblastic Leukemia (ALL) | Newly Diagnosed Philadelphia Chromosome Negative | Aged 60 Years or Older

United States
Phoenix Children's Hospital
Jazz Pharmaceuticals; Fisher Bioservices

No longer available

Erwinase Master Treatment Protocol (EMTP)

Acute Lymphoid Leukemia | Leukemia, Acute Lymphoblastic
ERYtech Pharma
Centre Leon Berard

Completed

Administration of Allogenic Red Blood Cells Loaded L-asparaginase in Cases of Relapse of Acute Lymphoblastic Leukaemia (GRASPALL)

Acute Lymphoblastic Leukemia

France
M.D. Anderson Cancer Center

Completed

Erwinase Study in Patients With Acute Lymphoblastic Leukemia

Leukemia

United States
Jazz Pharmaceuticals

Completed

A Study of Erwinaze Administered Intravenously in Patients Who Had an Allergy to Frontline Asparaginase Therapy

Acute Lymphoblastic Leukemia | Lymphoblastic Lymphoma

United States, Canada
medac GmbH
Syneos Health

Recruiting

PK, PD, Safety and Immunogenicity of Spectrila in Adults With Acute B-cell Lymphoblastic Leukaemia

Acute B-Cell Lymphoblastic Leukaemia

Brazil
Nordic Society for Pediatric Hematology and Oncology
Danish Child Cancer Foundation; Medac, Hamburg, Germany

Unknown

Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses

Acute Lymphoblastic Leukemia

Denmark
Jazz Pharmaceuticals

Approved for marketing

JZP458 - Recombinant Erwinia Asparaginase for Treatment of ALL / LBL Patients With Hypersensitivity to E. Coli-derived Asparaginase

Acute Lymphoblastic Leukemia | Lymphoblastic Lymphoma
Fudan University

Completed

L-asparaginase Monotherapy as Salvage Treatment in Patients With NK/T Cell Lymphoma

Lymphoma

China
ERYtech Pharma

Terminated

L-asparaginase Encapsulated in Red Blood Cells (Eryaspase) for Treatment of Adult Patients With ALL or LBL

Acute Lymphoblastic Leukemia | Lymphoblastic Lymphoma

United States
Children's Oncology Group

Recruiting

Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for Leukemia or Lymphoma

Lymphoblastic Lymphoma | B Acute Lymphoblastic Leukemia | B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 | T Acute Lymphoblastic Leukemia | Mixed Phenotype Acute Leukemia | B Acute Lymphoblastic Leukemia, BCR-ABL1-Like

United States, Canada
Jazz Pharmaceuticals

Withdrawn

An Open-Label, Single-Arm, Multicenter Pharmacokinetic Study of Intramuscular Erwinaze® (Asparaginase Erwinia Chrysanthemi)/Erwinase® (Crisantaspase)

Acute Lymphoblastic Leukemia (ALL)/Lymphoblastic Lymphoma (LBL)

Spain
Rigshospitalet, Denmark
Nordic Society for Pediatric Hematology and Oncology

Completed

ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia Intermittent Versus Continuous PEG Asparaginase

Acute Lymphoblastic Leukemia

Finland, Denmark, Norway, Sweden, Iceland
Rong Tao

Completed

Social Media-based Active Self-report on Incidence and Outcomes of Adverse Events in NK/TCL Patients

Extranodal NK-T-Cell Lymphoma, Nasal Type

China
ERYtech Pharma

Completed

GRASPA Treatment for Patients With Acute Myeloblastic Leukemia (ENFORCE)

Acute Myeloid Leukemia

France
ERYtech Pharma

No longer available

Expanded Access Program: Safety of Erythrocytes Encapsulating L-asparaginase (GRASPA®) in Combination With Polychemotherapy in Patients Under 55 Years Old With Acute Lymphoblastic Leukemia (ALL) at Risk to Receive Other Formulation of Asparaginase (EAP)

Acute Lymphoblastic Leukemia

France
ERYtech Pharma

Completed

GRASPA (Erythrocytes Encapsulating L-asparaginase) in Patients With Relapse of Acute Lymphoblastic Leukemia (GRASPIVOTALL)

Acute Lymphoblastic Leukemia, in Relapse

France, Belgium
Hunan Cancer Hospital

Recruiting

Anti-PD-1 Antibody Combined With Peg-Asparaginase and Chidamide for the Early Stage of NK/T Cell Lymphoma

Chemotherapy Effect | NK/T-cell Lymphoma of Nasal Cavity | Immune Checkpoint Inhibitor | Epigenetic Disorder

China
Aarhus University Hospital

Completed

The Association Between Asparaginase Enzyme Activity Levels and Toxicities in Childhood Acute Lymphoblastic Leukaemia in NOPHOALL 2008

Acute Lymphoblastic Leukemia

Denmark
Gruppo Italiano Malattie EMatologiche dell'Adulto

Terminated

Asparaginase Activity Monitoring (AAM) in Adult Patients With Acute Lymphoblastic Leukemia (ALL) (ALL2518)

Acute Lymphoblastic Leukemia

Italy
M.D. Anderson Cancer Center
Jazz Pharmaceuticals

Withdrawn

Phase II Study of Fludarabine, Cytarabine (ARA-C) and Erwinase IV in Patients With Relapsed or Refractory Hematologic Malignancies

Hematologic Malignancy
Xiamen Amoytop Biotech Co., Ltd.
Peking Union Medical College Hospital

Completed

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of Pegylated-Somatropin in Healthy Volunteers (Somatropin)

Healthy

China
Prolong Pharmaceuticals

Completed

Study to Assess the Safety and Impact on Humoral Sensitization of SANGUINATE in Patients With End Stage Renal Disease

Renal Insufficiency, Chronic

United States
Xiamen Amoytop Biotech Co., Ltd.

Completed

PK & PD Study of Pegylated rhEPO, and Evaluated Its Safety and Tolerability in Male Healthy Individual

Healthy

China
St. Jude Children's Research Hospital
Parexel; Jazz Pharmaceuticals

Completed

Compassionate Use of Erwinase For Pediatric Patients With Acute Lymphoblastic Leukemia Or Non Hodgkins Lymphoma

Acute Lymphoblastic Leukemia | Non Hodgkins Lymphoma

United States
OHSU Knight Cancer Institute
Genentech, Inc.; Oregon Health and Science University; Servier Pharmaceuticals...

Recruiting

Calaspargase Pegol-Mnkl and Cobimetinib for the Treatment of Locally Advanced or Metastatic Pancreatic Cancer

Stage II Pancreatic Cancer AJCC v8 | Stage III Pancreatic Cancer AJCC v8 | Stage IV Pancreatic Cancer AJCC v8 | Metastatic Pancreatic Adenocarcinoma | Locally Advanced Pancreatic Adenocarcinoma | Stage IIA Pancreatic Cancer AJCC v8 | Stage IIB Pancreatic Cancer AJCC v8

United States
The First Hospital of Jilin University

Recruiting

Mecapegfilgrastim(PEG-G-CSF) for Prophylaxis of Chemotherapy-induced Neutropenia in Patients With Lymphoma

Lymphoma | Chemotherapy-induced Neutropenia

China
Prolong Pharmaceuticals

Completed

A Phase 1 Safety Study of SANGUINATE™ In Patients With Acute Severe Anemia.

Acute Anemia

United States
Ludwig Institute for Cancer Research
Memorial Sloan Kettering Cancer Center; National Taiwan University Hospital; Duke... and other collaborators

Terminated

Study of ADI-PEG 20 in Patients With Relapsed Sensitive or Refractory Small Cell Lung Cancer

Small Cell Lung Cancer

United States, Taiwan, Germany, Belgium, United Kingdom
Universidade Federal do Rio de Janeiro

Completed

Hipoenergetic Effect of Diet Associated or Not With the Consumption of Coconut Flour in Women With Overweight

Obesity | Cardiovascular Risk Factor
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Withdrawn

Pembrolizumab and PEGPH20 in Treating Patients With Metastatic Pancreatic Cancer

Stage IV Pancreatic Cancer AJCC v8 | Metastatic Pancreatic Adenocarcinoma

United States
Eisai Inc.
Halozyme Therapeutics

Terminated

Study of Eribulin Mesylate in Combination With PEGylated Recombinant Human Hyaluronidase (PEGPH20) Versus Eribulin Mesylate Alone in Subjects With Human Epidermal Growth Factor Receptor 2 (HER2)-Negative, High-Hyaluronan (HA) Metastatic Breast Cancer (MBC)

Metastatic Breast Cancer

United States
Prolong Pharmaceuticals

Withdrawn

A Study on SANGUINATE™ for the Reduction of Delayed Graft Function in Kidney Transplant Patients

Delayed Function of Renal Transplant
Prolong Pharmaceuticals

Completed

Efficacy and Safety of SANGUINATE™ for Reduction of Delayed Graft Function in Patients Receiving a Kidney Transplant

Delayed Function of Renal Transplant

United States
Ashkan Emadi

Completed

1336GCC: Study of Erwinaze for Treatment of Acute Myeloid Leukemia (AML)

Acute Myeloid Leukemia

United States
Prolong Pharmaceuticals

Completed

Study of SANGUINATE™ In the Treatment of Sickle Cell Disease Patients With Vaso-Occlusive Crisis

Anemia, Sickle Cell

United States
Cancer Institute and Hospital, Chinese Academy...
Zhejiang Cancer Hospital; Changhai Hospital; Fudan University; Fujian Cancer Hospital and other collaborators

Completed

A Study Comparing Pegylated Filgrastim and Filgrastim in Support for Chemotherapy

Cancer
Aristotle University Of Thessaloniki

Unknown

Correlation of Polymorphisms of Lipoprotein Lipase (LpL) and Apolipoprotein E (Apo E) With Lipid Profile of Children With Acute Lymphoblastic Eukaemia During Therapy With L - Asparaginase.

Acute Lymphoblastic Leukemia

Greece
Jiangsu HengRui Medicine Co., Ltd.

Unknown

A Study of Pegylated rhG-CSF as Support to Advanced Non-Small-Cell Lung Cancer (NSCLC) Patients Receiving Chemotherapy Receiving Chemotherapy

NSCLC | Neutropenia | Febrile Neutropenia

China
Pfizer
Hospira, now a wholly owned subsidiary of Pfizer

Completed

A Study Of The Safety And Effects Of One Or More Doses Of HSP-130 Injected Under The Skin In Women With Breast Cancer That Has Not Spread To Distant Sites In The Body.

Non-metastatic Breast Cancer

Hungary, Spain
Sun Yat-sen University
JIANGSU JIBEIER PHARMACEUTICAL CO.,LTD

Not yet recruiting

A Multi-center, Randomized, Double-blind, Phase III Clinical Trial of Leucogen Versus Placebo on Leukocyte and Platelet Whole-course Management Assisted by PFLL Chemotherapy in the Treatment of Stage IV, Recurrent or Metastatic NPC

Nasopharyngeal Carcinoma | Chemotherapy | Myelosuppression | Leucogen

China
Marval Pharma Ltd.

Terminated

Single Dose Safety, Tolerability and Pharmacokinetic Study of NCTX in Healthy Volunteers

Healthy Volunteers

United States
Jiangsu HengRui Medicine Co., Ltd.

Completed

A Study Comparing Pegylated rhG-CSF and rhG-CSF as Support to Breast Cancer Patients Receiving Chemotherapy

Breast Cancer | Neutropenia | Febrile Neutropenia

China
Prolong Pharmaceuticals

Completed

A Study of SANGUINATE for the Treatment of Vaso-occlusive Crisis (VOC) in Adult Sickle Cell Disease Patients

Anemia, Sickle Cell

Colombia, Panama, Dominican Republic, Honduras
Dana-Farber Cancer Institute
Leadiant Biosciences, Inc.

Terminated

A Pilot Study of Oncaspar® + Dexamethasone in Patients With Relapsed or Refractory T-Cell Lymphoma

T-Cell Lymphoma | Relapsed T-Cell Lymphoma | Refractory T-Cell Lymphoma

United States

Search clinical trials for: Pegylated asparaginase

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Taiwan

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations