Search clinical trials for: Phosphodiesterase 5 Inhibitors

Total 68862 results

University Hospital, Angers

Completed

Sildenafil Efficacy Study on Time Walk From Peripheral Arterial Desease Patients (Stade II) With Arterial Claudication (ARTERIOFIL)

Peripheral Arterial Occlusive Disease
Pfizer's Upjohn has merged with Mylan to form Viatris...

Terminated

Effects of Oral Sildenafil on Mortality in Adults With PAH (AFFILIATE)

Pulmonary Arterial Hypertension

Hong Kong, Malaysia, Serbia, United States, Germany, Latvia, Australia, Croatia, Greece, Czechia, Bosnia and Herzegovina, Singapore, Belgium, Israel, Mexico, Poland, Romania, Russian Federation, South Africa, Spain, Thailand, Turkey, Ukrai...
University of Florence

Completed

Tadalafil Plus Tamsulosin for Male LUTS and ED

Lower Urinary Tract Symptoms | Metabolic Syndrome | Erectile Dysfunction | Prostatic Hyperplasia, Benign
Uniformed Services University of the Health Sciences
Walter Reed National Military Medical Center

Terminated

Cerebrovascular Reactivity Assessed With fNIRS as a Biomarker of TCVI After Acute Traumatic Brain Injury in Military

Traumatic Brain Injury

United States
Benha University

Completed

Silodosin, Tadalafil Alone vs. Silodosin Plus Tadalafil as MET for Lower Ureteric Stones

Lower Ureteric Stones | Medical Expulsive Therapy | Tadalafil | Silodosin

Egypt
Beni-Suef University

Active, not recruiting

Comparative Study Between Tadalafil Versus Tamsulosin as a Medical Expulsive Therapy for Lower Ureteric Stones

Lower Ureteric Stones

Egypt
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

A Long Term Extension Study Evaluating Safety Of Sildenafil Citrate When Used To Treat Pulmonary Arterial Hypertension (PAH) In Children

Pulmonary Arterial Hypertension

United States, Colombia, Russian Federation, Taiwan, Guatemala, India, Mexico, Japan, Italy, Brazil, Hungary, Poland, Malaysia, Sweden, Chile
Ain Shams University

Completed

Sildenafil Citrate in Early Unexplained Recurrent Pregnancy Loss

Miscarriage, Recurrent

Egypt
Mayo Clinic

Terminated

Study of Low Dose Nesiritide With or Without Sildenafil in Congestive Heart Failure Patients With Renal Dysfunction (BNP+PDEVI)

Congestive Heart Failure | Renal Dysfunction

United States
Tianjin Hemay Pharmaceutical Co., Ltd

Completed

Multiple Ascending Dose Study to Assess Safety and Pharmacokinetics of Hemay005 In Healthy Subjects (Hemay005)

Psoriasis

China
Ganzhou Hemay Pharmaceutical Co., Ltd

Completed

A Study of Hemay005 in Adult With Atopic Dermatitis

Hemay005, Atopic Dermatitis

China
Tianjin Hemay Bio-Tech Co., Ltd

Unknown

A Food Effect Study to Assess Pharmacokinetics of Hemay005 in Healthy Volunteers

Psoriasis
Boehringer Ingelheim

Completed

Pharmacokinetic of Tadalafil Co-administered With Tipranavir/Ritonavir to Healthy Male Volunteers

Healthy
ViiV Healthcare
Pfizer

Completed

Study To Investigate The Hemodynamic Effects Of Single Dose Vardenafil In Subjects Receiving Maraviroc

AIDS

Belgium
National Cancer Institute (NCI)

Completed

Nivolumab (Anti-PD1), Tadalafil and Oral Vancomycin in People With Refractory Primary Hepatocellular Carcinoma or Liver Dominant Metastatic Cancer From Colorectal or Pancreatic Cancers

Metastatic Colorectal Cancer | Hepatocellular Carcinoma | Hepatocellular Cancer | Metastatic Pancreatic Cancer | Liver Metastasis

United States
University of South Florida

Unknown

Sagene 2014 - Parkinson's Disease and Erectile Dysfunction

Parkinson's Disease | Erectile Dysfunction

United States
Amgen

Completed

To Evaluate the Preliminary Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of CC-11050 in Subjects With Discoid Lupus Erythematosus and Subacute Cutaneous Lupus Erythematosus

Cutaneous Lupus Erythematosus

United States
Tetra Discovery Partners

Recruiting

A Randomized Study of BPN14770 in Male Adolescents (Aged 9 to < 18 Years) With Fragile X Syndrome

Fragile X Syndrome

United States
Amgen

Completed

A Study to Evaluate the Safety, Tolerability Pharmacokinetics, and Pharmacodynamics of a New Spray Dried Dispersion (SDD) Formulation of CC-11050 After Single Dose of CC-11050 and to Evaluate the Pharmacokinetics of CC-11050 Under Fasted and Fed Conditions and After Coadministration With Omeprazole

Healthy Volunteers

United States
Tianjin Hemay Bio-Tech Co., Ltd

Unknown

Multiple Ascending Dose Study to Assess Safety and Pharmacokinetics of Hemay005 In Healthy Subjects

Psoriasis

China
Pharmtechnology LLC
ClinPharmInvest, LLC

Not yet recruiting

Bioequivalence Study of Two Formulations of Sildenafil Tablet 100 mg in Healthy Male Volunteers Under Fasting Conditions

Bioequivalence

Russian Federation
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

A Randomized, Double-Blind, Placebo-Controlled Study of Sildenafil in Children With Pulmonary Arterial Hypertension.

Pulmonary Arterial Hypertension, Children

United States, Taiwan, Guatemala, Russian Federation, Japan, Chile, Colombia, Canada, Italy, Hungary, Poland, Peru, Sweden, Brazil, India, Malaysia, Mexico
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Food Effect Study For New Formulation

Healthy

Singapore
GlaxoSmithKline
Hammersmith Medicines Research; Covance Harrogate

Completed

A Phase 1 Relative Bioavailability Study of Ambrisentan and Tadalfil Fixed Dose Combination Tablets in Healthy Subjects

Hypertension, Pulmonary

United Kingdom
farzaneh hojjat
Razieh dehghani firouzabadi; Robab davar

Completed

Effect of Adding Sildenafil to Protocol of Endometrial Preparation in Outcome of Frozen-thawed Embryo Transfer Cycles (sildenafil)

Frozen Embryo Transfer | Endometrial Preparation

Iran, Islamic Republic of
Rambam Health Care Campus

Unknown

Evaluation of Safety and Effectiveness of 2 Lower Dose Combined PDE5i's Versus Single Maximal Dose PDE5i Treatment (PDE5i)

Erectile Dysfunction

Israel
Philip Kern
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics

Obesity | Pre-diabetes

United States
Pfizer's Upjohn has merged with Mylan to form Viatris...

Withdrawn

A Bioequivalence Study of Sildenafil Citrate Orally-Disintegrating Film Dosage Form

Healthy
Actelion

Completed

A Study to Compare the Macitentan-tadalafil Fixed Dose Combination Tablet Relative to the Concomitant Administration of the Reference Tablets of Macitentan and Tadalafil in Healthy Subjects

Healthy Subjects

Germany
Pfizer

Terminated

Study Evaluating The Safety And Efficacy Of PF-03049423 In Subjects With Ischemic Stroke

Ischemic Stroke

United States, Taiwan, Korea, Republic of, India, Germany, Canada, France, Bulgaria, Czech Republic, Hungary
Seoul National University Hospital
Dong-A Pharmaceutical Co., Ltd.

Completed

Efficacy Study of PDE-5 Inhibitor and Calcium Channel Inhibitor for the Treatment of Secondary Raynaud Phenomenon

Raynaud Phenomenon

Korea, Republic of
University of Zurich

Completed

Blood Markers Predict Effect of Normobaric Hypoxia at Rest and During Exercise in Patients With Pulmonary Hypertension (HEXABM)

Hypertension, Pulmonary

Switzerland
University of Zurich

Completed

Effects of Normobaric Hypoxia During Exercise in Patients With Pulmonary Hypertension With/Without Sildenafil (HEXAS)

Hypertension, Pulmonary

Switzerland
Providence Health & Services
Eli Lilly and Company

Completed

Chemoimmunotherapy and Radiation in Pancreatic Cancer (CRIT)

Locally Advanced Malignant Neoplasm

United States
IlDong Pharmaceutical Co Ltd

Unknown

The Efficacy and Safety of the Combination of Tamsulosin and Tadalafil in Men With Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia and Erectile Dysfunction

Benign Prostatic Hyperplasia | Erectile Dysfunction

Korea, Republic of
Tianjin Hemay Bio-Tech Co., Ltd

Completed

Safety and Pharmacokinetics of Hemay005 In Healthy Male Subjects

Psoriasis

China
Tetra Discovery Partners

Enrolling by invitation

An Open-Label Extension Study of BPN14770 in Subjects With Fragile X Syndrome

Fragile X Syndrome

United States
National Institutes of Health Clinical Center (CC)

Completed

Evaluation of Hydroxyurea Plus L-arginine or Sildenafil to Treat Sickle Cell Anemia

Sickle Cell Anemia

United States
Pontificia Universidad Catolica de Chile

Completed

Topical 10 % Nifedipine Versus 5% Sildenafil in Secondary Raynaud

Lupus Erythematosus, Systemic | Dermatomyositis | Ultrasound Therapy; Complications | Raynaud Disease | Raynaud Phenomenon Due to Trauma | System; Sclerosis

Chile
Ganzhou Hemay Pharmaceutical Co., Ltd

Not yet recruiting

To Evaluate the Pharmacokinetics of Hemay005 Tablets in Subjects With Liver Damage

Psoriasis
Ganzhou Hemay Pharmaceutical Co., Ltd

Completed

In Vivo Mass Balance Study of [14C]Hemay005

Health Volunteer

China
Mansoura University

Active, not recruiting

Efficacy of Tadalafil/Solifenacin VS Tamsulosin/Solifenacin Combination Therapy for BPH/OAB

Overactive Bladder | Benign Prostatic Hyperplasia

Egypt
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

A Pivotal Bioequivalence Study Between The Sildenafil Powder For Oral Suspension (10 Mg/Ml) And The Sildenafil 10 Mg Immediate Release (IR) Tablet Relative To The Revatio 20 Mg IR Tablet In Healthy Volunteers Under Fasting Conditions

Pulmonary Arterial Hypertention

Belgium
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Bioavailability of 3 Sildenafil Oral Disintegrating Tablet Formulations Compared to the Standard Oral Tablet

Healthy Volunteers

United States
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Assessment Of Sildenafil On Erectile Function And Intercourse Satisfaction And To Validate A New Subject Questionnaire

Impotence

United States
Chong Kun Dang Pharmaceutical

Completed

Clinical Trial To Evaluate the Efficacy and Safety of CKD-397 in Benign Prostatic Hyperplasia Patients

Benign Prostatic Hyperplasia

Korea, Republic of
Pfizer

Completed

A Study To Evaluate The Safety And Tolerability Of Different Doses Of PF-03049423 In Healthy Adult Volunteers And Healthy Older Volunteers

Healthy

Belgium
Eli Lilly and Company

Completed

A Study for Patients With Erectile Dysfunction to Test Whether Tadalafil Taken Once a Day Can Better Improve Psychological Outcomes.

Erectile Dysfunction

Germany, Spain, United States, Australia, Brazil, Italy, Mexico, Puerto Rico, United Kingdom
GlaxoSmithKline

Completed

Healthy Volunteer Positron Emission Tomography (PET) Brain Occupancy Study of a Phosphodiesterase 4 (PDE4) Inhibitor in Huntington's Disease

Huntington Disease

United Kingdom
Ganzhou Hemay Pharmaceutical Co., Ltd

Not yet recruiting

To Evaluate the Pharmacokinetics of Hemay005 Tablets in Patients With Renal Impairment

Psoriasis

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