Search clinical trials for: Phosphodiesterase 5 Inhibitors

Total 68738 results

Ladoke Akintola University of Technology Teaching...

Recruiting

Intrapartum Sildenafil Citrate to Prevent Non Reassuring Foetal Status Among Parturients Delivering at Term

Foetal Hypoxia

Nigeria
Montefiore Medical Center

Completed

Sildenafil To Prevent Clot (SToPClot)

Thrombosis | Hemolysis

United States
University of Zurich

Completed

Effects of Normobaric Hypoxia During Exercise in Patients With Pulmonary Hypertension Receiving Sildenafil (HEXASH)

Hypertension, Pulmonary

Switzerland
Sir Takhtasinhji General Hospital

Completed

Oral Sildenafil in Persistent Pulmonary Hypertension Secondary to Meconium Aspiration Syndrome in Newborns (OSiNPH)

Meconium Aspiration Syndrome | Persistent Pulmonary Hypertension of Newborn

India
Bayer

Completed

Evaluation of the Pharmacodynamic Effect of the Combination of Sildenafil and Riociguat on Blood Pressure and Other Safety Parameters. (PATENT PLUS)

Pulmonary Hypertension

Spain, New Zealand, Germany, Austria, United States, Poland, Italy, United Kingdom, Czech Republic
Bayer

Completed

Assess the Effect of Daily Treatment of Vardenafil 20mg or Sildenafil 100mg and Placebo on Sperm Function

Erectile Dysfunction

United States
Duke University
National Heart, Lung, and Blood Institute (NHLBI); Pfizer

Completed

Evaluating the Effectiveness of Sildenafil at Improving Health Outcomes and Exercise Ability in People With Diastolic Heart Failure (The RELAX Study) (RELAX)

Heart Failure

United States, Canada
Dongkook Pharmaceutical Co., Ltd.

Completed

Efficacy and Safety of DKF-313 in Patients With Benign Prostatic Hyperplasia

Benign Prostatic Hyperplasia

Korea, Republic of
University of Alberta
Canadian Institutes of Health Research (CIHR)

Recruiting

Oral Sildenafil for Exercise Capacity, Dyspnea and Cardiopulmonary Function in COPD

Chronic Obstructive Pulmonary Disease

Canada
Cairo University

Unknown

Combined Effect of Continuous and Interval in Addition to Tadalafil Drug on Erectile Dysfunction

Erectile Dysfunction

Egypt
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Completed

Sildenafil Citrate Before Surgery in Improving Kidney Function in Patients With Kidney Cancer

Kidney Tumor

United States
Cedars-Sinai Medical Center

Completed

PDE Inhibitors in DMD Study (Acute Dosing Study)

Duchenne Muscular Dystrophy

United States
Sidney Kimmel Comprehensive Cancer Center at Johns...
National Cancer Institute (NCI); Lustgarten Foundation

Active, not recruiting

Study of CRS-207, Pembrolizumab, Ipilimumab, and Tadalafil in Metastatic Pancreatic Cancer

Pancreatic Cancer

United States
Rambam Health Care Campus

Unknown

Safety and Clinical Effectiveness of 2 Lower Dose Combined PDE5i's vs. Single Maximal Dose PDE5i

Impotence

Israel
Pfizer

Completed

A Randomized Double Blind, Placebo Controlled Balanced 4-Way Crossover Study To Assess The Efficacy Of Single Oral Doses

Impotence

Norway, United Kingdom
Eli Lilly and Company

Completed

A Study of Tadalafil in Men With Benign Prostatic Hyperplasia (BPH) and Erectile Dysfunction (ED)

Erectile Dysfunction | Benign Prostate Hyperplasia

China
WindMIL Therapeutics
Bristol-Myers Squibb

Terminated

Marrow Infiltrating Lymphocytes - Non-Small Cell Lung Cancer (MILs™ - NSCLC) Alone or in Combination With Nivolumab With or Without Tadalafil in Locally Advanced and Unresectable or Metastatic NSCLC

NSCLC | Lung Cancer | Lung Cancer Metastatic | Lung Cancer, Non-small Cell | Non Small Cell Lung Cancer | Non-small Cell Lung Cancer | Non-small Cell Lung Cancer Metastatic | Non Small Cell Lung Cancer Metastatic

United States
Fayoum University Hospital

Withdrawn

Sildenafil Citrate Added to Low Molecular Weight Heparin and Low Dose Aspirin in High-risk Pregnancy

High Risk Pregnancy

Egypt
Eli Lilly and Company

Completed

A Study of Tadalafil in Men With Benign Prostatic Hyperplasia

Benign Prostatic Hyperplasia (BPH)

Italy, France, Belgium, Australia, Greece, Austria, Netherlands, Germany, Mexico, Poland
Actelion

Terminated

Clinical Study Evaluating the Effects of First-line Oral cOmbination theraPy of maciTentan and tadalafIl in Patients With Newly Diagnosed pulMonary Arterial Hypertension (OPTIMA) (OPTIMA)

Pulmonary Arterial Hypertension

France
Ain Shams University
Drug Research Centre, Cairo, Egypt

Completed

A Comparative Pharmacokinetic and Pharmacodynamic Study of Sildenafil in Adult Smokers and Non Smokers

Smoking | Erectile Dysfunction | Pharmacokinetics | Pharmacodynamics

Egypt
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Assess the Efficacy and Safety of Sildenafil When Added to Bosentan in the Treatment of Pulmonary Arterial Hypertension

Pulmonary Arterial Hypertension

United States, Czechia, Germany, Israel, France, Australia, Taiwan, Greece, Italy, United Kingdom
Bayer
GlaxoSmithKline

Completed

FDA Phase IV - Commitment - Retinal Function Study

Safety
Rigshospitalet, Denmark

Completed

Combination Treatment With Bosentan and Sildenafil to Patients With Eisenmengers Syndrome

Eisenmenger Syndrome

Denmark
Nanjing First Hospital, Nanjing Medical University

Terminated

A Study to Investigate the Efficacy of PADN to Improved Functional Capacity and Hemodynamics in Patients With PAH (PADN-PAH)

Pulmonary Arterial Hypertension

China
International Islamic University, Islamabad

Completed

Psychotherapy and Pharmacotherapy in the Treatment of Erectile Dysfunction: A Pilot Study

Erectile Dysfunction

Pakistan
Vanderbilt University Medical Center

Completed

Effect of Prolonged PDE-5 Inhibition on Insulin Signaling in Skeletal Muscle.

Metabolic Syndrome

United States
Hospital Universitari Vall d'Hebron Research Institute

Unknown

Effectiveness of the Vasodilator Test With Revatio, Made in Patients With Acute Pulmonary Hypertension

Pulmonary Hypertension

Spain
VIVUS LLC

Completed

Study to Evaluate Hemodynamic Response to to a Sublingual Dose of Glyceryl Trinitrate in Subjects Receiving TA-1790, Sildenafil Citrate, and Placebo

Erectile Dysfunction

United States
NICHD Neonatal Research Network
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Active, not recruiting

Milrinone in Congenital Diaphragmatic Hernia

Persistent Pulmonary Hypertension of the Newborn | Congenital Diaphragmatic Hernia | Hypoxemic Respiratory Failure | Pulmonary Hypoplasia

United States
University of Alberta

Recruiting

The Impact of Sildenafil on the Pulmonary Circulation in Healthy Trained and Untrained Humans

Healthy

Canada
Eric A. Hoffman
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health...

Recruiting

Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema

Emphysema

United States
Bayer

Completed

Riociguat rEplacing PDE-5i Therapy evaLuated Against Continued PDE-5i thErapy (REPLACE)

Pulmonary Arterial Hypertension

Belgium, France, Spain, Portugal, Turkey, United States, Germany, Korea, Republic of, Mexico, Austria, Canada, Denmark, Poland, Italy, Greece, Taiwan, Czechia, Netherlands, Japan, Brazil, United Kingdom
Johns Hopkins University
Eli Lilly and Company; National Heart, Lung, and Blood Institute (NHLBI); The... and other collaborators

Completed

A Clinical Trial of Ambrisentan and Tadalafil in Pulmonary Arterial Hypertension Associated With Systemic Sclerosis (ATPAHSS)

Systemic Sclerosis | Pulmonary Arterial Hypertension | Pulmonary Hypertension | Connective Tissue Disease | Scleroderma Spectrum of Diseases

United States
Al Hayat National Hospital
Menoufia University

Unknown

Management of Acute Preterm Labor: Nifedipen Alone or Combined With Cildenafil Citrate

Labor Preterm Requiring Hospitalization

Egypt, Saudi Arabia
Kerckhoff Heart Center
Pfizer

Completed

VasoREACTivity Testing With Intravenous SILdenafil in Patients With Precapillary Pulmonary Hypertension (SIL-REACT)

Pulmonary Hypertension Associated With Connective Tissue Disease

Germany
University of Edinburgh
Pfizer

Completed

Blood Pressure Interaction Between Sildenafil and Sublingual Glyceryl Trinitrate (GTN) in Men With Angina

Angina Pectoris

United Kingdom
Kasr El Aini Hospital

Completed

Low Dose Tadalafil for Treatment of Female OAB Syndrome: Short Term Follow up.

Female Patients With Overactive Bladder Syndrome or Female Patients With Urgency or Urgency Urinary Incontinence

Egypt
Respira Therapeutics, Inc.

Recruiting

Vardenafil Inhaled for Pulmonary Arterial Hypertension PRN Phase 2B Study (VIPAH-PRN 2B)

Pulmonary Arterial Hypertension

United States
Institute for the Study of Urological Diseases,...

Recruiting

Low-intensity Shockwaves Therapy + Tadalafil 5mg for the Treatment of Severe Erectile Dysfunction

Erectile Dysfunction

Greece
Respira Therapeutics, Inc.

Completed

A Dose Escalation Study to Evaluate the Effect of RT234 in Subjects With Pulmonary Arterial Hypertension

Pulmonary Arterial Hypertension

Australia
Augusta University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Blood Flow and Vascular Function in Cystic Fibrosis (CF-FLOW)

Cystic Fibrosis

United States
Pfizer

Terminated

A Pharmacokinetic Drug-Drug Interaction (DDI) Study Between Sitaxsentan And Sildenafil, And Between Sitaxsentan And Tadalafil After Multiple Doses

Pulmonary Arterial Hypertension

Singapore
Pfizer

Completed

Study to Investigate Effect of a New Drug (PF-00446687) in Males Suffering From Erectile Dysfunction

Erectile Dysfunction

Norway, United Kingdom
The University of Texas Medical Branch, Galveston

Completed

The Effect of Sildenafil and Tadalafil on Skeletal Muscle and Perceptual Fatigue

Fatigue

United States
Actelion

Completed

The Efficacy and Safety of Initial Triple Versus Initial Dual Oral Combination Therapy in Patients With Newly Diagnosed Pulmonary Arterial Hypertension (TRITON)

Pulmonary Arterial Hypertension

United States, Spain, Denmark, Canada, Germany, United Kingdom, Belgium, Austria, Netherlands, Australia, France, Ireland, Sweden, Italy, Switzerland
Case Comprehensive Cancer Center
The Cleveland Clinic; University Hospitals Cleveland Medical Center

Terminated

Improving Erectile Function and Quality of Life After Prostate Cancer Treatment

Erectile Dysfunction | Prostate Cancer | Erectile Dysfunction Following Radical Prostatectomy | Erectile Dysfunction Following Simple Prostatectomy

United States
Ain Shams University

Unknown

Sildenafil Citrate of in Vitro Fertilization After Multiple IVF Failures Attributed to Poor Endometrial Development

IVF Failure

Egypt
Bayer

Completed

Assess Efficacy in Subjects With Traumatic Spinal Cord Injury (LEMDE)

Erectile Dysfunction | Spinal Cord Injury

Spain
Laboratório Teuto Brasileiro S/A

Unknown

A Study to Evaluate a Possible Superiority Expressed by the Faster Onset of Action and the Efficacy and Safety of Sildenafil Citrate 20mg Sublingual Tablet in the Treatment of Erectile Dysfunction of Different Etiologies

Erectile Dysfunction

Brazil

Search clinical trials for: Phosphodiesterase 5 Inhibitors

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